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Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children
Open accessAbstract
Objective To examine patterns of variability in social visual engagement and their relationship to standardized measures of social disability in a heterogeneous sample of school-aged children with autism spectrum disorders (ASD).Method Eye-tracking measures of visual fixation during free-viewing of dynamic social scenes were obtained for 109 children with ASD (mean age, 10.2 ± 3.2 years), 37 of whom were matched with 26 typically-developing (TD) children (mean age, 9.5 ± 2.2 years) on gender, age, and IQ. The smaller subset allowed between-group comparisons, whereas the larger group was used for within-group examinations of ASD heterogeneity.Results Between-group comparisons revealed significantly attenuated orientation to socially salient aspects of the scenes, with the largest effect size (Cohen's d = 1.5) obtained for reduced fixation on faces. Within-group analyses revealed a robust association between higher fixation on the inanimate environment and greater social disability. However, the associations between fixation on the eyes and mouth and social adaptation varied greatly, even reversing, when comparing different cognitive profile subgroups.Conclusions Although patterns of social visual engagement with naturalistic social stimuli are profoundly altered in children with ASD, the social adaptivity of these behaviors varies for different groups of children. This variation likely represents different patterns of adaptation and maladaptation that should be traced longitudinally to the first years of life, before complex interactions between early predispositions and compensatory learning take place. We propose that variability in these early mechanisms of socialization may serve as proximal behavioral manifestations of genetic vulnerabilities.
Overview
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Written from the paper’s full text.
TL;DR
Eye-tracking in school-age children with ASD showed altered visual engagement with dynamic social scenes, especially reduced face fixation, but the link between fixation patterns and social disability varied by cognitive profile. The authors argue this heterogeneity reflects different adaptive and maladaptive social-learning strategies rather than a single ASD visual phenotype.
Key findings
- In matched samples (37 ASD vs. 26 TD), ASD children spent less time fixating eyes (30.9% vs. 41.1%) and mouth (17.5% vs. 24.6%), and more time on body (27.6% vs. 19.0%) and objects (24.0% vs. 15.3%); face fixation was 48.4% vs. 65.7% (Cohen’s d=1.5).
- In the full ASD sample (N=109), higher object fixation was associated with greater social disability (r=.245, p=.014), while eyes and mouth fixation were weakly related to social disability (r=−.183, p<.1; r=−.135, p=.179).
- Cognitive profile moderated these relationships: in the VIQ Split group (N=18), higher mouth looking predicted lower social disability (r=−.65, p=.013), whereas in the Higher Even FSIQ group (FSIQ ≥ 98), higher mouth looking predicted greater social disability (r=.473, p<.01); these correlations differed significantly (z=−3.56, p<.001).
- FSIQ moderated the mouth-looking/social-disability relationship in even-IQ children (interaction β=.51, p=.008; model R²=17.8%), with the correlation becoming significant only at FSIQ ≥ 98 by Johnson-Neyman analysis.
Methods
- Children viewed two 5–7 minute dynamic social films while eye-tracking measured percent fixation time on eyes, mouth, body, and object regions of interest.
- Participants were 109 children with ASD (mean age 10.2 ± 3.2 years) and 26 TD children (mean age 9.5 ± 2.2 years); a subset of 37 ASD children was matched to TD controls on gender, age, and IQ for between-group comparisons, while the full ASD sample was used for within-group heterogeneity analyses.
- Social disability was measured with the ADOS Calibrated Severity Score; IQ was measured with the Differential Abilities Scale–Second Edition. Analyses included t-tests, correlations, hierarchical multiple regression, and Johnson-Neyman probing of moderation.
Limitations
- The authors state the sample is essentially non-intellectually disabled, so results do not generalize to intellectually disabled children with ASD; subgroup sizes were small, limiting power; and the IQ subgroupings are intended as suggestive, not definitive.
- The authors also note that other variables, such as communicative competence, may moderate the fixation–social adaptation relationship, and that the association does not establish directionality.
- Evident from the text: the design is cross-sectional and correlational, with multiple subgroup correlations, and the stimuli are paradigm-specific, so absolute fixation percentages may not be comparable across eye-tracking studies.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the associations between fixation on the eyes and mouth and social adaptation varied greatly, even reversing, when comparing different cognitive profile subgroups.”
