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Adolescents With Major Depression Demonstrate Increased Amygdala Activation
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“In the RDoC matrix, it is also evident that generalized and social anxiety and depression symptomatology are linked to dysfunction in the same neurocircuitry, such as sustained limbic hyperreactivity (18–20) and reduced adaptive flexibility of the default mode network (DMN) (20–22).”
From Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study (2017) · cites this paper as [18]
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“Previous and current fMRI studies from our group and others consistently show that depressed adolescents demonstrate increased hyperactivation of the amygdala, a key limbic structure involved in emotion generative processing (18) and aberrant functional connectivity between the amygdala and other emotional regulation areas (19, 23, 24).”
From Feasibility and preliminary efficacy of a novel RDoC-based treatment program for adolescent depression: "Training for Awareness Resilience and Action" (TARA)-A pilot study (2017) · cites this paper as [18]
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Metadata
- Authors
- Yang, T. T., Simmons, A. N., Matthews, S. C., Tapert, S. F., Frank, G. K., Max, J. E., Bischoff-Grethe, A., Lansing, A. E., Brown, G., Strigo, I. A., Wu, J., & Paulus, M. P.
- Affiliations
- University of California San Diego (US)
- University of Colorado Denver (US)
- Corresponding author
- Yang, Tony T.
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 49
- Issue
- 1
- Pages
- 42-51
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC2935523
- OpenAlex
- W2163349072
- Cited by
- 176
- References
- 47
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 13 · 2023: 15 · 2022: 8 · 2021: 9 · 2020: 12 · 2019: 15 · 2018: 7 · 2017: 12 · 2016: 13 · 2015: 14 · 2014: 11 · 2013: 15 · 2012: 12
- FWCI
- 7.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Alliance for Research on Schizophrenia and Depression
- National Institute of Mental Health (K23MH70791, K23MH070791, K23MH080135)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- adolescent depression, major depressive disorder, amygdala activation, amygdala hyperactivity, facial emotion recognition, emotional processing
- MeSH terms
- Adolescent, Amygdala, Brain Mapping, Major Depressive Disorder, Depressive Disorder, Major, Dominance, Cerebral, Emotions, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Pattern Recognition, Visual, Reference Values
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