IL-22 Inhibits Epidermal Differentiation and Induces Proinflammatory Gene Expression and Migration of Human Keratinocytes
Open accessAbstract
IL-22 belongs to a family of cytokines structurally related to IL-10, including IL-19, IL-20, IL-24, and IL-26. In contrast to IL-10, IL-22 has proinflammatory activities. IL-22 signals through a class II cytokine receptor composed of an IL-22-binding chain, IL-22RA1, and the IL-10RB subunit, which is shared with the IL-10R. In the present study, we show that short-term cultured human epidermal keratinocytes express a functional IL-22R but no IL-10R. Accordingly, IL-22 but not IL-10 induces STAT3 activation in keratinocytes. Using a cDNA array screening approach, real-time RT-PCR, and Western blot analysis, we demonstrate that IL-22 up-regulates, in a dose-dependent manner, the expression of S100A7, S100A8, S100A9, a group of proinflammatory molecules belonging to the S100 family of calcium-binding proteins, as well as the matrix metalloproteinase 3, the platelet-derived growth factor A, and the CXCL5 chemokine. In addition, IL-22 induces keratinocyte migration in an in vitro injury model and down-regulates the expression of at least seven genes associated with keratinocyte differentiation. Finally, we show that IL-22 strongly induces hyperplasia of reconstituted human epidermis. Taken together, these results suggest that IL-22 plays an important role in skin inflammatory processes and wound healing.
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In vitro studies suggest that IL-22 signals to epithelial keratinocytes of the skin to promote proliferation and migration and induce AMPs.
“In vitro studies have suggested that IL-22 signals to epithelial keratinocytes of the skin to promote proliferation and migration and inducing AMPs.85,86”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [85]
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- Authors
- Boniface, K., Bernard, F.-X., Garcia, M., Gurney, A. L., Lecron, J.-C., & Morel, F.
- Affiliations
- Université de Poitiers (FR)
- BIOalternatives , Gençay ,
- Genentech (US)
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-03
- Volume
- 174
- Issue
- 6
- Pages
- 3695-3702
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1576903429
- Cited by
- 864
- References
- 54
- Citations by year
- 2026: 10 · 2025: 31 · 2024: 36 · 2023: 35 · 2022: 46 · 2021: 55 · 2020: 35 · 2019: 34 · 2018: 38 · 2017: 56 · 2016: 45 · 2015: 55 · 2014: 48 · 2013: 56 · 2012: 73
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Centre Hospitalier Universitaire de Poitiers
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- IL-22, keratinocytes, epidermal differentiation, keratinocyte migration, STAT3 activation, IL-22 receptor, IL-10 receptor, S-100 protein, matrix metalloproteinase-3, PDGF-A, CXCL5, skin inflammation, wound healing, epidermal hyperplasia
- MeSH terms
- S100 Calcium Binding Protein A7, Interleukin-22, Base Sequence, Calcium-Binding Proteins, Cell Differentiation, Cell Movement, Cells, Cultured, DNA, DNA-Binding Proteins, Humans, Interleukins, S100 Proteins, Recombinant Proteins, RNA, Messenger, Signal Transduction, Trans-Activators, Keratinocytes, Gene Expression, Interleukin-10, Receptors, Interleukin, Inflammation Mediators, Matrix Metalloproteinase 3, Oligonucleotide Array Sequence Analysis, Calgranulin A, Calgranulin B, STAT3 Transcription Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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