Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models
Open accessAbstract
Heart failure (HF) with preserved ejection fraction (HFpEF) is a multifactorial disease accounting for a large and increasing proportion of all clinical HF presentations. As a clinical syndrome, HFpEF is characterized by typical signs and symptoms of HF, a distinct cardiac phenotype and raised natriuretic peptides. Non-cardiac comorbidities frequently co-exist and contribute to the pathophysiology of HFpEF. To date, no therapy has proven to improve outcomes in HFpEF, with drug development hampered, at least partly, by lack of consensus on appropriate standards for pre-clinical HFpEF models. Recently, two clinical algorithms (HFA-PEFF and H2FPEF scores) have been developed to improve and standardize the diagnosis of HFpEF. In this review, we evaluate the translational utility of HFpEF mouse models in the context of these HFpEF scores. We systematically recorded evidence of symptoms and signs of HF or clinical HFpEF features and included several cardiac and extra-cardiac parameters as well as age and sex for each HFpEF mouse model. We found that most of the pre-clinical HFpEF models do not meet the HFpEF clinical criteria, although some multifactorial models resemble human HFpEF to a reasonable extent. We therefore conclude that to optimize the translational value of mouse models to human HFpEF, a novel approach for the development of pre-clinical HFpEF models is needed, taking into account the complex HFpEF pathophysiology in humans.
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The murine model of HFpEF has several similarities with human HFpEF.
“We have shown previously that a murine model of HFpEF has several similarities with human HFpEF.27,28”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [27]
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Myocyte Turnover in the Aging Human Heart
Kajstura, J., Gurusamy, N., Ogórek, B., Goichberg, P., Clavo-Rondon, C., Hosoda, T., D'Amario, D., Bardelli, S., Beltrami, A. P., Cesselli, D., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.231498 · Cited by 287 · see citing works
RetractedAroor, A. R., Habibi, J., Kandikattu, H. K., Garro-Kacher, M. O., Barron, B. J., Chen, D., Hayden, M. R., Whaley‐Connell, A. T., Bender, S. B., Klein, T., et al. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0544-4 · Cited by 69 · see citing works
RetractedMcDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 19,618 · see citing works
Self-citation2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G. F., Coats, A. J. S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw128 · Cited by 11,429 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
A Novel Paradigm for Heart Failure With Preserved Ejection Fraction
Paulus, W. J., & Tschöpe, C. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.092 · Cited by 3,564 · see citing works
Spironolactone for heart failure with preserved ejection fraction
Pitt, B., Pfeffer, M. A., Assmann, S. F., Boineau, R., Anand, I. S., Claggett, B., Clausell, N., Desai, A. S., Diaz, R., Fleg, J. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313731 · Cited by 2,809 · see citing works
Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction
Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1908655 · Cited by 2,430 · see citing works
Self-citationChen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works
Pieske, B. M., Tschöpe, C., de Boer, R. A., Fraser, A. G., Anker, S. D., Donal, E., Edelmann, F., Fu, M. L. X., Guazzi, M., Lam, C. S. P., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz641 · Cited by 1,906 · see citing works
Self-citationExtension of murine life span by overexpression of catalase targeted to mitochondria
Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science · doi:10.1126/science.1106653 · Cited by 1,724 · see citing works
Epidemiology of heart failure with preserved ejection fraction
Dunlay, S. M., Roger, V. L., & Redfield, M. M. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.65 · Cited by 1,548 · see citing works
Reddy, Y. N. V., Carter, R. E., Obokata, M., Redfield, M. M., & Borlaug, B. A. (2018) · Circulation · doi:10.1161/circulationaha.118.034646 · Cited by 1,294 · see citing works
Redfield, M. M., Chen, H. H., Borlaug, B. A., Semigran, M. J., Lee, K. L., Lewis, G. D., LeWinter, M. M., Rouleau, J. L., Bull, D. A., Mann, D. L., et al. (2013) · JAMA · doi:10.1001/jama.2013.2024 · Cited by 1,156 · see citing works
OBESE, A NEW MUTATION IN THE HOUSE MOUSE*
INGALLS, A. M., DICKIE, M. M., & SNELL, G. D. (1950) · Journal of Heredity · doi:10.1093/oxfordjournals.jhered.a106073 · Cited by 1,090 · cited 1× · see citing works
“The ob/ob is a leptin-deficient mouse that spontaneously develops obesity (within 4 weeks) and T2DM secondary to hyperglycaemia and hyperinsulinemia.(141,142) The mice develop concentric hypertrophy with diastolic dysfunction possible due to lipid accumulation.”
BackgroundThe Mouse in Biomedical Research
(1983) · Elsevier eBooks · doi:10.1016/c2013-0-10677-0 · Cited by 1,021 · see citing works
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap
Shah, S. J., Kitzman, D. W., Borlaug, B. A., van Heerebeek, L., Zile, M. R., Kass, D. A., & Paulus, W. J. (2016) · Circulation · doi:10.1161/circulationaha.116.021884 · Cited by 1,003 · see citing works
Nitrosative stress drives heart failure with preserved ejection fraction
Schiattarella, G. G., Altamirano, F. J., Tong, D., French, K. M., Villalobos, E., Kim, S. Y., Luo, X., Jiang, N., May, H. I., Wang, Z. V., et al. (2019) · Nature · doi:10.1038/s41586-019-1100-z · Cited by 956 · see citing works
Self-citationMouse Models in Aging Research
Flurkey, K., MCURRER, J., & HARRISON, D. (2007) · Elsevier eBooks · doi:10.1016/b978-012369454-6/50074-1 · Cited by 904 · see citing works
Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy
Takimoto, E., Champion, H. C., Li, M., Belardi, D. F., Ren, S. V., Rodríguez, E. R., Bedja, D., Gabrielson, K. L., Wang, Y., & Kass, D. A. (2005) · Nature Medicine · doi:10.1038/nm1175 · Cited by 902 · see citing works
Heart Failure With Preserved Ejection Fraction In Perspective
Pfeffer, M. A., Shah, A. M., & Borlaug, B. A. (2019) · Circulation Research · doi:10.1161/circresaha.119.313572 · Cited by 843 · see citing works
Influence of chronic captopril therapy on the infarcted left ventricle of the rat.
