Genomewide DNA methylation analysis in combat veterans reveals a novel locus for PTSD
Abstract
Objective Epigenetic modifications such as DNA methylation may play a key role in the aetiology and serve as biomarkers for post-traumatic stress disorder (PTSD). We performed a genomewide analysis to identify genes whose DNA methylation levels are associated with PTSD. Method A total of 211 individuals comprising Australian male Vietnam War veterans (n = 96) and males from a general population belonging to the Grady Trauma Project (n = 115) were included. Genomewide DNA methylation was performed from peripheral blood using the Illumina arrays. Data analysis was performed using generalized linear regression models. Results Differential DNA methylation of 17 previously reported PTSD candidate genes was associated with PTSD symptom severity. Genomewide analyses revealed CpG sites spanning BRSK1, LCN8, NFG and DOCK2 genes were associated with PTSD symptom severity. We replicated the findings of DOCK2 in an independent cohort. Pathway analysis revealed that among the associated genes, genes within actin cytoskeleton and focal adhesion molecular pathways were enriched. Conclusion These data highlight the role of DNA methylation as biomarkers of PTSD. The results support the role of previous candidates and uncover novel genes associated with PTSD, such as DOCK2. This study contributes to our understanding of the biological underpinnings of PTSD.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Epigenetic studies have associated PTSD with differential DNA methylation and gene expression patterns in HPA-axis stress genes such as NR3C1 and FKBP5.
“Epigenetic studies have associated PTSD with differential DNA methylation and gene expression patterns in HPA-axis stress genes such as Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1) and FK06 Binding Protein 5 (FKBP5; e.g., Klengel, Pape, Binder & Mehta, 2014;Mehta et al., 2017).”
From DNA methylation of NR3C1 and FKBP5 is associated with posttraumatic stress disorder, posttraumatic growth, and resilience. (2020) · cites this paper as Mehta et al., 2017
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
Lovibond, P. F., & Lovibond, S. H. (1995) · Behaviour Research and Therapy · doi:10.1016/0005-7967(94)00075-u · Cited by 14,523 · see citing works
Second-generation PLINK: rising to the challenge of larger and richer datasets
Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015) · Gigascience · doi:10.1186/s13742-015-0047-8 · Cited by 12,709 · see citing works
Development of a new resilience scale: The Connor-Davidson Resilience Scale (CD-RISC)
Connor, K. M., & Davidson, J. R. T. (2003) · Depression and Anxiety · doi:10.1002/da.10113 · Cited by 11,793 · see citing works
Aryee, M. J., Jaffe, A. E., Bravo, H. C., Ladd‐Acosta, C., Feinberg, A. P., Hansen, K. D., & Irizarry, R. A. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu049 · Cited by 4,423 · see citing works
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works
Lecrubier, Y., Sheehan, D., Weiller, E., Amorim, P., Bonora, I., Sheehan, K. H., Janavs, J., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83296-8 · Cited by 3,513 · see citing works
Huber, W., von Heydebreck, A., Sültmann, H., Poustka, A., & Vingron, M. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.suppl_1.s96 · Cited by 2,440 · see citing works
Sheehan, D., Lecrubier, Y., Harnett Sheehan, K., Janavs, J., Weiller, E., Keskiner, A., Schinka, J., Knapp, E., Sheehan, M., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83297-x · Cited by 2,149 · see citing works
Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis
Leek, J. T., & Storey, J. D. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030161 · Cited by 1,930 · see citing works
Global epigenomic reconfiguration during mammalian brain development
Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830 · see citing works
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013
Wang, J., Duncan, D. T., Shi, Z., & Zhang, B. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt439 · Cited by 1,502 · see citing works
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J. C., Pariante, C. M., Pace, T. W. W., Mercer, K. B., Mayberg, H. S., Bradley, B., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3275 · Cited by 1,447 · see citing works
Self-citationRauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397 · see citing works
A data-driven approach to preprocessing Illumina 450K methylation array data
Pidsley, R., Y Wong, C. C., Volta, M., Lunnon, K., Mill, J., & Schalkwyk, L. C. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-293 · Cited by 1,143 · see citing works
Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063 · see citing works
SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips
Maksimovic, J., Gordon, L., & Oshlack, A. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r44 · Cited by 826 · see citing works
Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., et al. (2011) · Nature · doi:10.1038/nature09856 · Cited by 800 · see citing works
Self-citationHolocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation
Yehuda, R., Daskalakis, N. P., Bierer, L. M., Bader, H. N., Klengel, T., Holsboer, F., & Binder, E. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.005 · Cited by 782 · cited 1× · see citing works
“including transgenerational inheritance of DNA methylation marks (71).”
