Cited by 109Cardiovascular Health and Disease PreventionCardiovascular Function and Risk FactorsCardiovascular Health and Risk Factors

Aging-induced biological changes and cardiovascular diseases.

Open access
Fajemiroye, James Oluwagbamigbe, Cunha, Luiz Carlos da, Saavedra-Rodríguez, Roberto, Rodrigues, Karla Lima, Naves, Lara Marques, Mourão, Aline Andrade, Silva, Elaine Fernanda da, Williams, Nabofa Enivwenaye Egide +7 more·2018·BioMed Research International

Abstract

Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels. In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function. The accumulation of epigenetic changes also plays important roles in the development of CVDs. In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.

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Crossref · 10.1155/2018/7156435

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  • Aging-mediated structural and biochemical modifications coupled with gradual loss of autonomic nervous system regulation and vascular stiffening are consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels.

    “Aging-mediated structural and biochemical modifications coupled with gradual loss of autonomic nervous system regulation and vascular stiffening are consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels (Fajemiroye et al., 2018).”

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  1. [68]Longo M. J. Ferreira D. Correia M. J. Variabilidade da freqüência cardíaca Revista Portuguesa de Cardiologia 1995 14 241 262 7766445

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Authors
Fajemiroye, J. O., Cunha, L. C. D., Saavedra-Rodríguez, R., Rodrigues, K. L., Naves, L. M., Mourão, A. A., Silva, E. F. D., Williams, N. E. E., Martins, J. L. R., Sousa, R. B., Rebelo, A. C. S., Reis, A. A. D. S., Santos, R. D. S., Ferreira-Neto, M. L., & Pedrino, G. R.
Affiliations
  • Universidade Evangelica de Goiás (BR)
  • Center for Studies and Toxicological-Pharmacological Research, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil
  • Universidad Santo Tomás (CL)
  • Universidade Federal de Goiás (BR)
  • Babcock University (NG)
  • University Center of Anápolis-Unievangélica, 75083-515 Anápolis, GO, Brazil
  • Biological Sciences Institute, Federal University of Goiás, Goiânia, GO, Brazil
  • Laboratory of Experimental Physiology, Faculty of Physical Education, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil
Corresponding author
Fajemiroye, James Oluwagbamigbe
Venue
BioMed Research International
Publisher
Wiley
Published
2018-06-10
Volume
2018
Pages
1-14
ISSN
  • 1110-7243 (ISSN-L)
  • 2314-6133
  • 2314-6141
OpenAlex
W2807041150
Cited by
109
References
190
Citations by year
2026: 5 · 2025: 14 · 2024: 18 · 2023: 8 · 2022: 12 · 2021: 24 · 2020: 16 · 2019: 9 · 2018: 3
FWCI
2.42
Type
journal article
Language
en
Open access
Locations
  • BioMed Research International (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Fundação de Amparo à Pesquisa do Estado de Goiás
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
aging, cardiovascular disease, autonomic dysfunction, epigenetic modifications, atherosclerosis, stroke, arterial stiffness, collagen deposition, cardiomyocyte loss, cardiovascular homeostasis, therapeutic target
MeSH terms
Aging, Cardiovascular Diseases, Cardiovascular System, Cardiovascular Physiological Phenomena, Homeostasis, Humans, Myocytes, Cardiac

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