Pfeffer, J. M., Pfeffer, M. A., & D, E. B. M. (1985) · Circulation Research · doi:10.1161/01.res.57.1.84 · Cited by 810 · see citing works
Age- and Gender-Related Ventricular-Vascular Stiffening
Redfield, M. M., Jacobsen, S. J., Borlaug, B. A., Rodeheffer, R. J., & Kass, D. A. (2005) · Circulation · doi:10.1161/circulationaha.105.541078 · Cited by 810 · see citing works
Pfeffer, M. A., Pfeffer, J. M., Steinberg, C., & Finn, P. V. (1985) · Circulation · doi:10.1161/01.cir.72.2.406 · Cited by 717 · see citing works
Hypoxia induces heart regeneration in adult mice
Nakada, Y., Canseco, D. C., Thet, S., Abdisalaam, S., Asaithamby, A., Santos, C. X. C., Shah, A. M., Zhang, H., Faber, J. E., Kinter, M. T., et al. (2016) · Nature · doi:10.1038/nature20173 · Cited by 698 · see citing works
Self-citationEvaluation and management of heart failure with preserved ejection fraction
Borlaug, B. A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0363-2 · Cited by 675 · see citing works
Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Hage, C., Tan, R.-S., Beussink-Nelson, L., Ljung Faxén, U., Fermer, M. L., Broberg, M. A., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy531 · Cited by 656 · see citing works
Global Gender Disparities in Obesity: A Review
Kanter, R., & Caballero, B. H. (2012) · Advances in Nutrition · doi:10.3945/an.112.002063 · Cited by 648 · see citing works
Brouwers, F. P., de Boer, R. A., van der Harst, P., Voors, A. A., Gansevoort, R. T., Bakker, S. J., Hillege, H. L., van Veldhuisen, D. J., & van Gilst, W. H. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht066 · Cited by 610 · see citing works
Self-citationNoncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
Mentz, R. J., Kelly, J. P., von Lueder, T. G., Voors, A. A., Lam, C. S. P., Cowie, M. R., Kjeldsen, K., Jankowska, E. A., Atar, D., Butler, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.036 · Cited by 546 · see citing works
Self-citationLam, C. S. P., Roger, V. L., Rodeheffer, R. J., Bursi, F., Borlaug, B. A., Ommen, S. R., Kass, D. A., & Redfield, M. M. (2007) · Circulation · doi:10.1161/circulationaha.106.659763 · Cited by 544 · see citing works
Self-citationPettersson, U. S., Waldén, T. B., Carlsson, P., Jansson, L. E., & Phillipson, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046057 · Cited by 521 · see citing works
The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF
Savji, N., Meijers, W. C., Bartz, T. M., Bhambhani, V., Cushman, M., Nayor, M., Kizer, J. R., Sarma, A., Blaha, M. J., Gansevoort, R. T., et al. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.05.018 · Cited by 499 · see citing works
Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging
Dai, D., Santana, L. F., Vermulst, M., Tomazela, D. M., Emond, M. J., MacCoss, M. J., Gollahon, K. A., Martin, G. M., Loeb, L. A., Ladiges, W., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.822403 · Cited by 497 · see citing works
Terman, A., Kurz, T., Navratil, M., Arriaga, E. A., & Brunk, U. T. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2598 · Cited by 490 · see citing works
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Mitchell, S. J., Madrigal-Matute, J., Scheibye-Knudsen, M., Fang, E., Aon, M., González-Reyes, J. A., Cortassa, S., Kaushik, S., Gonzalez-Freire, M., Patel, B., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.027 · Cited by 451 · see citing works
Tribouilloy, C., Ruşinaru, D., Mahjoub, H., Soulière, V., Lévy, F., Peltier, M., Slama, M., & Massy, Z. A. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm554 · Cited by 441 · see citing works
Targeting Mitochondria-Inflammation Circuit by β-Hydroxybutyrate Mitigates HFpEF
Deng, Y., Xie, M., Li, Q., Xu, X., Ou, W., Zhang, Y., Xiao, H., Yu, H., Zheng, Y., Liang, Y., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317933 · Cited by 413 · see citing works
Cardiac Lipid Accumulation Associated with Diastolic Dysfunction in Obese Mice
Christoffersen, C., Bollano, E., Lindegaard, M. L. S., Bartels, E. D., Goetze, J. P., Andersen, C. B., & Nielsen, L. B. (2003) · Endocrinology · doi:10.1210/en.2003-0242 · Cited by 375 · see citing works
The Emerging Epidemic of Heart Failure with Preserved Ejection Fraction
Oktay, A. A., Rich, J. D., & Shah, S. J. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0155-7 · Cited by 374 · see citing works
Pieske, B., Maggioni, A. P., Lam, C. S. P., Pieske-Kraigher, E., Filippatos, G., Butler, J., Ponikowski, P., Shah, S. J., Solomon, S. D., Scalise, A.-V., et al. (2017) · European Heart Journal · doi:10.1093/eurheartj/ehw593 · Cited by 366 · see citing works
Self-citationPredicting Heart Failure With Preserved and Reduced Ejection Fraction
Ho, J. E., Enserro, D. M., Brouwers, F. P. J., Kizer, J. R., Shah, S. J., Psaty, B. M., Bartz, T. M., Santhanakrishnan, R., Lee, D. S., Chan, C., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.003116 · Cited by 364 · see citing works
Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
Dai, D., Chen, T., Szeto, H. H., Nieves‐Cintrón, M., Kutyavin, V. I., Santana, L. F., & Rabinovitch, P. S. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.12.044 · Cited by 363 · see citing works
The Physiology of Obese-Hyperglycemic Mice [ob/obMice]
Lindström, P. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.117 · Cited by 353 · see citing works
Kitzman, D. W., Nicklas, B. J., Kraus, W. E., Lyles, M. F., Eggebeen, J., Morgan, T. M., & Haykowsky, M. J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00004.2014 · Cited by 345 · see citing works
Boonman-de Winter, L. J. M., Rutten, F. H., Cramer, M. J. M., Landman, M. J., Liem, A. H., Rutten, G. E. H. M., & Hoes, A. W. (2012) · Diabetologia · doi:10.1007/s00125-012-2579-0 · Cited by 343 · see citing works
