The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
In Vivo 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging Provides a Noninvasive Measure of Carotid Plaque Inflammation in Patients
Open accessAbstract
OBJECTIVES Given the importance of inflammation in atherosclerosis, we sought to determine if atherosclerotic plaque inflammation could be measured noninvasively in humans using positron emission tomography (PET). BACKGROUND Earlier PET studies using fluorodeoxyglucose (FDG) demonstrated increased FDG uptake in atherosclerotic plaques. Here we tested the ability of FDG-PET to measure carotid plaque inflammation in patients who subsequently underwent carotid endarterectomy (CEA). METHODS Seventeen patients with severe carotid stenoses underwent FDG-PET imaging 3 h after FDG administration (13 to 25 mCi), after which carotid plaque FDG uptake was determined as the ratio of plaque to blood activity (target to background ratio, TBR). Less than 1 month after imaging, subjects underwent CEA, after which carotid specimens were processed to identify macrophages (staining with anti-CD68 antibodies). RESULTS There was a significant correlation between the PET signal from the carotid plaques and the macrophage staining from the corresponding histologic sections (r = 0.70; p < 0.0001). When mean FDG uptake (mean TBR) was compared with mean inflammation (mean percentage CD68 staining) for each of the 17 patients, the correlation was even stronger (r = 0.85; p < 0.0001). Fluorodeoxyglucose uptake did not correlate with plaque area, plaque thickness, or area of smooth muscle cell staining. CONCLUSIONS We established that FDG-PET imaging can be used to assess the severity of inflammation in carotid plaques in patients. If subsequent natural history studies link increased FDG-PET activity in carotid arteries with clinical events, this noninvasive measure could be used to identify a subset of patients with carotid atherosclerosis in need of intensified medical therapy or carotid artery intervention to prevent stroke.
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Cites
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Cited by
Tawakol, A., Ishai, A., Takx, R. A., Figueroa, A. L., Ali, A., Kaiser, Y., Truong, Q. A., Solomon, C. J., Calcagno, C., Mani, V., et al. (2017) · The Lancet · doi:10.1016/s0140-6736(16)31714-7 · Cited by 636
Self-citationNanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K., & Weissleder, R. (2008) · Circulation · doi:10.1161/circulationaha.107.741181 · Cited by 559
Imaging of atherosclerotic cardiovascular disease
Sanz, J., & Fayad, Z. A. (2008) · Nature · doi:10.1038/nature06803 · Cited by 558
Saba, L., Saam, T., Jäger, H. R., Yuan, C., Hatsukami, T. S., Saloner, D., Wasserman, B. A., Bonati, L. H., & Wintermark, M. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30035-3 · Cited by 513
Flögel, U., Ding, Z., Hardung, H., Jander, S., Reichmann, G., Jacoby, C., Schubert, R., & Schrader, J. (2008) · Circulation · doi:10.1161/circulationaha.107.737890 · Cited by 351
Metadata
- Authors
- Tawakol, A., Migrino, R. Q., Bashian, G. G., Bedri, S., Vermylen, D., Cury, R. C., Yates, D., LaMuraglia, G. M., Furie, K., Houser, S., Gewirtz, H., Muller, J. E., Brady, T. J., & Fischman, A. J.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 48
- Issue
- 9
- Pages
- 1818-1824
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2072242219
- Cited by
- 915
- References
- 29
- FWCI
- 30.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tawakol, A., Migrino, R. Q., Bashian, G. G., Bedri, S., Vermylen, D., Cury, R. C., Yates, D., LaMuraglia, G. M., Furie, K., Houser, S., Gewirtz, H., Muller, J. E., Brady, T. J., & Fischman, A. J. (2006). In Vivo 18F-Fluorodeoxyglucose Positron Emission Tomography Imaging Provides a Noninvasive Measure of Carotid Plaque Inflammation in Patients. Journal of the American College of Cardiology. https://doi.org/10.1016/j.jacc.2006.05.076
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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