CoChat
Sign Up
Cited by 624Cardiac pacing and defibrillation studiesCardiac Health and Mental HealthCardiac electrophysiology and arrhythmias

Quality of Life in the Antiarrhythmics Versus Implantable Defibrillators Trial: Impact of Therapy and Influence of Adverse Symptoms and Defibrillator Shocks

Schron, Eleanor B., Exner, Derek V., Yao, Qing, Jenkins, Louise S., Steinberg, Jonathan S., Cook, James R., Kutalek, Steven P., Friedman, Peter L. +4 more·2002·Circulation
DOI 10.1161/hc0502.103330
Open this paper in CoChat — free account

Abstract

Background — Implantable cardioverter defibrillator (ICD) use reduces mortality in patients with serious ventricular arrhythmias compared with antiarrhythmic drug (AAD) use. However, the relative impact of these therapies on self-perceived quality of life (QoL) is unknown. Methods and Results — Three self-administered instruments were used to measure generic and disease-specific QoL in Antiarrhythmics Versus Implantable Defibrillators trial participants. Generalized linear models were used to assess the relationships between self-perceived QoL and treatment (AAD versus ICD) and adverse symptoms and ICD shocks. To minimize the impact of missing data, only patients surviving 1 year were included in the primary analyses. Baseline characteristics among QoL participants (n=905) and nonparticipants (n=111) were similar, but participants who survived 1 year (n=800) were healthier at baseline than nonsurvivors (n=105). Of the 800 patients in the primary analysis, characteristics of those randomized to AAD (n=384) versus ICD (n=416) were similar. Overall, ICD and AAD use were associated with similar alterations in QoL. The development of sporadic shocks and adverse symptoms were each associated with reduced physical functioning and mental well-being and increased concerns among ICD recipients, whereas development of adverse symptoms was associated with reduced physical functioning and increased concerns among AAD recipients. Conclusions — ICD and AAD therapy are associated with similar alterations in self-perceived QoL over 1-year follow-up. Adverse symptoms were associated with reduced self-perceived QoL in both groups, and sporadic shocks were associated with reduced QoL in ICD recipients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/hc0502.103330

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • There was greater reduction in quality of life as the number of shocks increased.

    “Further, there was greater reduction in QOL as the number of shocks increased.”

    From Managing with pacemakers and implantable cardioverter defibrillators (2013) · cites this paper as [5]

    The ICD Shocks section reports reduced quality of life among recipients who experienced a shock, but says that more frequent shocks (three or more versus fewer than three) were associated with similar alterations. It therefore does not support the claimed greater reduction as shock count increased. (LLM, conf=0.88)

    Checked by a reasoning model — may be wrong.

    Experimental — accuracy not yet measured

  • In the AVID trial, baseline quality of life measured by SF-36 in ICD patients was similar to that of elderly patients with recent myocardial infarction or severe heart failure, but less than for ambulatory patients with heart failure.

    “In the Antiarrhythmics Versus Implanted Defibrillators (AVID) trial, baseline QOL measured by SF-36 in ICD patients was similar to that of elderly patients with recent myocardial infarction or severe heart failure, but less than for ambulatory patients with heart failure”

    From Managing with pacemakers and implantable cardioverter defibrillators (2013) · cites this paper as [5]

  • In the AVID trial, the occurrence of even 1 shock was associated with a reduction in mental well-being and physical function, even after controlling for multiple clinical factors.

    “Similarly, in the AVID trial, 5 the occurrence of even 1 shock was associated with a reduction in mental well-being and physical function, even after controlling for multiple clinical factors such as heart failure, index arrhythmia, and ejection fraction.”

    From Managing with pacemakers and implantable cardioverter defibrillators (2013) · cites this paper as [5]

  • Many studies suggest that ICD shocks can decrease quality of life.

    “As described above, many studies suggest that ICD shocks can decrease QOL.96”

    From Managing with pacemakers and implantable cardioverter defibrillators (2013) · cites this paper as [96]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 2

  1. [9]9. Croog SH. Current issues in conceptualizing and measuring quality of life. In: Quality of Life Assessment: Practice, Problems, and Promise. Proceedings of a workshop sponsored by the Office of the Director, National Institutes of Health. NIH Publication No. 93-3503; 1990.
  2. [20]20. Albert PS. Longitudinal data analysis (repeated measures) in clinical trials. Stat Med. 1999;18:1707-1732.

Cited by

Sorted by citations

Related

Authors
Schron, E. B., Exner, D. V., Yao, Q., Jenkins, L. S., Steinberg, J. S., Cook, J. R., Kutalek, S. P., Friedman, P. L., Bubien, R. S., Page, R. L., Powell, J., & the AVID Investigators
Affiliations
University of Maryland, Baltimore (US)
ORCID
Venue
Circulation
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-02-05
Volume
105
Issue
5
Pages
589-594
ISSN
  • 0009-7322 (ISSN-L)
  • 1524-4539
DOI
10.1161/hc0502.103330
OpenAlex
W2101541776
Semantic Scholar
216ffa4eb6d0222f0b0b6ea03afb7c4d6d95a1c3
Cited by
624
References
39
Citations by year
2026: 5 · 2025: 8 · 2024: 11 · 2023: 16 · 2022: 14 · 2021: 26 · 2020: 19 · 2019: 26 · 2018: 17 · 2017: 27 · 2016: 31 · 2015: 36 · 2014: 24 · 2013: 27 · 2012: 39
FWCI
13.52
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Fondation pour la Recherche Médicale
  • National Institutes of Health (n01hc025117-014)
  • Canadian Institutes of Health Research
  • National Heart, Lung, and Blood Institute (N01-HC-25117)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
quality of life, implantable cardioverter-defibrillator, antiarrhythmic drugs, ventricular arrhythmias, ICD shocks, adverse symptoms, physical function, psychological well-being, patient concerns
MeSH terms
Aged, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Demography, Electric Countershock, Electrocardiography, Female, Humans, Male, Middle Aged, Quality of Life, Surveys and Questionnaires, Treatment Outcome, Defibrillators, Implantable

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review