Innate immunity and adipose tissue biology

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819

TLR4 links innate immunity and fatty acid-induced insulin resistance

Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

Nishimura, S., Manabe, I., Nagasaki, M., Eto, K., Yamashita, H., Ohsugi, M., Otsu, M., Hara, K., Ueki, K., Sugiura, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.1964 · Cited by 2,230

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145

Adipose Tissue as an Endocrine Organ

Ahima, R. S., & Flier, J. S. (2000) · Trends in Endocrinology & Metabolism · doi:10.1016/s1043-2760(00)00301-5 · Cited by 1,608

Cooperation of Toll-like receptor signals in innate immune defence

Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,394

Normalization of obesity-associated insulin resistance through immunotherapy

Winer, S., Chan, Y., Paltser, G., Truong, D., Tsui, H., Bahrami, J., Dorfman, R., Wang, Y., Zielenski, J., Mastronardi, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2001 · Cited by 1,370

Glycerol contributes to tuberculosis susceptibility in male mice with type 2 diabetes

Martinez, N., Smulan, L. J., Jameson, M. L., Smith, C. M., Cavallo, K., Bellerose, M. M., Williams, J. T., West, K., Sassetti, C. M., Singhal, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41519-9 · Cited by 33

Transcriptome profiling reveals association of peripheral adipose tissue pathology with type-2 diabetes in Asian Indians

Saxena, A., Tiwari, P., Wahi, N., Soni, A., Bansiwal, R. C., Kumar, A., Sharma, B., Punjabi, P., Gupta, N., Malik, B., et al. (2019) · Adipocyte · doi:10.1080/21623945.2019.1595269 · Cited by 34

Pattern recognition receptor‐initiated innate antiviral response in mouse adipose cells

Yu, L., Yan, K., Liu, P., Li, N., Liu, Z., Zhu, W., Chen, Y., & Han, D. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.66 · Cited by 31

Far-off and close-up dry matter intake modulate indicators of immunometabolic adaptations to lactation in subcutaneous adipose tissue of pasture-based transition dairy cows

Vailati-Riboni, M., Farina, G., Batistel, F., Heiser, A., Mitchell, M. D., Crookenden, M. A., Walker, C. G., Kay, J. K., Meier, S., Roche, J. R., et al. (2017) · Journal of Dairy Science · doi:10.3168/jds.2016-11790 · Cited by 31

Synergistic association of high-sensitivity C-reactive protein and body mass index with insulin resistance in non-diabetic adults

Kim, G. R., Choi, D., Nam, C. M., Jang, S., & Park, E. (2020) · Scientific Reports · doi:10.1038/s41598-020-75390-1 · Cited by 33

Adipose gene expression profiles reveal insights into the adaptation of northern Eurasian semi-domestic reindeer (Rangifer tarandus)

Weldenegodguad, M., Pokharel, K., Niiranen, L., Soppela, P., Ammosov, I., Honkatukia, M., Lindeberg, H., Peippo, J., Reilas, T., Mazzullo, N., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02703-z · Cited by 27

Management of reproduction and pregnancy complications in maternal obesity: Which role for dietary polyphenols?

Santangelo, C., Varı́, R., Scazzocchio, B., Filesi, C., & Masella, R. (2013) · BioFactors · doi:10.1002/biof.1126 · Cited by 30

Analysis of adipose tissue immune gene expression after vaccination of rainbow trout with adjuvanted bacterins reveals an association with side effects

Veenstra, K. A., Wang, T., Alnabulsi, A., Douglas, A., Russell, K. S., Tubbs, L., Arous, J. B., & Secombes, C. J. (2017) · Molecular Immunology · doi:10.1016/j.molimm.2017.05.026 · Cited by 29

ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction

He, X., Ma, S., Tian, Y., Wei, C., Zhu, Y., Li, F., Zhang, P., Wang, P., Zhang, Y., & Zhong, H. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006347 · Cited by 29

Life-long control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia

Contreras, N. A., Sitnik, K., Jeftic, I. D., Coplen, C. P., Čičin‐Šain, L., & Nikolich‐Žugich, J. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007890 · Cited by 29

