Cited by 936Gut microbiota and healthImmune Response and InflammationT-cell and B-cell Immunology

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The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

Allaire, Joannie M., Crowley, Shauna M., Law, Hong T., Chang, Sun-Young, Ko, Hyun-Jeong, Vallance, Bruce A.·2018·Trends in Immunology

DOI 10.1016/j.it.2018.04.002

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Abstract

The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune system. It must tolerate the presence of the luminal microbiota and thus not respond to their products, but still protect the intestinal mucosa from potentially harmful dietary antigens and invading pathogens. The intestinal epithelium, composed of a single layer of cells, is crucial for preserving gut homeostasis and acts both as a physical barrier and as a coordinating hub for immune defense and crosstalk between bacteria and immune cells. We highlight here recent findings regarding communication between microbes and intestinal epithelial cells (IECs), as well as the immune mechanisms employed by distinct IEC subsets to promote homeostasis, emphasizing the central and active role that these cells play in host enteric defense.

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Authors: Allaire, J. M., Crowley, S. M., Law, H. T., Chang, S.-Y., Ko, H.-J., & Vallance, B. A.
Affiliations: University of British Columbia (CA)
Ajou University (KR)
Kangwon National University (KR)
Corresponding author: Vallance, Bruce A.
ORCID: Allaire, Joannie M.
Crowley, Shauna M.
Chang, Sun-Young
Ko, Hyun-Jeong
Vallance, Bruce A.
Venue: Trends in Immunology
Publisher: Elsevier BV
Published: 2018-09
Volume: 39
Issue: 9
Pages: 677-696
ISSN: 1471-4906 (ISSN-L)
DOI: 10.1016/j.it.2018.04.002
OpenAlex: W2801765418
Cited by: 933
References: 153
Citations by year: 2026: 98 · 2025: 112 · 2024: 148 · 2023: 134 · 2022: 147 · 2021: 139 · 2020: 94 · 2019: 44 · 2018: 15
FWCI: 7.15
Type: journal article
Language: en
Update notices: erratum (2019-02-01)
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Trends in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: intestinal epithelium, mucosal immunity, intestinal homeostasis, intestinal epithelial cells, microbiota-immune crosstalk, intestinal barrier, dietary antigens, pathogen defense, host defense
MeSH terms: Gastrointestinal Microbiome, Animals, Antigens, Cell Communication, Epithelial Cells, Homeostasis, Humans, Immune System, Immunity, Innate, Intestinal Mucosa, Signal Transduction, Immunity, Mucosal, Host-Pathogen Interactions, Dysbiosis

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The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

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