Cited by 235Influenza Virus Research Studiesinterferon and immune responsesImmune Response and Inflammation

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Innate immune responses to influenza A H5N1: friend or foe?

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Peiris, Joseph Sriyal Malik, Cheung, Chung Yan, Leung, Connie Yin Hung, Nicholls, John Malcolm·2009·Trends in Immunology

DOI 10.1016/j.it.2009.09.004PMC PMC5068224

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Abstract

Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.

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Authors: Peiris, J. S. M., Cheung, C. Y., Leung, C. Y. H., & Nicholls, J. M.
Affiliations: Queen Mary Hospital (CN)
University of Hong Kong (HK)
Corresponding author: Peiris, Joseph Sriyal Malik
ORCID: Cheung, Chung Yan
Leung, Connie Yin Hung
Nicholls, John Malcolm
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2009-12
Volume: 30
Issue: 12
Pages: 574-584
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2009.09.004
PMC: PMC5068224
OpenAlex: W2033321639
Cited by: 232
References: 99
Citations by year: 2026: 6 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 14 · 2020: 29 · 2019: 6 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 22 · 2012: 15
FWCI: 2.12
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Funders: University Grants Committee
National Institutes of Health
National Institute of Allergy and Infectious Diseases (HHSN266200700005C)
Topics: Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: H5N1 avian influenza, innate immune response, viral pathogenesis, acute respiratory distress syndrome, viral pneumonia, host-virus interaction, viral replication
MeSH terms: Animals, Humans, Immunity, Innate, Influenza, Human, Interferons, Orthomyxoviridae Infections, Respiratory Distress Syndrome, Tumor Necrosis Factor-alpha, Mice, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype

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Innate immune responses to influenza A H5N1: friend or foe?

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