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Cited by 13Atherosclerosis and Cardiovascular DiseasesAngiogenesis and VEGF in CancerMesenchymal stem cell research

Clonal Expansion in Cardiovascular Pathology

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Lin, Alexander, Brittan, Mairi, Baker, Andrew H., Dimmeler, Stefanie, Fisher, Edward A., Sluimer, Judith C., Misra, Ashish·2024·JACC: Basic to Translational Science
DOI 10.1016/j.jacbts.2023.04.008PMC PMC10864919
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Abstract

Clonal expansion refers to the proliferation and selection of advantageous "clones" that are better suited for survival in a Darwinian manner. In recent years, we have greatly enhanced our understanding of cell clonality in the cardiovascular context. However, our knowledge of the underlying mechanisms behind this clonal selection is still severely limited. There is a transpiring pattern of clonal expansion of smooth muscle cells and endothelial cells-and, in some cases, macrophages-in numerous cardiovascular diseases irrespective of their differing microenvironments. These findings indirectly suggest the possible existence of stem-like vascular cells which are primed to respond during disease. Subsequent clones may undergo further phenotypic changes to adopt either protective or detrimental roles. By investigating these clone-forming vascular cells, we may be able to harness this inherent clonal nature for future therapeutic intervention. This review comprehensively discusses what is currently known about clonal expansion across the cardiovascular field. Comparisons of the clonal nature of vascular cells in atherosclerosis (including clonal hematopoiesis of indeterminate potential), pulmonary hypertension, aneurysm, blood vessel injury, ischemia- and tumor-induced angiogenesis, and cerebral cavernous malformations are evaluated. Finally, we discuss the potential clinical implications of these findings and propose that proper understanding and specific targeting of these clonal cells may provide unique therapeutic options for the treatment of these cardiovascular conditions.

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  • Cells for bulk-RNAseq and scRNAseq were processed with actinomycin D to prevent transcriptomic changes.

    “Cells were kept on ice during all steps, except for the enzymatic digestion and cells for bulk-RNAseq and scRNAseq were processed always with actinomycin D (ActD) to prevent transcriptomic changes, as reported before 39 .”

    From Clonal hematopoiesis-associated motoric deficits caused by monocyte-derived microglia accumulating in aging mice (2025) · cites this paper as [39]

    The paper’s discussion of single-cell RNA sequencing in the Aneurysm section concerns cell fates, not sample processing. Neither that section nor the passages retrieved by searching for actinomycin D, ActD, and bulk- and single-cell RNA sequencing describe treating cells with actinomycin D to prevent transcriptomic changes. Page numbers were not available in our copy. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Lin, A., Brittan, M., Baker, A. H., Dimmeler, S., Fisher, E. A., Sluimer, J. C., & Misra, A.
Affiliations
  • The University of Sydney (AU)
  • The Queen's Medical Research Institute (GB)
  • Maastricht University Medical Centre (NL)
  • Goethe University Frankfurt (DE)
  • New York University (US)
Corresponding author
Misra, Ashish
ORCID
Venue
JACC: Basic to Translational Science
Publisher
Elsevier BV
Published
2024-01
Volume
9
Issue
1
Pages
120-144
ISSN
2452-302X (ISSN-L)
DOI
10.1016/j.jacbts.2023.04.008
PMC
PMC10864919
OpenAlex
W4384818022
Cited by
13
References
7
Citations by year
2026: 6 · 2025: 3 · 2024: 4
FWCI
0.36
Type
journal article
Language
en
Open access
Licence
Locations
  • JACC Basic to Translational Science (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
Diabetes Australia
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
Keywords
clonal expansion, clonal selection, vascular smooth muscle cells, endothelial cells, macrophages, atherosclerosis, clonal hematopoiesis of indeterminate potential, pulmonary hypertension, aneurysm, vascular injury, ischemia-induced angiogenesis, tumor angiogenesis, cerebral cavernous malformations, cardiovascular disease, therapeutic targeting

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