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis

Martínez, N., Cheng, C. Y., Ketheesan, N., Cullen, A. M., Tang, Y., Lum, J., West, K., Poidinger, M., Guertin, D. A., Singhal, A., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.052 · Cited by 28

Microbial Translocation and Metabolic and Body Composition Measures in Treated and Untreated HIV Infection

Timmons, T., Shen, C., Aldrovandi, G. M., Rollie, A., Gupta, S. K., Stein, J. H., & Dubé, M. P. (2013) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2013.0162 · Cited by 27

Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling

Hertzel, A. V., Xu, H., Downey, M. C., Kvalheim, N., & Bernlohr, D. (2017) · Journal of Lipid Research · doi:10.1194/jlr.m074542 · Cited by 26

Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila

He, L., Wu, B., Shi, J., Du, J., & Zhao, Z. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112912 · Cited by 25

Effects of Toll-like receptor antagonist 4,5-dihydro-3-phenyl-5-isoxasole acetic acid on the progression of kidney disease in mice on a high-fat diet

Min, H. S., Kim, J. E., Lee, M., Song, H. K., Lee, M. J., Lee, J. E., Kim, H. W., Joo, J., Hyun, Y. Y., Han, J., et al. (2014) · Kidney Research and Clinical Practice · doi:10.1016/j.krcp.2013.11.002 · Cited by 25

C5a Receptor Deficiency Alters Energy Utilization and Fat Storage

Roy, C., Gupta, A. K., Fisette, A., Lapointe, M., Poursharifi, P., Richard, D., Lü, H., Lu, B., Gerard, N. P., Gerard, C. J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062531 · Cited by 25

Deficiency of C5L2 Increases Macrophage Infiltration and Alters Adipose Tissue Function in Mice

Gauvreau, D., Gupta, A. K., Fisette, A., Tom, F.-Q., & Cianflone, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060795 · Cited by 24

Perinodal Adipose Tissue and Mesenteric Lymph Node Activation During Reactivated TNBS-Colitis in Rats

Acedo, S. C., Gotardo, É. M. F., Lacerda, J. M., de Oliveira, C. C., Carvalho, P. D. O., & Gambero, A. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1644-8 · Cited by 24

Genome-Wide DNA Methylation Changes between the Superficial and Deep Backfat Tissues of the Pig

Li, M., Wang, T., Wu, H., Zhang, J., Zhou, C., Jiang, A., Li, R., & Li, X. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13067098 · Cited by 23

Adipose-selective overexpression of ABHD5/CGI-58 does not increase lipolysis or protect against diet-induced obesity

Caviglia, J. M., Betters, J. L., Dapito, D., Lord, C. C., Sullivan, S., Chua, S. C., Yin, T. C., Sekowski, A., Mu, H., Shapiro, L. S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m019117 · Cited by 23

Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy

Chatterjee, R., Bhattacharya, P., Gavrilova, O., Glass, K., Moitra, J., Myakishev-Rempel, M., Pack, S., Jou, W., Feigenbaum, L., Eckhaus, M., et al. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0172 · Cited by 24

Relationship between adiponectin, leptin, IGF ‐1 and total lipid peroxides plasma concentrations in patients with systemic sclerosis: possible role in disease development

Winsz‐Szczotka, K., Kuźnik‐Trocha, K., Komosińska‐Vassev, K., Kucharz, E. J., Kotulska, A. T., & Olczyk, K. (2014) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.12332 · Cited by 23

Effect of Intermittent Fasting, Probiotic-Fermented Camel Milk, and Probiotic-Fermented Camel Milk Incorporating Sukkari Date on Diet-Induced Obesity in Rats

Aljutaily, T., Rehan, M., Moustafa, M. M. A., & Barakat, H. (2022) · Fermentation · doi:10.3390/fermentation8110619 · Cited by 22

Obesity Is Associated with Immunometabolic Changes in Adipose Tissue That May Drive Treatment Resistance in Breast Cancer: Immune-Metabolic Reprogramming and Novel Therapeutic Strategies

