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From molecules to behavior: Implications for perineuronal net remodeling in learning and memory

Sanchez, B., Kraszewski, P., Lee, S., & Cope, E. C. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.16036 · Cited by 37 · see citing works

Overexpression of Protein Kinase Mζ in the Prelimbic Cortex Enhances the Formation of Long-Term Fear Memory

Xue, Y.-X., Zhu, Z., Han, H.-B., Liu, J., Meng, S., Chen, C., Yang, J., Wu, P., & Lü, L. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.56 · Cited by 34 · see citing works

Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons

Mohan, V., Wyatt, E. V., Gotthard, I., Phend, K. D., Diestel, S., Duncan, B. W., Weinberg, R. J., Tripathy, A., & Maness, P. F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00346 · Cited by 34 · see citing works

Regulation of the E/I-balance by the neural matrisome

Mueller-Buehl, C., Wegrzyn, D., Bauch, J., & Faissner, A. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1102334 · Cited by 32 · see citing works

Fear Erasure Facilitated by Immature Inhibitory Neuron Transplantation

Yang, W., Liu, T., Cao, J.-W., Chen, X.-F., Liu, X., Wang, M., Su, X., Zhang, S., Qiu, B., Hu, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.11.018 · Cited by 33 · see citing works

Reduced perineuronal net expression in Fmr1 KO mice auditory cortex and amygdala is linked to impaired fear-associated memory

Reinhard, S. M., Rais, M., Afroz, S., Hanania, Y., Pendi, K., Espinoza, K., Rosenthal, R., Binder, D. K., Ethell, I. M., & Razak, K. A. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107042 · Cited by 33 · see citing works

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

Jovasevic, V., Zhang, H., Sananbenesi, F., Guedea, A. L., Soman, K. V., Wiktorowicz, J. E., Fischer, A., & Radulovic, J. (2021) · iScience · doi:10.1016/j.isci.2021.102617 · Cited by 32 · see citing works

Distinct roles for hyaluronan in neural stem cell niches and perineuronal nets

Su, W., Matsumoto, S. G., Sorg, B. A., & Sherman, L. S. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.01.022 · Cited by 32 · see citing works

Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice

Dubišová, J., Burianova, J. S., Svobodová, L., Makovický, P., Martínez-Varea, N., Cimpean, A., Fawcett, J. W., Kwok, J. C. F., & Kubinová, Š. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.01.011 · Cited by 31 · see citing works

Chondroitin sulfate proteoglycans: key modulators of neuronal plasticity, long-term memory, neurodegenerative, and psychiatric disorders

Yang, X. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0117 · Cited by 29 · see citing works

NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression

Bertocchi, I., Mele, P., Ferrero, G., Oberto, A., Carulli, D., & Eva, C. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108425 · Cited by 26 · see citing works

Hyaluronan degradation and release of a hyaluronan-aggrecan complex from perineuronal nets in the aged mouse brain

Sugitani, K., Egorova, D., Mizumoto, S., Nishio, S., Yamada, S., Kitagawa, H., Oshima, K., Nadano, D., Matsuda, T., & Miyata, S. (2021) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129804 · Cited by 28 · see citing works

Sexually dimorphic perineuronal nets in the rodent and primate reproductive circuit

Ciccarelli, A., Weijers, D., Kwan, W. C., Warner, C. E., Bourne, J. A., & Gross, C. T. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25167 · Cited by 28 · see citing works

Perineuronal nets affect memory and learning after synapse withdrawal

Růžička, J., Dalecká, M., Safrankova, K., Peretti, D., Mallucci, G. R., Jendelová, P., Kwok, J. C. F., & Fawcett, J. W. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02226-z · Cited by 27 · see citing works

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster

Widmer, Y. F., Bilican, A., Bruggmann, R., & Sprecher, S. G. (2018) · Genetics · doi:10.1534/genetics.118.301106 · Cited by 25 · see citing works

Elimination of perineuronal nets in CA1 disrupts GABA release and long‐term contextual fear memory retention