Barouch, L. A., Berkowitz, D. E., Harrison, R. W., O’Donnell, C. P., & Hare, J. M. (2003) · Circulation · doi:10.1161/01.cir.0000083716.82622.fd · Cited by 341 · see citing works
Senescence-accelerated mouse (SAM): a novel murine model of senescence
Takeda, T., Hosokawa, M., & Higuchi, K. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00036-8 · Cited by 332 · see citing works
Sex-Related Differences in Myocardial Remodeling
Piro, M., Bona, R. D., Abbate, A., Biasucci, L. M., & Crea, F. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.09.065 · Cited by 331 · see citing works
Hoendermis, E. S., Liu, L. C. Y., Hummel, Y. M., van der Meer, P., de Boer, R. A., Berger, R. M. F., van Veldhuisen, D. J., & Voors, A. A. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv336 · Cited by 323 · see citing works
ter Maaten, J. M., Damman, K., Verhaar, M. C., Paulus, W. J., Duncker, D. J., Cheng, C., van Heerebeek, L., Hillege, H. L., Lam, C. S. P., Navis, G. J., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.497 · Cited by 323 · see citing works
Self-citationHahn, V. S., Yanek, L. R., Vaishnav, J., Ying, W., Vaidya, D. M., Lee, Y. J., Riley, S. J., Subramanya, V., Brown, E. E., Hopkins, C. D., et al. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.04.007 · Cited by 312 · see citing works
Hamdani, N., Franssen, C., Lourenço, A. P., Falcão‐Pires, I., Fontoura, D., Leite, S., Plettig, L., López, B., Ottenheijm, C. A. C., Becher, P. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/circheartfailure.113.000539 · Cited by 307 · see citing works
Sex differences in cardiac adaptation to isolated systolic hypertension
Krumholz, H. M., Larson, M. G., & Levy, D. A. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)90678-6 · Cited by 297 · see citing works
Ichihara, S., Senbonmatsu, T., Price, E., Ichiki, T., Gaffney, F. A., & Inagami, T. (2001) · Circulation · doi:10.1161/01.cir.104.3.346 · Cited by 297 · see citing works
Douglas, P. S., Katz, S. E., Weinberg, E. O., Chen, M. H., Bishop, S. P., & Lorell, B. H. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00347-7 · Cited by 282 · see citing works
Dai, D., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A., & Rabinovitch, P. S. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00581.x · Cited by 280 · see citing works
Kennedy, D. J., Vetteth, S., Periyasamy, S. M., et al. (2006) · Hypertension · doi:10.1161/01.hyp.0000202594.82271.92 · Cited by 276 · see citing works
Borlaug, B. A., Anstrom, K. J., Lewis, G. D., Shah, S. J., Levine, J. A., Koepp, G. A., Givertz, M. M., Felker, G. M., LeWinter, M. M., Mann, D. L., et al. (2018) · JAMA · doi:10.1001/jama.2018.14852 · Cited by 268 · see citing works
Habibi, J., Aroor, A. R., Sowers, J. R., Jia, G., Hayden, M. R., Garro, M., Barron, B. J., Mayoux, E., Rector, R. S., Whaley‐Connell, A. T., et al. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0489-z · Cited by 264 · see citing works
de Boer, R. A., Nayor, M. G., deFilippi, C. R., Enserro, D. M., Bhambhani, V., Kizer, J. R., Blaha, M. J., Brouwers, F. P. J., Cushman, M., Lima, J. A. C., et al. (2018) · JAMA Cardiology · doi:10.1001/jamacardio.2017.4987 · Cited by 264 · see citing works
Sex-Specific Cardiovascular Structure and Function in Heart Failure with Preserved Ejection Fraction
Gori, M., Lam, C. S. P., Gupta, D. K., Santos, Â. B. S., Cheng, S. C., Shah, A. M., Claggett, B. L., Zile, M. R., Kraigher‐Krainer, E., Pieske, B. M., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.67 · Cited by 237 · see citing works
Self-citationZacchigna, S., Paldino, A., Falcão‐Pires, I., Daskalopoulos, E. P., Ferro, M. D., Vodret, S., Lesizza, P., Cannata, A. N., Miranda‐Silva, D., Lourenço, A. P., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa110 · Cited by 235 · see citing works
Why are women more likely than men to develop heart failure with preserved ejection fraction?
Scantlebury, D. C., & Borlaug, B. A. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834b7faf · Cited by 232 · see citing works
Withaar, C., Meems, L. M. G., Markousis-Mavrogenis, G., Boogerd, C. J., Silljé, H. H. W., Schouten, E. M., Dokter, M. M., Voors, A. A., Westenbrink, B. D., Lam, C. S. P., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa256 · Cited by 223 · see citing works
Chronic angiotensin-(1–7) prevents cardiac fibrosis in DOCA-salt model of hypertension
Grobe, J. L., Mecca, A. P., Mao, H., et al. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01170.2005 · Cited by 221 · see citing works
Sodium–glucose cotransporter 2 inhibitor Dapagliflozin attenuates diabetic cardiomyopathy
Arow, M., Waldman, M., Yadin, D., Nudelman, V., Shainberg, A., Abraham, N. G., Freimark, D., Kornowski, R., Aravot, D. J., Hochhauser, E., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0980-4 · Cited by 220 · see citing works
Chirinos, J. A., Orlenko, A., Zhao, L., Basso, M., Cvijic, M. E., Li, Z., Spires, T. E., Yarde, M., Wang, Z., Seiffert, D., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.12.069 · Cited by 218 · see citing works
Eaton, C. B., Pettinger, M. B., Rossouw, J. E., Martin, L. W., Foraker, R. E., Quddus, A., Liu, S., Wampler, N. S., Wu, W.-C., Manson, J. E., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002883 · Cited by 217 · see citing works
Gevaert, A. B., Shakeri, H., Leloup, A. J., Van Hove, C. E., De Meyer, G. R. Y., Vrints, C. J., Lemmens, K., & Van Craenenbroeck, E. M. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003806 · Cited by 211 · see citing works