BackgroundSelf-citationTrue, W. R. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820160019002 · Cited by 704 · see citing works
Posttraumatic stress disorder and risk of dementia among US veterans
Yaffe, K., Vittinghoff, E., Lindquist, K., Barnes, D., Covinsky, K. E., Neylan, T., Kluse, M., & Marmar, C. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.61 · Cited by 596 · see citing works
Mehta, D., Klengel, T., Conneely, K. N., Smith, A. K., Altmann, A., Pace, T. W., Rex-Haffner, M., Loeschner, A., Gonik, M., Mercer, K. B., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217750110 · Cited by 548 · see citing works
Self-citationEpigenetic and immune function profiles associated with posttraumatic stress disorder
Uddin, M., Aiello, A. E., Wildman, D. E., Koenen, K. C., Pawelec, G., de los Santos, R., Goldmann, E., & Galea, S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910794107 · Cited by 518 · see citing works
Weaver, I. C. G., D'Alessio, A. C., Brown, S. E., Hellstrom, I. C., Dymov, S., Sharma, S., Szyf, M., & Meaney, M. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4164-06.2007 · Cited by 508 · see citing works
Trauma exposure and stress-related disorders in inner city primary care patients
Gillespie, C. F., Bradley, B., Mercer, K., Smith, A. K., Conneely, K. N., Gapen, M., Weiss, T., Schwartz, A. C., Cubells, J. F., & Ressler, K. J. (2009) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2009.05.003 · Cited by 504 · see citing works
Self-citationZannas, A. S., Arloth, J., Carrillo-Roa, T., Iurato, S., Röh, S., Ressler, K. J., Nemeroff, C. B., Smith, A. K., Bradley, B., Heim, C., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0828-5 · Cited by 469 · see citing works
Self-citationHannon, E., Lunnon, K., Schalkwyk, L., & Mill, J. (2015) · Epigenetics · doi:10.1080/15592294.2015.1100786 · Cited by 455 · see citing works
Context Processing and the Neurobiology of Post-Traumatic Stress Disorder
Liberzon, I., & Abelson, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.039 · Cited by 420 · see citing works
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
Structural and functional plasticity of the human brain in posttraumatic stress disorder
Bremner, J. D., Elzinga, B. M., Schmahl, C. G., & Vermetten, E. H. G. J. M. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)67012-5 · Cited by 368 · see citing works
Epigenetics of Stress-Related Psychiatric Disorders and Gene × Environment Interactions
Klengel, T., & Binder, E. B. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.036 · Cited by 353 · see citing works
Self-citationThe role of DNA methylation in stress-related psychiatric disorders
Klengel, T., Pape, J., Binder, E. B., & Mehta, D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.013 · Cited by 309 · see citing works
Self-citationGenome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
Wockner, L. F., Noble, E. P., Lawford, B. R., Young, R. M., Morris, C. P., Whitehall, V., & Voisey, J. (2014) · Translational Psychiatry · doi:10.1038/tp.2013.111 · Cited by 306 · see citing works
Self-citationAccounting for Population Stratification in DNA Methylation Studies
Barfield, R., Almli, L. M., Kilaru, V., Smith, A. K., Mercer, K. B., Duncan, R., Klengel, T., Mehta, D., Binder, E. B., Epstein, M. P., et al. (2014) · Genetic Epidemiology · doi:10.1002/gepi.21789 · Cited by 240 · see citing works
Self-citationLogue, M. W., Baldwin, C. T., Guffanti, G., Melista, E., Wolf, E. J., Reardon, A. F., Uddin, M., Wildman, D. E., Galea, S., Koenen, K. C., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.113 · Cited by 238 · see citing works
Roozendaal, B., Hernandez, A., Cabrera, S. M., Hagewoud, R., Malvaez, M., Stefanko, D. P., Haettig, J., & Wood, M. A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5717-09.2010 · Cited by 233 · see citing works
Sartor, C. E., McCutcheon, V. V., Pommer, N. E., Nelson, E. C., Grant, J. D., Duncan, A. E., Waldron, M., Bucholz, K. K., Madden, P. A. F., & Heath, A. C. (2010) · Psychological Medicine · doi:10.1017/s0033291710002072 · Cited by 221 · see citing works
Sartor, C. E. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1385 · Cited by 212 · see citing works
Gene × environment vulnerability factors for PTSD: The HPA-axis
Mehta, D., & Binder, E. B. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.03.009 · Cited by 211 · see citing works
Self-citationMehta, D. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.50 · Cited by 200 · see citing works
Self-citationKoenen, K. C., Harley, R. M., Lyons, M. J., Wolfe, J., Simpson, J., Goldberg, J. H., Eisen, S. A., & Tsuang, M. T. (2002) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-200204000-00001 · Cited by 193 · see citing works
Posttraumatic Stress Disorder Among African Americans in an Inner City Mental Health Clinic
Schwartz, A. C., Bradley, R. G., Sexton, M., Sherry, A. R., & Ressler, K. J. (2005) · Psychiatric Services · doi:10.1176/appi.ps.56.2.212 · Cited by 193 · see citing works
Greater Prevalence and Incidence of Dementia in Older Veterans with Posttraumatic Stress Disorder
Qureshi, S. U., Kimbrell, T. A., Pyne, J. M., Magruder, K. M., Hudson, T. J., Petersen, N. J., Yu, H., Schulz, P. E., & Kunik, M. E. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02977.x · Cited by 191 · see citing works
Do genes influence exposure to trauma? A twin study of combat
