Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?

The Hallmarks of Aging

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lncRNA-Triggered Macrophage Inflammaging Deteriorates Age-Related Diseases

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Patho-Physiology of Aging and Immune-Senescence: Possible Correlates With Comorbidity and Mortality in Middle-Aged and Old COVID-19 Patients

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Aging Relevant Metabolite Itaconate Inhibits Inflammatory Bone Loss

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Acetylcholine Regulates Pulmonary Pathology During Viral Infection and Recovery

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Resveratrol promotes osteogenesis and angiogenesis through mediating immunology of senescent macrophages

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Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

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Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes

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Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging

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Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging

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Decreased antiviral immune response within the central nervous system of aged mice is associated with increased lethality of West Nile virus encephalitis

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The DARC Side of Inflamm-Aging: Duffy Antigen Receptor for Chemokines (DARC/ACKR1) as a Potential Biomarker of Aging, Immunosenescence, and Breast Oncogenesis among High-Risk Subpopulations

Jinna, N., Rida, P. C. G., Su, T., Gong, Z., Yao, S., LaBarge, M. A., Natarajan, R. D., Jovanović‐Talisman, T., Ambrosone, C. B., & Seewaldt, V. L. (2022) · Cells · doi:10.3390/cells11233818 · Cited by 21

Mechanisms of Extraorbital Lacrimal Gland Aging in Mice: An Integrative Analysis of the Temporal Transcriptome

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Aging and Cancer: The Waning of Community Bonds

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Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease

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A new insight into cell biological and biochemical changes through aging

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Overview of Innate Immune Cell Landscape in Liver Aging

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Microdose Lithium Treatment Reduced Inflammatory Factors and Neurodegeneration in Organotypic Hippocampal Culture of Old SAMP-8 Mice

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The immune response and aging in chronic inflammatory demyelinating polyradiculoneuropathy

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The Roles of Myeloid Cells in Aging-related Liver Diseases

Yao, J., Li, Y., & Wang, H. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82352 · Cited by 15

Rhodiola rosea: a review in the context of PPPM approach

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Sepsis in Aging Populations: A Review of Risk Factors, Diagnosis, and Management

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IL4 stimulated macrophages promote axon regeneration after peripheral nerve injury by secreting uPA to stimulate uPAR upregulated in injured axons

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GDF5 as a rejuvenating treatment for age-related neuromuscular failure

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Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages

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Clinical application of mesenchymal stem cells in immunosenescence: a qualitative review of their potential and challenges

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Metabolic dysregulation of trained immunity in immune aging and the impact of dietary patterns

Grigorescu, A., Riza, A., Streață, I., & Netea, M. G. (2025) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00153.2025 · Cited by 16

A comprehensive single-cell RNA transcriptomic analysis identifies a unique SPP1+ macrophages subgroup in aging skeletal muscle

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Precision Spatial Control of Tumor‐Stroma Interactions in Cancer Models via 3D Bioprinting for Advanced Research and Therapy

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Measuring Phagocytosis in Bone Marrow-Derived Macrophages and Peritoneal Macrophages with Aging

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The non-saponin fraction of Korean Red Ginseng ameliorates sarcopenia by regulating immune homeostasis in 22–26-month-old C57BL/6J mice

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Building the case for mitochondrial transplantation as an anti-aging cardiovascular therapy

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Sustained exposure to high glucose induces differential expression of cellular senescence markers in murine macrophages but impairs immunosurveillance response to senescent cells secretome

Diwan, B., Yadav, R., Goyal, R., & Sharma, R. (2024) · Biogerontology · doi:10.1007/s10522-024-10092-z · Cited by 11

Identification and validation of aging-related genes in heart failure based on multiple machine learning algorithms

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Mitochondrial dysfunction at the cornerstone of inflammatory exacerbation in aged macrophages

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Aging induces sarcopenia by disrupting the crosstalk between the skeletal muscle microenvironment and myofibers

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The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease

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Aging and lung diseases: Unraveling mechanisms and therapeutic targets

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Cellular senescence in recurrent tonsillitis and tonsillar hypertrophy in children

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S1P lyase inhibition prevents lung injury following high pressure-controlled mechanical ventilation in aging mice

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Sustained immune youth risks autoimmune disease in the aging host

