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Guidelines of care for the management of atopic dermatitis

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Sidbury, Robert, Davis, Dawn M., Cohen, David E., Cordoro, Kelly M., Berger, Timothy G., Bergman, James N., Chamlin, Sarah L., Cooper, Kevin D., Feldman, Steven R., Hanifin, Jon M., Krol, Alfons, Margolis, David J., Paller, Amy S., Schwarzenberger, Kathryn, Silverman, Robert A., Simpson, Eric L., Tom, Wynnis L., Williams, Hywel C., Elmets, Craig A., Block, Julie, Harrod, Christopher G., Begolka, Wendy Smith, Eichenfield, Lawrence F.·2014·Journal of the American Academy of Dermatology

Abstract

Atopic dermatitis (AD) is a chronic, pruritic inflammatory dermatosis that affects up to 25% of children and 2-3% of adults. This guideline addresses important clinical questions that arise in AD management and care, providing recommendations based on the available evidence. In this third of four sections, treatment of AD with phototherapy and systemic immunomodulators, antimicrobials, and antihistamines is reviewed, including indications for use and the risk-benefit profile of each treatment option.

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  1. Hanifin, 2004, Guidelines of care for atopic dermatitis, developed in accordance with the American Academy of Dermatology (AAD)/American Academy of Dermatology Association “administrative regulations for evidence-based clinical practice guidelines”, J Am Acad Dermatol, 50, 391, 10.1016/j.jaad.2003.08.003 · DOI · Paper page
  2. Nankervis, 2011, Mapping randomized controlled trials of treatments for eczema–the GREAT database (the Global Resource of EczemA Trials: a collection of key data on randomized controlled trials of treatments for eczema from 2000 to 2010), BMC Dermatol, 11, 10, 10.1186/1471-5945-11-10 · DOI
  3. Ring, 2012, Guidelines for treatment of atopic eczema (atopic dermatitis), part I, J Eur Acad Dermatol Venereol, 26, 1045, 10.1111/j.1468-3083.2012.04635.x · DOI · Paper page
  4. Ring, 2012, Guidelines for treatment of atopic eczema (atopic dermatitis), part II, J Eur Acad Dermatol Venereol, 26, 1176, 10.1111/j.1468-3083.2012.04636.x · DOI · Paper page
  5. Schneider, 2013, Atopic dermatitis: a practice parameter update 2012, J Allergy Clin Immunol, 131, 295, 10.1016/j.jaci.2012.12.672 · DOI · Paper page
  6. Ebell, 2004, Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature, J Am Board Fam Pract, 17, 59, 10.3122/jabfm.17.1.59 · DOI · Paper page
  7. Goeckerman, 1925, Treatment of psoriasis, Northwest Med, 24, 229
  8. Morison, 1978, Oral psoralen photochemotherapy of atopic eczema, Br J Dermatol, 98, 25, 10.1111/j.1365-2133.1978.tb07329.x · DOI · Paper page
  9. Meduri, 2007, Phototherapy in the management of atopic dermatitis: a systematic review, Photodermatol Photoimmunol Photomed, 23, 106, 10.1111/j.1600-0781.2007.00291.x · DOI
  10. Rombold, 2008, Efficacy of UVA1 phototherapy in 230 patients with various skin diseases, Photodermatol Photoimmunol Photomed, 24, 19, 10.1111/j.1600-0781.2008.00328.x · DOI
  11. Clayton, 2007, The treatment of severe atopic dermatitis in childhood with narrowband ultraviolet B phototherapy, Clin Exp Dermatol, 32, 28
  12. Jekler, 1988, UVB phototherapy of atopic dermatitis, Br J Dermatol, 119, 697
  13. Grundmann-Kollmann, 1999, Phototherapy for atopic eczema with narrow-band UVB, J Am Acad Dermatol, 40, 995, 10.1016/S0190-9622(99)70090-3 · DOI
  14. Tay, 1996, Experience with UVB phototherapy in children, Pediatr Dermatol, 13, 406, 10.1111/j.1525-1470.1996.tb00711.x · DOI
  15. Menter, 2010, Guidelines of care for the management of psoriasis and psoriatic arthritis, section 5: guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy, J Am Acad Dermatol, 62, 114, 10.1016/j.jaad.2009.08.026 · DOI · Paper page
  16. Morison, 1998, Consensus workshop on the toxic effects of long-term PUVA therapy, Arch Dermatol, 134, 595, 10.1001/archderm.134.5.595 · DOI · Paper page
  17. Goldsmith LK, Katz SI, Gilchrest B, Paller A, Lefell D, Wolff K. Fitzpatrick's dermatology in general medicine. 8th ed. New York: McGraw-Hill; 2012.
  18. Stern, 1997, Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA follow-up study, N Engl J Med, 336, 1041, 10.1056/NEJM199704103361501 · DOI · Paper page
  19. Uetsu, 2003, Treatment of persistent severe atopic dermatitis in 113 Japanese patients with oral psoralen photo-chemotherapy, J Dermatol, 30, 450, 10.1111/j.1346-8138.2003.tb00415.x · doi:10.1111/j.1346-8138.2003.tb00415.x
  20. Yoshiike, 1993, A proposed guideline for psoralen photochemotherapy (PUVA) with atopic dermatitis: successful therapeutic effect on severe and intractable cases, J Dermatol Sci, 5, 50, 10.1016/0923-1811(93)90105-X · doi:10.1016/0923-1811(93)90105-x
