Two-fold illumination in topical 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT) for superficial basal cell carcinoma (sBCC): A retrospective case series and cohort study
Abstract
Background There is limited literature on efficacy using a 2-fold illumination scheme in aminolevulinic acid (ALA) photodynamic therapy for superficial basal cell carcinoma (sBCC).Objectives We sought to determine the efficacy of ALA photodynamic therapy for sBCC using a 2-fold illumination scheme after a single ALA application. Treatment failure within 12 months posttreatment was assessed.Methods In this retrospective case series and cohort study, electronic files from patients treated between January 2010 and August 2011 were reviewed. Follow-up data were gathered until March 2014.Results A total of 323 sBCC were analyzed for recurrence. Cumulative probability of clinical recurrence-free survival was 88.8% (95% confidence interval [CI] 85.4-92.4), 81.8% (95% CI 77.3-86.3), and 77.1% (95% CI 71.0-83.6) at 12, 24, and 48 months, respectively. For histologically confirmed recurrences this was 90.2% (95% CI 86.9-93.5), 85.4% (95% CI 75.5-89.3), and 81.8% (95% CI 75.5-88.1), respectively. A worse recurrence-free survival for tumors in the head and neck area and tumors larger than 10 mm was observed.Limitations The retrospective nature and the lack of a control group are limitations.Conclusions ALA photodynamic therapy using a 2-fold illumination scheme might be a feasible treatment option with acceptable long-term results for small sBCC located outside the head and neck area.
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PDT is effective for superficial basal cell carcinoma (BCC).
“Photodynamic therapy (PDT) offers an effective treatment for AKs, and is also effective for superficial basal cell carcinoma (BCC).”
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- Authors
- Kessels, J., Hendriks, J., Nelemans, P., Mosterd, K., & Kelleners-Smeets, N.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Corresponding author
- Kessels, Janneke
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 74
- Issue
- 5
- Pages
- 899-906
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2235487483
- Cited by
- 20
- References
- 46
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 1
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- 5-aminolevulinic acid, photodynamic therapy, superficial basal cell carcinoma, recurrence-free survival, treatment failure, head and neck cancer, tumor size
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Carcinoma, Basal Cell, Basal Cell Carcinoma, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Invasiveness, Neoplasm Recurrence, Local, Neoplasm Staging, Photochemotherapy, Retrospective Studies, Skin Neoplasms, Cohort Studies, Confidence Intervals, Proportional Hazards Models, Survival Analysis, Treatment Outcome, Kaplan-Meier Estimate
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