Sorop, O., HEINONEN, I. H. A., van Kranenburg, M., van de Wouw, J., de Beer, V. J., Nguyen, I., Octavia, Y., van Duin, R. W. B., Stam, K., van Geuns, R., et al. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy038 · Cited by 211 · see citing works
Murine Models of Heart Failure With Preserved Ejection Fraction
Valero‐Muñoz, M., Backman, W., & Sam, F. (2017) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2017.07.013 · Cited by 207 · see citing works
Michel Komajda, N., Isnard, R., Solal, A. C., Metra, M., Pieske, B. M., Ponikowski, P. P., Voors, A. A., Dominjon, F., Henon‐Goburdhun, C., Pannaux, M., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.876 · Cited by 206 · see citing works
Murdoch, C. E., Chaubey, S., Zeng, L., Yu, B., Ívetic, A., Walker, S. J., Vanhoutte, D., Heymans, S. R. B., Grieve, D., Cave, A. C., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.02.572 · Cited by 200 · see citing works
Heart failure with preserved ejection fraction: a clinical dilemma
Michel Komajda, N., & Lam, C. S. P. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu067 · Cited by 198 · see citing works
Self-citationSorimachi, H., Obokata, M., Takahashi, N., Reddy, Y. N. V., Jain, C. C., Verbrugge, F. H., Koepp, K. E., Khosla, S., Jensen, M. D., & Borlaug, B. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa823 · Cited by 192 · see citing works
Heart Failure With Preserved Ejection Fraction
Loffredo, F. S., Nikolova, A., Pancoast, J. R., & Lee, R. T. (2014) · Circulation Research · doi:10.1161/circresaha.115.302929 · Cited by 181 · see citing works
Lovelock, J. D., Monasky, M. M., Jeong, E.-M., Lardin, H. A., Liu, H., Patel, B. G., Taglieri, D. M., Gu, L., Kumar, P., Pokhrel, N., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.258251 · Cited by 175 · see citing works
Validation of the HFA-PEFF Score for the Diagnosis of Heart Failure with Preserved Ejection Fraction
Aizpurua, A. B., Wijk, S. S., Rocca, H. B., Henkens, M. T. H. M., Heymans, S. R. B., Beussink‐Nelson, L., Shah, S. J., & van Empel, V. P. M. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1614 · Cited by 174 · see citing works
Obesity-Related Heart Failure With a Preserved Ejection Fraction
Packer, M., & Kitzman, D. W. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.01.009 · Cited by 172 · see citing works
Echocardiographic evaluation of diastolic function in mouse models of heart disease
Schnelle, M., Catibog, N., Zhang, M., Nabeebaccus, A., Anderson-Barker, G. C., Richards, D. A., Sawyer, G. J., Zhang, X., Toischer, K., Hasenfuss, G. P., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.10.006 · Cited by 170 · see citing works
Lekawanvijit, S., Kompa, A. R., Manabe, M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041281 · Cited by 169 · see citing works
Zhang, N., Feng, B., Ma, X., Sun, K., Xu, G., & Zhou, Y. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0914-1 · Cited by 167 · see citing works
Alex, L., Russo, I., Holoborodko, V., & Frangogiannis, N. G. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00238.2018 · Cited by 162 · see citing works
Impaired cardiac contractile function in ventricular myocytes from leptin-deficient ob/ob obese mice
Dong, F., Zhang, X., Yang, X., Esberg, L. B., Yang, H., Zhang, Z., Culver, B., & Ren, J. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06241 · Cited by 155 · see citing works
Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction
Tong, D., Schiattarella, G. G., Jiang, N., May, H. I., Lavandero, S., Gillette, T. G., & Hill, J. A. (2019) · Circulation · doi:10.1161/circulationaha.119.042267 · Cited by 153 · see citing works
Self-citationAnimal models for atrial fibrillation: clinical insights and scientific opportunities
Nishida, K., Michael, G., Dobrev, D., & Nattel, S. (2009) · EP Europace · doi:10.1093/europace/eup328 · Cited by 151 · see citing works
Selvaraj, S., Myhre, P. L., Vaduganathan, M., Claggett, B. L., Matsushita, K., Kitzman, D. W., Borlaug, B. A., Shah, A. M., & Solomon, S. D. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.03.013 · Cited by 150 · see citing works
Activin type II receptor signaling in cardiac aging and heart failure
Roh, J. D., Hobson, R., Chaudhari, V., Quintero, P. A., Yeri, A., Benson, M. D., Xiao, C., Zlotoff, D. A., Bezzerides, V. J., Houstis, N. E., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau8680 · Cited by 148 · see citing works
Role of Gender in Heart Failure with Normal Left Ventricular Ejection Fraction
Regitz‐Zagrosek, V., Brokat, S., & Tschöpe, C. (2006) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2006.08.011 · Cited by 142 · see citing works
Animal models of heart failure with preserved ejection fraction
Conceição, G., HEINONEN, I. H. A., Lourenço, A. P., Duncker, D. J., & Falcão‐Pires, I. (2016) · Netherlands Heart Journal · doi:10.1007/s12471-016-0815-9 · Cited by 134 · see citing works
Reil, J., Hohl, M., Reil, G., Granzier, H. L. M., Kratz, M. T., Kazakov, A., Fries, P., Müller, A., Lenski, M., Custodis, F., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs218 · Cited by 130 · see citing works
Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
Bode, D., Semmler, L., Wakula, P., Hegemann, N., Primeßnig, U., Beindorff, N., Powell, D. R., Dahmen, R., Ruetten, H., Oeing, C. U., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01208-z · Cited by 116 · see citing works
Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse
Reed, A. L., Tanaka, A., Sorescu, D., Liu, H., Jeong, E.-M., Sturdy, M., Walp, E. R., Dudley, S. C., & Sutliff, R. L. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00407.2010 · Cited by 113 · see citing works
Why Don’t We Have Proven Treatments for HFpEF?
