Aging-induced biological changes and cardiovascular diseases.
Open accessAbstract
Aging is characterized by functional decline in homeostatic regulation and vital cellular events. This process can be linked with the development of cardiovascular diseases (CVDs). In this review, we discussed aging-induced biological alterations that are associated with CVDs through the following aspects: (i) structural, biochemical, and functional modifications; (ii) autonomic nervous system (ANS) dysregulation; (iii) epigenetic alterations; and (iv) atherosclerosis and stroke development. Aging-mediated structural and biochemical modifications coupled with gradual loss of ANS regulation, vascular stiffening, and deposition of collagen and calcium often disrupt cardiovascular system homeostasis. The structural and biochemical adjustments have been consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels. In addition, cardiomyocyte loss in this process often reduces adaptive capacity and cardiovascular function. The accumulation of epigenetic changes also plays important roles in the development of CVDs. In summary, the understanding of the aging-mediated changes remains promising towards effective diagnosis, discovery of new drug targets, and development of new therapies for the treatment of CVDs.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Aging-mediated structural and biochemical modifications coupled with gradual loss of autonomic nervous system regulation and vascular stiffening are consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels.
“Aging-mediated structural and biochemical modifications coupled with gradual loss of autonomic nervous system regulation and vascular stiffening are consistently implicated in the progressive increase in mechanical burden and functional breakdown of the heart and vessels (Fajemiroye et al., 2018).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Fajemiroye et al., 2018
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
Autophagy: Renovation of Cells and Tissues
Mizushima, N., & Komatsu, M. (2011) · Cell · doi:10.1016/j.cell.2011.10.026 · Cited by 6,467 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Heart Disease and Stroke Statistics—2008 Update
Writing Group Members, Rosamond, W. D., Flegal, K. M., Furie, K. L., Go, A. S., Greenlund, K. J., Haase, N., Hailpern, S. M., Ho, M., Howard, V. J., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.187998 · Cited by 3,745 · see citing works
Cardiovascular Events Associated with Rofecoxib in a Colorectal Adenoma Chemoprevention Trial
Bresalier, R. S., Sandler, R. S., Quan, H., Bolognese, J. A., Oxenius, B., Horgan, K., Lines, C., Riddell, R., Morton, D., Lanas, A., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050493 · Cited by 2,519 · see citing works
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244 · see citing works
The progression from hypertension to congestive heart failure
Levy, D. (1996) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1996.03530440037034 · Cited by 2,155 · cited 1× · see citing works
“In fact, the LVH in hypertensive patients correlated to higher risk of developing systolic heart failure [187].”
BackgroundEaten alive: a history of macroautophagy
Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Feigin, V. L., Lawes, C. M., Bennett, D. A., & Anderson, C. S. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00266-7 · Cited by 1,932 · cited 1× · see citing works
“Stroke is the second most frequent cause of death after ischemic heart in the developed countries [138] and commonly occurs in individuals over 65 years [139, 140].”
BackgroundThe clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · cited 2× · see citing works
“(2003) [162] demonstrated that increased age was the strongest independent correlate of EDD [163].”
