Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age
Abstract
Background Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. Objective We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. Methods Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry. Results Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger. Limitations Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies. Conclusions This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age.
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GFF is capable of inhibiting the expression of cyclin-dependent kinase inhibitor 2A (CDKN2A or p16INK4A), which is a critical biomarker for facial senescence in epidermal keratinocytes.
“Moreover, GFF is capable of inhibiting the expression of cyclin-dependent kinase inhibitor 2A (CDKN2A or p16INK4A), which is a critical biomarker for facial senescence in epidermal keratinocytes [6,23].”
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Self-citation
- Authors
- Kimball, A. B., Alora-Palli, M. B., Tamura, M., Mullins, L. A., Soh, C., Binder, R. L., Houston, N. A., Conley, E. D., Tung, J. Y., Annunziata, N. E., Bascom, C. C., Isfort, R. J., Jarrold, B. B., Kainkaryam, R., Rocchetta, H. L., Swift, D. D., Tiesman, J. P., Toyama, K., Xu, J., Yan, X., & Osborne, R.
- Affiliations
- Harvard University (US)
- Procter & Gamble (United States) (US)
- Procter & Gamble Japan K.K. (Japan) (JP)
- 23andMe (United States) (US)
- Corresponding author
- Kimball, Alexa B.
- ORCID
- Venue
- Journal of the American Academy of Dermatology
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 78
- Issue
- 1
- Pages
- 29-39.e7
- ISSN
- 0190-9622 (ISSN-L)
- OpenAlex
- W2769485238
- Cited by
- 62
- References
- 8
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 5 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 7 · 2019: 6 · 2018: 4
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Academy of Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Procter and Gamble
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- skin aging, facial skin, gene expression profiling, photoaging, UV irradiation, photoprotection, skin barrier, oxidative stress, cellular senescence, energy metabolism, apparent age, chronological age, women, transcriptomics
- MeSH terms
- Adult, Aged, Aged, 80 and over, Biopsy, Needle, Facial Dermatoses, Female, Humans, Immunohistochemistry, Middle Aged, Prognosis, Risk Factors, Ultraviolet Rays, Skin Aging, Genetic Predisposition to Disease, White People, Young Adult
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