The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia
Open accessAbstract
Neuroinflammation is a common phenomenon in the pathology of many brain diseases. In this paper we explore whether selected vitamins and fatty acids known to modulate inflammation exert an effect on microglia, the key cell type involved in neuroinflammation. Previously these nutrients have been shown to exert anti-inflammatory properties acting on specific inflammatory pathways. We hypothesized that combining nutrients acting on converging anti-inflammatory pathways may lead to enhanced anti-inflammatory properties as compared to the action of a single nutrient. In this study, we investigated the anti-inflammatory effect of combinations of nutrients based on the ability to inhibit the LPS-induced release of nitric oxide and interleukin-6 from BV-2 cells. Results show that omega-3 fatty acids, vitamins A and D can individually reduce the LPS-induced secretion of the pro-inflammatory cytokines by BV-2 cells. Moreover, we show that vitamins A, D and omega-3 fatty acids (docosahexaenoic and eicosapentaenoic) at concentrations where they individually had little effect, significantly reduced the secretion of the inflammatory mediator, nitric oxide, when they were combined. The conclusion of this study is that combining different nutrients acting on convergent anti-inflammatory pathways may result in an increased anti-inflammatory efficacy.
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Lifetime omega-3 fatty acid, vitamin, sulforaphane, and prebiotic supplementation are effective universal prevention interventions to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis.
“lifetime omega-3 fatty acid [56–58], vitamin [57–59], sulforaphane [60], and prebiotic [61] supplementation to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [58]
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- Authors
- Kurtys, E., Eisel, U. L. M., Verkuyl, J. M., Broersen, L. M., Dierckx, R. A. J. O., & de Vries, E. F. J.
- Affiliations
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Nutricia Research (Netherlands) (NL)
- Venue
- Neurochemistry International
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 99
- Pages
- 206-214
- ISSN
- 0197-0186 (ISSN-L)
- OpenAlex
- W2502273697
- Cited by
- 40
- References
- 47
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 5 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 7
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurochemistry International (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- Danone
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- neuroinflammation, microglia, omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, vitamin A, vitamin D, anti-inflammatory activity, nitric oxide, interleukin-6, lipopolysaccharide, BV-2 cells, inflammatory cytokines
- MeSH terms
- Animals, Anti-Inflammatory Agents, Cell Line, Drug Therapy, Combination, Inflammation, Vitamin A, Vitamin D, Vitamins, Fatty Acids, Omega-3, Microglia, Inflammation Mediators, Mice
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