- Also stated in: § Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles? · plain
“Within this group, there was a significant relationship between visual fixation and ADOS severity scores (r=−.65, p=.013)—higher mouth looking predicted lower social disability, accounting for over 40% of the variance in ADOS scores (Figure 3).”
- Also stated in: § Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles? · plain
“However, eyes-looking was not predictive of disability (r=.10, p=.73).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Abstract > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
- Also stated in: § Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles? · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Between-group comparisons revealed significantly attenuated orientation to socially salient aspects of the scenes, with the largest effect size (Cohen’s d=1.5) obtained for reduced fixation on faces.”
- Also stated in: § Matched ASD (N=37) and TD (N=26) samples: Visual Fixation Time on Regions-of-Interest (ROI) · plain
“The ASD group and TD group, matched on age and IQ, had significantly different visual fixation times on all ROIs (eyes, mouth, body and object) (Figure 2).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Abstract > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
- Also stated in: § Matched ASD (N=37) and TD (N=26) samples: Visual Fixation Time on Regions-of-Interest (ROI) · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Within-group analyses revealed a robust association between higher fixation on the inanimate environment and greater social disability.”
- Also stated in: § Full Sample of School-age Children with ASD (N=109): Patterns of Visual Fixation Time as Predictors of Social Disability · plain
“In this larger and more heterogeneous sample of ASD school-age children, the association between higher object fixation and higher social disability was significant (r=.245; p=.014), although the effect size was small.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Abstract > Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
- Also stated in: § Full Sample of School-age Children with ASD (N=109): Patterns of Visual Fixation Time as Predictors of Social Disability · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“and more on the body [27.6% (7.3) vs. 19.0% (4.4), respectively, t61= 5.37, p<.001]”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Matched ASD (N=37) and TD (N=26) samples: Visual Fixation Time on Regions-of-Interest (ROI)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These two correlations were significantly different from each other (z=−3.56, p<.001).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“for the Lower Even FSIQ group, there was no significant relationship (r=−.083, p=.67)”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The 72 children had, on average, FSIQs and VIQs about fifteen points lower than the matched ASD subset.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-Age Children with ASD (N=109): Visual Fixation Time on Regions-of-Interest (ROIs)
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“While there was a main effect of FSIQ on ADOS scores (β=−.03, p=.03)”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“the interaction term FSIQ × Mouth Looking was also significant (β=.51, p=.008).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The correlation between object-looking and ADOS severity scores failed to reach significance (r=.32, p=.27), but this may have been due to the small sample size of this subgroup.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Strength:hedged· not yet calibratedn = 18Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
- It may state two separate claims as one. 24
- Probably not a substantial claim. 17
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The 72 children removed were comparable to the 37 used in the matched comparison in regards to gender ratio (Male/Female, 53/19 and 30/7, respectively) and chronological age (years, mean (sd), 10.02 (2.33) and 10.22 (3.53), respectively). Using the ADOS-derived severity score to assess autistic symptomatology, the two groups also had comparable levels of social disability (6.75 (2.48) and 7.45 (2.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“While this group did not significantly differ from the VIQ Split group on FSIQ or on the percentage of fixation time spent on the eyes, mouth or objects”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Strength:plain· not yet calibratedn = 30Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In regards to IQ scores, Full Scale IQ (FSIQ) was significantly lower for the N=72 excluded ASD children relative to the ASD subset (88.71 (19.85) and 112.03 (15.23), respectively, p<.001), as was Verbal IQ (VIQ) (88.54 (19.69) and 111.35 (16.30), respectively, p<.001), and Nonverbal IQ (NVIQ) (92.31 (19.44) and 111.35 (14.51), respectively, p<.001).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“for blinks, 26.06 (23.77), 48.24 (38.36), 38.54 (27.01), respectively, F2,132=7.44, p<.001; and for off-screen fixations, 45.47 (40.17), 19.24 (24.97), 8.44 (13.74), respectively, F2,132=15.56, p<.001”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Data Processing
