Cited by 1,023TGF-β signaling in diseasesT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

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TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

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Yang, Li, Pang, Yanli, Moses, Harold L.·2010·Trends in Immunology

DOI 10.1016/j.it.2010.04.002PMC PMC2891151

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Abstract

Transforming growth factor beta (TGF-beta) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-beta remain unclear. TGF-beta exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-beta enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-beta regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor microenvironment causing direct changes in tumor cells. Understanding TGF-beta regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-beta antagonists and biomarkers for patient selection and efficacy of TGF-beta antagonist treatment.

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Authors: Yang, L., Pang, Y., & Moses, H. L.
Affiliations: National Institutes of Health (US)
Vanderbilt University (US)
ORCID: Pang, Yanli
Moses, Harold L.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2010-06
Volume: 31
Issue: 6
Pages: 220-227
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2010.04.002
PMC: PMC2891151
OpenAlex: W2130229338
Cited by: 1,023
References: 87
Citations by year: 2026: 35 · 2025: 73 · 2024: 81 · 2023: 82 · 2022: 87 · 2021: 96 · 2020: 85 · 2019: 78 · 2018: 71 · 2017: 51 · 2016: 37 · 2015: 40 · 2014: 49 · 2013: 50 · 2012: 56
FWCI: 4.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (ZIABC011163)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords: TGF-beta, tumor microenvironment, tumor progression, immunosuppression, tumor surveillance, CD8+ T cells, natural killer cells, neutrophils, chemokines, cancer-associated fibroblasts, TGF-beta antagonists
MeSH terms: Animals, Humans, Killer Cells, Natural, Neoplasms, T-Lymphocytes, Signal Transduction, Transforming Growth Factor beta, Disease Progression

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TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

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