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Cited by 174Cardiovascular Function and Risk FactorsBlood Pressure and Hypertension StudiesDiabetes, Cardiovascular Risks, and Lipoproteins

Sex-specific determinants of increased left ventricular mass in the Tecumseh blood pressure study

Marcus, R, Krause, L, Weder, A B, Dominguez-Meja, A, Schork, N J, Julius, S·1994·Circulation
DOI 10.1161/01.cir.90.2.928
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Abstract

BACKGROUND: Left ventricular hypertrophy (LVH) defined by either ECG or echocardiographic criteria is a risk factor for cardiovascular morbidity and mortality. A number of determinants of LVH have been described in previous studies, principally male sex, hypertension, obesity, and aortic valvular stenosis. We examined the distribution of LV mass (LVM) in a population of 18- to 42-year-old normotensive men and women who were free of valvular heart disease to establish sex-specific normal values for LVM index (LVMI) and to determine the correlates of LVMI. METHODS AND RESULTS: LVM was derived from measurements obtained by M-mode echocardiography. Average LVMI is significantly greater in men (102.9 +/- 0.7 g/m2) than women (88.2 +/- 0.7 g/m2). By defining LVH as an LVMI greater than the 90th percentile, we developed sex-specific criteria for LVH: men, > 125.4 g/m2; women, > 110 g/m2. We found that LVH in men is associated with indices of enhanced sympathetic nervous system reactivity and with elevated fasting insulin and triglyceride levels, which may be caused by insulin resistance. In women, LVH was associated with higher body weight and obesity. CONCLUSIONS: Before the onset of hypertension, increased LVMI appears to have different determinants in men and women. We suggest that early LVH in young men is a manifestation of hyperkinetic borderline hypertension, a state previously shown to be associated with increased sympathetic nervous system activity and insulin resistance. The hyperkinetic state is less prevalent in young women, in whom increased adiposity seems to be the predominant factor associated with LVH.

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  • In human studies, indexes of left ventricular mass have tended to correlate with plasma norepinephrine values and cardiac noradrenaline spillover.

    “Also, in human studies, indexes of LVM have tended to correlate with plasma norepinephrine values (37)and cardiac noradrenaline spillover (38).”

    From Hypertensive left ventricular hypertrophy: relation to peripheral sympathetic drive (2001) · cites this paper as [37]

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Authors
Marcus, R., Krause, L., Weder, A. B., Dominguez-Meja, A., Schork, N. J., & Julius, S.
Affiliations
University of Michigan (US)
ORCID
Schork, N J
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1994-08
Volume
90
Issue
2
Pages
928-936
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/01.cir.90.2.928
OpenAlex
W2000559950
Cited by
174
References
59
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 3
FWCI
4.73
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
left ventricular hypertrophy, left ventricular mass, sex differences, normotensive young adults, sympathetic nervous system reactivity, insulin resistance, fasting insulin, triglycerides, obesity, body weight
MeSH terms
Adult, Blood Pressure, Body Constitution, Echocardiography, Female, Heart Rate, Humans, Hypertension, Male, Michigan, Prospective Studies, Reference Values, Risk Factors, Sex Factors, Prevalence, Hypertrophy, Left Ventricular

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