Savva, C., Copson, E., Johnson, P., Cutress, R., & Beers, S. A. (2023) · Cancers · doi:10.3390/cancers15092440 · Cited by 21

C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue

Poursharifi, P., Lapointe, M., Fisette, A., Lü, H., Roy, C., Munkonda, M. N., Fairlie, D. P., & Cianflone, K. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.019 · Cited by 22

Genes involved in the immediate early response and epithelial–mesenchymal transition are regulated by adipocytokines in the female reproductive tract

Yang, Z., Norwood, K. A., Smith, J. E., Kerl, J. G., & Wood, J. R. (2011) · Molecular Reproduction and Development · doi:10.1002/mrd.22006 · Cited by 21

Links between obesity, diabetes and ethnic disparities in breast cancer among Hispanic populations

Lopez, R., Agullo, P. A., & Lakshmanaswamy, R. (2013) · Obesity Reviews · doi:10.1111/obr.12030 · Cited by 21

Association Between Epicardial Adipose Tissue and Stroke

da Rosa, M. I., Grande, A. J., Lima, L. D., Dondossola, E. R., Uggioni, M. L. R., Hernández, A. V., Tse, G., Liu, T., Pontes‐Neto, O. M., Biondi‐Zoccai, G., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.658445 · Cited by 20

Correlation of epicardial fat quantification with severity of coronary artery disease: A study in Indian population

Khurana, R., Yadav, A., Buxi, T. B. S., Sawhney, J. P. S., Rawat, K. S., & Ghuman, S. S. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.08.009 · Cited by 20

Dietary alpha- and gamma-tocopherol (1:5 ratio) supplementation attenuates adipose tissue expansion, hepatic steatosis, and expression of inflammatory markers in a high-fat-diet–fed murine model

Juretić, N., Sepúlveda, R., D’Espessailles, A., Vera, D. B., Cadagan, C., de Miguel, M., Gonzalez‐Mañán, D., & Tapia, G. (2021) · Nutrition · doi:10.1016/j.nut.2021.111139 · Cited by 20

Regulation of CAMP (cathelicidin antimicrobial peptide) expression in adipocytes by TLR 2 and 4

Höpfinger, A., Karrasch, T., Schäffler, A., & Schmid, A. (2021) · Innate Immunity · doi:10.1177/1753425920988167 · Cited by 20

Octanoylated Ghrelin Inhibits the Activation of the Palmitic Acid-Induced TLR4/NF- κ B Signaling Pathway in THP-1 Macrophages

Liu, S., Li, X. Y., Li, Z., He, L., Xiao, Y., Yan, K., & Zhou, Z. (2012) · ISRN Endocrinology · doi:10.5402/2012/237613 · Cited by 21

Immune response in the adipose tissue of lean mice infected with the protozoan parasite Neospora caninum

Teixeira, L., Moreira, J., Melo, J., Bezerra, F., Marques, R. M., Ferreirinha, P., Correia, A., Monteiro, M. P., Ferreira, P. G., & Vilanova, M. (2015) · Immunology · doi:10.1111/imm.12440 · Cited by 21

Gut-derived peptidoglycan remotely inhibits bacteria dependent activation of SREBP by Drosophila adipocytes

Charroux, B., & Royet, J. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010098 · Cited by 18

TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis

Chen, J., Li, J., Yiu, J. H. C., Lam, J. K. W., Wong, C., Dorweiler, B., Xu, A., & Woo, C. W. (2017) · Science Signaling · doi:10.1126/scisignal.aal3336 · Cited by 20

Immuno-metabolism and adipose tissue: The key role of hematopoietic stem cells

Cousin, B., Casteilla, L., Laharrague, P. F., Luche, É., Lorsignol, A., Cuminetti, V., & Paupert, J. (2015) · Biochimie · doi:10.1016/j.biochi.2015.06.012 · Cited by 19

MIP-1a Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism

Ahmad, R., Akhter, N., Al-Roub, A., Kochumon, S., Wilson, A., Thomas, R., Ali, S., Tuomilehto, J., & Sindhu, S. T. A. K. (2019) · Cellular Physiology and Biochemistry · doi:10.33594/000000015 · Cited by 19