BackgroundHofstra, L., Tordoir, J. H. M., Kitslaar, P. J. E. H. M., Hoeks, A. P. G., & Daemen, M. J. A. P. (1996) · PubMed · doi:10.1161/01.cir.94.6.1283 · Cited by 1,603 · see citing works
The intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585 · see citing works
Cardiovascular disease in Europe: epidemiological update 2016
Townsend, N. P., Wilson, L., Bhatnagar, P., Wickramasinghe, K. K., Rayner, M., & Nichols, M. S. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw334 · Cited by 1,579 · see citing works
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
Nakai, A., Yamaguchi, O., Takeda, T., Higuchi, Y., Hikoso, S., Taniike, M., Omiya, S., Mizote, I., Matsumura, Y., Asahi, M., et al. (2007) · Nature Medicine · doi:10.1038/nm1574 · Cited by 1,520 · see citing works
Bouhlel, M. A., Derudas, B., Rigamonti, E., Dièvart, R., Brozek, J., Haulon, S., Zawadzki, C., Jude, B., Torpier, G., Marx, N., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.010 · Cited by 1,325 · see citing works
Atrial Fibrosis: Mechanisms and Clinical Relevance in Atrial Fibrillation
Burstein, B., & Nattel, S. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.09.064 · Cited by 1,248 · see citing works
Mechanical Factors in Arterial Aging
O’Rourke, M. F., & Hashimoto, J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.12.050 · Cited by 1,245 · see citing works
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016) · Science · doi:10.1126/science.aaf6659 · Cited by 1,195 · see citing works
The changing landscape of ischaemic brain injury mechanisms
Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102 · see citing works
Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study)
Furberg, C. D., Psaty, B. M., Manolio, T. A., Gardin, J. M., Smith, V. E., & Rautaharju, P. M. (1994) · The American Journal of Cardiology · doi:10.1016/0002-9149(94)90363-8 · Cited by 1,096 · see citing works
The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome
Zhang, J., Bottiglieri, T., & McCullough, P. A. (2016) · Cardiorenal Medicine · doi:10.1159/000452283 · Cited by 1,082 · see citing works
Mccraty, R., & Shaffer, F. (2015) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2014.073 · Cited by 1,039 · see citing works
Recent insights into the cellular biology of atherosclerosis
Tabas, I., García-Cardeña, G., & Owens, G. K. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201412052 · Cited by 1,016 · see citing works
The immunology of atherosclerosis
Gisterå, A., & Hansson, G. K. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.51 · Cited by 982 · see citing works
The Sympathetic Nervous System in Heart Failure
Triposkiadis, F., Karayannis, G., Giamouzis, G., Skoularigis, J., Louridas, G., & Butler, J. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.05.015 · Cited by 978 · see citing works
Wang (2012) · doi:10.1161/circresaha.111.261388 · Cited by 957 · see citing works
Rothwell, P., Coull, A., Silver, L., Fairhead, J., Giles, M., Lovelock, C., Redgrave, J., Bull, L. M., Welch, S. J. V., Cuthbertson, F. C., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67702-1 · Cited by 938 · see citing works
Blood–brain barrier: Ageing and microvascular disease – systematic review and meta-analysis
Farrall, A. J., & Wardlaw, J. M. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.07.015 · Cited by 882 · see citing works
Autophagy and aging: The importance of maintaining "clean" cells
Cuervo, A. M., Bergamini, E., Brunk, U. T., Dröge, W., Ffrench, M., & Terman, A. (2005) · Autophagy · doi:10.4161/auto.1.3.2017 · Cited by 792 · see citing works
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
Olivetti, G., Melissari, M., Capasso, J. M., & Anversa, P. (1991) · Circulation Research · doi:10.1161/01.res.68.6.1560 · Cited by 774 · see citing works
Mitchell, G. F. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90549.2008 · Cited by 764 · see citing works
Aging-Associated Cardiovascular Changes and Their Relationship to Heart Failure
Strait, J. B., & Lakatta, E. G. (2011) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.08.011 · Cited by 739 · see citing works
Cardiovascular Disease in Women
Mosca, L. J., Manson, J. E., Sutherland, S. E., Langer, R. D., Manolio, T. A., & Barrett-Connor, E. L. (1997) · Circulation · doi:10.1161/01.cir.96.7.2468 · Cited by 731 · see citing works
Aging and vascular endothelial function in humans
Seals, D. R., Jablonski, K. L., & Donato, A. J. (2011) · Clinical Science · doi:10.1042/cs20100476 · Cited by 725 · see citing works
Epigenetics and aging: the targets and the marks
Fraga, M. F., & Esteller, M. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.05.008 · Cited by 690 · cited 1× · see citing works
“In addition, autonomic nervous system (ANS) dysregulation and complex epigenetic changes also induced CVDs [10, 11].”