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In this larger and more heterogeneous sample of ASD school-age children, the association between higher object fixation and higher social disability was significant (r=.245; p=.014), although the effect size was small.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Patterns of Visual Fixation Time as Predictors of Social Disability
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Within this group, there was a significant relationship between visual fixation and ADOS severity scores (r=−.65, p=.013)—higher mouth looking predicted lower social disability, accounting for over 40% of the variance in ADOS scores (Figure 3).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The full sample of N=109 ASD school-age children covered a relatively wide distribution in age (± 1SD, ~ 7 to 13 years), IQ (± 1SD, FSIQ of ~ 75 to 118), and severity of autism 32 (± 1SD, ADOS Severity Score of ~ 4.5 to 9.5).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Children with ASD focused less on eyes and mouth regions and more on body and object regions.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“neither lower eyes nor lower mouth percent fixation was significantly associated with higher levels of social disability in the full ASD group”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“despite comparable levels of percent fixation on the mouth regions overall, higher mouth fixation predicted higher social disability in the children with higher FSIQ and an even IQ profile and lower social disability in the children with the VIQ split.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This Higher Even FSIQ group also had stronger relationships between less eyes-looking and greater social disability compared to children with Lower Even FSIQ, though these differences were not significant.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Typically, results indicated less fixation time on the eyes region of the face 10-13, with more variation in fixation on the mouth region; some studies found increased fixation on the mouth region of the face 12 whereas others found no differences in this regard 10,11.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
- Not checked yetcites [10] Pelphrey, 2002, Visual scanning of faces in autism, J Autism Dev Disord source
- Not checked yetcites [11] Dalton, 2005, Gaze fixation and the neural circuitry of face processing in autism, Nat Neurosci source
- Not checked yetcites [12] Spezio, 2007, Abnormal use of facial information in high-functioning autism, J Autism Dev Disord source
- Not checked yetcites [13] Spezio, 2007, Analysis of face gaze in autism using “bubbles”, Neuropsychologia source
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Genotypic heterogeneity has proved equally baffling, with unique identified mutations accounting for only a small number of cases 4-5.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“It is in this context that developmental cognitive science may provide the necessary bridge between molecular pathobiology and clinical behavior 6-7.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
Tests✓ Asserted: passes✗ Checkable: fails✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence.
In the paper
“Instead, increased fixation on the mouth region was a strong predictor of lower levels of social disability and higher levels of social ability.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
- Not checked yetcites [18] Klin, 2002, Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism, Arch Gen Psychiatry source
Strength:boosted· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“Adults with autism focused two times less on the eyes region of faces while focusing two times more on the mouth relative to controls.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
- Not checked yetcites [18] Klin, 2002, Visual fixation patterns during viewing of naturalistic social situations as predictors of social competence in individuals with autism, Arch Gen Psychiatry source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“In general, however, this literature is consistent with Langdell’s 14 original hypothesis: individuals with autism show attenuated reliance on information from the eyes region of the face and, at least in some situations, over-reliance on information from the mouth region of the face when performing structured viewing tasks (e.g., recognition of face identity or emotional expressions).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
- Not checked yetcites [14] Langdell, 1978, Recognition of faces: an approach to the study of autism, J Child Psychol Psychiatry source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“The profile may be linked to specific genetic loci 26 and neurophysiological differences 27 in ASD.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Introduction
What the sources say
Strength:hedged· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“These two groups were matched on both VIQ (t47=1.25, p=.22) and level of social disability (t47=−.527, p=.57).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Full Sample of School-age Children with ASD (N=109): Do Visual Fixation Patterns Predict Levels of Social Disability Differently in Individuals with Different Cognitive Profiles?