Roh, J. D., Houstis, N. E., & Rosenzweig, A. (2017) · Circulation Research · doi:10.1161/circresaha.116.310119 · Cited by 106 · see citing works
Manrique, C. M., DeMarco, V. G., Aroor, A. R., Mugerfeld, I., Garro, M., Habibi, J., Hayden, M. R., & Sowers, J. R. (2013) · Endocrinology · doi:10.1210/en.2013-1256 · Cited by 105 · see citing works
Efficacy and Safety of Spironolactone in Patients With HFpEF and Chronic Kidney Disease
Beldhuis, I. E., Myhre, P. L., Claggett, B. L., Damman, K., Fang, J. C.-T., Lewis, E. F., O’Meara, E., Pitt, B., Shah, S. J., Voors, A. A., et al. (2018) · JACC Heart Failure · doi:10.1016/j.jchf.2018.10.017 · Cited by 104 · see citing works
Decreased ATP production and myocardial contractile reserve in metabolic heart disease
Luptak, I., Sverdlov, A. L., Panagia, M., Qin, F., Pimentel, D. R., Croteau, D., Siwik, D. A., Ingwall, J. S., Bachschmid, M. M., Balschi, J. A., et al. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.01.017 · Cited by 103 · see citing works
Gender specific differences in left ventricular adaptation to obesity and hypertension
Kuch, B., Muscholl, M. W., Luchner, A., Döring, A., Riegger, G. A. J., Schunkert, H., & Hense, H.-W. (1998) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1000689 · Cited by 101 · see citing works
Plasma levels of heart failure biomarkers are primarily a reflection of extracardiac production
Du, W., Piek, A., Schouten, E. M., van de Kolk, C. W. A., Mueller, C. E., Mebazaa, A., Voors, A. A., de Boer, R. A., & Silljé, H. H. W. (2018) · Theranostics · doi:10.7150/thno.26055 · Cited by 98 · see citing works
Bostick, B., Habibi, J., Ma, L., Aroor, A. R., Rehmer, N., Hayden, M. R., & Sowers, J. R. (2014) · Metabolism · doi:10.1016/j.metabol.2014.04.002 · Cited by 97 · see citing works
Zakeri, R., Moulay, G., Chai, Q., Ogut, O., Hussain, S., Takahama, H., Lü, T., Wang, X.-L., Linke, W. A., Lee, H.-C., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.003238 · Cited by 96 · see citing works
Sex differences in the metabolic effects of diet-induced obesity vary by age of onset
Salinero, A. E., Anderson, B. M., & Zuloaga, K. L. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0023-3 · Cited by 95 · see citing works
Sex differences in obesity-related changes in left ventricular morphology: the Strong Heart Study
SIMONE, G. D., Devereux, R. B., Chinali, M., Roman, M. J., Barac, A., Panza, J. A., Lee, E. T., & Howard, B. V. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e328347a093 · Cited by 94 · see citing works
Exercise Training Attenuates Age-Associated Diastolic Dysfunction in Rats
Brenner, D. A., Apstein, C. S., & Saupe, K. W. (2001) · Circulation · doi:10.1161/01.cir.104.2.221 · Cited by 93 · see citing works
Valero‐Muñoz, M., Li, S. J., Wilson, R. M., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003381 · Cited by 91 · see citing works
Wijk, S. S., Aizpurua, A. B., Rocca, H. B., et al. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.2019 · Cited by 89 · see citing works
Hutchinson, K. R., Lord, C. K., West, T. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072080 · Cited by 88 · see citing works
The role of sex and body weight on the metabolic effects of high-fat diet in C57BL/6N mice
Ingvorsen, C., Karp, N. A., & Lelliott, C. J. (2017) · Nutrition and Diabetes · doi:10.1038/nutd.2017.6 · Cited by 88 · see citing works
Roh, J. D., Houstis, N. E., Yu, A., Chang, B. J., Yeri, A., Li, H., Hobson, R., Lerchenmüller, C., Vujić, A., Chaudhari, V., et al. (2020) · Aging Cell · doi:10.1111/acel.13159 · Cited by 88 · see citing works
Schwarzl, M., Hamdani, N., Seiler, S., Alogna, A., Manninger, M., Reilly, S. N., Zirngast, B., Kirsch, A. H., Paul Steendijk, A., Verderber, J., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00542.2015 · Cited by 87 · see citing works
Mohammed, S. F., Ohtani, T., Korinek, J. K., Lam, C. S. P., Larsen, K., Simari, R. D., Valencik, M. L., Burnett, J. C. J., & Redfield, M. M. (2010) · Circulation · doi:10.1161/circulationaha.109.915215 · Cited by 86 · see citing works
Self-citationTetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties
Jeong, E.-M., Monasky, M. M., Gu, L., Taglieri, D. M., Patel, B. G., Liu, H., Wang, Q., Greener, I. D., Dudley, S. C., & Solaro, R. J. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.12.003 · Cited by 84 · see citing works
van der Heijden, R. A., Bijzet, J., Meijers, W. C., Yakala, G. K., Kleemann, R., Nguyen, T. Q., de Boer, R. A., Schalkwijk, C. G., Hazenberg, B. P. C., Tietge, U. J. F., et al. (2015) · Scientific Reports · doi:10.1038/srep16474 · Cited by 83 · see citing works
H2FPEF Score as a Prognostic Value in HFpEF Patients
Sueta, D., Yamamoto, E., Nishihara, T., Tokitsu, T., Fujisue, K., Oike, F., Takae, M., Usuku, H., Takashio, S., Arima, Y., et al. (2019) · American Journal of Hypertension · doi:10.1093/ajh/hpz108 · Cited by 82 · see citing works
Kadoguchi, T., Kinugawa, S., Takada, S., Fukushima, A., Furihata, T., Homma, T., Masaki, Y., Mizushima, W., Nishikawa, M., Takahashi, M., et al. (2015) · Experimental Physiology · doi:10.1113/expphysiol.2014.084095 · Cited by 81 · see citing works
Ventricular Structure and Function in Aged Dogs With Renal Hypertension
Munagala, V. K., Hart, C. Y. T., Burnett, J. C. J., Meyer, D., & Redfield, M. M. (2005) · Circulation · doi:10.1161/01.cir.0000157183.21404.63 · Cited by 81 · see citing works
Magnetic resonance imaging of progressive cardiomyopathic changes in the <i>db/db</i> mouse
Yue, P., Arai, T., Terashima, M., Sheikh, A. Y., Cao, F., Charo, D., Hoyt, G., Robbins, R. C., Ashley, E. A., Wu, J., et al. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00856.2006 · Cited by 81 · see citing works
Meng, Q., Lai, Y., Kelly, N. J., Bueno, M., Baust, J., Bachman, T. N., Goncharov, D. A., Vanderpool, R. R., Radder, J. E., HU, J. L., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0177oc · Cited by 81 · see citing works
Bruder-Nascimento, T. B., Ekeledo, O. J., Anderson, R., Le, H. B. Q., & de Chantemèle, E. J. B. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00032 · Cited by 79 · see citing works
