The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Metabolic Alterations in Aging Macrophages: Ingredients for Inflammaging?
Open accessAbstract
Aging is a complex process with an impact on essentially all organs. Declined cellular repair causes increased damage at genomic and proteomic levels upon aging. This can lead to systemic changes in metabolism and pro-inflammatory cytokine production, resulting in low-grade inflammation, or 'inflammaging'. Tissue macrophages, gatekeepers of parenchymal homeostasis and integrity, are prime inflammatory cytokine producers, as well as initiators and regulators of inflammation. In this opinion piece, we summarize intrinsic alterations in macrophage phenotype and function with age. We propose that alternatively activated macrophages (M2-like), which are yet pro-inflammatory, can accumulate in tissues and promote inflammaging. Age-related increases in endoplasmic reticulum stress and mitochondrial dysfunction might be cell-intrinsic forces driving this unusual phenotype.
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Metadata
- Authors
- van Beek, A. A., Van den Bossche, J., Mastroberardino, P. G., de Winther, M. P. J., & Leenen, P. J. M.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Leenen, Pieter J.M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 40
- Issue
- 2
- Pages
- 113-127
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W2906988593
- Cited by
- 207
- References
- 112
- Citations by year
- 2026: 13 · 2025: 31 · 2024: 30 · 2023: 24 · 2022: 29 · 2021: 43 · 2020: 29 · 2019: 8
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion)
- Funders
- TI Food and Nutrition
- ZonMW
- Netherlands Heart Foundation
- Spark-Holding BV
- European Union and Fondation Leducq
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- inflammaging, low-grade inflammation, alternative activation, M2 macrophages, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, tissue homeostasis, cellular senescence
- MeSH terms
- Animals, Humans, Inflammation, Macrophages, Mitochondria, Cytokines, Cellular Senescence, Endoplasmic Reticulum Stress
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