Tumor-derived cystatin C enables amyloid clearance
Abstract
Li et al. described a tumor-derived neuroimmune mechanism that promotes clearance of established amyloid pathology in Alzheimer's disease. secreted cystatin C activates TREM2-dependent microglial phagocytosis, reducing plaques and improving cognition. This work introduces a context-dependent neuroimmune-modulatory strategy that shifts Alzheimer's therapy from broad immune activation toward substrate-coupled amyloid clearance.
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Cites
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Clonal hematopoiesis in Alzheimer’s brain: Protective, pathogenic, and context-dependent?
Zhao, H., King, K. Y., & Wong, S. T. C. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.06.009
Self-citation
- Authors
- Zambelas, J., Huang, Y., Zhao, H., & Wong, S. T. C.
- Affiliations
- Houston Methodist (US)
- Texas A&M University (US)
- Corresponding author
- Zhao, Hong
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2026-04
- Volume
- 47
- Issue
- 4
- Pages
- 246-248
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W7135021004
- Cited by
- 1
- References
- 12
- Citations by year
- 2026: 1
- FWCI
- 2.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Trends in Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cure Alzheimer's Fund
- National Cancer Institute Center for Strategic Scientific Initiatives
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- cystatin C, Alzheimer's disease, amyloid clearance, microglial phagocytosis, TREM2, neuroinflammation, amyloid plaques, tumor-derived factors, neuroimmunomodulation, cognition
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Humans, Membrane Glycoproteins, Neoplasms, Phagocytosis, Receptors, Immunologic, Amyloid beta-Peptides, Microglia, Cystatin C
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