Cited by 156Neuroinflammation and Neurodegeneration MechanismsT-cell and B-cell ImmunologyMultiple Sclerosis Research Studies

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Understanding the Role of T Cells in CNS Homeostasis

Ellwardt, Erik, Walsh, James T., Kipnis, Jonathan, Zipp, Frauke·2016·Trends in Immunology

DOI 10.1016/j.it.2015.12.008

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Abstract

T cells within the central nervous system (CNS) have been generally considered pathogenic, especially in the context of neuroinflammatory disease. However, recent findings have revealed varied functions for T cells in the healthy CNS, as well as more complex roles for these cells in infection and injury than previously appreciated. Here we review evidence indicating important roles for different T cell subsets in the maintenance of CNS homeostasis. We examine the contribution of T cells in limiting inflammation and damage upon CNS injury, infection, and in neurodegeneration, and discuss the current understanding of the cellular and molecular mechanisms involved. Insight into these processes will shed light on the adverse effects of T cell-depleting therapies and present inroads into new therapeutic approaches for treating diseases affecting the CNS.

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Authors: Ellwardt, E., Walsh, J. T., Kipnis, J., & Zipp, F.
Affiliations: University Medical Center of the Johannes Gutenberg University Mainz (DE)
University of Virginia (US)
Johannes Gutenberg University Mainz (DE)
Corresponding author: Ellwardt, Erik
ORCID: Walsh, James T.
Kipnis, Jonathan
Zipp, Frauke
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2016-02
Volume: 37
Issue: 2
Pages: 154-165
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2015.12.008
OpenAlex: W2233981766
Cited by: 156
References: 116
Citations by year: 2026: 11 · 2025: 8 · 2024: 16 · 2023: 18 · 2022: 21 · 2021: 29 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 5 · 2016: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (T32GM007267)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: T cells, CNS homeostasis, neuroinflammation, central nervous system injury, central nervous system infection, neurodegeneration, T cell subsets, neuroimmunology
MeSH terms: Animals, Central Nervous System, Homeostasis, Humans, Lymphocyte Depletion, T-Lymphocytes, T-Lymphocyte Subsets, Neurogenic Inflammation

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Understanding the Role of T Cells in CNS Homeostasis

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