Positive Remodeling of the Coronary Arteries Detected by Magnetic Resonance Imaging in an Asymptomatic Population
Open accessAbstract
Objectives The purpose of this study was to assess coronary arterial remodeling as a marker of subclinical atherosclerosis using coronary wall magnetic resonance imaging (MRI) in an asymptomatic population-based cohort.Background In early atherosclerosis, compensatory enlargement of both the outer wall of the vessel as well as the lumen, termed compensatory enlargement or positive remodeling, occurs before luminal narrowing.Methods One hundred seventy-nine participants in the MESA (Multi-Ethnic Study of Atherosclerosis) trial were evaluated using black-blood coronary wall MRI. Coronary cross-sectional area (vessel size), lumen area, and mean wall thickness of the proximal coronary arteries were measured.Results Men had a greater vessel size, lumen area, and mean wall thickness than women (38.3 +/- 11.3 mm2 vs. 32.6 +/- 9.4 mm2, 6.7 +/- 3.2 mm2 vs. 5.3 +/- 2.4 mm2, and 2.0 +/- 0.3 mm vs. 1.9 +/- 0.3 mm, respectively, p < 0.05). No significant coronary artery narrowing was present by magnetic resonance angiography. Overall, coronary vessel size increased 25.9 mm2 per millimeter increase in coronary wall thickness, whereas lumen area increased only slightly at 3.1 mm2 for every millimeter increase in wall thickness (difference in slopes, p < 0.0001). Adjusting for age and sex, participants with an Agatston score >0 were more likely to have wall thickness >2.0 mm (odds ratio: 2.0, 95% confidence interval: 1.01 to 3.84).Conclusions Coronary wall MRI detected positive arterial remodeling in asymptomatic men and women with subclinical atherosclerosis.
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Coronary wall MRI detected positive remodelling in asymptomatic patients with subclinical atherosclerosis.
“Recently, coronary wall MRI detected positive remodelling in asymptomatic patients with subclinical atherosclerosis, opening up a new research field in the prevention of CVD.143”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [143]
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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490 · see citing works
- Authors
- Miao, C., Chen, S., Macedo, R., Lai, S., Liu, K., Li, D., Wasserman, B. A., Vogel-Clausen, J., Lima, J. A. C., & Bluemke, D. A.
- Affiliations
- Johns Hopkins University (US)
- Northwestern University (US)
- National Institutes of Health (US)
- Corresponding author
- Bluemke, David A.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 53
- Issue
- 18
- Pages
- 1708-1715
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC2793325
- OpenAlex
- W172653803
- Cited by
- 143
- References
- 29
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 10 · 2018: 7 · 2017: 11 · 2016: 13 · 2015: 10 · 2014: 13 · 2013: 11 · 2012: 15
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Update notices
- erratum (2009-06-09)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (n01hc95164-17-0-1, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, n01hc95166-21-0-1, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, Z99CL999999, n01hc95163-22-0-1, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01-HC-95160, N01-HC095169, N01 HC-95168, N01 HC95167, (N01-HC-95163, N01 HC-95161, N01 HC95165, N01HC95164, R01HL078909, N01-HC-095159, R01 HL78909, N01‐HC‐95166, N01 HC-95162, N01 HC95169)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- coronary artery remodeling, positive remodeling, subclinical atherosclerosis, coronary lumen area, asymptomatic population, sex differences, Multi-Ethnic Study of Atherosclerosis
- MeSH terms
- Aged, Aged, 80 and over, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Prospective Studies, Biomarkers, Confidence Intervals, Odds Ratio, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Cine
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