Lyons, M. J., Goldberg, J., Eisen, S. A., True, W., Tsuang, M. T., Meyer, J. M., & Henderson, W. G. (1993) · American Journal of Medical Genetics · doi:10.1002/ajmg.1320480107 · Cited by 183 · see citing works
Genome-wide Association Studies of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers
Stein, M. B., Chen, C., Ursano, R. J., Cai, T., Gelernter, J. E., Heeringa, S. G., Jain, S., Jensen, K. P., Maihofer, A. X., Mitchell, C. M., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0350 · Cited by 182 · see citing works
Cornelis, M. C., Nugent, N. R., Amstadter, A. B., & Koenen, K. C. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0126-6 · Cited by 178 · see citing works
Genome-wide Association Study Identifies New Susceptibility Loci for Posttraumatic Stress Disorder
Xie, P., Kranzler, H. R., Yang, C., Zhao, H., Farrer, L. A., & Gelernter, J. E. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.013 · Cited by 166 · see citing works
Nievergelt, C. M., Maihofer, A. X., Mustapić, M., Yurgil, K. A., Schork, N. J., Miller, M. W., Logue, M. W., Geyer, M. A., Risbrough, V. B., O’Connor, D. T., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.017 · Cited by 166 · see citing works
Logue, M. W., Amstadter, A. B., Baker, D. G., Duncan, L. E., Koenen, K. C., Liberzon, I., Miller, M. W., Morey, R. A., Nievergelt, C. M., Ressler, K. J., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.118 · Cited by 159 · see citing works
Self-citationPosttraumatic Stress Disorder in DSM-5: New Criteria, New Measures, and Implications for Assessment
Weathers, F. W., Marx, B. P., Friedman, M. J., & Schnurr, P. P. (2014) · Psychological Injury and Law · doi:10.1007/s12207-014-9191-1 · Cited by 156 · see citing works
PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus
Stevens, J. S., Almli, L. M., Fani, N., Gutman, D. A., Bradley, B., Norrholm, S. D., Reiser, E., Ely, T. D., Dhanani, R., Glover, E. M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318954111 · Cited by 132 · see citing works
Rusiecki, J. A., Chen, L., Srikantan, V., Zhang, L., Yan, L., Polin, M., & Baccarelli, A. (2012) · Epigenomics · doi:10.2217/epi.11.116 · Cited by 132 · see citing works
Genetic approaches to understanding post-traumatic stress disorder
Almli, L. M., Fani, N., Smith, A. K., & Ressler, K. J. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713001090 · Cited by 124 · see citing works
Self-citationGuffanti, G., Galea, S., Yan, L., Roberts, A. L., Solovieff, N., Aiello, A. E., Smoller, J. W., De Vivo, I., Ranu, H., Uddin, M., et al. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.08.014 · Cited by 120 · see citing works
A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice
Lee, R. S., Tamashiro, K. L., Yang, X., Purcell, R. H., Huo, Y., Rongione, M. A., Potash, J. B., & Wand, G. S. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2307-3 · Cited by 109 · see citing works
Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD
Maddox, S. A., Kilaru, V., Shin, J. H., Jovanović, T., Almli, L. M., Dias, B. G., Norrholm, S. D., Fani, N., Michopoulos, V., Ding, Z., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.250 · Cited by 104 · see citing works
Self-citationThe DRD2 gene 957C>T polymorphism is associated with Posttraumatic Stress Disorder in war veterans
Voisey, J., Swagell, C. D., Hughes, I. P., Morris, C. P., van Daal, A., Noble, E. P., Kann, B., Heslop, K., Young, R. M., & Lawford, B. R. (2008) · Depression and Anxiety · doi:10.1002/da.20517 · Cited by 100 · see citing works
Self-citationAshley‐Koch, A. E., Garrett, M. E., Gibson, J., Liu, Y., Dennis, M. F., Kimbrel, N. A., Beckham, J. C., & Hauser, M. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.03.049 · Cited by 97 · see citing works
Ryan, J., Chaudieu, I., Ancelin, M.-L., & Saffery, R. (2016) · Epigenomics · doi:10.2217/epi-2016-0083 · Cited by 85 · see citing works
Almli, L. M., Stevens, J. S., Smith, A. K., Kilaru, V., Meng, Q., Flory, J., Abu‐Amara, D., Hammamieh, R., Yang, R., Mercer, K. B., et al. (2015) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32315 · Cited by 80 · see citing works
Self-citationImmune regulatory functions of DOCK family proteins in health and disease
Nishikimi, A., Kukimoto-Niino, M., Yokoyama, S., & Fukui, Y. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.07.024 · Cited by 80 · see citing works
Weiner, M. W., Veitch, D. P., Hayes, J., Neylan, T. C., Grafman, J. H., Aisen, P. S. S., Petersen, R. C., Jack, C. R., Jagust, W., Trojanowski, J. Q., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.04.005 · Cited by 78 · see citing works
Kim, T. Y., Kim, S. J., Chung, H. G., Choi, J. H., Kim, S. H., & Kang, J. I. (2017) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12675 · Cited by 76 · see citing works
Epigenetic pathways through which experiences become linked with biology
McGowan, P. O., & Roth, T. L. (2015) · Development and Psychopathology · doi:10.1017/s0954579415000206 · Cited by 72 · see citing works
Bezdjian, S., Schneider, K. G., Burchett, D. L., Baker, M. T., & Garb, H. N. (2016) · Psychological Assessment · doi:10.1037/pas0000370 · Cited by 72 · see citing works
Circuit dysregulation and circuit-based treatments in posttraumatic stress disorder
Sheynin, J., & Liberzon, I. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.014 · Cited by 68 · cited 1× · see citing works
“The three major neural circuits implicated in PTSD include the fear learning circuitry, context processing circuitry and emotion regulation circuitry (78).”