  21. Atherton, 1988, The role of psoralen photochemotherapy (PUVA) in the treatment of severe atopic eczema in adolescents, Br J Dermatol, 118, 791, 10.1111/j.1365-2133.1988.tb02597.x · doi:10.1111/j.1365-2133.1988.tb02597.x
  22. Jury, 2006, Narrowband ultraviolet B (UVB) phototherapy in children, Clin Exp Dermatol, 31, 196, 10.1111/j.1365-2230.2006.02061.x · DOI
  23. Tzung, 2006, Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitis, Acta Derm Venereol, 86, 34
  24. Koek, 2009, Home versus outpatient ultraviolet B phototherapy for mild to severe psoriasis: pragmatic multicenter randomized controlled non-inferiority trial (PLUTO study), BMJ, 338, b1542, 10.1136/bmj.b1542 · DOI
  25. Baltas, 2006, Treatment of atopic dermatitis with the xenon chloride excimer laser, J Eur Acad Dermatol Venereol, 20, 657, 10.1111/j.1468-3083.2006.01495.x · doi:10.1111/j.1468-3083.2006.01495.x
  26. Morita, 1993, Clinical application of low reactive level laser therapy (LLLT) for atopic dermatitis, Keio J Med, 42, 174, 10.2302/kjm.42.174 · doi:10.2302/kjm.42.174
  27. Syed, 2008, A pilot study showing pulsed-dye laser treatment improves localized areas of chronic atopic dermatitis, Clin Exp Dermatol, 33, 243, 10.1111/j.1365-2230.2007.02644.x · DOI
  28. Radenhausen, 2004, Bicenter experience in the treatment of severe generalized atopic dermatitis with extracorporeal photochemotherapy, J Dermatol, 31, 961, 10.1111/j.1346-8138.2004.tb00638.x · doi:10.1111/j.1346-8138.2004.tb00638.x
  29. Prinz, 1999, Long-term application of extracorporeal photochemotherapy in severe atopic dermatitis, J Am Acad Dermatol, 40, 577, 10.1016/S0190-9622(99)70440-8 · doi:10.1016/s0190-9622(99)70440-8
  30. Schram, 2011, A randomized trial of methotrexate versus azathioprine for severe atopic eczema, J Allergy Clin Immunol, 128, 353, 10.1016/j.jaci.2011.03.024 · DOI · Paper page
  31. Haeck, 2011, Enteric-coated mycophenolate sodium versus cyclosporin A as long-term treatment in adult patients with severe atopic dermatitis: a randomized controlled trial, J Am Acad Dermatol, 64, 1074, 10.1016/j.jaad.2010.04.027 · DOI · Paper page
  32. Schmitt, 2010, Prednisolone vs cyclosporin for severe adult eczema: an investigator-initiated double-blind placebo-controlled multicenter trial, Br J Dermatol, 162, 661, 10.1111/j.1365-2133.2009.09561.x · DOI
  33. Hoare, 2000, Systematic review of treatments for atopic eczema, Health Technol Assess, 4, 1, 10.3310/hta4370 · DOI · Paper page
  34. van Joost, 1994, Cyclosporin in atopic dermatitis: a multicenter placebo-controlled study, Br J Dermatol, 130, 634, 10.1111/j.1365-2133.1994.tb13111.x · DOI · Paper page
  35. Czech, 2000, A body-weight-independent dosing regimen of cyclosporine microemulsion is effective in severe atopic dermatitis and improves the quality of life, J Am Acad Dermatol, 42, 653
  36. Zurbriggen, 1999, Comparison of two formulations of cyclosporin A in the treatment of severe atopic dermatitis: a double-blind, single-center, cross-over pilot study, Dermatology, 198, 56, 10.1159/000018065 · DOI
  37. Schmitt, 2007, Cyclosporin in the treatment of patients with atopic eczema–a systematic review and meta-analysis, J Eur Acad Dermatol Venereol, 21, 606, 10.1111/j.1468-3083.2006.02023.x · DOI · Paper page
  38. Menter, 2009, Guidelines of care for the management of psoriasis and psoriatic arthritis, section 4: guidelines of care for the management and treatment of psoriasis with traditional systemic agents, J Am Acad Dermatol, 61, 451, 10.1016/j.jaad.2009.03.027 · DOI · Paper page
  39. Harper, 2000, Cyclosporin for severe childhood atopic dermatitis: short course versus continuous therapy, Br J Dermatol, 142, 52, 10.1046/j.1365-2133.2000.03241.x · DOI · Paper page
  40. Meggitt, 2006, Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomized controlled trial, Lancet, 367, 839, 10.1016/S0140-6736(06)68340-2 · DOI · Paper page
  41. Berth-Jones, 2002, Azathioprine in severe adult atopic dermatitis: a double-blind, placebo-controlled, crossover trial, Br J Dermatol, 147, 324, 10.1046/j.1365-2133.2002.04989.x · DOI · Paper page
  42. Perrett, 2008, Azathioprine treatment photosensitizes human skin to ultraviolet A radiation, Br J Dermatol, 159, 198, 10.1111/j.1365-2133.2008.08610.x · DOI
  43. el-Azhary, 2009, Thioguanine nucleotides and thiopurine methyltransferase in immunobullous diseases: optimal levels as adjunctive tools for azathioprine monitoring, Arch Dermatol, 145, 644, 10.1001/archdermatol.2009.81 · DOI
  44. Caufield, 2013, Oral azathioprine for recalcitrant pediatric atopic dermatitis: clinical response and thiopurine monitoring, J Am Acad Dermatol, 68, 29, 10.1016/j.jaad.2012.07.001 · DOI
