Light Fractionation Significantly Improves the Response of Superficial Basal Cell Carcinoma to Aminolaevulinic Acid Photodynamic Therapy: Five-year Follow-up of a Randomized, Prospective Trial

Vijlder, H; Sterenborg, H; Neumann, H; Robinson, D; Haas, E

doi:10.2340/00015555-1448

Cited by 89Nonmelanoma Skin Cancer StudiesPhotodynamic Therapy Research StudiesPorphyrin Metabolism and Disorders

Light Fractionation Significantly Improves the Response of Superficial Basal Cell Carcinoma to Aminolaevulinic Acid Photodynamic Therapy: Five-year Follow-up of a Randomized, Prospective Trial

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Vijlder, H, Sterenborg, H, Neumann, H, Robinson, D, Haas, E·2012·Acta Dermato Venereologica

DOI 10.2340/00015555-1448

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Abstract

Photodynamic therapy (PDT) using topical porphyrin-precursors is a promising treatment for superficial basal cell carcinoma (sBCC), but it needs further optimization. The aim of this study was to compare 5-year lesion (complete) response rates of sBCC treated with topical aminolaevulinic acid (ALA)-PDT using a single illumination vs. ALA-PDT using a 2-fold illumination scheme. A prospective, randomized study was performed, in which 91 patients with 299 lesions were treated with a 2-fold illumination scheme with 2 light fractions of 20 and 80 J/cm2 delivered 4 and 6 h after a single application of 20% ALA, and 106 patients with 274 lesions were treated with a single illumination of 75 J/cm2 4 h after a single application of 20% ALA. All lesions were treated at a fluence rate of 50 mW/cm2. An interim time to event analysis of complete response (CR) rates at 12 months showed encouraging results, and therefore lesions were followed for 5 years post-therapy. A third group of 50 patients with 172 lesions treated with 2-fold illumination were included after the initial period and analysed separately. The CR rate was significantly greater following the 2-fold illumination than the single illumination (p = 0.0002, log-rank test). Five years after therapy the CR rate after 2-fold illumination was 88%, whereas the CR rate after single illumination was 75%. The CR rate in the third group of lesions, treated with 2-fold illumination was 97% and 88% at 12 months and 5 years after therapy, respectively. Long-term follow-up indicates superior efficacy in sBCC of ALA-PDT with 2-fold illumination compared with ALA-PDT with single illumination.

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A follow-up study at five years after treatment still showed better responses in BCC patients treated with double-illumination PDT.
“A follow-up study at five years after treatment still showed better responses in BCC patients treated with double-illumination PDT [67].”
From 5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy (2023) · cites this paper as [67]

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Self-citation

Authors: Vijlder, H., Sterenborg, H., Neumann, H., Robinson, D., & Haas, E.
Affiliations: Erasmus MC (NL)
ORCID: Sterenborg, H
Robinson, D
Venue: Acta Dermato Venereologica
Publisher: MJS Publishing, Medical Journals Sweden AB
Published: 2012
Volume: 92
Issue: 6
Pages: 641-647
ISSN: 0001-5555 (ISSN-L)
DOI: 10.2340/00015555-1448
OpenAlex: W2002522254
Cited by: 89
References: 44
Citations by year: 2026: 5 · 2025: 7 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 5 · 2018: 9 · 2017: 6 · 2016: 12 · 2015: 10 · 2014: 5 · 2013: 5 · 2012: 2
FWCI: 5.27
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Acta Dermato Venereologica (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
Keywords: superficial basal cell carcinoma, aminolaevulinic acid, photodynamic therapy, multiple illumination, complete response rate, long-term follow-up, porphyrin precursors, skin cancer treatment
MeSH terms: Administration, Cutaneous, Adult, Aged, Aged, 80 and over, Aminolevulinic Acid, Carcinoma, Basal Cell, Basal Cell Carcinoma, Female, Follow-Up Studies, Humans, Male, Middle Aged, Netherlands, Photochemotherapy, Prospective Studies, Skin Neoplasms, Time Factors, Treatment Outcome, Photosensitizing Agents, Kaplan-Meier Estimate

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Light Fractionation Significantly Improves the Response of Superficial Basal Cell Carcinoma to Aminolaevulinic Acid Photodynamic Therapy: Five-year Follow-up of a Randomized, Prospective Trial

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