Re-emergence of fatal human influenza A subtype H5N1 disease
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Human disease associated with influenza A subtype H5N1 re-emerged in January, 2003, for the first time since an outbreak in Hong Kong in 1997. Patients with H5N1 disease had unusually high serum concentrations of chemokines (eg, interferon induced protein-10 [IP-10] and monokine induced by interferon gamma [MIG]). Taken together with a previous report that H5N1 influenza viruses induce large amounts of proinflammatory cytokines from macrophage cultures in vitro, our findings suggest that cytokine dysfunction contributes to the pathogenesis of H5N1 disease. Development of vaccines against influenza A (H5N1) virus should be made a priority.
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The paradigm of 'hit hard and hit early' popularized for the treatment of AIDS also appears to apply to the way H5N1 avian influenza virus causes tissue damage in human infections.
“The paradigm of “hit hard and hit early” popularized for the treatment of AIDS also appears to apply to the way H5N1 avian influenza virus causes tissue damage in human infections.”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [116]
The rapid and intense nature of the host inflammatory response is the suspected cause of severe lung damage.
“The rapid and intense nature of the host inflammatory response is the suspected cause of severe lung damage (116).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [116]
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Human influenza A H5N1 virus related to a highly pathogenic avian influenza virus
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- Authors
- Peiris, J., Yu, W., Leung, C., Cheung, C., Ng, W., Nicholls, J., Ng, T., Chan, K., Lai, S., Lim, W., Yuen, K., & Guan, Y.
- Affiliations
- Queen Mary Hospital (CN)
- Princess Margaret Hospital (HK)
- Department of Health (CN)
- ORCID
- Guan, Y
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-02
- Volume
- 363
- Issue
- 9409
- Pages
- 617-619
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7112424
- OpenAlex
- W2052374402
- Cited by
- 812
- References
- 5
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 13 · 2023: 20 · 2022: 22 · 2021: 20 · 2020: 20 · 2019: 22 · 2018: 26 · 2017: 20 · 2016: 10 · 2015: 32 · 2014: 42 · 2013: 47 · 2012: 40
- FWCI
- 55.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- Wellcome Trust
- National Institutes of Health (n01ai095357-001)
- National Institute of Allergy and Infectious Diseases (N01 AI095357, AI 95357)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- H5N1 avian influenza, avian influenza, fatal influenza, chemokines, monokine induced by interferon-gamma, inflammatory cytokines, pathogenesis, influenza vaccine development, 2003 outbreak
- MeSH terms
- Animals, China, Disease Outbreaks, Influenza in Birds, Hong Kong, Humans, Influenza, Human, Influenza A virus, Poultry, Poultry Diseases, Zoonoses, Influenza A Virus, H5N1 Subtype
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