  45. Evans, 2001, Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine, J Clin Oncol, 19, 2293, 10.1200/JCO.2001.19.8.2293 · DOI · Paper page
  46. Murphy, 2002, A retrospective evaluation of azathioprine in severe childhood atopic eczema, using thiopurine methyltransferase levels to exclude patients at high risk of myelosuppression, Br J Dermatol, 147, 308, 10.1046/j.1365-2133.2002.04922.x · DOI
  47. Hon, 2009, Efficacy and tolerability at 3 and 6 months following use of azathioprine for recalcitrant atopic dermatitis in children and young adults, J Dermatolog Treat, 20, 141, 10.1080/09546630802512646 · DOI
  48. Weatherhead, 2007, An open-label, dose-ranging study of methotrexate for moderate-to-severe adult atopic eczema, Br J Dermatol, 156, 346, 10.1111/j.1365-2133.2006.07686.x · DOI
  49. Lyakhovitsky, 2010, Low-dose methotrexate treatment for moderate-to-severe atopic dermatitis in adults, J Eur Acad Dermatol Venereol, 24, 43, 10.1111/j.1468-3083.2009.03351.x · DOI
  50. Kalb, 2009, Methotrexate and psoriasis: 2009 National Psoriasis Foundation consensus conference, J Am Acad Dermatol, 60, 824, 10.1016/j.jaad.2008.11.906 · DOI · Paper page
  51. El-Khalawany, 2013, Methotrexate versus cyclosporine in the treatment of severe atopic dermatitis in children: a multicenter experience from Egypt, Eur J Pediatr, 172, 351, 10.1007/s00431-012-1893-3 · DOI · Paper page
  52. Dadlani, 2005, Treatment of children and adolescents with methotrexate, cyclosporine, and etanercept: review of the dermatologic and rheumatologic literature, J Am Acad Dermatol, 52, 316, 10.1016/j.jaad.2004.07.043 · doi:10.1016/j.jaad.2004.07.043
  53. Murray, 2007, Mycophenolate mofetil therapy for moderate to severe atopic dermatitis, Clin Exp Dermatol, 32, 23
  54. Heller, 2007, Mycophenolate mofetil for severe childhood atopic dermatitis: experience in 14 patients, Br J Dermatol, 157, 127, 10.1111/j.1365-2133.2007.07947.x · DOI
  55. Hanifin, 1993, Recombinant interferon gamma therapy for atopic dermatitis, J Am Acad Dermatol, 28, 189, 10.1016/0190-9622(93)70026-P · DOI · Paper page
  56. Jang, 2000, Clinical improvement and immunohistochemical findings in severe atopic dermatitis treated with interferon gamma, J Am Acad Dermatol, 42, 1033, 10.1067/mjd.2000.104793 · DOI
  57. Daley-Yates, 2004, Relationship between systemic corticosteroid exposure and growth velocity: development and validation of a pharmacokinetic/pharmacodynamic model, Clin Ther, 26, 1905, 10.1016/j.clinthera.2004.11.017 · DOI
  58. Keaney, 2012, Open-label, pilot study examining sequential therapy with oral tacrolimus and topical tacrolimus for severe atopic dermatitis, J Am Acad Dermatol, 67, 636, 10.1016/j.jaad.2011.10.033 · DOI
  59. Boguniewicz, 2001, Effects of cefuroxime axetil on Staphylococcus aureus colonization and superantigen production in atopic dermatitis, J Allergy Clin Immunol, 108, 651, 10.1067/mai.2001.118598 · DOI
  60. Bath-Hextall, 2010, Interventions to reduce Staphylococcus aureus in the management of atopic eczema: an updated Cochrane review, Br J Dermatol, 163, 12, 10.1111/j.1365-2133.2010.09743.x · DOI · Paper page
  61. Ewing, 1998, Flucloxacillin in the treatment of atopic dermatitis, Br J Dermatol, 138, 1022, 10.1046/j.1365-2133.1998.02271.x · DOI
  62. Weinberg, 1992, The use of cefadroxil in superinfected atopic dermatitis, Curr Ther Res, 52, 671, 10.1016/S0011-393X(05)80509-0 · doi:10.1016/s0011-393x(05)80509-0
  63. Aronson, 2011, Delayed acyclovir and outcomes of children hospitalized with eczema herpeticum, Pediatrics, 128, 1161, 10.1542/peds.2011-0948 · doi:10.1542/peds.2011-0948
  64. Diepgen, 2002, Early Treatment of the Atopic Child Study Group. Long-term treatment with cetirizine of infants with atopic dermatitis: a multi-country, double-blind, randomized, placebo-controlled trial (the ETAC trial) over 18 months, Pediatr Allergy Immunol, 13, 278, 10.1034/j.1399-3038.2002.01047.x · DOI · Paper page
  65. Sher, 2012, Relieving the pruritus of atopic dermatitis: a meta-analysis, Acta Derm Venereol, 92, 455, 10.2340/00015555-1360 · DOI
  66. Klein, 1999, An evidence-based review of the efficacy of antihistamines in relieving pruritus in atopic dermatitis, Arch Dermatol, 135, 1522, 10.1001/archderm.135.12.1522 · DOI · Paper page
  67. Hannuksela, 1993, Dose ranging study: cetirizine in the treatment of atopic dermatitis in adults, Ann Allergy, 70, 127
  68. Epstein, 1964, A blind study, Arch Dermatol, 89, 548, 10.1001/archderm.1964.01590280048008 · DOI
  69. Schad, 2008, Antihistamines in the pediatric population: achieving optimal outcomes when treating seasonal allergic rhinitis and chronic urticaria, Allergy Asthma Proc, 29, 7, 10.2500/aap2008.29.3080 · doi:10.2500/aap2008.29.3080