BackgroundBlood brain barrier: ageing and microvascular disease-systematic review and meta-analysis
Farrall, A., & Wardlaw, J. M. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.02.089 · Cited by 639 · see citing works
Development of microRNA therapeutics is coming of age
van Rooij, E., & Kauppinen, S. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201100899 · Cited by 625 · see citing works
Adrenergic Nervous System in Heart Failure
Lymperopoulos, A., Rengo, G., & Koch, W. J. (2013) · Circulation Research · doi:10.1161/circresaha.113.300308 · Cited by 608 · see citing works
Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age
Sundlöf, G., & Wallin, B. G. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012170 · Cited by 601 · see citing works
Gender differences and aging: Effects on the human heart
Olivetti, G., Giordano, G., Corradi, D., Melissari, M., Lagrasta, C. A. M., Gambert, S. R., & Anversa, P. (1995) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00282-8 · Cited by 574 · see citing works
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
Walther, D. M., Kasturi, P., Zheng, M., Pinkert, S., Vecchi, G., Ciryam, P., Morimoto, R. I., Dobson, C. M., Vendruscolo, M., Mann, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.032 · Cited by 569 · see citing works
Cardiac Fibrosis in Patients With Atrial Fibrillation
Dzeshka, M. S., Lip, G. Y. H., Snezhitskiy, V. А., & Shantsila, E. (2015) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.06.1313 · Cited by 557 · see citing works
Emerging Risk Factors for Atherosclerotic Vascular Disease
Hackam, D. G., & Anand, S. S. (2003) · JAMA · doi:10.1001/jama.290.7.932 · Cited by 548 · see citing works
Circadian Profile of Cardiac Autonomic Nervous Modulation in Healthy Subjects:
Bonnemeier, H., WIEGAND, U. K. H., Brandes, A., Kluge, N., Katus, H. A., Richardt, G., & Potratz, J. (2003) · Journal of Cardiovascular Electrophysiology · doi:10.1046/j.1540-8167.2003.03078.x · Cited by 532 · see citing works
Protective effects of estrogen on the cardiovascular system
Mendelsohn, M. E. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02405-0 · Cited by 532 · see citing works
Kochanek, K. D., Murphy, S. L., Xu, J., & Tejada‐Vera, B. (2016) · PubMed · Cited by 520 · see citing works
Lipsitz, L. A., Mietus, J. E., Moody, G. B., & Goldberger, A. L. (1990) · Circulation · doi:10.1161/01.cir.81.6.1803 · Cited by 519 · see citing works
Greendale, G. A., Lee, N. P., & Arriola, E. R. (1999) · The Lancet · doi:10.1016/s0140-6736(98)05352-5 · Cited by 467 · see citing works
Biernacka, A., & Frangogiannis, N. G. (2011) · Europe PMC (PubMed Central) · Cited by 456 · see citing works
Inhibition of autophagy in the heart induces age-related cardiomyopathy
Taneike, M., Yamaguchi, O., Nakai, A., Hikoso, S., Takeda, T., Mizote, I., Oka, T., Tamai, T., Oyabu, J., Murakawa, T., et al. (2010) · Autophagy · doi:10.4161/auto.6.5.11947 · Cited by 450 · see citing works
Pokushalov, E. A., Romanov, A. B., CORBUCCI, G., Николаевич, А. С., Викторовна, Б. В., Туров, А. Н., Shirokova, N., Karaskov, A. M., Mittal, S., & Steinberg, J. S. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.05.036 · Cited by 435 · see citing works
Electrical Stimulation to Identify Neural Elements on the Heart: Their Role in Atrial Fibrillation
Scherlag, B. J., Nakagawa, H., Jackman, W. M., Yamanashi, W. S., Patterson, E. S., Po, S. S., & Lazzara, R. (2005) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-005-2492-2 · Cited by 425 · see citing works
Human ageing and the sympathoadrenal system
Seals, D. R., & Esler, M. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00407.x · Cited by 408 · see citing works
