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Short- and Long-Term Prognosis of Syncope, Risk Factors, and Role of Hospital Admission
Open accessAbstract
Objective We sought to assess short- and long-term prognosis of syncope and associated risk factors.Background Syncope is a common clinical event, but our knowledge of its short-term outcome is largely incomplete. Further, it is unknown whether hospital admission might positively affect a patient's syncope prognosis.Methods We screened 2,775 consecutive subjects who presented for syncope at 4 emergency departments between January and July 2004. Short- and long-term severe outcomes (i.e., death and major therapeutic procedures) and related risk factors were compared in all enrolled patients arrayed according to hospital admission or discharge.Results A total of 676 subjects were included in the study. Forty-one subjects (6.1%) experienced severe outcomes (5 deaths, 0.7%; 36 major therapeutic procedures, 5.4%) in the 10 days after presentation. An abnormal electrocardiogram, concomitant trauma, absence of symptoms of impending syncope, and male gender were associated with short-term unfavorable outcomes. Long-term severe outcomes were 9.3% (40 deaths, 6.0%; 22 major therapeutic procedures, 3.3%), and their occurrence was correlated with an age >65 years, history of neoplasms, cerebrovascular diseases, structural heart diseases, and ventricular arrhythmias. Short-term major therapeutic procedures were more common (p < 0.05) in subjects who had been admitted to hospital (13.3%) than in discharged (1.6%), whereas mortality was similar. One-year mortality was greater (p < 0.05) in admitted (14.7%) than in discharged (1.8%) patients.Conclusions Risk factors for short- and long-term adverse outcomes after syncope differed. Hospital admission favorably influenced syncope short term prognosis. Instead, 1-year mortality was unaffected by hospital admission and related to comorbidity.
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“A few prospective studies developed clinical decision tools to identify patients at risk of serious adverse events within 30 days. 8,9,13,14”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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“However, they have poor diagnostic test characteristics and several methodological flaws that preclude their widespread adoption by clinicians.”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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“Five prospective syncope studies attempted to develop tools for identification of short-term risk of serious adverse events. 8,9,13,14,26”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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“Clinical decision rules can predict poor outcomes, but most syncope deaths and many poor outcomes are associated with underlying illness rather than syncope per se , 58 particularly in the long term. 56”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [56]
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“Several previous prospective studies have reported heart disease and abnormal ECG findings as independent risk factors for serious outcomes among patients with syncope. 13,14,29”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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“The Short-Term Prognosis in Syncope (STePS) Study identified risk factors for death and therapeutic interventions within 10 days. 14”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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“Three of the studies 13,14,26 included re admission to hospital without identification of serious underlying conditions as an outcome.”
From Development of the Canadian Syncope Risk Score to predict serious adverse events after emergency department assessment of syncope (2016) · cites this paper as [14]
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Cites
Incidence and Prognosis of Syncope
Soteriades, E. S., Evans, J. C., Larson, M. G., Chen, M. H., Chen, L., Benjamin, E. J., & Levy, D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012407 · Cited by 1,364
Guidelines on management (diagnosis and treatment) of syncope
Brignole, M. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2739 · Cited by 951
A Prospective Evaluation and Follow-up of Patients with Syncope
Kapoor, W. N., Karpf, M., Wieand, S., Peterson, J. R., & Levey, G. S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198307283090401 · Cited by 779
Guidelines on Management (diagnosis and treatment) of syncope ? update 2004
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janousek, J., et al. (2004) · EP Europace · doi:10.1016/j.eupc.2004.08.008 · Cited by 650
Evaluation and outcome of emergency room patients with transient loss of consciousness
Day, S. C., Cook, E. F., Funkenstein, H., & Goldman, L. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90913-5 · Cited by 587
Guidelines on management (diagnosis and treatment) of syncope-update 2004. Executive Summary.
