Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice
Abstract
Intestinal barrier involves in the pathogeny of inflammatory bowel disease (IBD) and hydrogen sulfide (H2S) has been reported to improve intestinal barrier integrity. Thus, this study investigated the effects of GYY4137, a slow-release H2S donor, on DSS-induced inflammation and intestinal dysfunction. In vitro model, cellular permeability was significantly increased and expression of tight junctions (ZO-1, Cauldin4, and Occludin) was downregulated in Caco-2 cells. GYY4137 treatment markedly attenuated DSS-induced inflammation and barrier dysfunction. Cystathionine β-synthase (CBS)-siRNA transfection further demonstrated that endogenous H2S system involves in DSS-induced inflammation and mediates barrier function. In vivo model, DSS exposure caused colonic inflammation and injury in mice and GYY4137 injection alleviated inflammatory response and improved intestinal barrier via reducing intestinal permeability and upregulating of tight junctions. In conclusion, endogenous H2S system involves in DSS-induced inflammation and H2S addition alleviated inflammation and intestinal dysfunction in vitro and in vivo.
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Lower concentrations of endogenously derived H2S exert beneficial cytoprotective, antioxidant and anti-inflammatory actions.
“On one hand, it appears that lower concentrations of endogenously derived H2S exert beneficial cytoprotective, antioxidant and anti-inflammatory actions[344,348–351]”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [349]
Cites
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works
Hydrogen sulfide protects neurons from oxidative stress
Kimura, Y., & Kimura, H. (2004) · The FASEB Journal · doi:10.1096/fj.04-1815fje · Cited by 874 · see citing works
Intestinal Permeability Regulation by Tight Junction: Implication on Inflammatory Bowel Diseases
Lee, S. H. (2015) · Intestinal Research · doi:10.5217/ir.2015.13.1.11 · Cited by 810 · see citing works
Intestinal barrier in inflammatory bowel disease
Antoni, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1165 · Cited by 416 · see citing works
Lee, Z., Zhou, J., Chen, C.-S., Zhao, Y., Tan, C., Li, L., Moore, P. K., & Deng, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021077 · Cited by 382 · see citing works
l ‐Cysteine metabolism and its nutritional implications
Yin, J., Ren, W., Yang, G., Duan, J., Huang, X., Fang, R., Li, C.-Y., Li, Y., Yin, Y., Hou, Y., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500031 · Cited by 355 · see citing works
Role of the intestinal barrier in inflammatory bowel disease
Laukoetter, M. G., Nava, P., & Nusrat, A. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.401 · Cited by 301 · see citing works
Inflammation and nerve fiber interaction in endometriotic pain
McKinnon, B. D., Bertschi, D., Bersinger, N. A., & Mueller, M. D. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.10.003 · Cited by 214 · see citing works
Liu, Z., Han, Y., Li, L., Lu, H., Meng, G., Li, X., Atan, M. S. B. M., Peh, M. T., Xie, L., Zhou, S., et al. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12246 · Cited by 181 · see citing works
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
Herder, C., Dalmas, É., Böni‐Schnetzler, M., & Donath, M. Y. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.08.001 · Cited by 169 · see citing works
Shi, C., Liang, Y., Yang, J., Xia, Y., Chen, H., Han, H., Yang, Y. P., Wu, W., Gao, R., & Qin, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066814 · Cited by 163 · see citing works
Mikami, Y., Shibuya, N., Kimura, Y., Nagahara, N., Yamada, M., & Kimura, H. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.298208 · Cited by 141 · see citing works
Role of interleukins in obesity: implications for metabolic disease
Febbraio, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.004 · Cited by 130 · see citing works
Vlantis, K., Polykratis, A., Welz, P.-S., Loo, G., Pasparakis, M., & Wullaert, A. (2015) · Gut · doi:10.1136/gutjnl-2014-308323 · Cited by 126 · see citing works
Yin, J., Duan, J., Cui, Z., Ren, W., Li, Y., & Yin, Y. (2015) · RSC Advances · doi:10.1039/c4ra13557a · Cited by 125 · see citing works