Angiogenesis in the atherosclerotic plaque
Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401 · see citing works
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400 · see citing works
Human and economic burden of stroke
Carlo, A. D. (2008) · Age and Ageing · doi:10.1093/ageing/afn282 · Cited by 388 · see citing works
Ragnauth, C. D., Warren, D. T., Liu, Y., McNair, R., Tajsic, T., Figg, N. L., Shroff, R. C., Skepper, J. N., & Shanahan, C. M. (2010) · Circulation · doi:10.1161/circulationaha.109.902056 · Cited by 380 · see citing works
Anti-inflammatory therapies for atherosclerosis
Bäck, M., & Hansson, G. K. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.5 · Cited by 380 · see citing works
Local Shear Stress and Brachial Artery Flow-Mediated Dilation
Mitchell, G. F., Parise, H., Vita, J. A., Larson, M. G., Warner, E., Keaney, J. F., Keyes, M. J., Levy, D. A., Vasan, R. S., & Benjamin, E. J. (2004) · Hypertension · doi:10.1161/01.hyp.0000137305.77635.68 · Cited by 376 · see citing works
Virmani, R., Avolio, A. P., Mergner, W. J., Robinowitz, M., Herderick, E. E., Cornhill, J. F., Guo, S., Liu, T. H., Ou, D. Y., & O’Rourke, M. F. (1991) · PubMed Central · Cited by 371 · see citing works
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4179 · Cited by 334 · see citing works
Effects of Age and Sex on Postprandial Glucose Metabolism
Basu, R., Dalla Man, C., Campioni, M., Basu, A., Klee, G., Toffolo, G., Cobelli, C., & Rizza, R. A. (2006) · Diabetes · doi:10.2337/db05-1692 · Cited by 334 · see citing works
Coronary Intraplaque Hemorrhage Evokes a Novel Atheroprotective Macrophage Phenotype
Boyle, J. J., Harrington, H. A., Piper, E., Elderfield, K., Stark, J., Landis, R. C., & Haskard, D. O. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080431 · Cited by 319 · see citing works
Late-life rapamycin treatment reverses age-related heart dysfunction
Flynn, J. M., O’Leary, M. N., Zambataro, C. A., Academia, E. C., Presley, M. P., Garrett, B., Zykovich, A., Mooney, S. D., Strong, R., Rosen, C. J., et al. (2013) · Aging Cell · doi:10.1111/acel.12109 · Cited by 311 · see citing works
Yamazaki, T., Tobe, K., Hoh, E., Maemura, K., Kaida, T., Komuro, I., Tamemoto, H., Kadowaki, T., Nagai, R., & Yazaki, Y. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50309-x · Cited by 286 · see citing works
Aging Effects on Cerebral Blood and Cerebrospinal Fluid Flows
Stoquart‐ElSankari, S., Balédent, O., Gondry‐Jouet, C., Makki, M., Godefroy, O., & Meyer, M.-É. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600462 · Cited by 281 · see citing works
Aging and the cardiac collagen matrix: Novel mediators of fibrotic remodelling
Horn, M., & Trafford, A. W. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.005 · Cited by 273 · see citing works
Necrotic and apoptotic myocyte cell death in the aging heart of Fischer 344 rats
Kajstura, J., Cheng, W. N., Ranganathan, S., Li, P., Li, B., Nitahara, J., Chapnick, S., Krzysztof Reiss, F., Olivetti, G., & Anversa, P. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.3.h1215 · Cited by 272 · see citing works
Mechanisms of Endothelial Dysfunction, Injury, and Death
Pober, J. S., Wang, M., & Bradley, J. R. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092155 · Cited by 272 · see citing works
Kitada, M., Ogura, Y., & Koya, D. (2016) · Aging · doi:10.18632/aging.101068 · Cited by 270 · see citing works
Everett, T. H., Li, H., Mangrum, J. M., McRury, I. D., Mitchell, M. A., Redick, J. A., & Haines, D. E. (2000) · Circulation · doi:10.1161/01.cir.102.12.1454 · Cited by 252 · see citing works
Cardiac aging and heart disease in humans
Steenman, M., & Lande, G. (2017) · Biophysical Reviews · doi:10.1007/s12551-017-0255-9 · Cited by 249 · see citing works
