CoChat
Sign Up
Cited by 343Dermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisAsthma and respiratory diseases

The DOI matches its Crossref record; 31 of the 33 references it cites were found in a registry or an index.

Efficacy and safety of fezakinumab (an IL-22 monoclonal antibody) in adults with moderate-to-severe atopic dermatitis inadequately controlled by conventional treatments: A randomized, double-blind, phase 2a trial

Open access
Guttman-Yassky, Emma, Brunner, Patrick M., Neumann, Avidan U., Khattri, Saakshi, Pavel, Ana B., Malik, Kunal, Singer, Giselle K., Baum, Danielle, Gilleaudeau, Patricia, Sullivan-Whalen, Mary, Rose, Sharon, Jim On, Shelbi, Li, Xuan, Fuentes-Duculan, Judilyn, Estrada, Yeriel, Garcet, Sandra, Traidl-Hoffmann, Claudia, Krueger, James G., Lebwohl, Mark G.·2018·Journal of the American Academy of Dermatology
DOI 10.1016/j.jaad.2018.01.016PMC PMC8711034
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND: Interleukin 22 promotes epidermal hyperplasia and inhibits skin barrier function. OBJECTIVE: Evaluate interleukin 22 blockade in adults with moderate-to-severe atopic dermatitis (AD). METHODS: We performed a randomized, double-blind, placebo-controlled trial with intravenous fezakinumab monotherapy every 2 weeks for 10 weeks, with follow-up assessments until 20 weeks. The change in SCOring AD (SCORAD) score from baseline at 12 weeks served as the primary end point. RESULTS: At 12 weeks, the mean declines in SCORAD for the entire study population were 13.8 ± 2.7 in the fezakinumab arm and 8.0 ± 3.1 in the placebo arm (P = .134). In the severe AD patient subset (with a baseline SCORAD of ≥50), SCORAD decline was significantly stronger in the drug-treated patients than placebo-treated patients at 12 weeks (21.6 ± 3.8 vs 9.6 ± 4.2, P = .029) and 20 weeks (27.4 ± 3.9 vs 11.5 ± 5.1, P = .010). At 12 weeks, improvements in body surface area involvement in the entire population were significantly stronger in the drug-treated than placebo-treated patients (12.4% ± 2.4 vs 6.2% ± 2.7; P = .009), and in the severe AD subset, the decline in Investigator Global Assessment was significantly higher in the drug-treated than placebo-treated patients (0.7 ± 0.2 vs 0.3 ± 0.1; P = .034). All scores showed progressive improvements after last dosing (10 weeks) until end of study (20 weeks). Common adverse events were upper respiratory tract infections. LIMITATIONS: The limited sample size and lack of assessment with Eczema Area and Severity Index and a pruritus numerical rating scale were limiting factors. Significance was primarily obtained in severe AD. CONCLUSION: Fezakinumab was well-tolerated, with sustained clinical improvements after last drug dosing.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jaad.2018.01.016

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Show all 33 references

2 of the 33 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Items 301–343 of 343

Related

See all

Metadata

Authors
Guttman-Yassky, E., Brunner, P. M., Neumann, A. U., Khattri, S., Pavel, A. B., Malik, K., Singer, G. K., Baum, D., Gilleaudeau, P., Sullivan-Whalen, M., Rose, S., Jim On, S., Li, X., Fuentes-Duculan, J., Estrada, Y., Garcet, S., Traidl-Hoffmann, C., Krueger, J. G., & Lebwohl, M. G.
Affiliations
  • Rockefeller University (US)
  • University of Zurich (CH)
  • Icahn School of Medicine at Mount Sinai (US)
ORCID
Venue
Journal of the American Academy of Dermatology
Publisher
Elsevier BV
Published
2018-05
Volume
78
Issue
5
Pages
872-881.e6
ISSN
0190-9622 (ISSN-L)
DOI
10.1016/j.jaad.2018.01.016
PMC
PMC8711034
OpenAlex
W2783616522
Cited by
343
References
33
Citations by year
2026: 20 · 2025: 31 · 2024: 35 · 2023: 40 · 2022: 38 · 2021: 46 · 2020: 49 · 2019: 50 · 2018: 33
FWCI
48.14
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American Academy of Dermatology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion, other-oa)
  • Site cant be reached (submittedVersion, cc-by-nc-nd)
  • PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
  • OPUS (Augsburg University) (submittedVersion, cc-by-nc-nd)
Funders
  • Amgen
  • Eli Lilly and Company
  • Pfizer
  • GlaxoSmithKline
  • Sanofi
  • Celgene
  • Danone
  • Regeneron Pharmaceuticals
  • Dermira
  • Glenmark Pharmaceuticals
  • Galderma
  • LEO Pharma
  • National Institutes of Health (UL1TR001866)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (UM1AR063917)
  • National Center for Advancing Translational Sciences (UL1TR0001866)
Topics
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
atopic dermatitis, moderate-to-severe atopic dermatitis, monoclonal antibody therapy, SCORAD, body surface area involvement, upper respiratory tract infection, adverse events, treatment efficacy
MeSH terms
Interleukin-22, Adult, Antibodies, Monoclonal, Dermatitis, Atopic, Dose-Response Relationship, Drug, Double-Blind Method, Drug Administration Schedule, Female, Follow-Up Studies, Humans, Infusions, Intravenous, Interleukins, Male, Middle Aged, Severity of Illness Index, Treatment Outcome, Antibodies, Monoclonal, Humanized

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review