Flannigan, K. L., Agbor, T. A., Blackler, R. W., Kim, J., Khan, W. I., Verdu, E. F., Ferraz, J. G., & Wallace, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1413390111 · Cited by 97 · see citing works
Hirata, I., Naito, Y., Takagi, T., Mizushima, K., Suzuki, T., Omatsu, T., Handa, O., Ichikawa, H., Ueda, H., & Yoshikawa, T. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1461-5 · Cited by 72 · see citing works
Chen, S.-W., Zhu, J., Zuo, S., Zhang, J., Chen, Z., Chen, G., Wang, X., Pan, Y., Liu, Y., & Wang, P. (2015) · Inflammation Research · doi:10.1007/s00011-015-0862-5 · Cited by 69 · see citing works
Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling
Rios, E. C. S., Szczęsny, B., Soriano, F. G., Oláh, G., & Szabó, C. (2015) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2015.2176 · Cited by 65 · see citing works
Geng, Y., Li, E., Mu, Q., Zhang, Y., Wei, X., Li, H., Cheng, L., & Zhang, B. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.223 · Cited by 59 · see citing works
Xu, W., Chen, J., LIN, J., LIU, D., Mo, L., Pan, W., Feng, J., Wu, W., & Zheng, D. (2014) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2014.2007 · Cited by 59 · see citing works
Type 1 Diabetes and Dysfunctional Intestinal Homeostasis
D’Addio, F., & Fiorina, P. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.04.005 · Cited by 47 · see citing works
Cheng, J., Zhang, L., Dai, W., Mao, Y., Li, S., Wang, J., Li, H., Guo, C., & Fan, X. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.083 · Cited by 37 · see citing works
Chloride Channel ClC-2 is a Key Factor in the Development of DSS-induced Murine Colitis
Nighot, P. K., Young, K. M., Nighot, M., Rawat, M., Sung, E. J., Maharshak, N., Plevy, S. E., Ma, T., & Blikslager, A. T. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a82ae9 · Cited by 33 · see citing works
Fermented milk derives bioactive peptides with antihypertensive effects
Shori, A. B., & Baba, A. S. (2015) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000126 · Cited by 21 · see citing works
Rashti, Z., & Koohsari, H. (2015) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000129 · Cited by 11 · see citing works
Ranganathan, P. V., Jayakumar, C., Li, D. Y., & Ramesh, G. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12280 · Cited by 10 · see citing works
Gut Microbiota Cool-Down Burning Fat! The Immune Hypothesis
Burcelin, R., & Pomié, C. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.12.002 · Cited by 9 · see citing works
Status of food intake and elemental nutrition in patients with Crohn’s disease
Yamaguchi, M., & Emory University School of Medicine (2015) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000118 · Cited by 9 · see citing works
Howell, K. S., Yan, F., Tokich, A., & Ng, K. (2015) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000127 · Cited by 7 · see citing works
Effect of Broccoli Intake on Antioxidants in the Liver and Kidneys Tissues of Hyperglycemic Rats
El-Hendy, H. A. R., & El-Hendy, H. H. A. R. (2013) · Alexandria Science Exchange Journal · doi:10.21608/asejaiqjsae.2013.159251 · Cited by 6 · see citing works
Effect of body composition intake with nano-lactic acid in rats
centigrade, W. R. W. I. H. I. C. A. T. O. 2. ±. 1. D., feeding, A. 4.-6. H. A. B. 2. W. B. O. P., water, 2. R. W. D. 4. G. E. 5. R. A. W. F. S. C. P. F. D. A., control (group: C) as high-carb meal (344 kcal/100g), style, J., high-carb meal with high levels lactobacillus (group: CL), high-fat same calorifacient feed (597 kcal/100g) and water (group: F), high-fat meal with high levels lactobacillus (group: FL), law, A. F. C. T. O. A. D. I. W. D. T. L. 5. B. P. 1. B. O. R. S. T. T. A. E. W. C. O. I. A. W. T. J., which allows experiments on laboratory animals in Nippon Sport Science University accordance to the principle of laboratory animal care. During the experimental period of two weeks body weight was measured every one week. After two weeks of experimental feed, et al. (2015) · Integrative Food Nutrition and Metabolism · doi:10.15761/ifnm.1000120 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Szabó, C., & Papapetropoulos, A. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014050 · Cited by 423 · see citing works
Desulfovibrio in the Gut: The Enemy within?