BackgroundIyer, S., Kilaru, V., Almli, L., Stevens, J. S., Jovanović, T., Conneely, K., Wingo, A., Smith, A. K., Ressler, K. J., Lori, A., et al. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.69 · Cited by 68 · see citing works
Self-citationInterindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSD
Zovkic, I. B., Meadows, J. P., Kaas, G. A., & Sweatt, J. D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00060 · Cited by 62 · see citing works
Koenen, K. C., Vivo, I. D., Rich-Edwards, J. W., Smoller, J. W., Wright, R. J., & Purcell, S. (2009) · BMC Psychiatry · doi:10.1186/1471-244x-9-29 · Cited by 60 · see citing works
Amstadter, A. B., Sumner, J. A., Acierno, R. E., Ruggiero, K. J., Koenen, K. C., Kilpatrick, D. G., Galea, S., & Gelernter, J. E. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.189 · Cited by 51 · see citing works
Pohlack, S. T., Nees, F., Ruttorf, M., Cacciaglia, R., Winkelmann, T., Schad, L. R., Witt, S. H., Rietschel, M., & Flor, H. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.12.018 · Cited by 50 · see citing works
Cimino, P. J., Sokal, I., Leverenz, J., Fukui, Y., & Montine, T. J. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090443 · Cited by 49 · see citing works
Progress towards understanding the genetics of posttraumatic stress disorder
Voisey, J., Young, R. M., Lawford, B. R., & Morris, C. P. (2014) · Journal of Anxiety Disorders · doi:10.1016/j.janxdis.2014.09.014 · Cited by 46 · see citing works
Self-citationNOS1AP is associated with increased severity of PTSD and depression in untreated combat veterans
Lawford, B. R., Morris, C. P., Swagell, C. D., Hughes, I. P., Young, R. M., & Voisey, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.10.013 · Cited by 44 · see citing works
Self-citationKoenen, K. C., Duncan, L. E., Liberzon, I., & Ressler, K. J. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.08.022 · Cited by 43 · see citing works
Cimino, P. J., Yang, Y., Li, X., Hemingway, J. F., Cherne, M. K., Khademi, S. B., Fukui, Y., Montine, K. S., Montine, T. J., & Keene, C. D. (2013) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2013.01.002 · Cited by 36 · see citing works
McCarren, M., Janes, G. R., Goldberg, J. H., Eisen, S. A., True, W. R., & Henderson, W. G. (1995) · Journal of Traumatic Stress · doi:10.1007/bf02105410 · Cited by 32 · see citing works
H3K9 Trimethylation Precedes DNA Methylation during Sheep Oogenesis
Russo, V., Bernabò, N., Giacinto, O. D., Martelli, A., Mauro, A., Berardinelli, P., Curini, V., Nardinocchi, D., Mattioli, M., & Barboni, B. (2012) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155412463923 · Cited by 31 · see citing works
Chen, Y., Li, X., Kobayashi, I., Tsao, D., & Mellman, T. A. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.07.045 · Cited by 26 · see citing works
Test-Retest Reliability of the Trauma and Life Events Self-Report Inventory
Hovens, J. E. J. M., Bramsen, I., van der Ploeg, H. M., & Reuling, I. E. W. (2000) · Psychological Reports · doi:10.2466/pr0.2000.87.3.750 · Cited by 15 · see citing works
The role of epigenetic transcriptional regulation in BRCA1-mediated tumor suppression
Chang, S., & Sharan, S. K. (2013) · Transcription · doi:10.4161/trns.22600 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C.-Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Gelernter, J., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12576-w · Cited by 635 · see citing works
Self-citationRecent Genetics and Epigenetics Approaches to PTSD
Daskalakis, N. P., Rijal, C. M., King, C. D., Huckins, L. M., & Ressler, K. J. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0898-7 · Cited by 146 · see citing works
Jowf, G. I. A., Ahmed, Z. T., Reijnders, R. A., de Nijs, L., & Eijssen, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065238 · Cited by 129 · see citing works
Brewin, C. R., Atwoli, L., Bisson, J. I., Galea, S., Koenen, K. C., & Lewis‐Fernández, R. (2025) · World Psychiatry · doi:10.1002/wps.21269 · Cited by 111 · see citing works
the Traumatic Stress Brain Study Group, Logue, M. W., Miller, M. W., Wolf, E. J., Huber, B. R., Morrison, F. G., Zhou, Z., Zheng, Y., Smith, A. K., Daskalakis, N. P., et al. (2020) · Clinical Epigenetics · doi:10.1186/s13148-020-0820-0 · Cited by 102 · see citing works
