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Cited by 110Cardiac Health and Mental HealthCardiac pacing and defibrillation studiesCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Risk of Ventricular Arrhythmia After Implantable Defibrillator Treatment in Anxious Type D Patients

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van den Broek, Krista C., Nyklíček, Ivan, van der Voort, Pepijn H., Alings, Marco, Meijer, Albert, Denollet, Johan·2009·Journal of the American College of Cardiology
DOI 10.1016/j.jacc.2009.04.043
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Abstract

Objectives We sought to examine the combination of adverse psychological factors (anxiety, depression, and distressed or Type D personality) as a predictor of ventricular arrhythmias in patients with implantable cardioverter-defibrillators (ICDs).Background Little is known about the role of psychological factors and their clustering in the occurrence of life-threatening arrhythmias.Methods In this prospective study, 391 patients with an ICD (81% men, age 62.3 +/- 10.4 years) completed anxiety, depression, and Type D personality scales at the time of implantation. The end point was occurrence of ventricular arrhythmia, defined as appropriate ICD therapies, in the first year after implantation.Results Ventricular arrhythmias occurred in 19% (n = 75) of patients. Increased symptoms of depression (p = 0.81) or anxiety (p = 0.31) did not predict arrhythmias. However, anxious patients with a Type D personality had a significantly increased rate of ventricular arrhythmias (21 of 71; 29.6%) as compared with other ICD patients (54 of 320; 16.9%; hazard ratio [HR]: 1.89; 95% confidence interval [CI]: 1.14 to 3.13; p = 0.013). When controlled for the effects of sex, age, ischemic etiology, left ventricular dysfunction, prolonged QRS duration, and medication, anxious Type D patients (HR: 1.72; 95% CI: 1.03 to 2.89; p = 0.039) and secondary prevention patients (HR: 1.91; 95% CI: 1.14 to 3.20; p = 0.014) were at increased risk of ventricular arrhythmias.Conclusions Personality modulated the effect of emotional distress; anxiety predicted a 70% increase in risk of arrhythmia in Type D patients but not in other patients. Anxious Type D patients may be identified and offered additional behavioral support after ICD implantation.

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Metadata

Authors
van den Broek, K. C., Nyklíček, I., van der Voort, P. H., Alings, M., Meijer, A., & Denollet, J.
Affiliations
  • Tilburg University (NL)
  • Amphia Ziekenhuis (NL)
  • Catharina Ziekenhuis (NL)
ORCID
Venue
Journal of the American College of Cardiology
Publisher
Elsevier BV
Published
2009-08
Volume
54
Issue
6
Pages
531-537
ISSN
0735-1097 (ISSN-L)
DOI
10.1016/j.jacc.2009.04.043
OpenAlex
W2068137454
Cited by
110
References
58
Citations by year
2025: 2 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 8 · 2016: 7 · 2015: 6 · 2014: 5 · 2013: 11 · 2012: 18
FWCI
10.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of the American College of Cardiology (publishedVersion)
  • Research portal (Tilburg University) (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Nederlandse Organisatie voor Wetenschappelijk Onderzoek (453-04-004)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
ventricular arrhythmias, implantable cardioverter-defibrillator, Type D personality, anxiety, depression, psychological distress, personality traits, appropriate ICD shocks, secondary prevention, behavioral support
MeSH terms
Aged, Anxiety Disorders, Arrhythmias, Cardiac, Depressive Disorder, Female, Humans, Male, Middle Aged, Personality, Risk Factors, Defibrillators, Implantable

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