Subcutaneous adipose tissue: Implications in dermatological diseases and beyond

Ziadlou, R., Pandian, G. N., Hafner, J., Akdiş, C. A., Stingl, G., Maverakis, E., & Brüggen, M. (2024) · Allergy · doi:10.1111/all.16295 · Cited by 19

Palmitate Potentiates Lipopolysaccharide-Induced IL-6 Production via Coordinated Acetylation of H3K9/H3K18, p300, and RNA Polymerase II

Kochumon, S., JACOB, T. K., Koshy, M., Al‐Rashed, F., Sindhu, S. T. A. K., Al‐Ozairi, E., Al‐Mulla, F., Rosen, E. D., & Ahmad, R. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100928 · Cited by 19

Novel Superactive Leptin Antagonists and their Potential Therapeutic Applications

Gertler, A., & Elinav, E. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990014 · Cited by 19

Dermal white adipose tissue: A new modulator in wound healing and regeneration

Wu, Z., Wang, Z., Chen, T., Wang, D., Zhou, F., Zhang, G., Wei, S., & Wu, Y. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.11.015 · Cited by 20

Prognostic significance of crown-like structures to trastuzumab response in patients with primary invasive HER2 + breast carcinoma

Birts, C. N., Savva, C., Laversin, S. A., Lefas, A. Y., Krishnan, J. V., Schapira, A., Ashton‐Key, M., Crispin, M., Johnson, P., Blaydes, J. P., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11696-6 · Cited by 17

The Emerging Role of Cardiovascular Magnetic Resonance Imaging in the Evaluation of Metabolic Cardiomyopathies

Mavrogeni, S. I., Markousis‐Mavrogenis, G., Markussis, V., & Kolovou, G. D. (2015) · Hormone and Metabolic Research · doi:10.1055/s-0035-1555913 · Cited by 17

Quantification and regulation of adipsin in human cerebrospinal fluid ( CSF )

Schmid, A., Höpfinger, A., Berghoff, M., Schlegel, J., Karrasch, T., Kaps, M., & Schäffler, A. (2015) · Clinical Endocrinology · doi:10.1111/cen.12856 · Cited by 17

Does maternal grandmother's support improve maternal and child nutritional health outcomes? Evidence from Merida, Yucatan, Mexico

Vázquez‐Vázquez, A., Fewtrell, M. S., Chan‐García, H., Batún‐Marrufo, C., Dickinson, F., & Wells, J. C. K. (2021) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2020.0035 · Cited by 20

Gene networks and pathways for plasma lipid traits via multitissue multiomics systems analysis

Blencowe, M., Ahn, I. S., Saleem, Z., Luk, H., Cely, I., Mäkinen, V., Zhao, Y., & Yang, X. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000713 · Cited by 17

Novel micro-computed tomography contrast agents to visualise the human cardiac conduction system and surrounding structures in hearts from normal, aged, and obese individuals

Aminu, A. J., Chen, W., Yin, Z., Kuniewicz, M., Walocha, J. A., Perde, F., Molenaar, P., Iaizzo, P. A., Dobrzynski, H., & Atkinson, A. J. (2022) · Translational Research in Anatomy · doi:10.1016/j.tria.2022.100175 · Cited by 16

The roles of tissue-resident macrophages in sepsis-associated organ dysfunction

Gao, Y., Tian, X., Zhang, X., Nkoua, G. D. M., Chen, F., Liu, Y., & Chai, Y. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21391 · Cited by 17

Transcriptome changes associated with fat deposition in the longissimus thoracis of Korean cattle following castration

Na, S. W., Park, S. J., Hong, S. J., & Baik, M. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13393 · Cited by 16

Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.