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“All aspects of the experimental protocol were performed by personnel blind to diagnostic status of child. Most aspects of data acquisition and all aspects of coding, processing, and data summary were automated to ensure separation between the diagnostic characterization protocol and the experimental protocol.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Data Processing
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“For this study, however, the focus is on valid, analyzed fixation data, which were comparable across all groups.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Data Processing
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“While there was a wide range in FSIQ (42-149), the overall level of cognitive functioning of the full ASD sample was still relatively high.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
Strength:plain· not yet calibratedn = 109Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“In the rare case of disagreement between ADOS and ADI-R criteria, as a widely accepted gold standard, the clinician-assigned, best estimate diagnosis took priority 34,35.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
What the sources say
- Not checked yetcites [34] Chawarska, 2007, Autism spectrum disorder in the second year: stability and change in syndrome expression, J Child Psychol Psychiatry source
- Not checked yetcites [35] Lord, 2005, Diagnostic instruments in autistic spectrum disorders
Strength:boosted· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“A subset (N=37) of the entire ASD sample was matched to the TD group on gender ratio, chronological age, FSIQ, VIQ, and NVIQ.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
In the paper
“All children passed by saccading to a target within 500 milliseconds and maintaining stable foveation with less than 5°/sec of drift for at least 1 second 37.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Stimuli
What the sources say
- Not checked yetcites [37] Leigh, 1999
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is not unexpected: the past studies used mostly close-ups on faces, whereas the current stimuli portrayed whole individuals.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Results > Matched ASD (N=37) and TD (N=26) samples: Visual Fixation Time on Regions-of-Interest (ROI)
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Rests on an assumption: The dynamic social scenes used in the eye-tracking task approximate children's everyday social experiences.
In the paper
“Given the wide range of ADOS modules used in this large sample (Modules 2, 3, and 4), we used the ADOS Calibrated Severity Score 32 (higher scores denote more severe autistic symptomatology), a measure standardized across modules.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Participants
What the sources say
- Not checked yetcites [32] Gotham, 2009, Standardizing ADOS scores for a measure of severity in autism spectrum disorders, J Autism Dev Disord source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The system was mounted unobstrusively on the bill of a baseball cap and utilized a target-tracking method that enables highly accurate eye-tracking without having to restrain the participant’s head (accuracy within ± 0.3° over a ± 20° horizontal and vertical range).”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Method > Experimental Procedure
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Without dynamic stimuli and the accompanying audio, the mouth-language pairing present in naturalistic social interaction would be absent.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“this is essentially a non-intellectually disabled sample of children with ASD. Thus, our results do not generalize to the population of intellectually disabled children with ASD.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Strength:plain· not yet calibratedn = 109Tests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“in Higher Even FSIQ children mouth looking was associated with a detriment in social adaptation; in VIQ split children mouth looking was associated with an enhancement in social adaptation.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“for some children at least, an attempt to normalize their social behavior may not contribute to increased social adaptation.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesProbably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“this association does not necessarily imply directionality.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Strength:hedged· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“so much learning is accomplished through shared experiences with others and that communication is by definition a social adaptive function 19.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
What the sources say
- Not checked yetcites [19] Klin, 2003, The enactive mind—from actions to cognition: lessons from autism, Phil Trans R Soc Lond B Biol Sci source
Strength:plain· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“our evaluation of the difference between these coefficients was based on sample size and strength of association, values which are independent of our significance threshold.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“The search for successful endophenotypic constructs is more likely to succeed through studies of infants and a focus on evolutionarily highly conserved and developmentally early emerging social adaptive skills 20.”
§ Parsing Heterogeneity in Autism Spectrum Disorders: Visual Scanning of Dynamic Social Scenes in School-Aged Children > Discussion
What the sources say
- Not checked yetcites [20] Klin, 2009, Two-year-olds with autism fail to orient towards human biological motion but attend instead to non-social, physical contingencies, Nature source
Strength:hedged· not yet calibratedCausal:conditional· not yet calibratedTests✓ Asserted: passes✗ Checkable: fails✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. It may be too vague to check against evidence. The paper’s conclusions may not depend on it.
The paper relies on this without support.
The dynamic social scenes used in the eye-tracking task approximate children's everyday social experiences.
“These were intended to reflect everyday experiences of this age group”
“targeting a defining symptom of the condition within an experimental setup that approximates their everyday social experiences”
The paper relies on this without support.
The regions-of-interest (eyes, mouth, body, object) meaningfully capture social versus inanimate aspects of the scenes.
“Eye movements identified as fixations were coded relative to four regions-of-interest (ROIs) that were defined within all video stimuli: eyes, mouth, body (neck, shoulders, and contours around eyes and mouth such as hair), and object (surrounding inanimate stimuli) (Figure 1b).”
The paper relies on this without support.