Liu, L., Zhang, Y., Men, S., Li, X., Hou, S., & Ju, J. (2023) · Hippocampus · doi:10.1002/hipo.23503 · Cited by 26 · see citing works

Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders

Li, X., Wu, X., Lu, T., Kuang, C., Si, Y., Zheng, W., Li, Z., & Xue, Y.-X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063412 · Cited by 25 · see citing works

Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets

Brown, T. E., & Sorg, B. A. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01337-x · Cited by 25 · see citing works

Atrx Deletion in Neurons Leads to Sexually Dimorphic Dysregulation of miR-137 and Spatial Learning and Memory Deficits

Tamming, R. J., Dumeaux, V., Jiang, Y. Y., Shafiq, S., Langlois, L., Ellegood, J., Qiu, L. R., Lerch, J. P., & Bérubé, N. G. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107838 · Cited by 24 · see citing works

Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke

Dzyubenko, E., Willig, K. I., Yin, D., Sardari, M., Tokmak, E., Labus, P., Schmermund, B., & Hermann, D. M. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00971-x · Cited by 24 · see citing works

Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory

Alexander, G. M., Nikolova, V. D., Stöber, T. M., Gruzdev, A., Moy, S. S., & Dudek, S. M. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1626-24.2024 · Cited by 24 · see citing works

The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma

Elder, G. A., Sosa, M. A. G., Gasperi, R. D., Garcia, G. S. P., Perez, G. M., Abutarboush, R., Kawoos, U., Zhu, C. W., Janssen, W. G. M., Stone, J. R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021150 · Cited by 24 · see citing works

Learning Induces Transient Upregulation of Brevican in the Auditory Cortex during Consolidation of Long-Term Memories

Niekisch, H., Steinhardt, J., Berghäuser, J., Bertazzoni, S., Kaschinski, E., Kasper, J., Kisse, M., Mitlöhner, J., Singh, J. B., Weber, J., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.2499-18.2019 · Cited by 22 · see citing works

Mapping and Deciphering Neural Codes of NMDA Receptor-Dependent Fear Memory Engrams in the Hippocampus

Zhang, H., Chen, G., Kuang, H., & Tsien, J. Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079454 · Cited by 21 · see citing works

Perineuronal Net Receptor PTPσ Regulates Retention of Memories

Lesnikova, A., Casarotto, P., Moliner, R., Fred, S. M., Biojone, C., & Castrén, E. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.672475 · Cited by 21 · see citing works

Cocaine memory reactivation induces functional adaptations within parvalbumin interneurons in the rat medial prefrontal cortex

Jorgensen, E. T., Gonzalez, A. E., Harkness, J. H., Hegarty, D. M., Thakar, A., Burchi, D. J., Aadland, J. A., Aicher, S. A., Sorg, B. A., & Brown, T. E. (2020) · Addiction Biology · doi:10.1111/adb.12947 · Cited by 20 · see citing works

Neuronal Plasticity in the Juvenile and Adult Brain Regulated by the Extracellular Matrix

Happel, M. F. K., & Frischknecht, R. (2016) · InTech eBooks · doi:10.5772/62452 · Cited by 19 · see citing works

Pre-treatment with microRNA-181a Antagomir Prevents Loss of Parvalbumin Expression and Preserves Novel Object Recognition Following Mild Traumatic Brain Injury

Griffiths, B. B., Sahbaie, P., Rao, A. N., Arvola, O., Xu, L., Liang, D., Ouyang, Y., Clark, J. D., Giffard, R. G., & Stary, C. M. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08532-y · Cited by 18 · see citing works

Hyaluronidase reduced edema after experimental traumatic brain injury

Washington, P. M., Lee, C., Dwyer, M. K., Konofagou, E., Kernie, S., & Morrison, B. (2020) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1177/0271678x19882780 · Cited by 12 · see citing works

The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex

El‐Tabbal, M., Niekisch, H., Henschke, J. U., Budinger, E., Frischknecht, R., Deliano, M., & Happel, M. F. K. (2021) · Communications Biology · doi:10.1038/s42003-021-01837-4 · Cited by 15 · see citing works