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Heterochronic Fecal Microbiota Transfer Reverses Hallmarks of the Aging Murine Gut, Eye and BrainPreprint

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Understanding the Complex Dynamics of Immunosenescence in Multiple Sclerosis: From Pathogenesis to Treatment

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Beyond polarization: macrophage senescence in immunoregulation and cancer therapy

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Keep your macrophages fit for healthy aging

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Bibliometric and visualization analysis of global research trends on immunosenescence (1970–2021)

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A multidimensional immunological perspective on long COVID

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Tapping the immunological imprints to design chimeric SARS-CoV-2 vaccine for elderly population

Biswas, A., Mandal, R. S., Chakraborty, S., & Maiti, G. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1925267 · Cited by 7

Senescent Polarization of Macrophages and Inflammatory Biomarkers in Cardiovascular Disease

Ihan, A. (2025) · Cells · doi:10.3390/cells14171374 · Cited by 6

Iron oxide nanoparticles-driven mitochondrial renewal rejuvenates the aged bone marrow niche

Sun, X., Wang, X., Zhang, M., Liu, S., Zhu, Y., He, J., & Wu, Y. (2026) · Biomaterials · doi:10.1016/j.biomaterials.2026.123989 · Cited by 6

Macrophages in Lung Repair and Fibrosis

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Factors for COVID-19 Infection that Govern the Severity of Illness

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Polyphenol Supplementation Reverses Age-Related Changes in Microglial Signaling Cascades

Jalloh, A., Flowers, A., Hudson, C., Chaput, D., Guergues, J., Stevens, S. M., & Bickford, P. C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126373 · Cited by 5

Amino acid metabolism modulates chronic kidney disease progression by mediating the aging process: Mechanistic insights and therapeutic interventions

Song, Y., Zhou, H., Ye, L., Liu, Y., Guo, F., & Qin, G. (2026) · Diabetes Obesity and Metabolism · doi:10.1111/dom.70463 · Cited by 5

Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration

Fard, D., Barbiera, A., Dobrowolny, G., Tamagnone, L., & Scicchitano, B. M. (2023) · Aging and Disease · doi:10.14336/ad.2023.0801 · Cited by 4

CD47-mediated regulation of glucose and lipid metabolism: implications for the pathogenesis of MASLD

Jiang, X., Zhao, W., Shen, B., Han, Y., & Chen, K. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1535382 · Cited by 6

Mitochondrial DNA alterations in aged macrophage migration inhibitory factor-knockout mice

Herbst, A. J., Hoang, A. N., Woo, W., McKenzie, D. I., Aiken, J. M., Miller, R. A., Allison, D. B., Liu, N., & Wanagat, J. (2019) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2019.111126 · Cited by 4

Zapalenie starcze - mechanizmy i szlaki sygnałowe

Grabowska, K., Nowacka-Chmielewska, M. M., Barski, J. J., & Liśkiewicz, D. (2021) · Postępy Biochemii · doi:10.18388/pb.2021_375 · Cited by 4

Comprehensive analysis of gene signatures associated with aging in human aortic dissection

Yan, J., & Tan, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31298 · Cited by 4

Acetylcholine regulates pulmonary inflammation and facilitates the transition from active immunity to tissue repair during respiratory viral infectionPreprint

Horkowitz, A. P., Schwartz, A. V., Alvarez, C. A., Herrera, E. B., Thoman, M. L., Chatfield, D. A., Osborn, K. G., Feuer, R., George, U. Z., & Phillips, J. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.02.184226 · Cited by 4

MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide

Rice, M. C., Imun, M., Jung, S., Park, C., Kim, J., Lai, R., Barr, C. R., Son, J., Tor, K., Kim, E., et al. (2023) · eLife · doi:10.1101/2023.03.02.530691 · Cited by 5

Anti-inflammaging effects of black soybean and black rice mixture extract by reprogramming of mitochondrial respirations in murine macrophages

Yu, S., Park, H., & Kim, W. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105114 · Cited by 3

Dose-response relationship between weekly physical activity level and the frequency of colds in Chinese middle-aged and elderly individuals

Tang, X., Yu, Y., Wu, X., Xu, C., Zhang, Z., & Lu, Y. (2024) · PeerJ · doi:10.7717/peerj.17459 · Cited by 3