Heart rate variability in healthy subjects is related to age and gender
Jensen‐Urstad, K., Storck, N., BOUVIER, F., Ericson, M. O., LINDBLAND, L. E., & Jensen‐Urstad, M. (1997) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1997.00142.x · Cited by 242 · see citing works
Age related changes of the collagen network of the human heart
Debessa, C. R. G., Maifrino, L. B. M., & de Souza, R. R. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00238-x · Cited by 242 · see citing works
Griffith, E. C., Su, Z., Niwayama, S., Ramsay, C. A., Chang, Y.-H., & Liu, J. O. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.26.15183 · Cited by 238 · see citing works
Effects of estrogen on gender-related autonomic differences in humans
Liu, C.-C., Kuo, T. B. J., & Yang, C. C. H. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00256.2003 · Cited by 233 · see citing works
microRNA-33 regulates macrophage autophagy in atherosclerosis
Ouimet, M., Ediriweera, H., Afonso, M. S., Ramkhelawon, B., Singaravelu, R., Liao, X., Bandler, R. C., Rahman, K., Fisher, E. A., Rayner, K. J., et al. (2017) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.116.308916 · Cited by 221 · see citing works
Katholi, R. E., & Couri, D. M. (2011) · International Journal of Hypertension · doi:10.4061/2011/495349 · Cited by 217 · see citing works
Cerebral Perfusion and Cerebrovascular Reactivity Are Reduced in White Matter Hyperintensities
Marstrand, J. R., Garde, E., Rostrup, E., Ring, P., Rosenbaum, S., Mortensen, E. L., & Larsson, H. B. W. (2002) · Stroke · doi:10.1161/01.str.0000012808.81667.4b · Cited by 215 · see citing works
Lemery, R., Birnie, D. H., Tang, A., Green, M. S., & Gollob, M. H. (2006) · Heart Rhythm · doi:10.1016/j.hrthm.2006.01.009 · Cited by 209 · see citing works
Mortuza, R., Chen, S., Feng, B., Sen, S., & Chakrabarti, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054514 · Cited by 205 · see citing works
Histone methylation makes its mark on longevity
Han, S., & Brunet, A. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.11.001 · Cited by 204 · see citing works
Hua, Y., Zhang, Y., Ceylan‐Isik, A. F., Wold, L. E., Nunn, J. M., & Ren, J. T. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0222-8 · Cited by 204 · see citing works
Increased Expression of Matrix Metalloproteinase-2 in the Thickened Intima of Aged Rats
Li, Z., Froehlich, J. P., Galis, Z. S., & Lakatta, E. G. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.116 · Cited by 203 · see citing works
Peripheral Vascular Endothelial Dysfunction and Apoptosis in Old Monkeys
Asai, K., Kudej, R. K., Shen, Y.-T., Yang, G.-P., Takagi, G., Kudej, A. B., Geng, Y., Sato, N., Nazareno, J. B., Vatner, D. E., et al. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.6.1493 · Cited by 189 · see citing works
Age as a modifiable risk factor for cardiovascular disease
Sniderman, A. D., & Furberg, C. D. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60313-x · Cited by 185 · see citing works
The role of myocardial fibrillar collagen in ventricular remodeling and function
Janicki, J. S., & Brower, G. L. (2002) · Journal of Cardiac Failure · doi:10.1054/jcaf.2002.129260 · Cited by 184 · see citing works
DiLoreto, R., & Murphy, C. T. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-06-1084 · Cited by 184 · see citing works
Collagen accumulation in heart ventricles as a function of growth and aging
Eghbali, M., Eghbali, M., Robinson, T. F., Seifter, S., & Blumenfeld, O. O. (1989) · Cardiovascular Research · doi:10.1093/cvr/23.8.723 · Cited by 183 · see citing works
Epicardial Adipose Tissue Extent: Relationship With Age, Body Fat Distribution, and Coronaropathy