Zhou, C., Su, W., Han, H., Li, N., Ma, G., & Cui, L. (2020) · Europe PMC (PubMed Central) · Cited by 16

Obesity-Mediated Inflammation and Its Influence on Inflammatory Bowel Disease: Pathophysiology, Clinical Impact, and Therapeutic Implications

Deza, D. C., García‐López, S., Monterde, V. B., Cuadro, C. P., Caballero, C. Y., & Arbonés-Mainar, J. M. (2025) · Biomolecules · doi:10.3390/biom15081185 · Cited by 20

The Impact of Nonalcoholic Fatty Liver Disease on Severe Community-Acquired Pneumonia Outcomes

Gjurašin, B., Jeličić, M., Kutleša, M., & Papić, N. (2022) · Life · doi:10.3390/life13010036 · Cited by 15

Expression of genes for interleukins, neuropeptides, growth hormone receptor, and leptin receptor in adipose tissue from growing broiler chickens

Hausman, G. J., Barb, C. R., Fairchild, B. D., Gamble, J. T., & Lee-Rutherford, L. (2012) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2012.03.008 · Cited by 15

Adipokines and Inflammation Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts and Endothelial Cells

Hasseli, R., Frommer, K., Schwarz, M., Hülser, M.-L., Schreiyäck, C., Arnold, M., Diller, M., Tarner, I. H., Lange, U., Pons‐Kühnemann, J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00925 · Cited by 16

High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue

Stutte, S., Ishikawa-Ankerhold, H. C., Lynch, L., Eickhoff, S., Nasiscionyte, S., Guo, C., van den Heuvel, D., Setzensack, D., Colonna, M., Begandt, D., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100022 · Cited by 17

Prognostic effect of steatosis on hepatocellular carcinoma patients after liver resection

Wu, T.-H., Yu, M.-C., Chan, K.-M., Lee, C.-F., Chen, T.-C., Chang, H.-C., Chou, H.-S., Wu, T.-J., Eldeen, F. Z., Chen, M. F., et al. (2011) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2011.04.004 · Cited by 15

Immunohistochemical examination of immune cells in adipose tissue of rainbow trout (Oncorhynchus mykiss) following intraperitoneal vaccination

Veenstra, K. A., Alnabulsi, A., Tubbs, L., Arous, J. B., & Secombes, C. J. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.02.001 · Cited by 15

Multi-Omics Data Analysis Uncovers Molecular Networks and Gene Regulators for Metabolic Biomarkers

Jung, S. Y. (2021) · Biomolecules · doi:10.3390/biom11030406 · Cited by 13

Lipedema: From Women’s Hormonal Changes to Nutritional Intervention

Tomada, I. (2025) · Endocrines · doi:10.3390/endocrines6020024 · Cited by 15

Modulation of the inflammatory response to LPS by the recruitment and activation of brown and brite adipocytes in mice

Munro, P. M., Dufies, O., Rekima, S., Loubat, A., Duranton, C., Boyer, L., & Pisani, D. F. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00279.2020 · Cited by 13

The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes

Karrasch, T., Höpfinger, A., Schäffler, A., & Schmid, A. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155663 · Cited by 14

Activation of the Adipose Tissue NLRP3 Inflammasome Pathway in Cancer Cachexia

de Jesus, J. D. C. R., Murari, A. S. D. P., Radloff, K., de Moraes, R. C. M., Figuerêdo, R. G., Pessoa, A. F. M., Neto, J. C. R., de Matos‐Neto, E. M., de Alcântara, P. S. M., Tokeshi, F., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.729182 · Cited by 13

Innate immunity orchestrates adipose tissue homeostasis

Lin, Y.-W., & Wei, L. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0013 · Cited by 13

Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

Mejia, P., Trevino-Villarreal, J. H., Niz, M. D., Meibalan, E., Longchamp, A., Reynolds, J. S., Turnbull, L. B., Opoka, R. O., Roussilhon, C., Spielmann, T., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe2484 · Cited by 13

Inflammation and the cardiovascular system

Demyanets, S., Huber, K., & Wojta, J. (2011) · European surgery. Supplement/European surgery · doi:10.1007/s10353-011-0607-9 · Cited by 13

Plasma levels of lipopolysaccharide correlate with insulin resistance in HIV patients