Singh, S., Carroll‐Portillo, A., & Lin, H. C. (2023) · Microorganisms · doi:10.3390/microorganisms11071772 · Cited by 268 · see citing works
Koch, C. D., Gladwin, M. T., Freeman, B. A., Lundberg, J. O., Weitzberg, E., & Morris, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.015 · Cited by 186 · see citing works
Blachier, F., Andriamihaja, M., Larraufie, P., Ahn, E., Lan, A., & Kim, E. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00261.2020 · Cited by 175 · see citing works
Yan, L., Gu, Q.-S., Jiang, W., Tan, M., Tan, Z.-K., Mao, G.-J., Fen, X., & Li, C. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.1c04169 · Cited by 153 · see citing works
The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis
Puri, P., Liangpunsakul, S., Christensen, J. E., Shah, V. H., Kamath, P. S., Gores, G. J., Walker, S., Comerford, M., Katz, B. P., Borst, A. J., et al. (2017) · Hepatology · doi:10.1002/hep.29623 · Cited by 128 · see citing works
Zhang, J., Li, C., Zhang, X., Tang, C., Chen, Y., Zhang, Y., Yu, M., Lü, C., Li, M., Li, S., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102469 · Cited by 110 · see citing works
Barnig, C., Bezema, T., Calder, P. C., Charloux, A., Frossard, N., Garssen, J., Haworth, O., Dilevskaya, K., Levi‐Schaffer, F., Lonsdorfer‐Wolf, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01699 · Cited by 99 · see citing works
Protective Actions of H 2 S in Acute Myocardial Infarction and Heart Failure
Donnarumma, E., Trivedi, R. K., & Lefer, D. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160023 · Cited by 96 · see citing works
Oh, C., Lee, W., Park, J., Choi, J., Lee, S., Li, S., Jung, H. N., Lee, J.-S., Hwang, J.-E., Park, J., et al. (2023) · ACS Nano · doi:10.1021/acsnano.2c08898 · Cited by 72 · see citing works
Role of Hydrogen Sulfide in Inflammatory Bowel Disease
Stummer, N., Feichtinger, R. G., Weghuber, D., Kofler, B., & Schneider, A.-M. (2023) · Antioxidants · doi:10.3390/antiox12081570 · Cited by 71 · see citing works
Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells
Zhuang, S., Zhong, J., Zhou, Q., Zhong, Y., Liu, P., & Liu, Z. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.03.030 · Cited by 69 · see citing works
Hydrogen sulfide protects against DSS-induced colitis by inhibiting NLRP3 inflammasome
Qin, M., Long, F., Wu, W., Yang, D., Huang, M., Xiao, C., Chen, X., Liu, X., & Zhu, Y. Z. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.04.025 · Cited by 66 · see citing works
Gasotransmitters and the immune system: Mode of action and novel therapeutic targets
Fagone, P., Mazzon, E., Bramanti, P., Bendtzen, K., & Nicoletti, F. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.07.026 · Cited by 63 · see citing works
Role of hydrogen sulfide in health and disease
Jin, Y., Yuan, H., Liu, Y., Zhu, Y., Wang, Y., Liang, X., Gao, W., Ren, Z., Ji, X., & Wu, D. (2024) · MedComm · doi:10.1002/mco2.661 · Cited by 54 · see citing works
Contribution of sulfate-reducing bacteria to homeostasis disruption during intestinal inflammation
Figliuolo, V. R., Coutinho‐Silva, R., & Coutinho, C. M. L. M. (2018) · Life Sciences · doi:10.1016/j.lfs.2018.11.009 · Cited by 51 · see citing works
Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis
Li, S., Zhang, Y., Li, K., Liu, Y., Chi, S., Wang, Y., & Tang, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054602 · Cited by 48 · see citing works
Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter
Liu, J., Mesfin, F. M., Hunter, C., Olson, K. R., Shelley, W. C., Brokaw, J. P., Manohar, K., & Markel, T. A. (2022) · Antioxidants · doi:10.3390/antiox11091788 · Cited by 43 · see citing works
Chen, K.-J., Chen, Y., Ueng, S., Hwang, T., Kuo, L.-M., & Hsieh, P. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111152 · Cited by 42 · see citing works
Effects of gut microbiota on atherosclerosis through hydrogen sulfide
Gui, D.-D., Luo, W., Yan, B., Ren, Z., Tang, Z., Liu, L.-S., Zhang, J., & Jiang, Z.-S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.173916 · Cited by 40 · see citing works
Role of Gut Microbial Metabolites in Cardiovascular Diseases—Current Insights and the Road Ahead
Datta, S., Pasham, S., Sandeep, I. S., Boini, K. M., & Koka, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810208 · Cited by 42 · see citing works
