The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
CD28− T cells: their role in the age-associated decline of immune function
Open accessAbstract
Summary The accumulation of CD28− T cells, particularly within the CD8 subset, is one of the most prominent changes during T cell homeostasis and function associated with aging in human. CD28, a major co-stimulatory receptor, is responsible for the optimal antigen-mediated T cell activation, proliferation, and survival of T cells. CD28− T cells exhibit reduced antigen receptor diversity, defective antigen-induced proliferation, and a shorter replicative lifespan while showing enhanced cytotoxicity and regulatory functions. Gene expression analyses reveal profound changes of CD28− T cells in comparison to their CD28+ counterparts and support their functional differences. Here we review the recent advance of our understanding of CD28− T cells and their role in age-associated decline of immune function.
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Cites
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Cited by
NAD+ metabolism and its roles in cellular processes during ageing
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Metabolic Regulation of T Lymphocytes
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Rescue of exhausted CD8 T cells by PD-1–targeted therapies is CD28-dependent
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Self-citationCauses, consequences, and reversal of immune system aging
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Metadata
- Authors
- Weng, N.-P., Akbar, A. N., & Goronzy, J.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 30
- Issue
- 7
- Pages
- 306-312
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2167350292
- Cited by
- 633
- References
- 20
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
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