Self-citationA review of epigenetic contributions to post-traumatic stress disorder
Howie, J. H., Rijal, C. M., & Ressler, K. J. (2019) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2019.21.4/kressler · Cited by 95 · see citing works
Mehta, D., Miller, O., Bruenig, D., David, G., & Shakespeare‐Finch, J. (2020) · Journal of Traumatic Stress · doi:10.1002/jts.22472 · Cited by 66 · see citing works
Self-citationRaber, J., Arzy, S., Bertolus, J. B., Depue, B., Haas, H. E., Hofmann, S. G., Kangas, M., Kensinger, E., Lowry, C. A., Marusak, H. A., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.015 · Cited by 62 · see citing works
Miller, O., Shakespeare-Finch, J., Bruenig, D., & Mehta, D. (2020) · Psychological Trauma: Theory, Research, Practice, and Policy · doi:10.1037/tra0000574 · Cited by 56 · see citing works
Self-citationGenomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative
Nievergelt, C. M., Ashley‐Koch, A. E., Dalvie, S., Hauser, M. A., Morey, R. A., Smith, A. K., & Uddin, M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.020 · Cited by 56 · see citing works
Self-citationA Review of Epigenetics of PTSD in Comorbid Psychiatric Conditions
Blacker, C. J., Frye, M. A., Morava, É., Kozicz, T., & Veldić, M. (2019) · Genes · doi:10.3390/genes10020140 · Cited by 56 · see citing works
DNA methylation correlates of PTSD: Recent findings and technical challenges
Morrison, F. G., Miller, M. W., Logue, M. W., Assef, M., & Wolf, E. J. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.11.011 · Cited by 52 · see citing works
Jowf, G. I. A., Snijders, C., Rutten, B. P. F., de Nijs, L., & Eijssen, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910743 · Cited by 49 · see citing works
Mehta, D., Bruenig, D., Lawford, B. R., Harvey, W., Carrillo‐Roa, T., Morris, C. P., Jovanović, T., Young, R. M., Binder, E. B., & Voisey, J. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.04.001 · Cited by 46 · see citing works
Self-citationTranscriptome analysis reveals novel genes and immune networks dysregulated in veterans with PTSD
Mehta, D., Voisey, J., Bruenig, D., Harvey, W., Morris, C. P., Lawford, B. R., & Young, R. M. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.08.014 · Cited by 41 · see citing works
Self-citationDNA methylation from germline cells in veterans with PTSD
Mehta, D., Pelzer, E. S., Bruenig, D., Lawford, B., McLeay, S., Morris, C. P., Gibson, J. N., Young, R. M., Voisey, J., McLeay, S., et al. (2019) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2019.06.001 · Cited by 37 · see citing works
Self-citationDifferential BDNF methylation in combat exposed veterans and the association with exercise
Voisey, J., Lawford, B., Bruenig, D., Harvey, W., Morris, C. P., Young, R. M., & Mehta, D. (2019) · Gene · doi:10.1016/j.gene.2019.02.067 · Cited by 37 · see citing works
Self-citationNeuroepigenetics of Post-Traumatic Stress Disorder
Kim, G. S., Smith, A. K., Nievergelt, C. M., & Uddin, M. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2018.04.001 · Cited by 37 · see citing works
Self-citationPrimary cilia are required for the persistence of memory and stabilization of perineuronal nets
Jovasevic, V., Zhang, H., Sananbenesi, F., Guedea, A. L., Soman, K. V., Wiktorowicz, J. E., Fischer, A., & Radulovic, J. (2021) · iScience · doi:10.1016/j.isci.2021.102617 · Cited by 32 · see citing works
Katrinli, Ş., Wani, A. H., Maihofer, A. X., Ratanatharathorn, A. D., Daskalakis, N. P., Montalvo‐Ortiz, J. L., Núñez-Ríos, D. L., Zannas, A. S., Zhao, X., Aiello, A. E., et al. (2024) · Genome Medicine · doi:10.1186/s13073-024-01417-1 · Cited by 35 · see citing works
Self-citationMontalvo‐Ortiz, J. L., Gelernter, J. E., Cheng, Z., Girgenti, M. J., Xu, K., Zhang, X., Gopalan, S., Zhou, H., Duman, R. S., Southwick, S. M., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01822-3 · Cited by 32 · see citing works
Nöthling, J., Abrahams, N., Toikumo, S., Suderman, M. J., Mhlongo, S., Lombard, C. J., Seedat, S., & Hemmings, S. M. J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01608-z · Cited by 31 · see citing works
Beydoun, M. A., Hossain, S. A., Chitrala, K. N., Tajuddin, S. M., Beydoun, H. A., Evans, M. K., & Zonderman, A. B. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.032 · Cited by 30 · see citing works