Pedro, M. N., Magro, D. O., da Silva, E. U. P. P., Guadagnini, D., Santos, A., Pedro, R. D. J., & Saad, M. J. A. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0308-7 · Cited by 13

Role of Complement and Complement‐Related Adipokines in Regulation of Energy Metabolism and Fat Storage

Saleh, J., Al‐Maqbali, M., & Abdel‐Hadi, D. (2019) · Comprehensive physiology · doi:10.1002/cphy.c170037 · Cited by 15

Plasmodium berghei ANKA infection results in exacerbated immune responses from C57BL/6 mice displaying hypothalamic obesity

de Carvalho, R. A., Soares, S. M. A., Gualberto, A. C. M., Evangelista, G. C. M., Duque, J. A. M., Ferreira, A. P., Macedo, G. C., & Gameiro, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.025 · Cited by 12

Epicardial fat thickness is significantly increased and related to LDL cholesterol level in patients with familial hypercholesterolemia

Dönmez, Y., & Bulut, A. (2019) · Journal of Ultrasound · doi:10.1007/s40477-019-00368-3 · Cited by 15

Acute Inflammation Is a Predisposing Factor for Weight Gain and Insulin Resistance

de Oliveira, E. M., Silva, J. C., Ascar, T. P., Sandri, S., Marchi, A. F., Migliorini, S., Nakaya, H. I., Fock, R. A., & Čampa, A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030623 · Cited by 12

Impact of Obesity on the IL-6 Immune Marker and Th17 Immune Cells in C57BL/6 Mice Models with Imiquimod-Induced Psoriasis

Park, S. H., Lee, K. A., Choi, J.-H., Park, S., Kim, D., & Jung, S. Y. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065592 · Cited by 12

Association of Immune and Metabolic ReceptorsC5aRandC5L2with Adiposity in Women

Poursharifi, P., Rezvani, R., Gupta, A. K., Lapointe, M., Marceau, P., Tchernof, A., & Cianflone, K. (2014) · Mediators of Inflammation · doi:10.1155/2014/413921 · Cited by 10

Elicitation of integrated immunity in mice by a novel pneumococcal polysaccharide vaccine conjugated with HBV surface antigen

Qian, W., Huang, Z., Chen, Y., Yang, J., Wang, L., Wu, K., Chen, M., Chen, N., Duan, Y., Shi, J., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-62185-7 · Cited by 12

The Serosal Immune System of the Thorax in Toxicology

Kuper, C. F., van Bilsen, J. H. M., & Wijnands, M. V. W. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy085 · Cited by 13

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Cornelli, U., BELCARO, G. V., & Finco, A. (2011) · Journal of Cosmetics Dermatological Sciences and Applications · doi:10.4236/jcdsa.2011.13011 · Cited by 13

Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells

Schmid, A., Vlacil, A.-K., Schuett, J., Karrasch, T., Schieffer, B., Schäffler, A., & Grote, K. (2021) · Cells · doi:10.3390/cells10082146 · Cited by 11

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Efremov, L., Lacruz, M. E., Tiller, D., Medenwald, D., Greiser, K. H., Kluttig, A., Wienke, A., Nuding, S., & Mikolajczyk, R. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s263727 · Cited by 11

Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology

Binişor, I. D., Baniţă, I. M., Alexandru, D. O., MEHEDINTI, M. C., Jurja, S., Andrei, A. M., & Pisoschi, C. G. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10772 · Cited by 10

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Arrari, F., Jabri, M., Ayari, A., Dakhli, N., Fayala, C. B., Boubaker, S., & Sebaï, H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30103 · Cited by 15

Refractory neutrophil activation in type 2 diabetics with chronic periodontitis

Herrmann, J. M., Sonnenschein, S. K., Groeger, S. E., Ewald, N., Arneth, B. M., & Meyle, J. (2020) · Journal of Periodontal Research · doi:10.1111/jre.12717 · Cited by 10

Toll-like Receptor 7 (TLR7) Is Expressed in Adipocytes and the Pharmacological TLR7 Agonist Imiquimod and Adipocyte-Derived Cell-Free Nucleic Acids (cfDNA) Regulate Adipocyte Function

