Traditional Cardiovascular Risk Factors in Relation to Left Ventricular Mass, Volume, and Systolic Function by Cardiac Magnetic Resonance Imaging
Open accessAbstract
Objectives The goal of this study was to examine the cross-sectional associations of cardiovascular risk factors with left ventricular (LV) geometry and systolic function measured by cardiac magnetic resonance imaging (MRI) in the Multiethnic Study of Atherosclerosis (MESA).Background Cardiovascular risk factors including hypertension, smoking, and obesity are known to be associated with increased LV mass, but less is known about the association of risk factors with LV systolic function, particularly in populations without clinical cardiovascular disease.Methods Participants were from 4 racial/ethnic groups and were free of clinical cardiovascular disease. Blood pressure, health habits, body mass index, lipid levels, and glucose abnormalities were assessed and MRI exams performed at baseline (n = 4,869). Multivariable linear regression was used to model the association of risk factors with LV mass, end-diastolic volume, stroke volume, ejection fraction, and cardiac output.Results The mean age was 62 years, and 52% of the participants were women. After adjustment for sociodemographic variables and height, higher systolic blood pressure and body mass index were associated with larger LV mass and volumes. Current smoking and diabetes were associated with greater LV mass (+7.7 g, 95% confidence interval [CI] +5.5 to +9.9 and +3.5 g, 95% CI +1.2 to +5.8, respectively), and with lower stroke volume (-1.9 ml, 95% CI -3.3 to -0.5 and -4.5 ml, 95% CI -6.0 to -3.0, respectively) and lower ejection fraction (-1.6%, 95% CI -2.1 to -1.0 and -0.8%, 95% CI -1.5 to -0.2, respectively).Conclusions In this cohort free of clinical cardiovascular disease, modifiable risk factors were associated with subclinical alterations in LV size and systolic function as detected by cardiac MRI.
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Both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls.
“In addition, the results indicate that both LV cavity size and wall thickness are increased in obese subjects compared with age-matched controls (22, 134, 151, 156, 242, 279, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [134]
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- Authors
- Heckbert, S. R., Post, W., Pearson, G. D. N., Arnett, D. K., Gomes, A. S., Jerosch-Herold, M., Hundley, W. G., Lima, J. A., & Bluemke, D. A.
- Affiliations
- University of Washington (US)
- Johns Hopkins University (US)
- Columbia University (US)
- University of Alabama at Birmingham (US)
- University of California, Los Angeles (US)
- Wake Forest University Health Sciences (US)
- Corresponding author
- Heckbert, Susan R.
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 48
- Issue
- 11
- Pages
- 2285-2292
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC1794681
- OpenAlex
- W1825509420
- Cited by
- 292
- References
- 31
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 20 · 2020: 17 · 2019: 16 · 2018: 18 · 2017: 16 · 2016: 17 · 2015: 20 · 2014: 21 · 2013: 18 · 2012: 16
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc95164-17-0-1, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc95166-21-0-1, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc95163-22-0-1, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC-95160, N01-HC-095165, (N01-HC-95163, N01 HC095163, N01 HC-95161, N01 HC95165, N01HC95164, N01-HC-095159, N01 HC095168, N01-HC-095162, HC-95168, N01-HC-095161, N01-HC-095160, N01 HC095166, N01 HC095164, N01‐HC‐95166, N01 HC-95162)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- cardiovascular risk factors, left ventricular mass, left ventricular volume, left ventricular systolic function, ejection fraction, stroke volume, systolic blood pressure, body mass index, smoking, diabetes mellitus, hypertension, obesity, Multi-Ethnic Study of Atherosclerosis
- MeSH terms
- Aged, Aged, 80 and over, Asian, Black or African American, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Female, Heart, Hispanic or Latino, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Myocardium, Risk Factors, Smoking, Stroke Volume, Systole, Cohort Studies, Body Mass Index, White People, Diabetes Complications, Atherosclerosis
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