Garrett, M. E., Qin, X., Mehta, D., Dennis, M. F., Marx, C. E., Grant, G. A., Workgroup, V. M.-A. M., Initiative, P., Stein, M. B., Kimbrel, N. A., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.678548 · Cited by 30 · see citing works
Self-citationNúñez-Ríos, D. L., Martínez‐Magaña, J. J., Nagamatsu, S. T., Andrade-Brito, D., Forero, D. A., Orozco, C. A., & Montalvo‐Ortiz, J. L. (2022) · Biomedicines · doi:10.3390/biomedicines10051107 · Cited by 27 · see citing works
Genome-by-Trauma Exposure Interactions in Adults With Depression in the UK Biobank
Chuong, M., Adams, M. J., Kwong, A. S. F., Haley, C., Amador, C., & McIntosh, A. M. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.2983 · Cited by 27 · see citing works
Immune system regulation and role of the human leukocyte antigen in posttraumatic stress disorder
Katrinli, Ş., & Smith, A. K. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100366 · Cited by 25 · see citing works
Self-citationUsing Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine
Bainomugisa, C. K., Sutherland, H. G. E., Parker, R., McRae, A. F., Haupt, L. M., Griffiths, L. R., Heath, A. C., Nelson, E. C., Wright, M. J., Hickie, I. B., et al. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.678350 · Cited by 24 · see citing works
Self-citationCao-Lei, L., Saumier, D., Fortin, J., & Brunet, A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.857087 · Cited by 24 · see citing works
Raza, Z., Hussain, S. F., Foster, V. S., Wall, J., Coffey, P. J., Martin, J. F., & Gomes, R. S. M. (2023) · Frontiers in Epidemiology · doi:10.3389/fepid.2023.1066158 · Cited by 23 · see citing works
The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder
Comes, A. L., Czamara, D., Adorjan, K., Anderson‐Schmidt, H., Andlauer, T. F. M., Budde, M., Gade, K., Heilbronner, M., Kalman, J. L., Papiol, S., et al. (2020) · International Journal of Bipolar Disorders · doi:10.1186/s40345-019-0176-6 · Cited by 23 · see citing works
Bam, M., Yang, X., Ginsberg, J. P., Aiello, A. E., Uddin, M., Galea, S., Nagarkatti, P. S., & Nagarkatti, M. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-01971-5 · Cited by 20 · see citing works
Novel Pharmacological Targets of Post-Traumatic Stress Disorders
Marazziti, D., Carmassi, C., Cappellato, G., Chiarantini, I., Massoni, L., Mucci, F., Arone, A., Violi, M., Palermo, S., Iorio, G. D., et al. (2023) · Life · doi:10.3390/life13081731 · Cited by 18 · see citing works
MicroRNAs as biomarker and novel therapeutic target for posttraumatic stress disorder in Veterans
Gupta, S., Guleria, R. S., & Szabo, Y. Z. (2021) · Psychiatry Research · doi:10.1016/j.psychres.2021.114252 · Cited by 18 · see citing works
de Assis, S. G., Tavares, P. H., Oliveira, N. C. D. S., Serpeloni, F., & Avanci, J. Q. (2025) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.70042 · Cited by 15 · see citing works
Nicoloro‐SantaBarbara, J. M., Carroll, J., Minissian, M., Kilpatrick, S. J., Cole, S. W., Merz, C. N. B., & Accortt, E. E. (2022) · American Journal of Reproductive Immunology · doi:10.1111/aji.13619 · Cited by 15 · see citing works
Brown, K., Hui, Q., Huang, Y., Taylor, J. Y., Prescott, L., Barcelona, V., Crusto, C. A., & Sun, Y. V. (2019) · Chronic Stress · doi:10.1177/2470547019879088 · Cited by 14 · see citing works
Pfeiffer, J. R., Mutesa, L., & Uddin, M. (2018) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-018-0143-z · Cited by 14 · see citing works
Mattonet, K., Scharpf, F., Block, K., Kumsta, R., & Hecker, T. (2023) · European Journal of Psychotraumatology · doi:10.1080/20008066.2023.2228155 · Cited by 12 · see citing works
Young, R. M., Lawford, B. R., Mellor, R., Morris, C. P., Voisey, J., McLeay, S. C., Harvey, W., Romaniuk, M., Crawford, D. H., Colquhoun, D., et al. (2021) · Gene · doi:10.1016/j.gene.2021.145898 · Cited by 12 · see citing works
Self-citationYang, M., Barrios, J., Yan, J., Zhao, W., Yuan, S., Dong, E., & Ai, X. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105375 · Cited by 11 · see citing works
Bellizzi, D., Guarasci, F., Iannone, F., Passarino, G., & Rose, G. (2019) · Springer eBooks · doi:10.1007/978-3-030-20762-5_7 · Cited by 10 · see citing works
