The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Guidelines of care for the management of atopic dermatitis
Open accessAbstract
Atopic dermatitis (AD) is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2-3% of adults. This guideline addresses important clinical questions that arise in AD management and care, providing recommendations based on the available evidence. In this third of four sections, treatment of AD with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heil, P. M., Maurer, D., Klein, B., Hultsch, T., & Stingl, G. (2010) · JDDG: Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07497.x · Cited by 197
Research works printed but not linked: 69
- Hanifin, 2004, Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association “administrative regulations for evidence-based clinical practice guidelines”, J Am Acad Dermatol, 50, 391, 10.1016/j.jaad.2003.08.003 · DOI · Paper page
- Nankervis, 2011, Mapping randomized controlled trials of treatments for eczema–the GREAT database (the Global Resource of EczemA Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010), BMC Dermatol, 11, 10, 10.1186/1471-5945-11-10 · DOI
- Ring, 2012, Guidelines for treatment of atopic eczema (atopic dermatitis), part I, J Eur Acad Dermatol Venereol, 26, 1045, 10.1111/j.1468-3083.2012.04635.x · DOI · Paper page
- Ring, 2012, Guidelines for treatment of atopic eczema (atopic dermatitis), part II, J Eur Acad Dermatol Venereol, 26, 1176, 10.1111/j.1468-3083.2012.04636.x · DOI · Paper page
- Schneider, 2013, Atopic dermatitis: a practice parameter update 2012, J Allergy Clin Immunol, 131, 295, 10.1016/j.jaci.2012.12.672 · DOI · Paper page
- Ebell, 2004, Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature, J Am Board Fam Pract, 17, 59, 10.3122/jabfm.17.1.59 · DOI · Paper page
- Goeckerman, 1925, Treatment of psoriasis, Northwest Med, 24, 229
- Morison, 1978, Oral psoralen photochemotherapy of atopic eczema, Br J Dermatol, 98, 25, 10.1111/j.1365-2133.1978.tb07329.x · DOI · Paper page
- Meduri, 2007, Phototherapy in the management of atopic dermatitis: a systematic review, Photodermatol Photoimmunol Photomed, 23, 106, 10.1111/j.1600-0781.2007.00291.x · DOI
- Rombold, 2008, Efficacy of UVA1 phototherapy in 230 patients with various skin diseases, Photodermatol Photoimmunol Photomed, 24, 19, 10.1111/j.1600-0781.2008.00328.x · DOI
- Clayton, 2007, The treatment of severe atopic dermatitis in childhood with narrowband ultraviolet B phototherapy, Clin Exp Dermatol, 32, 28
- Jekler, 1988, UVB phototherapy of atopic dermatitis, Br J Dermatol, 119, 697
- Grundmann-Kollmann, 1999, Phototherapy for atopic eczema with narrow-band UVB, J Am Acad Dermatol, 40, 995, 10.1016/S0190-9622(99)70090-3 · DOI
- Tay, 1996, Experience with UVB phototherapy in children, Pediatr Dermatol, 13, 406, 10.1111/j.1525-1470.1996.tb00711.x · DOI
- Menter, 2010, Guidelines of care for the management of psoriasis and psoriatic arthritis, section 5: guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy, J Am Acad Dermatol, 62, 114, 10.1016/j.jaad.2009.08.026 · DOI · Paper page
- Morison, 1998, Consensus workshop on the toxic effects of long-term PUVA therapy, Arch Dermatol, 134, 595, 10.1001/archderm.134.5.595 · DOI · Paper page
- Goldsmith LK, Katz SI, Gilchrest B, Paller A, Lefell D, Wolff K. Fitzpatrick's dermatology in general medicine. 8th ed. New York: McGraw-Hill; 2012.
