Three-dimensional black-blood cardiac magnetic resonance coronary vessel wall imaging detects positive arterial remodeling in patients with nonsignificant coronary artery disease
Abstract
Background — Direct noninvasive visualization of the coronary vessel wall may enhance risk stratification by quantifying subclinical coronary atherosclerotic plaque burden. We sought to evaluate high-resolution black-blood 3D cardiovascular magnetic resonance (CMR) imaging for in vivo visualization of the proximal coronary artery vessel wall. Methods and Results — Twelve adult subjects, including 6 clinically healthy subjects and 6 patients with nonsignificant coronary artery disease (10% to 50% x-ray angiographic diameter reduction) were studied with the use of a commercial 1.5 Tesla CMR scanner. Free-breathing 3D coronary vessel wall imaging was performed along the major axis of the right coronary artery with isotropic spatial resolution (1.0×1.0×1.0 mm 3 ) with the use of a black-blood spiral image acquisition. The proximal vessel wall thickness and luminal diameter were objectively determined with an automated edge detection tool. The 3D CMR vessel wall scans allowed for visualization of the contiguous proximal right coronary artery in all subjects. Both mean vessel wall thickness (1.7±0.3 versus 1.0±0.2 mm) and wall area (25.4±6.9 versus 11.5±5.2 mm 2 ) were significantly increased in the patients compared with the healthy subjects (both P <0.01). The lumen diameter (3.6±0.7 versus 3.4±0.5 mm, P =0.47) and lumen area (8.9±3.4 versus 7.9±3.5 mm 2 , P =0.47) were similar in both groups. Conclusions — Free-breathing 3D black-blood coronary CMR with isotropic resolution identified an increased coronary vessel wall thickness with preservation of lumen size in patients with nonsignificant coronary artery disease, consistent with a “Glagov-type” outward arterial remodeling. This novel approach has the potential to quantify subclinical disease.
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Three-dimensional black blood vessel wall imaging permits in vivo distinction of normal and diseased vessel walls.
“The current fast technical improvement has led to three-dimensional black blood vessel wall imaging, which permits in vivo distinction of 'normal' and diseased vessel walls.145”
From European Guidelines on cardiovascular disease prevention in clinical practice (version 2012) (2012) · cites this paper as [145]
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European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
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- Authors
- Kim, W. Y., Stuber, M., Börnert, P., Kissinger, K. V., Manning, W. J., & Botnar, R. M.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- From the Department of Medicine (W.Y.K., M.S., W.J.M, R.M.B.), Cardiovascular Division, and the Department of Radiology (W.J.M.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass; The MR-Center, Department of Cardiology (W.Y.K.) and Institute of Experimental Clinical Research, Aarhus University Hospital, Skejby Sygehus, Denmark; Philips Medical Systems (M.S., R.M.B.), Best, the Netherlands; and Philips Research Laboratories (P.B.), Hamburg, Germany.
- Venue
- Circulation
- Published
- 2002-07-16
- Volume
- 106
- Issue
- 3
- Pages
- 296-299
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2156244896
- Cited by
- 302
- References
- 17
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 10 · 2018: 3 · 2017: 8 · 2016: 15 · 2015: 11 · 2014: 10 · 2013: 21 · 2012: 12
- FWCI
- 17.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Coronary Artery Anomalies
- Keywords
- coronary artery remodeling, vessel wall thickness, lumen diameter, subclinical coronary atherosclerosis, risk stratification, right coronary artery
- MeSH terms
- Adult, Aged, Coronary Artery Disease, Coronary Vessels, Female, Humans, Male, Middle Aged, Coronary Angiography, Magnetic Resonance Angiography, Imaging, Three-Dimensional
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