The DOI matches its Crossref record; 98 of the 99 references it cites were found in a registry or an index.
Innate immune responses to influenza A H5N1: friend or foe?
Open accessAbstract
Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.
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“The influenza virus neuraminidase protein promotes adherence and invasion of S. pneumoniae through cleavage of sialic acid from the surfaces of host cells, thus exposing receptors for pneumococci (208).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [208]
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Cites
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Research works printed but not linked: 1
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Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
The cytokine storm of severe influenza and development of immunomodulatory therapy
Liu, Q., Zhou, Y., & Yang, Z. (2015) · Cellular and Molecular Immunology · doi:10.1038/cmi.2015.74 · Cited by 725
Host and viral determinants of influenza A virus species specificity
Long, J. S., Mistry, B., Haslam, S. M., & Barclay, W. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0115-z · Cited by 701
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Pathogenesis of influenza-induced acute respiratory distress syndrome
Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 556
Metadata
- Authors
- Peiris, J. S. M., Cheung, C. Y., Leung, C. Y. H., & Nicholls, J. M.
- Affiliations
- Queen Mary Hospital (CN)
- University of Hong Kong (HK)
- Corresponding author
- Peiris, Joseph Sriyal Malik
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 30
- Issue
- 12
- Pages
- 574-584
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC5068224
- OpenAlex
- W2033321639
- Cited by
- 232
- References
- 99
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 9 · 2022: 13 · 2021: 14 · 2020: 29 · 2019: 6 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 14 · 2014: 18 · 2013: 22 · 2012: 15
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- University Grants Committee
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (HHSN266200700005C)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- H5N1 avian influenza, innate immune response, viral pathogenesis, acute respiratory distress syndrome, viral pneumonia, host-virus interaction, viral replication
- MeSH terms
- Animals, Humans, Immunity, Innate, Influenza, Human, Interferons, Orthomyxoviridae Infections, Respiratory Distress Syndrome, Tumor Necrosis Factor-alpha, Mice, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza A Virus, H5N1 Subtype
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