- Stern, 1997, Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA follow-up study, N Engl J Med, 336, 1041, 10.1056/NEJM199704103361501 · DOI · Paper page
- Uetsu, 2003, Treatment of persistent severe atopic dermatitis in 113 Japanese patients with oral psoralen photo-chemotherapy, J Dermatol, 30, 450, 10.1111/j.1346-8138.2003.tb00415.x · doi:10.1111/j.1346-8138.2003.tb00415.x
- Yoshiike, 1993, A proposed guideline for psoralen photochemotherapy (PUVA) with atopic dermatitis: successful therapeutic effect on severe and intractable cases, J Dermatol Sci, 5, 50, 10.1016/0923-1811(93)90105-X · doi:10.1016/0923-1811(93)90105-x
- Atherton, 1988, The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents, Br J Dermatol, 118, 791, 10.1111/j.1365-2133.1988.tb02597.x · doi:10.1111/j.1365-2133.1988.tb02597.x
- Jury, 2006, Narrowband ultraviolet B (UVB) phototherapy in children, Clin Exp Dermatol, 31, 196, 10.1111/j.1365-2230.2006.02061.x · DOI
- Tzung, 2006, Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis, Acta Derm Venereol, 86, 34
- Koek, 2009, Home versus outpatient ultraviolet B phototherapy for mild to severe psoriasis: pragmatic multicenter randomized controlled non-inferiority trial (PLUTO study), BMJ, 338, b1542, 10.1136/bmj.b1542 · DOI
- Baltas, 2006, Treatment of atopic dermatitis with the xenon chloride excimer laser, J Eur Acad Dermatol Venereol, 20, 657, 10.1111/j.1468-3083.2006.01495.x · doi:10.1111/j.1468-3083.2006.01495.x
- Morita, 1993, Clinical application of low reactive level laser therapy (LLLT) for atopic dermatitis, Keio J Med, 42, 174, 10.2302/kjm.42.174 · doi:10.2302/kjm.42.174
- Syed, 2008, A pilot study showing pulsed-dye laser treatment improves localized areas of chronic atopic dermatitis, Clin Exp Dermatol, 33, 243, 10.1111/j.1365-2230.2007.02644.x · DOI
- Radenhausen, 2004, Bicenter experience in the treatment of severe generalized atopic dermatitis with extracorporeal photochemotherapy, J Dermatol, 31, 961, 10.1111/j.1346-8138.2004.tb00638.x · doi:10.1111/j.1346-8138.2004.tb00638.x
- Prinz, 1999, Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis, J Am Acad Dermatol, 40, 577, 10.1016/S0190-9622(99)70440-8 · doi:10.1016/s0190-9622(99)70440-8
- Schram, 2011, A randomized trial of methotrexate versus azathioprine for severe atopic eczema, J Allergy Clin Immunol, 128, 353, 10.1016/j.jaci.2011.03.024 · DOI · Paper page
- Haeck, 2011, Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: a randomized controlled trial, J Am Acad Dermatol, 64, 1074, 10.1016/j.jaad.2010.04.027 · DOI · Paper page
- Schmitt, 2010, Prednisolone vs cyclosporin for severe adult eczema: an investigator-initiated double-blind placebo-controlled multicenter trial, Br J Dermatol, 162, 661, 10.1111/j.1365-2133.2009.09561.x · DOI
- Hoare, 2000, Systematic review of treatments for atopic eczema, Health Technol Assess, 4, 1, 10.3310/hta4370 · DOI · Paper page
- van Joost, 1994, Cyclosporin in atopic dermatitis: a multicenter placebo-controlled study, Br J Dermatol, 130, 634, 10.1111/j.1365-2133.1994.tb13111.x · DOI · Paper page
- Czech, 2000, A body-weight-independent dosing regimen of cyclosporine microemulsion is effective in severe atopic dermatitis and improves the quality of life, J Am Acad Dermatol, 42, 653
- Zurbriggen, 1999, Comparison of two formulations of cyclosporin A in the treatment of severe atopic dermatitis: a double-blind, single-center, cross-over pilot study, Dermatology, 198, 56, 10.1159/000018065 · DOI
- Schmitt, 2007, Cyclosporin in the treatment of patients with atopic eczema–a systematic review and meta-analysis, J Eur Acad Dermatol Venereol, 21, 606, 10.1111/j.1468-3083.2006.02023.x · DOI · Paper page
