The DOI matches its Crossref record; 86 of the 87 references it cites were found in a registry or an index.
TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression
Open accessAbstract
Transforming growth factor beta (TGF-beta) plays an important role in tumor initiation and progression, functioning as both a suppressor and a promoter. The mechanisms underlying this dual role of TGF-beta remain unclear. TGF-beta exerts systemic immune suppression and inhibits host immunosurveillance. Neutralizing TGF-beta enhances CD8+ T-cell- and NK-cell-mediated anti-tumor immune responses. It also increases neutrophil-attracting chemokines resulting in recruitment and activation of neutrophils with an antitumor phenotype. In addition to its systemic effects, TGF-beta regulates infiltration of inflammatory/immune cells and cancer-associated fibroblasts in the tumor microenvironment causing direct changes in tumor cells. Understanding TGF-beta regulation at the interface of tumor and host immunity should provide insights into developing effective TGF-beta antagonists and biomarkers for patient selection and efficacy of TGF-beta antagonist treatment.
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“Cancer tissue is riddled with immune cells which support tumor growth, while inflammation is also evident at the whole‐body level.33, 34”
From Hypoalbuminemia: Pathogenesis and Clinical Significance (2019) · cites this paper as [34]
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Cites
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Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
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Smad-dependent and Smad-independent pathways in TGF-β family signalling
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Microenvironmental regulation of metastasis
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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
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Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Massagué, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3434 · Cited by 3,239
Inflammation and tumor progression: signaling pathways and targeted intervention
Zhao, H., Wu, L., Yan, G., Chen, Y., Zhou, M., Wu, Y., & Li, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00658-5 · Cited by 3,058
Hypoalbuminemia: Pathogenesis and Clinical Significance
Soeters, P. B., Wolfe, R. R., & Shenkin, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1451 · Cited by 1,448
Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428
Metadata
- Authors
- Yang, L., Pang, Y., & Moses, H. L.
- Affiliations
- National Institutes of Health (US)
- Vanderbilt University (US)
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 31
- Issue
- 6
- Pages
- 220-227
- ISSN
- 1471-4906 (ISSN-L)
- PMC
- PMC2891151
- OpenAlex
- W2130229338
- Cited by
- 1,023
- References
- 87
- Citations by year
- 2026: 35 · 2025: 73 · 2024: 81 · 2023: 82 · 2022: 87 · 2021: 96 · 2020: 85 · 2019: 78 · 2018: 71 · 2017: 51 · 2016: 37 · 2015: 40 · 2014: 49 · 2013: 50 · 2012: 56
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (ZIABC011163)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- TGF-beta, tumor microenvironment, tumor progression, immunosuppression, tumor surveillance, CD8+ T cells, natural killer cells, neutrophils, chemokines, cancer-associated fibroblasts, TGF-beta antagonists
- MeSH terms
- Animals, Humans, Killer Cells, Natural, Neoplasms, T-Lymphocytes, Signal Transduction, Transforming Growth Factor beta, Disease Progression
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