Prior research on school-age ASD children has identified cognitive profiles as helpful for parsing heterogeneity.
“Past studies of school-age children with ASD have highlighted profiles of cognitive functioning as useful in parsing heterogeneity in the disorder.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Patients with ASD have been shown to have altered gaze patterns and reduced attention to social imagery45–47.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [47]
In the citing paper
“It has been shown that infants, toddlers and adolescents with autism spectrum disorder (ASD) all show disrupted patterns of eye movements in response to images/videos of human faces or naturalistic social scenes, including avoidance of the eye region of faces, atypical fixation targets to the nonsocial aspects of social scenes and a lack of attentional bias toward faces, as measured by faster sacc”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [61]
In the citing paper
“In humans, the majority of psychiatric and neurodevelopmental disorders show disruption in the use of eyes and eye contact during social interactions [38-42].”
From Neurons in the Monkey Amygdala Detect Eye Contact during Naturalistic Social Interactions (2014) · cites this paper as [39]
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Consistentz = -2.15reported p = .031 · recomputed p = .032
“(z=−2.15, p = .031”
- Consistentz = -3.56reported p < .001 · recomputed p < .001
“(z=−3.56, p < .001”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Discussion reverses the higher-IQ group's mouth-looking association
MajorThe discussion says higher mouth fixation was associated with lower social disability in the Higher Even FSIQ group. The results report the opposite: higher mouth-looking was significantly associated with greater social disability in that group.
“Higher mouth fixation and lower social disability were significantly more strongly correlated for children with Higher Even FSIQ.”
“for the Higher Even FSIQ group, higher mouth-looking was significantly associated with greater social disability (r=.473, p<.01)”
Full ASD sample's age summary conflicts with subgroup ages
MinorThe stated 72- and 37-child subgroup age means yield a mean of about 10.09 years for all 109 children, which rounds to 10.1 rather than the abstract's 10.2. Their reported standard deviations also imply a combined standard deviation of about 2.8 years, not 3.2.
“109 children with ASD (mean age=10.2 ± 3.2 years)”
“chronological age (years, mean (sd), 10.02 (2.33) and 10.22 (3.53), respectively)”
Citations
Cites
Preacher, K. J., Curran, P. J., & Bauer, D. J. (2006) · Journal of Educational and Behavioral Statistics · doi:10.3102/10769986031004437 · Cited by 5,044
The Neurology of Eye Movements
Leigh, R. J., & Zee, D. S. (2015) · Oxford University Press eBooks · doi:10.1093/med/9780199969289.001.0001 · Cited by 3,829
Holmbeck, G. N. (1997) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.65.4.599 · Cited by 3,036
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., Donaldson, A., & Varley, J. (2010) · Pediatrics · doi:10.1542/peds.2009-0958 · Cited by 2,835
Handbook of Autism and Pervasive Developmental Disorders
(2005) · Wiley eBooks · doi:10.1002/9780470939352 · Cited by 2,262
Klin, A., Jones, W., Schultz, R., Volkmar, F., & Cohen, D. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.9.809 · Cited by 2,120
Self-citationAdvances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
Adult outcome for children with autism
Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2004.00215.x · Cited by 1,813
Association between Microdeletion and Microduplication at 16p11.2 and Autism
Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A. R., Green, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa075974 · Cited by 1,666
Standardizing ADOS Scores for a Measure of Severity in Autism Spectrum Disorders
Gotham, K., Pickles, A., & Lord, C. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0674-3 · Cited by 1,605
Flagged first, then by citations
2 of the 50 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 201–218 of 218
Understanding Social Communication Differences in ASD and First-Degree Relatives
Lee, M., & Losh, M. C. (2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_102466
Social-Emotional Inhibition of Return
Antezana, L., & Yerys, B. E. (2020) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_102380-1
Lee, M., & Losh, M. C. (2020) · Springer eBooks · doi:10.1007/978-1-4614-6435-8_102466-1
Liu, M.-J. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1458101 · Cited by 1
Jeppesen, A. C. E., Andresen, J., Parvaiz, R., et al. (2024) · medRxiv · doi:10.1101/2024.12.14.24319035
Gaze behavior when looking at paintings may predict autistic traits
Zhou, Y., Nishimura, M., & Kawabata, H. (2025) · PsyCh Journal · doi:10.1002/pchj.810
“A similar trend was also observed by showing clips of movies to groups of people with ASD (Rice et al., 2012).”