- Menter, 2009, Guidelines of care for the management of psoriasis and psoriatic arthritis, section 4: guidelines of care for the management and treatment of psoriasis with traditional systemic agents, J Am Acad Dermatol, 61, 451, 10.1016/j.jaad.2009.03.027 · DOI · Paper page
- Harper, 2000, Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy, Br J Dermatol, 142, 52, 10.1046/j.1365-2133.2000.03241.x · DOI · Paper page
- Meggitt, 2006, Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomized controlled trial, Lancet, 367, 839, 10.1016/S0140-6736(06)68340-2 · DOI · Paper page
- Berth-Jones, 2002, Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial, Br J Dermatol, 147, 324, 10.1046/j.1365-2133.2002.04989.x · DOI · Paper page
- Perrett, 2008, Azathioprine treatment photosensitizes human skin to ultraviolet A radiation, Br J Dermatol, 159, 198, 10.1111/j.1365-2133.2008.08610.x · DOI
- el-Azhary, 2009, Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring, Arch Dermatol, 145, 644, 10.1001/archdermatol.2009.81 · DOI
- Caufield, 2013, Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring, J Am Acad Dermatol, 68, 29, 10.1016/j.jaad.2012.07.001 · DOI
- Evans, 2001, Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine, J Clin Oncol, 19, 2293, 10.1200/JCO.2001.19.8.2293 · DOI · Paper page
- Murphy, 2002, A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression, Br J Dermatol, 147, 308, 10.1046/j.1365-2133.2002.04922.x · DOI
- Hon, 2009, Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults, J Dermatolog Treat, 20, 141, 10.1080/09546630802512646 · DOI
- Weatherhead, 2007, An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema, Br J Dermatol, 156, 346, 10.1111/j.1365-2133.2006.07686.x · DOI
- Lyakhovitsky, 2010, Low-dose methotrexate treatment for moderate-to-severe atopic dermatitis in adults, J Eur Acad Dermatol Venereol, 24, 43, 10.1111/j.1468-3083.2009.03351.x · DOI
- Kalb, 2009, Methotrexate and psoriasis: 2009 National Psoriasis Foundation consensus conference, J Am Acad Dermatol, 60, 824, 10.1016/j.jaad.2008.11.906 · DOI · Paper page
- El-Khalawany, 2013, Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt, Eur J Pediatr, 172, 351, 10.1007/s00431-012-1893-3 · DOI · Paper page
- Dadlani, 2005, Treatment of children and adolescents with methotrexate, cyclosporine, and etanercept: review of the dermatologic and rheumatologic literature, J Am Acad Dermatol, 52, 316, 10.1016/j.jaad.2004.07.043 · doi:10.1016/j.jaad.2004.07.043
- Murray, 2007, Mycophenolate mofetil therapy for moderate to severe atopic dermatitis, Clin Exp Dermatol, 32, 23
- Heller, 2007, Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients, Br J Dermatol, 157, 127, 10.1111/j.1365-2133.2007.07947.x · DOI
- Hanifin, 1993, Recombinant interferon gamma therapy for atopic dermatitis, J Am Acad Dermatol, 28, 189, 10.1016/0190-9622(93)70026-P · DOI · Paper page
- Jang, 2000, Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma, J Am Acad Dermatol, 42, 1033, 10.1067/mjd.2000.104793 · DOI
- Daley-Yates, 2004, Relationship between systemic corticosteroid exposure and growth velocity: development and validation of a pharmacokinetic/pharmacodynamic model, Clin Ther, 26, 1905, 10.1016/j.clinthera.2004.11.017 · DOI
- Keaney, 2012, Open-label, pilot study examining sequential therapy with oral tacrolimus and topical tacrolimus for severe atopic dermatitis, J Am Acad Dermatol, 67, 636, 10.1016/j.jaad.2011.10.033 · DOI
- Boguniewicz, 2001, Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis, J Allergy Clin Immunol, 108, 651, 10.1067/mai.2001.118598 · DOI
- Bath-Hextall, 2010, Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review, Br J Dermatol, 163, 12, 10.1111/j.1365-2133.2010.09743.x · DOI · Paper page