Bostick, B., Habibi, J., DeMarco, V. G., Jia, G., Domeier, T. L., Lambert, M. D., Aroor, A. R., Nistala, R., Bender, S. B., Garro, M., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00898.2014 · Cited by 78 · see citing works
Dijk, C. V., Oosterhuis, N. R., Xu, Y. J., Brandt, M. M., Paulus, W. J., van Heerebeek, L., Duncker, D. J., Verhaar, M. C., Fontoura, D., Lourenço, A. P., et al. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002760 · Cited by 78 · see citing works
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice
Carbone, S., Mauro, A. G., Mezzaroma, E., Kraskauskas, D., Marchetti, C., Buzzetti, R., Tassell, B. W. V., Abbate, A., & Toldo, S. A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.136 · Cited by 77 · see citing works
Clément, K. (2006) · Comptes Rendus Biologies · doi:10.1016/j.crvi.2005.10.009 · Cited by 76 · see citing works
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue
Valero‐Muñoz, M., Li, S. J., Wilson, R. M., Hulsmans, M., Aprahamian, T. R., Fuster, J. J., Nahrendorf, M., Scherer, P. E., & Sam, F. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002724 · Cited by 75 · see citing works
Heart Failure in Women – Insights from the Framingham Heart Study
Kenchaiah, S., & Vasan, R. S. (2015) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-015-6599-0 · Cited by 74 · see citing works
Westermann, D., Becher, P. M., Lindner, D., et al. (2012) · Basic Research in Cardiology · doi:10.1007/s00395-012-0308-y · Cited by 74 · see citing works
Western Diet-Fed, Aortic-Banded Ossabaw Swine
Olver, T. D., Edwards, J. C., Jurrissen, T. J., Veteto, A. B., Jones, J. L., Gao, C., Rau, C., Warren, C. M., Klutho, P. J., Alex, L., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.02.004 · Cited by 74 · see citing works
Sex Differences in Adipose Tissue CD8+ T Cells and Regulatory T Cells in Middle-Aged Mice
Ahnstedt, H. W., Roy-O’Reilly, M. A., Spychala, M. S., Mobley, A. S., Bravo-Alegria, J. B., Chauhan, A., Aronowski, J. A., Marrelli, S. P., & McCullough, L. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00659 · Cited by 73 · see citing works
Deliberating the Diagnostic Dilemma of Heart Failure With Preserved Ejection Fraction
Ho, J. E., Redfield, M. M., Lewis, G. D., Paulus, W. J., & Lam, C. S. P. (2020) · Circulation · doi:10.1161/circulationaha.119.041818 · Cited by 72 · see citing works
Self-citationRole of Heart Rate Reduction in the Prevention of Experimental Heart Failure
Becher, P. M., Lindner, D., Miteva, K., Savvatis, K., Zietsch, C., Schmack, B., Linthout, S. V., Westermann, D., Schultheiss, H., & Tschöpe, C. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.183913 · Cited by 71 · see citing works
Regan, J. A., Mauro, A. G., Carbone, S., Marchetti, C., Gill, R., Mezzaroma, E., Raleigh, J. V., Salloum, F. N., Tassell, B. W. V., Abbate, A., et al. (2015) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00282.2015 · Cited by 71 · see citing works
Interferon-γ ablation exacerbates myocardial hypertrophy in diastolic heart failure
Garcia, A. G., Wilson, R. M., Heo, J., Murthy, N. R., Baid, S., Ouchi, N., & Sam, F. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00298.2012 · Cited by 70 · see citing works
Granzyme B Deficiency Protects against Angiotensin II–Induced Cardiac Fibrosis
Shen, Y., Cheng, F., Sharma, M., Merkulova, Y., Raithatha, S. A., Parkinson, L. G., Zhao, H., Westendorf, K., Bohunek, L., Bozin, T., et al. (2015) · American Journal Of Pathology · doi:10.1016/j.ajpath.2015.09.010 · Cited by 70 · see citing works
Khan, M. S., Fonarow, G. C., Khan, H., Greene, S. J., Anker, S. D., Gheorghiade, M., & Butler, J. (2017) · ESC Heart Failure · doi:10.1002/ehf2.12204 · Cited by 69 · see citing works
Van den Bergh, A., Flameng, W., & Herijgers, P. (2006) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2006.03.001 · Cited by 68 · see citing works
Angiotensin II-induced dilated cardiomyopathy in Balb/c but not C57BL/6J mice
Peng, H., Yang, X.-P., Carretero, O. A., Nakagawa, P., D’Ambrosio, M. A., Leung, P., Xu, J., Peterson, E. L., Gonzalez, G. E., Harding, P., et al. (2011) · Experimental Physiology · doi:10.1113/expphysiol.2011.057612 · Cited by 67 · see citing works
Tanaka, K., Wilson, R. M., Essick, E. E., Duffen, J., Scherer, P. E., Ouchi, N., & Sam, F. (2014) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001279 · Cited by 67 · see citing works
Sex-related changes in cardiac function following myocardial infarction in mice
Shioura, K. M., Geenen, D. L., & Goldspink, P. H. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90342.2008 · Cited by 62 · see citing works
Sukumaran, V., Tsuchimochi, H., Tatsumi, E., Shirai, M., & Pearson, J. T. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.07.022 · Cited by 62 · see citing works
Goyal, P., Paul, T. K., Almarzooq, Z., Peterson, J. C., Krishnan, U., Swaminathan, R. V., Feldman, D. N., Wells, M. T., Karas, M. G., Sobol, I., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.003330 · Cited by 61 · see citing works
Follistatin like 1 regulates hypertrophy in heart failure with preserved ejection fraction
Tanaka, K., Valero-Muñoz, M., Wilson, R. M., Essick, E. E., Fowler, C. T., Nakamura, K., van den Hoff, M., Ouchi, N., & Sam, F. (2016) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2016.04.002 · Cited by 59 · see citing works
Bartels, E. D., Nielsen, J. M., Bisgaard, L. S., Goetze, J. P., & Nielsen, L. B. (2010) · Endocrinology · doi:10.1210/en.2010-0355 · Cited by 58 · see citing works
Nguyen, I., Brandt, M. M., van de Wouw, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232399 · Cited by 58 · see citing works
The senescence accelerated mouse prone 8 (SAMP8): A novel murine model for cardiac aging
Karuppagounder, V., Arumugam, S., Babu, S. S., Palaniyandi, S. S., Watanabe, K., Cooke, J. P., & Thandavarayan, R. A. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.10.006 · Cited by 56 · see citing works
Short-term high-fat diet compromises myocardial function: a radial strain rate imaging study
Ternacle, J., Wan, F., Sawaki, D., Surénaud, M., Pini, M., Mercedes, R., Ernande, L., Audureau, É., Dubois‐Randé, J., Adnot, S., et al. (2016) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jew316 · Cited by 54 · see citing works