Núñez-Ríos, D. L., Martínez‐Magaña, J. J., Nagamatsu, S. T., Krystal, J. H., Martínez, K., Giusti‐Rodríguez, P., & Montalvo‐Ortiz, J. L. (2023) · Complex Psychiatry · doi:10.1159/000529536 · Cited by 9 · see citing works
Sheerin, C. M., Lancaster, E. E., York, T. P., Walker, J. H., Danielson, C. K., & Amstadter, A. B. (2021) · Journal of Traumatic Stress · doi:10.1002/jts.22655 · Cited by 8 · see citing works
Epigenetic Alterations in Post-Traumatic Stress Disorder: Comprehensive Review of Molecular Markers
Golubeva, E., Zeltser, A., Zorkina, Y., Ochneva, A., Tsurina, A. M., Andreyuk, D., Kostyuk, G. P., & Morozova, A. Y. (2024) · Complex Psychiatry · doi:10.1159/000541822 · Cited by 7 · see citing works
Baghaei, A., Zoshk, M. Y., Hosseini, M., Dastjerdi, H. F., Nassireslami, E., Shayesteh, S., Laripour, R., Amoli, A. E., Heidari, R., & Chamanara, M. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09276-0 · Cited by 7 · see citing works
How stress affects gene expression through epigenetic modifications
Bainomugisa, C. K., & Mehta, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00014-9 · Cited by 6 · see citing works
Self-citationFreeman, J., Salberg, S., Noel, M. E., & Mychasiuk, R. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03267-w · Cited by 6 · see citing works
Epigenetic and genomic mechanisms in the pathogenesis of posttraumatic stress disorder (review)
Павлова», Ф. Г. Б. О. У. В. О. «. Г. М. У. И. А. И. П., Faustova, A. G., Юров, И. Ю., & здоровья», Ф. Г. Б. Н. У. «. Ц. П. (2022) · RESEARCH RESULTS IN BIOMEDICINE · doi:10.18413/2658-6533-2022-8-1-0-2 · Cited by 6 · see citing works
Epigenetic Approach to PTSD: In the Aspects of Rat Models
Aykaç, A., & Kalkan, R. (2021) · Global Medical Genetics · doi:10.1055/s-0041-1736633 · Cited by 6 · see citing works
Li, H., Wang, J., Cruz, D. A., Modliszewski, J. L., Corcoran, D. L., Martínez‐Magaña, J. J., Montalvo‐Ortiz, J. L., Roache, J. D., Averill, L. A., Young‐McCaughan, S., et al. (2023) · medRxiv · doi:10.1101/2023.04.18.23288704 · Cited by 6 · see citing works
Guo, J., Yang, Y.-J., Zheng, X.-A., Jiang, X., Min, G., Wang, X., Gao, Y., Fu, L., & Chen, X. (2018) · Europe PMC (PubMed Central) · Cited by 5 · see citing works
Reed, K., Cleveland, S., Thomas, J. L., Hsu, A., Jeong, A., Nguyen, J., Patel, A., Zhang, S., & Sumner, J. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00016-2 · Cited by 4 · see citing works
Sheerin, C. M., Vladimirov, V. I., Williamson, V. S., Bountress, K. E., Danielson, C. K., Ruggiero, K. J., & Amstadter, A. B. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1688935 · Cited by 4 · see citing works
Gao, M., Shen, Y., Yang, P. C., Yuan, C., Sun, Y., & Li, Z. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1414089 · Cited by 3 · see citing works
Li, H., Liu, Y., Shi, Y., Wang, J., Nguyen, T. P., Xie, Y., Zheng, W., Cheng, Y., Cruz, D. A., Modliszewski, J. L., et al. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.10.032 · Cited by 3 · see citing works
An Update on the Psychiatric Genomics of Posttraumatic Stress Disorder (PTSD)
Norrholm, S. D. (2025) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2025.01.013 · Cited by 3 · see citing works
Naidoo, V., Martínez-Iglesias, O. A., & Cacabelos, R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00012-5 · Cited by 3 · see citing works
Marra, P. S., Seki, T., Nishizawa, Y., Chang, G., Yamanishi, K., Nishiguchi, T., Shibata, K., Braun, P., & Shinozaki, G. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.241 · Cited by 3 · see citing works
Сучкова, И. О., Patkin, E. L., Tsikunov, S. G., & Софронов, Г. А. (2025) · Medical academic journal · doi:10.17816/maj632018 · Cited by 2 · see citing works
Epigenome-wide association study of posttraumatic stress disorder in a South African populationPreprint
Toikumo, S., Katrinli, Ş., du Plessis, M., Malan‐Müller, S., van den Heuvel, L. L., Tromp, G. C., Smith, A. K., Seedat, S., & Hemmings, S. M. J. (2025) · medRxiv · doi:10.1101/2025.05.07.25327159 · Cited by 2 · see citing works
Self-citationRubens, M., Paul, R. P., Sathyanarayanan, A., Miller, O. K., Mullens, A. B., Bruenig, D., Obst, P. L., Shakespeare‐Finch, J., & Mehta, D. (2025) · Epigenomes · doi:10.3390/epigenomes9040039 · Cited by 1 · see citing works
