The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA)
Open accessAbstract
BACKGROUND: Photochemotherapy with oral methoxsalen (psoralen) and ultraviolet A radiation (PUVA) is an effective treatment for psoriasis. However, PUVA is mutagenic, increases the risk of squamous-cell skin cancer, and can cause irregular, pigmented skin lesions. We studied the occurrence of melanoma among patients treated with PUVA. METHODS: We prospectively identified cases of melanoma and documented the extent of exposure to PUVA among 1380 patients with psoriasis who were first treated with PUVA in 1975 or 1976. Using incidence data, we calculated the expected incidence of melanoma in this cohort and compared it with the observed incidence. Using regression models, we assessed the risks of melanoma associated with a long time (> or = 15 years) since the first treatment and with a large number of PUVA treatments (> or = 250). RESULTS: From 1975 through 1990, we detected four malignant melanomas, about the number expected in the overall population (relative risk, 1.1). From 1991 through 1996, we detected seven malignant melanomas (relative risk, 5.4; 95 percent confidence interval, 2.2 to 11.1). The risk of melanoma was higher in the later period than in the earlier one (incidence-rate ratio, 3.8) and higher among patients who received at least 250 PUVA treatments than among those who received fewer treatments (incidence-rate ratio, 3.1). CONCLUSIONS: About 15 years after the first treatment with PUVA, the risk of malignant melanoma increases, especially among patients who receive 250 treatments or more.
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Cites
Photochemotherapy of Psoriasis with Oral Methoxsalen and Longwave Ultraviolet Light
Parrish, J. A., Fitzpatrick, T. B., Tanenbaum, L., & Pathak, M. A. (1974) · New England Journal of Medicine · doi:10.1056/nejm197412052912301 · Cited by 1,376
Wavelengths effective in induction of malignant melanoma.
Setlow, R. B., Grist, E., Thompson, K., & Woodhead, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6666 · Cited by 719
Cutaneous Squamous-Cell Carcinoma in Patients Treated with PUVA
Stern, R. S., Laird, N., Melski, J., Parrish, J. A., Fitzpatrick, T. B., & Bleich, H. L. (1984) · New England Journal of Medicine · doi:10.1056/nejm198405033101805 · Cited by 452
Self-citationKoh, H. K. (1991) · New England Journal of Medicine · doi:10.1056/nejm199107183250306 · Cited by 403
The carcinogenic risk of treatments for severe psoriasis
Stern, R. S., Laird, N., & Study, F. T. P. F.-U. (1994) · Cancer · doi:10.1002/1097-0142(19940601)73:11<2759::aid-cncr2820731118>3.0.co;2-c · Cited by 354
Self-citationThe carcinogenic risk of treatments for severe psoriasis
Dahl, M. V. (1995) · Journal of the American Academy of Dermatology · doi:10.1016/0190-9622(95)90084-5 · Cited by 318
Stern, R. S., & Study*, M. O. T. P. F.-U. (1990) · New England Journal of Medicine · doi:10.1056/nejm199004193221601 · Cited by 307
Self-citationCorona, R., Mele, A., Amini, M., De Rosa, G., Coppola, G., Piccardi, P., Fucci, M., Pasquini, P., & Faraggiana, T. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.4.1218 · Cited by 266
PUVA and cancer: a large-scale epidemiological study
LINDELOF, B. (1991) · The Lancet · doi:10.1016/0140-6736(91)90083-2 · Cited by 251
Skin tumors in the European PUVA Study
Henseler, T., Christophers, E., Hönigsmann, H., & Wolff, K. (1987) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(87)70010-3 · Cited by 175
Cited by
Toxic effects of ultraviolet radiation on the skin
Matsumura, Y., & Ananthaswamy, H. N. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.08.019 · Cited by 1,270
Human skin pigmentation: Melanocytes modulate skin color in response to stress
Costin, G.-E., & Hearing, V. J. (2007) · The FASEB Journal · doi:10.1096/fj.06-6649rev · Cited by 976
Kabat-Zinn, J., Wheeler, E., Light, T., Skillings, A., Scharf, M. J., Cropley, T. G., Hosmer, D., & Bernhard, J. D. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199809000-00020 · Cited by 826
Guidelines of care for the management of psoriasis and psoriatic arthritis
Gottlieb, A., Korman, N. J., Gordon, K. B., Feldman, S. R., Lebwohl, M., Koo, J. Y. M., Van Voorhees, A. S., Elmets, C. A., Leonardi, C. L., Beutner, K. R., et al. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.02.040 · Cited by 769
Alkhalifah, A., Alsantali, A., Wang, E., McElwee, K. J., & Shapiro, J. (2010) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2009.10.032 · Cited by 732
Metadata
- Authors
- Stern, R. S., Nichols, K. T., & Väkevä, L. H.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1997-04-10
- Volume
- 336
- Issue
- 15
- Pages
- 1041-1045
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2324161037
- Cited by
- 656
- References
- 21
- FWCI
- 21.48
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Stern, R. S., Nichols, K. T., & Väkevä, L. H. (1997). Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA). New England Journal of Medicine. https://doi.org/10.1056/nejm199704103361501
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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