The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Imaging Atherosclerotic Plaque Inflammation With [ 18 F]-Fluorodeoxyglucose Positron Emission Tomography
Abstract
Background — Atherosclerotic plaque rupture is usually a consequence of inflammatory cell activity within the plaque. Current imaging techniques provide anatomic data but no indication of plaque inflammation. The glucose analogue [ 18 F]-fluorodeoxyglucose ( 18 FDG) can be used to image inflammatory cell activity non-invasively by PET. In this study we tested whether 18 FDG-PET imaging can identify inflammation within carotid artery atherosclerotic plaques. Methods and Results — Eight patients with symptomatic carotid atherosclerosis were imaged using 18 FDG-PET and co-registered CT. Symptomatic carotid plaques were visible in 18 FDG-PET images acquired 3 hours post- 18 FDG injection. The estimated net 18 FDG accumulation rate (plaque/integral plasma) in symptomatic lesions was 27% higher than in contralateral asymptomatic lesions. There was no measurable 18 FDG uptake into normal carotid arteries. Autoradiography of excised plaques confirmed accumulation of deoxyglucose in macrophage-rich areas of the plaque. Conclusions — This study demonstrates that atherosclerotic plaque inflammation can be imaged with 18 FDG-PET, and that symptomatic, unstable plaques accumulate more 18 FDG than asymptomatic lesions.
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Citations
Cites
Atherosclerosis--an inflammatory disease
Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725
Cited by
Tawakol, A., Migrino, R. Q., Bashian, G. G., Bedri, S., Vermylen, D., Cury, R. C., Yates, D., LaMuraglia, G. M., Furie, K., Houser, S., et al. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.05.076 · Cited by 915
Nanoparticle PET-CT Imaging of Macrophages in Inflammatory Atherosclerosis
Nahrendorf, M., Zhang, H., Hembrador, S., Panizzi, P., Sosnovik, D. E., Aikawa, E., Libby, P., Swirski, F. K., & Weissleder, R. (2008) · Circulation · doi:10.1161/circulationaha.107.741181 · Cited by 559
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Chen, W., Schilperoort, M., Cao, Y., Shi, J., Tabas, I., & Tao, W. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00629-x · Cited by 518
Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography
Hyafil, F., Cornily, J.-C., Feig, J. E., Gordon, R., Vucic, E., Amirbekian, V., Fisher, E. A., Fuster, V., Feldman, L. J., & Fayad, Z. A. (2007) · Nature Medicine · doi:10.1038/nm1571 · Cited by 467
Dweck, M. R., Jones, C., Joshi, N. V., Fletcher, A. M., Richardson, H., White, A., Marsden, M., Pessotto, R., Clark, J. C., Wallace, W. A., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.051052 · Cited by 337
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Metadata
- Authors
- Rudd, J. H. F., Warburton, E. A., Fryer, T. D., Jones, H. A., Clark, J. C., Antoun, N., Johnström, P., Davenport, A. P., Kirkpatrick, P. J., Arch, B. N., Pickard, J. D., & Weissberg, P. L.
- Venue
- Circulation
- Published
- 2002-06-11
- Volume
- 105
- Issue
- 23
- Pages
- 2708-2711
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2148706200
- Cited by
- 1,226
- References
- 1
- FWCI
- 22.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Imaging Atherosclerotic Plaque Inflammation With [ 18 F]-Fluorodeoxyglucose Positron Emission Tomography. https://app.cochat.ai/papers/10.1161/01.cir.0000020548.60110.76
- The paper
- Rudd, J. H. F., Warburton, E. A., Fryer, T. D., Jones, H. A., Clark, J. C., Antoun, N., Johnström, P., Davenport, A. P., Kirkpatrick, P. J., Arch, B. N., Pickard, J. D., & Weissberg, P. L. (2002). Imaging Atherosclerotic Plaque Inflammation With [ 18 F]-Fluorodeoxyglucose Positron Emission Tomography. Circulation. https://doi.org/10.1161/01.cir.0000020548.60110.76
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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