Brignole, M., Alboni, P., Benditt, D. G., Bergfeldt, L., Blanc, J., Thomsen, P. E. B., van Dijk, J. G., Fitzpatrick, A. P., Hohnloser, S. H., Janoušek, J., et al. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.09.004 · Cited by 566
Evaluation and Outcome of Patients with Syncope
KAPOOR, W. N. (1990) · Medicine · doi:10.1097/00005792-199005000-00004 · Cited by 539
Derivation of the San Francisco Syncope Rule to predict patients with short-term serious outcomes
Quinn, J. V., Stiell, I. G., McDermott, D. A., Sellers, K. L., Kohn, M. A., & Wells, G. A. (2004) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(03)00823-0 · Cited by 432
Colivicchi, F. (2003) · European Heart Journal · doi:10.1016/s0195-668x(02)00827-8 · Cited by 359
Brignole, M., Menozzi, C., Bartoletti, A., Giada, F., Lagi, A., Ungar, A., Ponassi, I., Mussi, C., Maggi, R., Re, G., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi647 · Cited by 332
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Items 201–246 of 246
Risk Stratification of Patients Presenting with Transient Loss of Consciousness
Puppala, V. K., Akkaya, M., Dickinson, O., & Benditt, D. G. (2013) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2013.08.011 · Cited by 1
Yapar, N., Altınbilek, E., Öztürk, D., Ikızcelı, İ., Kavalcı, C., Serin, M., Çaltılı, Ç., & Çelik, B. (2015) · Journal of Pharmaceutical and Scientific Innovation · doi:10.7897/2277-4572.04223 · Cited by 1
Managing Syncope/Collapse in the Emergency Department
Reed, M. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-44507-2_12 · Cited by 1
Kiradoh, S., Craven, T. E., Rangel, M. O., Nosow, L. M., Zarrinkhoo, E., Menon, S., Chevli, P. A., Islam, T., & Thazhatuveetil-Kunhahamed, L. A. (2023) · 老年心脏病学杂志：英文版 · doi:10.26599/1671-5411.2023.01.008 · Cited by 1
Syncope and mortality: The critical component of the pathway or an innocent bystander?
Raj, S. R. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.07.043 · Cited by 1
Synkope - harmlos oder gefährlich?
(2009) · Kardiovask Med · doi:10.4414/cvm.2009.01380
Torres, C. B. (2022) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · doi:10.48713/10336_5019
Transient Loss of Consciousness (T-LOC) Risk Stratification
Brignole, M., & Benditt, D. G. (2010) · Springer eBooks · doi:10.1007/978-0-85729-201-8_6
Höhler, H. (2009) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-009-1164-x
Cambournac-Buan, A., Dadone, B. C., & Trinh-Duc, A. (2015) · EMC - Urgenze · doi:10.1016/s1286-9341(15)70472-2
Managing patients affected by syncope in ER: differential diagnosis and risk stratification
Vitale, E., Maggi, R., Demarchi, P. G., Casagranda, I., & Brignole, M. (2009) · Emergency Care Journal · doi:10.4081/ecj.2009.1.8
Initial Evaluation of Patients with Presumed Syncope
Can, I., & Benditt, D. G. (2008) · Journal of Arrhythmia · doi:10.1016/s1880-4276(08)80018-x
Nsoor, N. A., & Mhearat, A. S. (2009) · Sudan Journal of Medical Sciences · doi:10.4314/sjms.v4i3.48316
Acute alcohol ingestion and sympathetic neural responses during orthostatic stress in humans
Stream, S. F. (2012) · doi:10.37099/mtu.dc.etds/185
“It is due to a decrease in cerebral perfusion, which causes a brief loss of consciousness, followed by a spontaneous recovery (Mosqueda-Garcia et al., 2000; Vaddadi et al., 2007; Chen et al., 2008; Costantino et al., 2008; Moya et al., 2009).”
BackgroundBeleslin, B., Deljanin, M., Kanjuh, V., Parapid, B. J., Giga, V. L., Prostran, M. S., Angelkov, L., Balinovac, J., Bikicki, M., Ambrosio, G., et al. (2013)
Rusconi, A. M. (2013) · Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) · doi:10.13130/rusconi-anna-maria_phd2013-03-25
“giorni potrebbero essere meno affidabili, a causa del numero di pazienti persi al follow-up (16, 18).”
BackgroundClinical Factors associated with Comorbid Cerebral Lesions in Syncope Patients
Chung, J. Y., Kang, H. G., Choo, I. S., Kim, H., Kim, J. H., & Ahn, S. H. (2016) · Journal of the Korean Neurological Association · doi:10.17340/jkna.2016.2.2
“J Korean Neurol Assoc 34(2):99-104, 2016”
BackgroundInfluentialKwong, K. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5825
Syncope, vertigo, and dizziness
Young, W. F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-323-07167-3.00025-5
Emkanjoo, Z., Rezaie, A. R., Kheirkhah, J., & Keikhavani, A. (2016) · doi:10.17795/cce-7206
“Other investigations have shown that hypertension can be a risk factor of cardiovascular mortality in vasovagal syncope (5-8).”
