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Cited by 32Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

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Jovasevic, Vladimir, Zhang, Hui, Sananbenesi, Farahnaz, Guedea, Anita L., Soman, Kizhake V., Wiktorowicz, John E., Fischer, Andre, Radulovic, Jelena·2021·iScience
DOI 10.1016/j.isci.2021.102617PMC PMC8185192
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Abstract

It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales. Early mechanisms of memory formation (synaptic consolidation) have been extensively characterized. However, delayed mechanisms, which maintain hippocampal activity as memories stabilize in cortical circuits, are not well understood. Here we demonstrate that contrary to the transient expression of early- and delayed-response genes, the expression of cytoskeleton- and extracellular matrix-associated genes remains dynamic even at remote time points. The most profound expression changes clustered around primary cilium-associated and collagen genes. These genes most likely contribute to memory by stabilizing perineuronal nets in the dorsohippocampal CA1 subfield, as revealed by targeted disruptions of the primary cilium or perineuronal nets. The findings show that nonsynaptic, primary cilium-mediated mechanisms are required for the persistence of context memory.

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  • Neuron-specific inhibition of primary cilium formation has no impact on short-term memory but impairs long-term memory retention.

    “Furthermore, the neuron-specific inhibition of primary cilium formation showed no impact on short-term memory but resulted in impaired long-term memory retention (Jovasevic et al. 2021).”

    From Astrocyte-specific inhibition of the primary cilium suppresses C3 expression in reactive astrocyte (2024) · cites this paper as Jovasevic et al. 2021

    The Results (Figure 2 and accompanying text; page unavailable) report that depleting primary cilia in mouse hippocampal CA1 did not impair recent memory tested at day 4, but impaired remote memory at days 21–35. This supports the retention finding, but the paper tested recent versus remote memory, not short-term memory in the usual sense. (LLM, conf=0.86)

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Authors
Jovasevic, V., Zhang, H., Sananbenesi, F., Guedea, A. L., Soman, K. V., Wiktorowicz, J. E., Fischer, A., & Radulovic, J.
Affiliations
  • Northwestern University (US)
  • Albert Einstein College of Medicine (US)
  • German Center for Neurodegenerative Diseases (DE)
  • The University of Texas Medical Branch at Galveston (US)
Corresponding author
Jovasevic, Vladimir
ORCID
Venue
iScience
Publisher
Elsevier BV
Published
2021-06
Volume
24
Issue
6
Pages
102617
ISSN
2589-0042 (ISSN-L)
DOI
10.1016/j.isci.2021.102617
PMC
PMC8185192
OpenAlex
W3165518847
Cited by
32
References
9
Citations by year
2026: 7 · 2025: 11 · 2024: 9 · 2023: 2 · 2022: 2 · 2021: 1
FWCI
1.83
Type
journal article
Language
en
Open access
Licence
Locations
  • iScience (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • DZNE Pub (submittedVersion, cc-by-nc-nd)
Funders
National Institute of Mental Health (MH078064)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
primary cilia, perineuronal nets, memory consolidation, episodic memory, hippocampus, CA1, contextual memory, extracellular matrix, collagen genes, cytoskeletal genes, gene expression dynamics, memory stabilization

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