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Metadata

Authors
Sidbury, R., Davis, D. M., Cohen, D. E., Cordoro, K. M., Berger, T. G., Bergman, J. N., Chamlin, S. L., Cooper, K. D., Feldman, S. R., Hanifin, J. M., Krol, A., Margolis, D. J., Paller, A. S., Schwarzenberger, K., Silverman, R. A., Simpson, E. L., Tom, W. L., Williams, H. C., Elmets, C. A., Block, J., Harrod, C. G., Begolka, W. S., & Eichenfield, L. F.
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2014-08
Volume
71
Issue
2
Pages
327-349
ISSN
0190-9622 (ISSN-L)
OpenAlex
W189068515
Cited by
885
References
1
FWCI
58.65
Type
journal article
Language
en
Open access
green
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Funders
National Institutes of Health (NIH)/National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) research career development grant (K23AR060274)

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CoChat. (2026). Citation check: Guidelines of care for the management of atopic dermatitis. https://app.cochat.ai/papers/10.1016/j.jaad.2014.03.030
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Sidbury, R., Davis, D. M., Cohen, D. E., Cordoro, K. M., Berger, T. G., Bergman, J. N., Chamlin, S. L., Cooper, K. D., Feldman, S. R., Hanifin, J. M., Krol, A., Margolis, D. J., Paller, A. S., Schwarzenberger, K., Silverman, R. A., Simpson, E. L., Tom, W. L., Williams, H. C., Elmets, C. A., . . . Eichenfield, L. F. (2014). Guidelines of care for the management of atopic dermatitis. Journal of the American Academy of Dermatology. https://doi.org/10.1016/j.jaad.2014.03.030

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