Hydrogen Sulfide Plays an Important Role by Influencing NLRP3 inflammasome
Wang, H., Shi, X., Qiu, M., Lv, S., Zheng, H., Niu, B., & Liu, H. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47595 · Cited by 40 · see citing works
Xu, Z., Yan, Z., Qiao, R., Cao, S., Fang, Y., Bo, X., Zhu, H., Ying, C., Sun, Y. X., & Zheng, J. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.141000 · Cited by 34 · see citing works
Chen, G., Kuang, Z., Li, F., & Li, J. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1293333 · Cited by 30 · see citing works
Hayes, J. A., Lunger, A. W., Sharma, A. S., Fernez, M. T., Carrier, R. L., Koppes, A. N., Koppes, R. A., & Woolston, B. M. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113481 · Cited by 27 · see citing works
Sun, N., Cao, L.-S., Xia, W.-Y., Wang, J., & Wu, Q. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03500-9 · Cited by 24 · see citing works
Sato, N., García-Castillo, V., Yuzawa, M., Islam, M. A., Albarracín, L., Tomokiyo, M., Ikeda‐Ohtsubo, W., García, A., Takahashi, H., Villena, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02174 · Cited by 23 · see citing works
Tomuschat, C., O’Donnell, A. M., Coyle, D., & Puri, P. (2017) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2017.06.011 · Cited by 22 · see citing works
Chen, K.-J., Huang, Y., Kuo, L.-M., Chen, Y., Hung, C., & Hsieh, P. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154092 · Cited by 22 · see citing works
González-Quilen, C., Grau‐Bové, C., Jorba, R., Caro, A., Pinent, M., Ardèvol, A., Beltrán‐Debón, R., Terra, X., & Blay, M. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02222-3 · Cited by 22 · see citing works
TLR2 and TLR4 interact with sulfide system in the modulation of mouse colonic motility
Grasa, L., Abecia, L., Peña‐Cearra, A., Robles, S., Layunta, E., Latorre, E., Mesonero, J. E., & Forcén, R. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13648 · Cited by 13 · see citing works
Liu, Y., Liao, R., Qiang, Z., Yang, W., Cao, J., & Zeng, H. (2021) · DNA and Cell Biology · doi:10.1089/dna.2020.6380 · Cited by 13 · see citing works
The Role of H2S in the Gastrointestinal Tract and Microbiota
Xiao, A., Liu, C., & Li, J. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-16-0991-6_4 · Cited by 13 · see citing works
Jia, Y., Liu, X., Gao, X., Yin, S., Wu, K., Meng, X., Ren, H. J., Liu, J., Liu, Z., Li, H., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156827 · Cited by 11 · see citing works
Casertano, M., Esposito, E., Bello, I., Indolfi, C., Putra, M. Y., Mannelli, L. D. C., Ghelardini, C., Menna, M., Sorrentino, R., Cirino, G., et al. (2023) · Marine Drugs · doi:10.3390/md21120641 · Cited by 10 · see citing works
Protective Actions of H 2 S in Acute Myocardial Infarction and Heart Failure
Donnarumma, E., Trivedi, R. K., & Lefer, D. J. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00754.x · Cited by 10 · see citing works
Role of Pyroptosis in inflammatory bowel disease.
Xiao, Z., Xie, J.-L., Zhao, X., Chen, X.-J., Lu, Y.-H. C. S., Xu, Y., Wu, M., An, L., & Li, Q. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114619 · Cited by 11 · see citing works
Wang, X.-M., Huang, H., Sun, X., Wei, R.-Q., Chen, H. Y., Liu, C., & Liu, S. (2025) · Microorganisms · doi:10.3390/microorganisms13040916 · Cited by 10 · see citing works
Bidirectional Mendelian randomization links gut microbiota to primary biliary cholangitis
Zhou, Z., Li, W., Wu, Y., Wang, T., Zhang, J., You, L., Li, H., Zheng, C., Gao, Y., & Sun, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-79227-z · Cited by 8 · see citing works
The Physicochemical, Sensory, and Functional Properties of Yogurt Containing Millet and Milk
Wang, H., Zhang, Y., Han, Y., Hou, J., Zuo, Y., Li, Y., & Wu, H. (2025) · Foods · doi:10.3390/foods14203491 · Cited by 8 · see citing works
Cicchinelli, S., Gemma, S., Pignataro, G., Piccioni, A., Ojetti, V., Gasbarrini, A., Franceschi, F., & Candelli, M. (2024) · Pharmaceuticals · doi:10.3390/ph17040490 · Cited by 8 · see citing works
A novel colorimetric NIR fluorescent probe for turn-on detection and imaging of hydrogen sulfide
Lu, G., Duan, L., Hu, Q., Meng, S., Cai, P., Chen, Y., Wang, X., & Dong, T. (2023) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2023.115309 · Cited by 8 · see citing works