ChABC infusions into medial prefrontal cortex, but not posterior parietal cortex, improve the performance of rats tested on a novel, challenging delay in the touchscreen TUNL task

Anderson, M. D., Paylor, J. W., Scott, G. A., Greba, Q., Winship, I. R., & Howland, J. G. (2020) · Learning &amp; Memory · doi:10.1101/lm.050245.119 · Cited by 16 · see citing works

Light Promotes Neural Correlates of Fear Memory via Enhancing Brain-Derived Neurotrophic Factor (BDNF) Expression in the Prelimbic Cortex

Sun, W., Yang, Y., Chen, X., Cheng, Y., Li, X., & An, L. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00081 · Cited by 15 · see citing works

Long term effects of 24-h-restraint stress on the connectivity and structure of interneurons in the basolateral amygdala

Pesarico, A. P., Carceller, H., Guirado, R., Coviello, S., & Nácher, J. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110512 · Cited by 16 · see citing works

Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction

Illa, M., Brito, V., Plà, L., Eixarch, E., Arbat‐Plana, A., Batallé, D., Muñoz‐Moreno, E., Crispi, F., Udina, E., Figueras, F., et al. (2017) · Fetal Diagnosis and Therapy · doi:10.1159/000481171 · Cited by 16 · see citing works

Amplified cortical neural responses as animals learn to use novel activity patterns

Akitake, B., Douglas, H. M., LaFosse, P. K., Beirán, M., Deveau, C. E., O’Rawe, J. F., Li, A. J., Ryan, L., Duffy, S. P., Zhou, Z., et al. (2023) · Current Biology · doi:10.1016/j.cub.2023.04.032 · Cited by 14 · see citing works

Do Perineuronal Nets Stabilize the Engram of a Synaptic Circuit?

Lev‐Ram, V., Lemieux, S. P., Deerinck, T. J., Bushong, E. A., Perez, A. J., Pritchard, D. R., Toyama, B. H., Park, S. K. R., McClatchy, D. B., Savas, J. N., et al. (2024) · Cells · doi:10.3390/cells13191627 · Cited by 15 · see citing works

Disruption of Extracellular Matrix and Perineuronal Nets Modulates Extracellular Space Volume and Geometry

Syková, E., Voříšek, I., Starčuk, Z., Kratochvíla, J., Pavlova, I., Ichikawa, Y., Kwok, J. C. F., Kmonı́čková, E., Myronchenko, S., Hromádka, T., et al. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0517-24.2024 · Cited by 13 · see citing works

Perineuronal nets in HVC and plasticity in male canary song

Cornez, G., Valle, S. R., dos Santos, E. B., Chiver, I., Müller, W., Ball, G. F., Cornil, C. A., & Balthazart, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252560 · Cited by 13 · see citing works

Aberrant perineuronal nets alter spinal circuits, impair motor function, and increase plasticity

Sánchez-Ventura, J., Canal, C., Hidalgo, J., Penas, C., Navarro, X., Espin, A. T., Fouad, K., & Udina, E. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114220 · Cited by 12 · see citing works

Perineuronal nets: Role in normal brain physiology and aging, and pathology of various diseases

Zhu, K., Fu, Y., Zhao, Y., Niu, B., & Han, L. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102756 · Cited by 16 · see citing works

Insights from extracellular matrix studies in the hypothalamus: structural variations of perineuronal nets and discovering a new perifornical area of the anterior hypothalamus

Horii‐Hayashi, N., Sasagawa, T., & Nishi, M. (2016) · Anatomical Science International · doi:10.1007/s12565-016-0375-5 · Cited by 12 · see citing works

Chronic fluoxetine dissociates contextual from auditory fear memory

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Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss

Mueller-Buehl, C., Pakusch, J., Bader, V., Winklhofer, K. F., Mark, M. D., & Faissner, A. (2025) · Scientific Reports · doi:10.1038/s41598-025-89580-2 · Cited by 9 · see citing works

Degradation of Perineuronal Nets in the Cerebellar Interpositus Nucleus Ameliorated Social Deficits in Shank3-deficient Mice