Thomalla, M., Schmid, A., Hehner, J., Koehler, S., Neumann, E., Müller‐Ladner, U., Schäffler, A., & Karrasch, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158475 · Cited by 10

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p204‐mediated innate antiviral responses in mouse adipose cells and their effects on cell functions

Yu, L., Liu, P., Liu, Z., Zhu, W., Yan, K., Chen, Q., & Han, D. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.83 · Cited by 10

MicroRNAs Responsible for Inflammation in Obesity

Brettfeld, C., Maver, A., Aumüller, E., Peterlin, B., & Haslberger, A. G. (2017) · Journal of Endocrinology and Metabolism · doi:10.14740/jem399w · Cited by 10

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Obesity and Thyroid Cancer

Marcello, M. A., Cunha, L. L., Batista, F. D. A., & Ward, L. S. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_17 · Cited by 9

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Park, H., Seo, S., Cho, Y. M., Oh, S. J., Seong, H., Lee, S. H., & Lim, D. (2012) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.2011.11347 · Cited by 9

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Kuper, C. F., Pieters, R. H. H., & van Bilsen, J. H. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052610 · Cited by 8

Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes

Needell, J. C., Brown, M. N., & Zipris, D. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0131 · Cited by 8

Rolle der Metaflammation als systemische Manifestation bei Stoffwechselerkrankungen

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Predictors of Serum Levels of High Sensitivity C-Reactive Protein and Systolic Blood Pressure in Overweight and Obese Nondiabetic Women in Tehran: A Cross-Sectional Study

Neyestani, T. R., Salekzamani, S., Kalayi, A., Majd, H. A., Houshiarrad, A., Nikooyeh, B., & Shariátzadeh, N. (2010) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2010.0075 · Cited by 7

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Santos, A. L., & Sinha, S. (2023) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-26576-1_15 · Cited by 8

The contribution of Toll-like receptors to placental inflammation in diet-induced maternal obesity

Thompson, J. A., Hardigan, T., Carrillo-Sepúlveda, M. A., MINTZ, J. D., Ergul, A., Diamond, M. P., & Webb, R. C. (2015) · Placenta · doi:10.1016/j.placenta.2015.07.132 · Cited by 7

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Schmid, A., Roderfeld, M., Gehl, J., Roeb, E., Nist, A., Chung, H., Stiewe, T., Karrasch, T., & Schäffler, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041670 · Cited by 8

Single-Cell and Single-Nuclei transcriptomics profiling reveals dynamic cellular features in tumor-related adipose microenvironment of breast cancer patients with high BMI

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Short-term High-fat Overfeeding Does Not Induce NF-κB Inflammatory Signaling in Subcutaneous White Adipose Tissue

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Receptor regulation of senile phenoptosis

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Innate Immunity and Inflammation

McKarns, S. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64228-9 · Cited by 6

Increased maternal C1q/TNF-related protein-1 (CTRP-1) serum levels in pregnancies with preeclampsia

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Construction and Synergistic Effect of Recombinant Yeast Co-expressing Pig IL-2/4/6 on Immunity of Piglets to PRRS Vaccination

Luo, G., Luyi, Y., Ge, L., Wan, X., Chen, C., Wang, B., Chen, J., Zeng, K., Zhan, S., Chen, X., et al. (2015) · Procedia in Vaccinology · doi:10.1016/j.provac.2015.05.011 · Cited by 5

Adipose tissue as an immunological organ: Toll-like receptors, C1q/TNFs and CTRPs

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Presence of functional TLR2 and TLR4 on human adipocytes

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Role of innate immune receptors TLR2 and TLR4 as mediators of the inflammatory reaction in human visceral adipose tissue.

Fusaru, A. M., Stănciulescu, C. E., Şurlin, V., Taisescu, C. I., Bold, A., Pop, O. T., Baniţă, I. M., Crăiţoiu, Ş., & Pisoschi, C. G. (2012) · PubMed · Cited by 15

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Is the Adipose Tissue the Key Road to Inflammation?

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