- Ewing, 1998, Flucloxacillin in the treatment of atopic dermatitis, Br J Dermatol, 138, 1022, 10.1046/j.1365-2133.1998.02271.x · DOI
- Weinberg, 1992, The use of cefadroxil in superinfected atopic dermatitis, Curr Ther Res, 52, 671, 10.1016/S0011-393X(05)80509-0 · doi:10.1016/s0011-393x(05)80509-0
- Aronson, 2011, Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum, Pediatrics, 128, 1161, 10.1542/peds.2011-0948 · doi:10.1542/peds.2011-0948
- Diepgen, 2002, Early Treatment of the Atopic Child Study Group. Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months, Pediatr Allergy Immunol, 13, 278, 10.1034/j.1399-3038.2002.01047.x · DOI · Paper page
- Sher, 2012, Relieving the pruritus of atopic dermatitis: a meta-analysis, Acta Derm Venereol, 92, 455, 10.2340/00015555-1360 · DOI
- Klein, 1999, An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis, Arch Dermatol, 135, 1522, 10.1001/archderm.135.12.1522 · DOI · Paper page
- Hannuksela, 1993, Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults, Ann Allergy, 70, 127
- Epstein, 1964, A blind study, Arch Dermatol, 89, 548, 10.1001/archderm.1964.01590280048008 · DOI
- Schad, 2008, Antihistamines in the pediatric population: achieving optimal outcomes when treating seasonal allergic rhinitis and chronic urticaria, Allergy Asthma Proc, 29, 7, 10.2500/aap2008.29.3080 · doi:10.2500/aap2008.29.3080
Cited by
Griffiths, C. E. M., Armstrong, A. W., Gudjonsson, J. E., & Barker, J. N. W. N. (2021) · The Lancet · doi:10.1016/s0140-6736(20)32549-6 · Cited by 2,383
Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110
Self-citationAnti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
Ruzicka, T., Hanifin, J. M., Furue, M., Pulka, G., Mlynarczyk, I., Wollenberg, A., Galus, R., Etoh, T., Mihara, R., Yoshida, H., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606490 · Cited by 592
Self-citationThaçi, D., Simpson, E. L., Beck, L. A., Bieber, T., Blauvelt, A., Papp, K., Soong, W., Worm, M., Szepietowski, J. C., Sofen, H., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00388-8 · Cited by 572
Self-citationJAK inhibitors in the treatment of atopic dermatitis
Chovatiya, R., & Paller, A. S. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.08.009 · Cited by 398
Self-citation
Metadata
- Authors
- Sidbury, R., Davis, D. M., Cohen, D. E., Cordoro, K. M., Berger, T. G., Bergman, J. N., Chamlin, S. L., Cooper, K. D., Feldman, S. R., Hanifin, J. M., Krol, A., Margolis, D. J., Paller, A. S., Schwarzenberger, K., Silverman, R. A., Simpson, E. L., Tom, W. L., Williams, H. C., Elmets, C. A., Block, J., Harrod, C. G., Begolka, W. S., & Eichenfield, L. F.
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 71
- Issue
- 2
- Pages
- 327-349
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W189068515
- Cited by
- 885
- References
- 1
- FWCI
- 58.65
- Type
- journal article
- Language
- en
- Open access
- green
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- Funders
- National Institutes of Health (NIH)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) research career development grant (K23AR060274)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Guidelines of care for the management of atopic dermatitis. https://app.cochat.ai/papers/10.1016/j.jaad.2014.03.030
- The paper
- Sidbury, R., Davis, D. M., Cohen, D. E., Cordoro, K. M., Berger, T. G., Bergman, J. N., Chamlin, S. L., Cooper, K. D., Feldman, S. R., Hanifin, J. M., Krol, A., Margolis, D. J., Paller, A. S., Schwarzenberger, K., Silverman, R. A., Simpson, E. L., Tom, W. L., Williams, H. C., Elmets, C. A., . . . Eichenfield, L. F. (2014). Guidelines of care for the management of atopic dermatitis. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2014.03.030
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.