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Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
Open accessAbstract
Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or 'inflammaging'. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
Hetz, C. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3270 · Cited by 4,223
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569
Autophagy and the Integrated Stress Response
Kroemer, G., Mariño, G., & Levine, B. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.023 · Cited by 3,506
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802
Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase
Yeung, F., Hoberg, J. E., Ramsey, C. S., Keller, M. D., Jones, D. R., Frye, R. A., & Mayo, M. W. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600244 · Cited by 2,750
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
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Amor, S., Blanco, L. F., & Baker, D. (2020) · Clinical & Experimental Immunology · doi:10.1111/cei.13523 · Cited by 114
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Lewis, E. D., Wu, D., & Meydani, S. N. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110576 · Cited by 111
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Zhang, F., Guo, J., Yu, S., Zheng, Y., Duan, M., Zhao, L., Wang, Y., Yang, Z., & Jiang, X. (2024) · 癌症：英文版 · doi:10.1002/cac2.12591 · Cited by 100
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Suzuki, M., Sujino, T., Chiba, S., Harada, Y., Goto, M., Takahashi, R., Mita, M., Hamase, K., Kanai∥, T., Ito, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6480 · Cited by 68
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Tidball, J. G., Flores, I., Welc, S. S., Wehling-Henricks, M., & Ochi, E. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2020.111200 · Cited by 66
Sellegounder, D., Zafari, P., Rajabinejad, M., Taghadosi, M., & Kapahi, P. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107806 · Cited by 70
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Du, M., Sun, L., Guo, J. J., & Lv, H. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107198 · Cited by 51
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Horiba, S., Kami, R., Tsutsui, T., & Hosoi, J. (2022) · JID Innovations · doi:10.1016/j.xjidi.2022.100112 · Cited by 39
Serrano‐López, J., & Martín-Antonio, B. (2021) · Cells · doi:10.3390/cells10102562 · Cited by 40
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Zandi, S., Pfister, I. B., Traine, P. G., Tappeiner, C., Despont, A., Rieben, R., Skowronska, M., & Garweg, J. G. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214674 · Cited by 34
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Hall, B. M., Gleiberman, A. S., Strom, E., Krasnov, P. A., Frescas, D., Vujcic, S., Leontieva, O. V., Antoch, M. P., Kogan, V., Koman, I. E., et al. (2020) · Aging Cell · doi:10.1111/acel.13219 · Cited by 33
Changes in Circadian Rhythms Dysregulate Inflammation in Ageing: Focus on Leukocyte Trafficking
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Marongiu, F., & DeGregori, J. V. (2022) · Molecular Oncology · doi:10.1002/1878-0261.13275 · Cited by 38
Roth‐Walter, F., Adcock, I. M., Benito‐Villalvilla, C., Bianchini, R., Bjermer, L. H., Caramori, G., Cari, L., Chung, K. F., Diamant, Z., Eguíluz‐Gracia, I., et al. (2023) · Allergy · doi:10.1111/all.15977 · Cited by 31
Salminen, A. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102694 · Cited by 33
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Li, C., Xu, W. L., Li, L., Zhou, Y., Yao, G., Chen, G., Xu, L., Yang, N., Yan, Z., Chen, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202408044 · Cited by 29
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Tobin, S. W., Alibhai, F. J., Weisel, R. D., & Li, R. (2020) · Cells · doi:10.3390/cells9081894 · Cited by 30
Gu, M., Liu, Y., Zheng, W., Jing, Z., Li, X., Guo, W., Zhao, Z., Yang, X., Liu, Z., Zhu, X., et al. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.08.006 · Cited by 29
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Mineralocorticoid receptor promotes cardiac macrophage inflammaging
Fraccarollo, D., Geffers, R., Galuppo, P., & Bauersachs, J. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01032-6 · Cited by 32
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Li, P., Zhang, R., Cheng, L., Liu, J., & Chen, H. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101165 · Cited by 29
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Regnault, V., Challande, P., Pinet, F., Li, Z., & Lacolley, P. J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa318 · Cited by 27
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Pandey, S., Kant, S., Khawary, M., & Tripathi, D. (2021) · Infection and Immunity · doi:10.1128/iai.00291-21 · Cited by 28
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Tissue-resident macrophage inflammaging aggravates homeostasis dysregulation in age-related diseases
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Vascular Metabolism as Driver of Atherosclerosis: Linking Endothelial Metabolism to Inflammation
Dzobo, K. E., Hanford, K., & Kroon, J. (2021) · Immunometabolism · doi:10.20900/immunometab20210020 · Cited by 27
Lipid Droplets as Regulators of Metabolism and Immunity
Boucher, D. M., Vijithakumar, V., & Ouimet, M. I. (2021) · Immunometabolism · doi:10.20900/immunometab20210021 · Cited by 26
Vascular ageing in hypertension: Focus on mitochondria
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The Role of Microbiota in Neutrophil Regulation and Adaptation in Newborns
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Dysregulated metabolism: A friend-to-foe skewer of macrophages
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Classic and new mediators for in vitro modelling of human macrophages
Luque-Martin, R., Mander, P. K., Leenen, P. J. M., & de Winther, M. P. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ru0620-018r · Cited by 24
Self-citation
Metadata
- Authors
- van Beek, A. A., Van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J., & Leenen, P. J. M.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Leenen, Pieter J.M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 40
- Issue
- 2
- Pages
- 113-127
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2906988593
- Cited by
- 207
- References
- 112
- Citations by year
- 2026: 13 · 2025: 31 · 2024: 30 · 2023: 24 · 2022: 29 · 2021: 43 · 2020: 29 · 2019: 8
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- TI Food and Nutrition
- ZonMW
- Netherlands Heart Foundation
- Spark-Holding BV
- European Union and Fondation Leducq
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- inflammaging, low-grade inflammation, alternative activation, M2 macrophages, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, tissue homeostasis, cellular senescence
- MeSH terms
- Animals, Humans, Inflammation, Macrophages, Mitochondria, Cytokines, Cellular Senescence, Endoplasmic Reticulum Stress
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