Oh, C., Hwang, J.-E., Yim, H., Park, H., Kim, S.-Y., Lee, J. K., & Im, H. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03753-9 · Cited by 7 · see citing works
Mackos, A. R., Allen, J. M., Kim, E., Ladaika, C., Gharaibeh, R. Z., Moore, C. C., Parry, N. M., Boyaka, P. N., & Bailey, M. T. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02062 · Cited by 6 · see citing works
Pan, S., Yan, H., Zhu, J., Ma, Y., Wang, P., Liu, Y., & Chen, Z. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1476407 · Cited by 6 · see citing works
Mazzei, A., Serino, G., Romano, A., Piccinno, E., Scalavino, V., Valentini, A. M., Armentano, R., Schiavone, R., Giannelli, G., Verri, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113170 · Cited by 6 · see citing works
Update of gut gas metabolism in ulcerative colitis
Zhang, X., Zhang, X., & Yang, Y. (2024) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2024.2383635 · Cited by 6 · see citing works
A Promising Biomimetic Hydrogen Sulfide System for Advancing Inflammatory Disease Treatment
Qiao, C., Wang, L., Zhang, R., Shi, Y., Huang, C., Ji, Y., Yang, Z., Feng, Y., Chen, Z., Liu, J., et al. (2025) · Advanced Materials · doi:10.1002/adma.202510602 · Cited by 5 · see citing works
Wang, S., Ding, Y., & Jiang, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.966881 · Cited by 5 · see citing works
Xie, Z., Eriksen, D. B., Johnsen, P. R., Nielsen, D. S., & Frøkiær, H. (2025) · BioFactors · doi:10.1002/biof.70007 · Cited by 4 · see citing works
Gas entrapping materials for damage control
Alves, P. K. N., Sutton, I. C., Byrne, J. D., & Otterbein, L. E. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115813 · Cited by 3 · see citing works
Akahoshi, N., Hasegawa, R., Yamamoto, S., Takemoto, R., Yoshizawa, T., Kamichatani, W., & Ishii, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032659 · Cited by 3 · see citing works
Rivera, D. S., Beltrán, V., Gutiérrez-Cortés, I., Vargas, C., & Alfaro, F. D. (2024) · Microorganisms · doi:10.3390/microorganisms12061194 · Cited by 3 · see citing works
Chin, K. T.-C., Yiu, J. H. C., Cheung, K. W., Yuen, L. C., Wong, W. Y.-L., Cai, J., Cheung, S. W. M., Li, R., & Woo, C. W. (2025) · iScience · doi:10.1016/j.isci.2025.111933 · Cited by 2 · see citing works
Almenas, F. A., Törő, G., Szaniszlo, P., Maskey, M., Thanki, K. K., Koltun, W. A., Yochum, G. S., Pinchuk, I. V., Chao, C., Hellmich, M. R., et al. (2024) · Antioxidants · doi:10.3390/antiox13091067 · Cited by 2 · see citing works
Kim, T. E., Son, S., Rho, Y., & Shin, K. (2026) · Nutrition Research and Practice · doi:10.4162/nrp.2026.20.2.182 · Cited by 1 · see citing works
Richie, T. G., Wiechman, H., Vogt, B., Ingold, C., Heeren, L., Kamke, A., Pogranichniy, S., Monk, K., Summers, T., Ran, Q., et al. (2026) · Microbiome · doi:10.1186/s40168-026-02457-y · Cited by 5 · see citing works
DXFD-1 alleviates DSS-induced ulcerative colitis by targeting NF-κB and Nrf2 signaling
Li, S., Fu, X., Cheng, C., Zhao, Y., Wu, T., & Xu, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115934
Hou, W., Wang, S., Tan, M., & Ran, H. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.214941
Yuan, Y., Zhang, Z.-Y., Li, X., Liu, X.-Y., Ma, Z.-X., Lv, M.-C., Yu, Z.-P., & Li, Y. (2026) · Small · doi:10.1002/smll.74979
Sun, Y., Lv, J., Meng, X., Sun, Y., Fu, H., Xu, W., & Du, Z. (2026) · Life · doi:10.3390/life16081355
- Authors
- Zhao, H., Yan, R., Zhou, X., Ji, F., & Zhang, B.
- Affiliations
- Xinjiang Medical University (CN)
- Corresponding author
- Zhang, Bing
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 39
- Pages
- 121-127
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2499516840
- Cited by
- 61
- References
- 33
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 1
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- hydrogen sulfide, GYY4137, intestinal barrier integrity, DSS-induced colitis, inflammatory bowel disease, tight junctions, intestinal permeability, cystathionine beta-synthase, Caco-2 cells, colonic inflammation
- MeSH terms
- Animals, Cell Membrane Permeability, Colitis, Colon, Cystathionine beta-Synthase, Female, Humans, Hydrogen Sulfide, Mice, Inbred Strains, Morpholines, Organothiophosphorus Compounds, Dextran Sulfate, Caco-2 Cells, Tight Junctions, RNA, Small Interfering, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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