Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy
Open accessAbstract
Cardiac hypertrophy is a stereotypic response of the heart to increased workload. The nature of the workload increase may vary depending on the stimulus (repetitive, chronic, pressure, or volume overload). If the heart fully adapts to the new loading condition, the hypertrophic response is considered physiological. If the hypertrophic response is associated with the ultimate development of contractile dysfunction and heart failure, the response is considered pathological. Although divergent signalling mechanisms may lead to these distinct patterns of hypertrophy, there is some overlap. Given the close relationship between workload and energy demand, any form of cardiac hypertrophy will impact the energy generation by mitochondria, which are the key organelles for cellular ATP production. Significant changes in the expression of nuclear and mitochondrially encoded transcripts that impact mitochondrial function as well as altered mitochondrial proteome composition and mitochondrial energetics have been described in various forms of cardiac hypertrophy. Here, we review mitochondrial alterations in pathological and physiological hypertrophy. We suggest that mitochondrial adaptations to pathological and physiological hypertrophy are distinct, and we shall review potential mechanisms that might account for these differences.
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Both types of hypertrophy differ at the molecular level in their response to divergent stimuli.
“Both types of hypertrophy differ at the molecular level in their response the divergent stimuli (1).”
From The Hippo signal transduction network for exercise physiologists (2016) · cites this paper as [1]
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- Authors
- Abel, E. D., & Doenst, T.
- Affiliations
- University of Utah (US)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Abel, E. D.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-01-21
- Volume
- 90
- Issue
- 2
- Pages
- 234-242
- ISSN
- 0008-6363 (ISSN-L)
- PMC
- PMC3115280
- OpenAlex
- W2139425458
- Cited by
- 263
- References
- 109
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 8 · 2023: 12 · 2022: 11 · 2021: 14 · 2020: 18 · 2019: 15 · 2018: 19 · 2017: 20 · 2016: 16 · 2015: 24 · 2014: 31 · 2013: 26 · 2012: 22
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cardiovascular Research (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (UO1 HL087947, U01HL087947)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK092065)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- cardiac hypertrophy, mitochondrial function, physiological hypertrophy, pathological hypertrophy, heart failure, mitochondrial proteome, mitochondrial bioenergetics, mitochondrial DNA, nuclear DNA, energy demand, pressure overload, fluid overload, contractile dysfunction
- MeSH terms
- Adaptation, Physiological, Animals, Heart, Cardiomegaly, Humans, Mitochondria, Myocardial Contraction, Signal Transduction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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