BackgroundBrignole, M., Blanc, J., Sutton, R., & Moyá, A. (2009)
Sorajja, D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99803-9
Syncope and Risk of Sudden Death
Adkisson, W. O., Krishnan, B., & Benditt, D. G. (2017) · Cardiovascular medicine · doi:10.1007/978-3-319-58000-5_19
A syncope megközelítése a kórházi gyakorlatban
Rudas, L. (2017) · Cardiologia Hungarica · doi:10.26430/chungarica.2017.47.4.271
Syncope in the young athlete: Assessment of prognosis in subjects with hypertrophic cardiomyopathy
Magalhães-Ribeiro, C., & Freitas, J. P. (2016) · Revista Portuguesa de Cardiologia (English Edition) · doi:10.1016/j.repce.2016.04.004
Electrophysiology Testing: Appropriate Indications in TLOC/Collapse
Sorajja, D. (2020) · Springer eBooks · doi:10.1007/978-3-030-44507-2_16
Hanna, E. B. (2022) · Wiley eBooks · doi:10.1002/9781119832737.ch26
Syncope : ce qu’il ne faut pas manquer
Kouakam, C. (2013) · Journal Européen des Urgences et de Réanimation · doi:10.1016/j.jeurea.2012.12.002
Bianco, C. M., Nekkanti, R., Latif, F., Hung, P. N., Tran, P., An, H. T., & Nguyen, T. N. (2016) · Wiley eBooks · doi:10.1002/9781118965061.ch10
Brignole, M., Blanc, J., Sutton, R., & Moya‐Mitjans, À. (2009) · doi:10.1093/med/9780199566990.003.026
Windsor, T. A., & Mattu, A. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139136365.028
Good clinical practice and scientific research in the EU - Rome, 2-4 November 2011
Editors, T. M. A. F. C. D. (2012) · Emergency Care Journal · doi:10.4081/ecj.2012.1.22
Sheldon, R. S., Morillo, C. A., Krahn, A. D., & Kuriachan, V. P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0285-9.00050-8
Mace, S. E. (2017) · Cambridge University Press eBooks · doi:10.1017/9781139136365.025
Morillo, C. A., & Expósito-García, V. (2009) · Springer eBooks · doi:10.1007/978-1-84882-927-5_3
Fouad-Tarazi, F. M., Shoemaker, L. K., Mayuga, K., & Jaeger, F. J. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6643-9.00022-9
Sorajja, D., & Shen, W.-K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99803-x
Hanna, E. B. (2017) · doi:10.1002/9781119233503.ch26
Quinn, J., Kim, D. A., Rice, B. T., & Hao, W. D. (2022) · Health Science Reports · doi:10.1002/hsr2.904
Quinn, J. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-3548-2.00064-1
Silva, L. O. J. E., & Bellolio, F. (2023) · Wiley eBooks · doi:10.1002/9781119616870.ch20
Adrian-Lancelle, M., & Trinh-Duc, A. (2023) · EMC - Urgenze · doi:10.1016/s1286-9341(23)47925-2
Benditt, D. G., Lü, F., & Sakaguchi, S. (2009) · Wiley eBooks · doi:10.1002/9781444309768.ch42
Driving With Syncope and Arrhythmia Disorders
Sorajja, D., & Shen, W.-K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15734-9.00052-2
Synkopendiagnostik im Notfallzentrum – Stellenwert der ESC-Leitlinien
Epping, H., Müller-Schilling, M., Dirrigl, G., Rockmann, F., & Brünnler, T. (2025) · Medizinische Klinik - Intensivmedizin und Notfallmedizin · doi:10.1007/s00063-025-01326-0
Metadata
- Authors
- Costantino, G., Perego, F., Dipaola, F., Borella, M., Galli, A., Cantoni, G., Dell’Orto, S., Dassi, S., Filardo, N., Duca, P. G., Montano, N., & Furlan, R.
- Affiliations
- University of Milan (IT)
- Corresponding author
- Furlan, Raffaello
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 51
- Issue
- 3
- Pages
- 276-283
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2169409503
- Cited by
- 246
- References
- 33
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 2 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 12 · 2019: 15 · 2018: 19 · 2017: 22 · 2016: 18 · 2015: 12 · 2014: 27 · 2013: 19 · 2012: 19
- FWCI
- 17.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Regione Lombardia
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Keywords
- syncope, prognosis, risk factors, hospitalization, mortality, electrocardiographic abnormalities, comorbidities, ventricular arrhythmias, structural heart disease, cerebrovascular disease, emergency department patients
- MeSH terms
- Adult, Age Factors, Aged, Analysis of Variance, Arrhythmias, Cardiac, Cardiovascular Diseases, Cause of Death, Female, Hospitalization, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Syncope, Comorbidity
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