The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging
Open accessAbstract
Background— In this study, we developed and validated a new approach for in vivo visualization of inflammatory processes by magnetic resonance imaging using biochemically inert nanoemulsions of perfluorocarbons (PFCs). Methods and Results— Local inflammation was provoked in 2 separate murine models of acute cardiac and cerebral ischemia, followed by intravenous injection of PFCs. Simultaneous acquisition of morphologically matching proton ( 1 H) and fluorine ( 19 F) images enabled an exact anatomic localization of PFCs after application. Repetitive 1 H/ 19 F magnetic resonance imaging at 9.4 T revealed a time-dependent infiltration of injected PFCs into the border zone of infarcted areas in both injury models, and histology demonstrated a colocalization of PFCs with cells of the monocyte/macrophage system. We regularly found the accumulation of PFCs in lymph nodes. Using rhodamine-labeled PFCs, we identified circulating monocytes/macrophages as the main cell fraction taking up injected nanoparticles. Conclusions— PFCs can serve as a “positive” contrast agent for the detection of inflammation by magnetic resonance imaging, permitting a spatial resolution close to the anatomic 1 H image and an excellent degree of specificity resulting from the lack of any 19 F background. Because PFCs are nontoxic, this approach may have a broad application in the imaging and diagnosis of numerous inflammatory disease states.
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Microglial and macrophage polarization—new prospects for brain repair
Hu, X., Leak, R. K., Shi, Y., Suenaga, J., Gao, Y., Zheng, P., & Chen, J. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.207 · Cited by 1,366
Imaging macrophages with nanoparticles
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis
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Nanotechnology for protein delivery: Overview and perspectives
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Imaging in sepsis-associated encephalopathy—insights and opportunities
Stubbs, D. J., Yamamoto, A. K., & Menon, D. K. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2013.177 · Cited by 118
Metadata
- Authors
- Flögel, U., Ding, Z., Hardung, H., Jander, S., Reichmann, G., Jacoby, C., Schubert, R., & Schrader, J.
- Venue
- Circulation
- Published
- 2008-07-08
- Volume
- 118
- Issue
- 2
- Pages
- 140-148
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2010048516
- Cited by
- 351
- References
- 21
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Flögel, U., Ding, Z., Hardung, H., Jander, S., Reichmann, G., Jacoby, C., Schubert, R., & Schrader, J. (2008). In Vivo Monitoring of Inflammation After Cardiac and Cerebral Ischemia by Fluorine Magnetic Resonance Imaging. Circulation. https://doi.org/10.1161/circulationaha.107.737890
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