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The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses
Open accessAbstract
Psoriasis is a complex inflammatory process resulting from activation of the well-defined IL-23/T17 cytokine axis. We review the role of key cytokines interleukin (IL)-17 and IL-23 in psoriasis, as well as tumor necrosis factor alpha (TNα), focusing on therapeutic cytokine interventions and what they reveal about psoriatic inflammation. The potential role of recently described epidermal IL-36RN and CARD14 genetic mutations in psoriasis pathogenesis will also be explored, as they augment keratinocyte responses to pro-inflammatory cytokines. The discovery of these genetic mutations in familial and pustular psoriasis suggest new links between cytokine-induced gene products and IL-1 family members from keratinocytes, which may regulate features of the disease, including epidermal hyperplasia and neutrophil infiltrating responses.
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Metadata
- Authors
- Lowes, M. A., Russell, C. B., Martin, D. A., Towne, J. E., & Krueger, J. G.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 34
- Issue
- 4
- Pages
- 174-181
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W1981177225
- Cited by
- 537
- References
- 98
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.