Sex and Heart Failure with Preserved Ejection Fraction: From Pathophysiology to Clinical Studies
Tadic, M. V., Cuspidi, C., Plein, S., Belyavskiy, E., Heinzel, F. R., & Galderisi, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060792 · Cited by 52 · see citing works
Sharp, T. E., Scarborough, A. L., Li, Z., Polhemus, D. J., Hidalgo, H. A., Schumacher, J., Matsuura, T. R., Jenkins, J. S., Kelly, D. P., Goodchild, T. T., et al. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2020.11.012 · Cited by 52 · see citing works
Gutkowska, J., Broderick, T. L., Danalache, B. A., Wang, D., Lavoie, J.-M., & Jankowski, M. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.176461 · Cited by 51 · see citing works
Gaspari, T. A., Brdar, M., Lee, H. W., Spizzo, I., Hu, Y., Widdop, R. E., Simpson, R. W., & Dear, A. E. (2015) · Diabetes and Vascular Disease Research · doi:10.1177/1479164115605000 · Cited by 49 · see citing works
Gai, Z., Hiller, C., Chin, S. H., Hofstetter, L., Stieger, B., Konrad, D., & Kullak-Ublick, G. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.001 · Cited by 46 · see citing works
Churchill, T. W., Li, S. X., Curreri, L. A., et al. (2021) · Circulation · doi:10.1161/circulationaha.120.050757 · Cited by 46 · see citing works
Wilson, R. M., Silva, D. S. D., Sato, K., Izumiya, Y., & Sam, F. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.134932 · Cited by 45 · see citing works
Maréchaux, S., Six-Carpentier, M., Bouabdallaoui, N., Montaigne, D., Bauchart, J.-J., Mouquet, F., Auffray, J.-L., Tourneau, T. L., Asseman, P., LeJemtel, T. H., et al. (2010) · Heart and Vessels · doi:10.1007/s00380-010-0057-5 · Cited by 44 · see citing works
van Bilsen, M., Daniels, A., Brouwers, O., Janssen, B. J., Derks, W. J. A., Brouns, A. E., Munts, C., Schalkwijk, C. G., Vusse, G. J., & van Nieuwenhoven, F. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085078 · Cited by 44 · see citing works
Cannon, M. V., Silljé, H. H. W., Sijbesma, J. W. A., Khan, M. A. F., Steffensen, K. R., van Gilst, W. H., & de Boer, R. A. (2015) · Diabetologia · doi:10.1007/s00125-015-3827-x · Cited by 44 · see citing works
Bongartz, L. G., Braam, B. G., Verhaar, M. C., Cramer, M. J., Goldschmeding, R., Gaillard, S., Doevendans, P. A., & Joles, J. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00727.2009 · Cited by 43 · see citing works
Role of a selective aldosterone blocker in mice with chronic heart failure
Wang, D., Liu, Y.-H., Yang, X.-P., et al. (2004) · Journal of Cardiac Failure · doi:10.1016/s1071-9164(03)00578-5 · Cited by 42 · see citing works
Charles, C. J., Lee, P. M., Li, R. R., et al. (2019) · ESC Heart Failure · doi:10.1002/ehf2.12536 · Cited by 42 · see citing works
Baltgalvis, K. A., White, K., Li, W., Claypool, M. D., Lang, W., Alcantara, R. R., Singh, B., Friera, A. M., McLaughlin, J. R., Hansen, D., et al. (2014) · American Journal of Physiology. Heart and Circulatory Physiology · doi:10.1152/ajpheart.00839.2013 · Cited by 41 · see citing works
Bostick, B., Aroor, A. R., Habibi, J., Durante, W., Ma, L., DeMarco, V. G., Garro, M., Hayden, M. R., Booth, F. W., & Sowers, J. R. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.005 · Cited by 41 · see citing works
Curl, C. L., Danes, V. R., Bell, J. R., Raaijmakers, A. J. A., Ip, W. T. K., Chandramouli, C., Harding, T. W., Porrello, E. R., Erickson, J. R., Charchar, F. J., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.007451 · Cited by 41 · see citing works
Piek, A., Koonen, D. P. Y., Schouten, E., Lindtstedt, E. L., Michaëlsson, E., de Boer, R. A., & Silljé, H. H. W. (2019) · Scientific Reports · doi:10.1038/s41598-019-55263-y · Cited by 41 · see citing works
Wachter, R., Shah, S. J., Cowie, M., Szecsödy, P., Shi, V. C., Ibram, G., Zhao, Z., Gong, J., Klebs, S. H. G., & Pieske, B. M. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12694 · Cited by 40 · see citing works
Ferferieva, V., den Bergh, A. V., Claus, P., Jasaitytė, R., Gerche, A. L., Rademakers, F. E., Herijgers, P., & D’hooge, J. (2012) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jes274 · Cited by 39 · see citing works
Gyöngyösi, M., Pávó, N., Lukovic, D., Zlabinger, K., Spannbauer, A., Traxler, D., Goliasch, G., Mandic, L., Bergler-Klein, J. K., Gugerell, A., et al. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-017-1299-0 · Cited by 39 · see citing works
Cellular mechanisms of metabolic syndrome-related atrial decompensation in a rat model of HFpEF
Hohendanner, F., Bode, D., Primeßnig, U., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.12.012 · Cited by 39 · see citing works
Tanisawa, K., Miyamoto‐Mikami, E., Fuku, N., Honda, Y., Honda, S., Ohsawa, I., Ito, M., Endo, S., Ihara, K., Ohno, K., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-248 · Cited by 38 · see citing works
Cardiac steatosis potentiates angiotensin II effects in the heart
Glenn, D. J., Cardema, M. C., Ni, W., Zhang, Y., Yeghiazarians, Y., Grapov, D., Fiehn, O., & Gardner, D. G. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00742.2014 · Cited by 38 · see citing works
Suzuki, H. R., Schaefer, L., Ling, H., et al. (1995) · American Journal of Nephrology · doi:10.1159/000168817 · Cited by 37 · see citing works
Reddy, S. S., Agarwal, H., & Barthwal, M. K. (2018) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2018.08.017 · Cited by 36 · see citing works
Parcha, V., Malla, G., Kalra, R., Patel, N., Wijk, S. S., Pandey, A., Shah, S. J., Arora, G., & Arora, P. K. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13288 · Cited by 36 · see citing works
Faxén, U. L., Venkateshvaran, A., Shah, S. J., Lam, C. S. P., Svedlund, S., Saraste, A., Beussink‐Nelson, L., Fermer, M. L., Gan, L., Hage, C., et al. (2021) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2021.02.005 · Cited by 35 · see citing works
Self-citationSchauer, A., Adams, V., Augstein, A., Jannasch, A., Draskowski, R., Kirchhoff, V., Goto, K., Mittag, J., Galli, R., Männel, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073570 · Cited by 35 · see citing works
