The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
Open accessAbstract
Psoriasis is a complex inflammatory process resulting from activation of the well-defined IL-23/T17 cytokine axis. We review the role of key cytokines interleukin (IL)-17 and IL-23 in psoriasis, as well as tumor necrosis factor alpha (TNα), focusing on therapeutic cytokine interventions and what they reveal about psoriatic inflammation. The potential role of recently described epidermal IL-36RN and CARD14 genetic mutations in psoriasis pathogenesis will also be explored, as they augment keratinocyte responses to pro-inflammatory cytokines. The discovery of these genetic mutations in familial and pustular psoriasis suggest new links between cytokine-induced gene products and IL-1 family members from keratinocytes, which may regulate features of the disease, including epidermal hyperplasia and neutrophil infiltrating responses.
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Cites
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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
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Risk of myocardial infarction in patients with psoriasis
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β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
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Structure and signalling in the IL-17 receptor family
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Self-citation
Cited by
Lowes, M. A., Suárez-Fariñas, M., & Krueger, J. G. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120225 · Cited by 1,650
Self-citationTeng, M. W. L., Bowman, E. P., McElwee, J. J., Smyth, M. J., Casanova, J.-L., Cooper, A. M., & Cua, D. J. (2015) · Nature Medicine · doi:10.1038/nm.3895 · Cited by 873
Villanova, F., Flutter, B., Tosi, I., Grys, K., Sreeneebus, H., Perera, G. K., Chapman, A., Smith, C. H., Di Meglio, P., & Nestle, F. O. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2013.477 · Cited by 386
Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions
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Tarcha, E. J., Olsen, C. M., Probst, P., Peckham, D., Muñoz-Elías, E. J., Kruger, J. G., & Iadonato, S. P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0180762 · Cited by 167
Metadata
- Authors
- Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 34
- Issue
- 4
- Pages
- 174-181
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W1981177225
- Cited by
- 537
- References
- 9
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. https://app.cochat.ai/papers/10.1016/j.it.2012.11.005
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- Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G. (2013). The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends in Immunology. https://doi.org/10.1016/j.it.2012.11.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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