Hypothalamic Microinflammation: New Paradigm In Obesity And Metabolic Disease

Meiliana, A., Dewi, N. M., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i3.1235 · Cited by 2

cGAS-STING signaling is blunted in senescent macrophages and monocytes in obesity

Schmitz, C. R. R., Grün, L. K., Makiyama, B. K., Piazza, L. S., Padoin, A. V., Mottin, C. C., Bauer, M. E., Guma, F. T. C. R., & Barbé‐Tuana, F. M. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112140 · Cited by 3

Transcriptional Study of Radiofrequency Device Using Experimental Mouse Model

Li, X., Wang, Z., Li, X., Fan, X., Lu, X., Li, Y., Pan, Y., Zhu, Z., Zhu, M., Li, W., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094460 · Cited by 2

Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes

Zeng, F., Zhu, L. Q., Liao, Q., Li, X., & Zhou, Y. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30688 · Cited by 2

The Human Mitochondrial Genome Encodes for an Interferon-Responsive Host Defense PeptidePreprint

Rice, M. C., Kim, J., Imun, M., Jung, S., Park, C., Lai, R., Barr, C. R., Son, J., Tor, K., Kim, E., et al. (2023) · doi:10.7554/elife.87615.1 · Cited by 2

Niche-specific macrophage loss promotes skin capillary agingPreprint

Mesa, K. R., O’Connor, K. A., Ng, C., Salvatore, S., Dolynuk, A., Lomeli, M. R., & Littman, D. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.25.554832 · Cited by 2

Treating Cellular Stress and Damage : Use of Healthy Mitochondria Isolated from Donor Cells in the Artificial Mitochondria Transfer / Transplant (Amt/T) to Repair Mitochondrial Disfunction in Differentiated (Peripheral Blood Mononuclear Cells) and Germinal Cells (Oocytes)

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Severe Cases of COVID-19 and High Association with Causes of Immune Dysregulation: A Systematic Review

Torres, A., Marchioro, S. B., Ribeiro, M. B., de Morais, I. R. B., Freire, S. M., & Nascimento, R. J. M. (2021) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2021039675 · Cited by 2

Nicotinamide Adenine Dinucleotide and Aging

Jiang, Z., Luo, L., Qin, Y., Huang, Y., & Yan, S. (2025) · Springer eBooks · doi:10.1007/978-981-97-9877-3_28 · Cited by 1

Aging‐associated changes in immunological parameters: Implications for COVID‐19 immune response in the elderly

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Transcriptome-wide gene-age interaction study and multi-omics comprehensive analysis reveals heterogeneous regulation of NLRC4 during aging on HNSCC prognosis and immune microenvironment

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A Brief Review of the Role of Macrophage Hypoxia in SiO 2 ‐Induced Pulmonary Fibrosis

Fu, Y., Liu, Y., Hu, H., Zhang, Z., & Gong, W. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.4906 · Cited by 1

Age-related changes in circulating immune factors reveal biomarkers of immunosenescence

Zhang, X., Xu, S., Lu, Y., Yin, J., Zhang, M., Jin, Y., & Li, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1729112 · Cited by 1

Sex-associated transcriptional changes to synovial macrophages in the aging joint

Dapas, M., DeJong, E. N., Wang, Y., Mills, C., Dowling, S. D., Mayer, M., Therron, T., Hamilton, S., Cuda, C. M., Bowdish, D. M. E., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1724385 · Cited by 2

The vicious cycle of SASP and inflammaging promotes aging and age-related diseases

Liu, Q., Zheng, Y., & Sun, C. (2026) · Communications Biology · doi:10.1038/s42003-026-10826-4 · Cited by 1

Brain Aging and Cellular Senescence Trigger Neuroimmunological Dysregulation and Neurodegeneration

Vega-García, A., Apolinar, L. M., Feria-Romero, I. A., Campos‐Bedolla, P., Alberto, G.-G. C., Luna‐Munguía, H., Sofía, R.-H., & Orozco-Suárez, S. A. (2026) · Brain Sciences · doi:10.3390/brainsci16101019 · Cited by 1

Cannabinoids

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Additional file 4 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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Additional file 3 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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Additional file 1 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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Additional file 2 of Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease

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