Exercise capacity, physical activity, and morbidity
Brunjes, D. L., Kennel, P. J., & Schulze, P. C. (2017) · Heart Failure Reviews · doi:10.1007/s10741-016-9592-1 · Cited by 31 · see citing works
Manolescu, D.-C., Jankowski, M., Danalache, B. A., Wang, D., Broderick, T. L., Chiasson, J., & Gutkowska, J. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0005 · Cited by 30 · see citing works
Agrawal, V., Fortune, N. L., Yu, S., Fuentes, J. L., Shi, F., Nichols, D. S., Gleaves, L. A., Poovey, E., Wang, T. J., Brittain, E. L., et al. (2019) · Pulmonary Circulation · doi:10.1177/2045894019895452 · Cited by 29 · see citing works
Downregulation in GATA4 and Downstream Structural and Contractile Genes in the db/db Mouse Heart
Broderick, T. L., Jankowski, M., Wang, D., Danalache, B. A., Parrott, C. R., & Gutkowska, J. (2012) · ISRN Endocrinology · doi:10.5402/2012/736860 · Cited by 28 · see citing works
Myhre, P. L., Vaduganathan, M., Claggett, B. L., Lam, C. S. P., Desai, A. S., Anand, I. S., Sweitzer, N. K., Fang, J. C., O’Meara, E., Shah, S. J., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1542 · Cited by 27 · see citing works
Self-citationChristoffersen, C., Bartels, E. D., & Nielsen, L. B. (2006) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2006.01596.x · Cited by 26 · see citing works
Bowen, T. S., Eisenkolb, S., Drobner, J., Fischer, T., Werner, S., Linke, A., Mangner, N., Schuler, G. C., & Adams, V. (2016) · The FASEB Journal · doi:10.1096/fj.201600672r · Cited by 26 · see citing works
Goto, K., Schauer, A., Augstein, A., Methawasin, M., Granzier, H. L. M., Halle, M., Craenenbroeck, E. M. V., Rolim, N. P. L., Gielen, S., Pieske, B. M., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.13142 · Cited by 25 · see citing works
Age-dependent effects of high fat-diet on murine left ventricles: role of palmitate
Aurich, A.-C., Niemann, B., Pan, R., Gruenler, S., Issa, H., Silber, R., & Rohrbach, S. (2013) · Basic Research in Cardiology · doi:10.1007/s00395-013-0369-6 · Cited by 24 · see citing works
Bustamante, M., Garate‐Carrillo, A., Ito, B. R., Garcia, R., Carson, N., Ceballos, G. M., Ramírez‐Sánchez, I., Omens, J. H., & Villarreal, F. J. (2019) · The Journal of Physiology · doi:10.1113/jp277479 · Cited by 24 · see citing works
Broderick, T. L., Wang, D., Jankowski, M., & Gutkowska, J. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.12.005 · Cited by 23 · see citing works
Harada, E., Mizuno, Y., Kugimiya, F., Shono, M., Maeda, H., Yano, N., & Yasue, H. (2018) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2018.06.009 · Cited by 23 · see citing works
High fat diet induced alterations of atrial electrical activities in mice.
Zhang, F., Hartnett, S., Sample, A., Schnack, S., & Li, Y. (2016) · Europe PMC (PubMed Central) · Cited by 22 · see citing works
Fraccarollo, D., Galuppo, P., Sieweke, J., et al. (2015) · ESC Heart Failure · doi:10.1002/ehf2.12053 · Cited by 18 · see citing works
Penumatsa, K. C., Falcão‐Pires, I., Leite, S., Leite-Moreira, A. F., Bhedi, C. D., Nasirova, S., Ma, J., Sutliff, R. L., & Fanburg, B. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.560019 · Cited by 18 · see citing works
Elkholey, K., Morris, L. M., Niewiadomska, M., et al. (2021) · Experimental Physiology · doi:10.1113/ep089163 · Cited by 17 · see citing works
Aboumsallem, J. P., Muthuramu, I., Mishra, M., & Geest, B. D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092222 · Cited by 15 · see citing works
Fighting HFpEF in women: taking aim at belly fat
Withaar, C., Meems, L. M. G., & de Boer, R. A. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa952 · Cited by 10 · see citing works
Self-citationBode, D., Rolim, N. P. L., Guthof, T., Hegemann, N., Wakula, P., Primeßnig, U., Berre, A. M. O., Adams, V., Wisløff, U., Pieske, B. M., et al. (2021) · ESC Heart Failure · doi:10.1002/ehf2.13308 · Cited by 10 · see citing works
A model for evaluation of thiazide-induced hypotension
Willard, P. W. (1969) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1969.tb08280.x · Cited by 7 · see citing works
Validating the HFA-PEFF Score – Or how to Define a Disease?
Coats, A. J. S. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1770 · Cited by 6 · see citing works
Parcha, V., Kalra, R., Malla, G., et al. (2020) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2020.09.115 · Cited by 3 · see citing works
Iwakura, K., Onishi, T., Okada, M., et al. (2020) · European Heart Journal · doi:10.1093/ehjci/ehaa946.0998 · Cited by 2 · see citing works
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The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74 · see citing works
Self-citation
- Authors
- Withaar, C., Lam, C. S. P., Schiattarella, G. G., de Boer, R. A., & Meems, L. M. G.
- Affiliations
- University Medical Center Groningen (NL)
- Max Delbrück Center (DE)
- Department of Cardiology, University of Groningen, University Medical Center Groningen , Hanzeplein 1, 9713 GZ, Groningen, the Netherlands
- Venue
- European Heart Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2021-08-20
- Volume
- 42
- Issue
- 43
- Pages
- 4420-4430
- ISSN
- 0195-668X (ISSN-L)
- 1522-9645
- PMC
- PMC8599003
- OpenAlex
- W3194858310
- Cited by
- 150
- References
- 197
- Citations by year
- 2026: 25 · 2025: 28 · 2024: 34 · 2023: 26 · 2022: 34 · 2021: 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- European Heart Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by-nc)
- Funders
- German Center for Cardiovascular Research
- Junior Research Group Excellence Grant
- National Medical Research Council of Singapore
- Netherlands Heart Foundation (2017-21, 2017-11, 2018-30, 2020B005)
- leDucq Foundation
- European Research Council (818715)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- heart failure with preserved ejection fraction, translational model, HFA-PEFF score, H2FPEF score, natriuretic peptides, non-cardiac comorbidities
- MeSH terms
- Algorithms, Animals, Heart Failure, Humans, Stroke Volume, Consensus, Natriuretic Peptides, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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