Stefanidou, C. A. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
The impact of attention to social information on the development of socialization in childhood
Fujioka, T., & Kosaka, H. (2025) · Scandinavian Journal of Child and Adolescent Psychiatry and Psychology · doi:10.2478/sjcapp-2025-0005
Autism Prediction Using Machine Learning Enhancing Early Intervention
Tandon, A., Mazumdar, B. D., Pal, M. K., & Sahu, N. K. (2025) · Lecture notes in networks and systems · doi:10.1007/978-981-96-7131-1_21
Saitovitch, A. (2014) · theses.fr (ABES) · doi:10.70675/ddd5f246z0fe4z4134z8a28z27d0a24aed40
Garry, C. (2018) · theses.fr (ABES) · doi:10.70675/beecef9dz529bz48b5zaef3zf9866e93aeea
“En particulier, ceux ayant plus de difficultés socio-émotionnelles et/ou communicatives et/ou des troubles plus sévères seraient moins attirés par le social (Falck-Ytter et al., 2010; Ostfield, 2009; Rice et al., 2012; Sasson et al., 2008).”
BackgroundInfluentialResearch Progress on Animate Attention Bias in Individuals with Autism Spectrum Disorder
赵, 欣. (2026) · Advances in Psychology · doi:10.12677/ap.2026.164185
Ceyhun, A. T. (2026) · Developmental Neurorehabilitation · doi:10.1080/17518423.2026.2674762
Zhao, X., Ji, Y., & Li, L. (2026) · Behavioral Sciences · doi:10.3390/bs16050738
“Studies using broader animacy-related materials have also reported reduced attention to such stimuli in ASD (Frazier et al., 2017; Klin et al., 2002; Klin et al., 2009; Rice et al., 2012).”
Navigating the Noise: Strategies Used by Autistic Adults to Manage Difficult Listening Situations
Sturrock, A., Bendo, G. J., Jarvis, E., Hanks, G., Gowen, E., Plack, C. J., & Guest, H. (2026) · Journal of Speech Language and Hearing Research · doi:10.1044/2026_jslhr-25-00137
Li, S., & Chen, L. (2026) · Research in Autism · doi:10.1016/j.reia.2026.202996
Sex and Cognitive Ability‐Based Stratification of Social Attention in Autism
Griffin, J. W., Shic, F., Naples, A. J., Dommer, K. J., Dawson, G., Faja, S., Jeste, S., Kleinhans, N. M., Dziura, J. D., Sugar, C. A., et al. (2026) · Autism Research · doi:10.1002/aur.70356
Metadata
- Authors
- Rice, K., Moriuchi, J. M., Jones, W., & Klin, A.
- Affiliations
- Emory University (US)
- Corresponding author
- Klin, Ami
- ORCID
- Klin, Ami
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 51
- Issue
- 3
- Pages
- 238-248
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC3306820
- OpenAlex
- W2082605724
- Cited by
- 237
- References
- 50
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 11 · 2023: 9 · 2022: 9 · 2021: 25 · 2020: 44 · 2019: 20 · 2018: 16 · 2017: 8 · 2016: 14 · 2015: 19 · 2014: 23 · 2013: 19 · 2012: 5
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Science Foundation (0532610)
- Emory University
- Children's Healthcare of Atlanta
- National Institutes of Health (5r01hd042127-04)
- School of Medicine, Emory University
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD042127, R01HD42127)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Developmental and Educational Psychology › Child and Animal Learning Development
- Keywords
- autism spectrum disorder, eye tracking, social dysfunction, social adaptation, within-group variation, school-aged children, genetic susceptibility
- MeSH terms
- Adolescent, Child, Child Development Disorders, Pervasive, Eye Movements, Female, Fixation, Ocular, Humans, Male, Motion Pictures, Neuropsychological Tests, Personality Development, Photic Stimulation, Psychiatric Status Rating Scales, Social Adjustment, Visual Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-08, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-08 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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