Liu, P., Zhao, Y., Xiong, W., Pan, Y., Zhu, M., & Zhu, X. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.12.024 · Cited by 9 · see citing works

Enhanced Fear Extinction Through Infralimbic Perineuronal Net Digestion: The Modulatory Role of Adolescent Alcohol Exposure

Obray, J. D., Denton, A. R., Carroll-Deaton, J., Marquardt, K., Chandler, L. J., & Scofield, M. D. (2024) · Alcohol · doi:10.1016/j.alcohol.2024.12.006 · Cited by 8 · see citing works

MMP-2/9 inhibition modulates sharp wave abundance, inhibitory proteoglycan sulfation, and fear memory in juvenile zebrafish: relevance to affective disorders

Blanco, I., Deasy, S., Amontree, M., Gabriel, M., Caccavano, A., Vicini, S., Glasgow, E., & Conant, K. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03007-y · Cited by 4 · see citing works

Designing Tools for Assumption-Proof Brain Mapping

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Extracellular matrix controls neuronal features that mediate the persistence of fear

Pignataro, A., Pagano, R., Guarneri, G., Middei, S., & Ammassari‐Teule, M. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1440-0 · Cited by 7 · see citing works

Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease

Sakata, J. T., Alonge, K. M., Diethorn, E. J., Krishnan, K., Milman, N., Ramsaran, A. I., Wan, X., & Sorg, B. A. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1367-25.2025 · Cited by 6 · see citing works

Protocol for assessing the role of hippocampal perineuronal nets in aversive memories

Jovasevic, V., Zhang, H., Petrovic, Z., Cicvaric, A., & Radulović, J. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100931 · Cited by 6 · see citing works

Protocols for the Evaluation of Neurodevelopmental Alterations in Rabbit Models In Vitro and In Vivo

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Perineuronal Nets: From Structure to Neurological Disorders

Li, X., Li, N., Zhao, P., Ren, D., Luo, B., & Zhou, T. G. (2023) · Current Medicinal Chemistry · doi:10.2174/0109298673258290231009111633 · Cited by 6 · see citing works

Extracellular zinc regulates contextual fear memory formation in male rats through MMP-BDNF-TrkB pathway in dorsal hippocampus and basolateral amygdala

Khan, M. Z., Zheng, Y., Yuan, K., Han, Y., & Lü, L. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114230 · Cited by 5 · see citing works

Perineuronal nets and the neuronal extracellular matrix can be imaged by genetically encoded labeling of HAPLN1 in vitro and in vivoPreprint

Lemieux, S. P., Lev‐Ram, V., Tsien, R. Y., & Ellisman, M. H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.29.569151 · Cited by 5 · see citing works

Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons

Shi, W., Wei, X., Wang, X., Du, S., Liu, W., Song, J., & Wang, Y. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902680116 · Cited by 122 · see citing works

Elimination of perineuronal nets in CA1 disrupts GABA release and long‐term contextual fear memory retention

Liu, L., Zhang, Y., Men, S., Li, X., Hou, S., & Ju, J. (2023) · Hippocampus · doi:10.1002/hipo.23503 · Cited by 26 · see citing works

Footshock drives remodeling of perineuronal nets in retrosplenial cortex during contextual fear memory formation

Dargam, S., de Olmos, S., Pautassi, R. M., & Lorenzo, A. (2024) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2024.107990

Combined loss of brevican, neurocan, tenascin-C and tenascin-R leads to impaired fear retrieval due to perineuronal net loss

Müller-Bühl, C. (. R. N. )., Pakusch, J. (. S. )., Bader, V. (. R. N. )., Winklhofer, K. (. D. )., Mark, M. D. (. D. P. )., & Faissner, A. (2025) · Dokumentenrepositorium der RUB (Ruhr University Bochum)

Perineuronal nets affect memory and learning after synapse withdrawal

Růžička, J., Dalecká, M., Safrankova, K., Peretti, D., Mallucci, G. R., Jendelová, P., Kwok, J. C. F., & Fawcett, J. W. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02226-z · Cited by 27 · see citing works