Self-citationKuts, K., KREINIS, H., Perchuk, I. V., Antypchuk, K. Y., VASYLENKO, Z., Kravchenko, V. I., & Drozdova, N. V. (2025) · Проблеми радіаційної медицини та радіобіології = Problems of Radiation Medicine and Radiobiology · doi:10.33145/2304-8336-2025-30-32-68 · Cited by 1 · see citing works
Thong, C.-Y. N., & Yap, Y. H. Y. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150301 · Cited by 1 · see citing works
Epigenomic biomarkers of posttraumatic stress disorder
Montalvo‐Ortiz, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00020-4 · Cited by 1 · see citing works
Bountress, K. E., Brick, L. A. D., Cusack, S. E., Sheerin, C. M., Nugent, N. R., & Amstadter, A. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816022-0.00008-9
Posttraumatic stress disorder, major depressive disorder, and noncoding RNAs
Braný, D., Dvorská, D., Lockwood, L. E., Strnádel, J., & Youssef, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-823039-8.00011-3
Genomic markers and psychological health outcomes of drinking behaviours in veterans
Turner, M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.235393
Loci Associated with Postpartum Depression: A Genome-Wide Association StudyPreprint
Tomita, H., Li, X., Takahashi, N., Narita, A., Nakamura, Y., Sakurai‐Yageta, M., Murakami, K., Ishikuro, M., Obara, T., Kikuya, M., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2612367/v1
Sociobehavioral-induced epigenetic variation and psychiatric diseases
Petroff, R., Goodrich, J. M., Bakulski, K. M., & Dolinoy, D. C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824010-6.00032-0
Mental Disorders and DNA Methylation
Örenay-Boyacıoğlu, S., Boyacıoğlu, O., & Döndü, A. (2024) · Springer eBooks · doi:10.1007/978-3-031-32035-4_148-1
Patkin, E. L., Олеговна, С. И., Tsikunov, S. G., & Sofronov, H. A. (2024) · Успехи физиологических наук · doi:10.31857/s0301179824040011
Mental Disorders and DNA Methylation
Örenay-Boyacıoğlu, S., Boyacioglu, O., & Döndü, A. (2025) · Springer eBooks · doi:10.1007/978-3-031-73368-0_148
Sargsyan, L., & PETROSYAN, A. (2025) · Bulletin of Yerevan Brusov State University of Languages and Social Sciences Pedagogy and Social Sciences · doi:10.51307/182931072015233260-25.71-112
Logue, M. W., Miller, M. W., Wolf, E. J., Huber, B. R., Morrison, F. G., Zhou, Z., Zheng, Y., Smith, A. K., Daskalakis, N. P., Ratanatharathorn, A. D., et al. (2020) · Figshare · doi:10.6084/m9.figshare.11986023
Self-citationRubens, M. (2026) · Queensland University of Technology · doi:10.5204/thesis.eprints.263605
Epigenome-wide DNA methylation signatures associated with combined hormonal contraceptive usePreprint
Musaoğlu, M. N., Zillich, L., Edelmann, S., Comasco, E., Derntl, B., Kimmig, A.-C. S., & Nieratschker, V. (2026) · Research Square · doi:10.21203/rs.3.rs-10760657/v1
Epigenetic mechnisms involved in posttraumatic stress disorder
CHEISHVILI, D., Yaakov, H., & Shrira, A. (2026) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19043-8.00027-x
- Authors
- Mehta, D., Bruenig, D., Carrillo‐Roa, T., Lawford, B., Harvey, W., Morris, C. P., Smith, A. K., Binder, E. B., Young, R. M., & Voisey, J.
- Affiliations
- Queensland University of Technology (AU)
- Max Planck Institute of Psychiatry (DE)
- Greenslopes Private Hospital (AU)
- Emory University (US)
- Corresponding author
- Mehta, D.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2017-08-09
- Volume
- 136
- Issue
- 5
- Pages
- 493-505
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2743062830
- Cited by
- 78
- References
- 81
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 7 · 2023: 9 · 2022: 13 · 2021: 10 · 2020: 7 · 2019: 9 · 2018: 9
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Queensland University of Technology
- Gallipoli Medical Research Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Keywords
- post-traumatic stress disorder, DNA methylation, epigenetics, combat veterans, Vietnam War veterans, DOCK2, actin cytoskeleton, focal adhesions, PTSD symptom severity
- MeSH terms
- Aged, Australia, Combat Disorders, Humans, Male, Stress Disorders, Post-Traumatic, Veterans, Biomarkers, DNA Methylation, Guanine Nucleotide Exchange Factors, GTPase-Activating Proteins, Vietnam Conflict
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review