The DOI matches its Crossref record; 151 of the 153 references it cites were found in a registry or an index.
The Intestinal Epithelium: Central Coordinator of Mucosal Immunity
Abstract
The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune system. It must tolerate the presence of the luminal microbiota and thus not respond to their products, but still protect the intestinal mucosa from potentially harmful dietary antigens and invading pathogens. The intestinal epithelium, composed of a single layer of cells, is crucial for preserving gut homeostasis and acts both as a physical barrier and as a coordinating hub for immune defense and crosstalk between bacteria and immune cells. We highlight here recent findings regarding communication between microbes and intestinal epithelial cells (IECs), as well as the immune mechanisms employed by distinct IEC subsets to promote homeostasis, emphasizing the central and active role that these cells play in host enteric defense.
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“In the gut, the GM and its metabolites have been shown to modulate gastrointestinal functions via their effects on intestinal permeability (32–35), mucosal immune function (36–38), intestinal motility and sensitivity (39, 40), and the enteric nervous system (ENS) (21, 24, 25, 41).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [37]
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Cites
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2 of the 153 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
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Gut Microbiota as a Trigger for Metabolic Inflammation in Obesity and Type 2 Diabetes
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Self-citationMaterials for oral delivery of proteins and peptides
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Metadata
- Authors
- Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A.
- Affiliations
- University of British Columbia (CA)
- Ajou University (KR)
- Kangwon National University (KR)
- Corresponding author
- Vallance, Bruce A.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 39
- Issue
- 9
- Pages
- 677-696
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2801765418
- Cited by
- 933
- References
- 153
- Citations by year
- 2026: 98 · 2025: 112 · 2024: 148 · 2023: 134 · 2022: 147 · 2021: 139 · 2020: 94 · 2019: 44 · 2018: 15
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-02-01)
- Open access
- closed
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- intestinal epithelium, mucosal immunity, intestinal homeostasis, intestinal epithelial cells, microbiota-immune crosstalk, intestinal barrier, dietary antigens, pathogen defense, host defense
- MeSH terms
- Gastrointestinal Microbiome, Animals, Antigens, Cell Communication, Epithelial Cells, Homeostasis, Humans, Immune System, Immunity, Innate, Intestinal Mucosa, Signal Transduction, Immunity, Mucosal, Host-Pathogen Interactions, Dysbiosis
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