Silaghi, A., Piercecchi‐Marti, M., Grino, M., Leonetti, G., Alessi, M. C., Clement, K., Dadoun, F., & Dutour, A. (2008) · Obesity · doi:10.1038/oby.2008.379 · Cited by 181 · see citing works
de Jong, G. I., Farkas, E., Stienstra, C. M., Plass, J. R. M., Keijser, J. N., de la Torre, J. C., & Luiten, P. G. M. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00659-9 · Cited by 181 · see citing works
Changes in heart rate variability with age
REARDON, M., & MALIK, M. (1996) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.1996.tb03241.x · Cited by 180 · see citing works
Chiao, Y. A., Ramirez, T. A., Zamilpa, R., Okoronkwo, S. M., Dai, Q., Zhang, J., Jin, Y.-F., & Lindsey, M. L. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs275 · Cited by 178 · see citing works
The role of neuronal signaling in controlling cerebral blood flow
DRAKE, C., & IADECOLA, C. (2007) · Brain and Language · doi:10.1016/j.bandl.2006.08.002 · Cited by 177 · see citing works
Yamamoto, K., Takeshita, K., Shimokawa, T., Yi, H., Isobe, K., Loskutoff, D. J., & Saito, H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.022608799 · Cited by 163 · see citing works
Hotta, H., & Uchida, S. (2010) · Geriatrics & Gerontology International · doi:10.1111/j.1447-0594.2010.00592.x · Cited by 154 · see citing works
Sudden Cardiac Death in End-Stage Renal Disease Patients
Wang, A. Y.-M., Lam, C. W.-K., Chan, I. H.-S., Wang, M., Lui, S., & Sanderson, J. E. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.151167 · Cited by 153 · see citing works
Left ventricular remodeling with age in normal men versus women
Hees, P. S., Fleg, J. L., Lakatta, E. G., & Shapiro, E. P. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02840-0 · Cited by 152 · see citing works
Aging Enhances the Basal Production of IL-6 and CCL2 in Vascular Smooth Muscle Cells
Song, Y., Shen, H., Schenten, D., Shan, P., Lee, P. J., & Goldstein, D. R. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.236349 · Cited by 151 · see citing works
The Role of the Autonomic Ganglia in Atrial Fibrillation
Stavrakis, S., Nakagawa, H., Po, S. S., Scherlag, B. J., Lazzara, R., & Jackman, W. M. (2015) · JACC. Clinical electrophysiology · doi:10.1016/j.jacep.2015.01.005 · Cited by 147 · see citing works
Ueno, M., Tomimoto, H., Akiguchi, I., Wakita, H., & Sakamoto, H. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200201000-00012 · Cited by 147 · see citing works
Protection in the aged heart: preventing the heart-break of old age?
Juhaszova, M., Rabuel, C., Zorov, D. B., Lakatta, E. G., & Sollott, S. J. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.020 · Cited by 142 · see citing works
Liu, J., Masurekar, M. R., Vatner, D. E., et al. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00516.2003 · Cited by 142 · see citing works
Heart-brain interactions in cardiac arrhythmias: role of the autonomic nervous system.
Zipes, D. P. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s94 · Cited by 137 · see citing works
Menezes, A. R., Lavie, C. J., DiNicolantonio, J. J., O’Keefe, J. H., Morin, D. P., Khatib, S., & Milani, R. V. (2013) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2013.01.022 · Cited by 136 · see citing works
Resting cerebral blood flow, attention, and aging
Bertsch, K., Hagemann, D., Hermes, M., Walter, C., Khan, R., & Naumann, E. (2009) · Brain Research · doi:10.1016/j.brainres.2009.02.053 · Cited by 132 · see citing works
Zhang, Y., Mi, S., Hu, N., Doser, T. A., Sun, A., Ge, J., & Ren, J. T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.03.018 · Cited by 132 · see citing works
Elevated Heart Rate Variability in Physically Active Young and Older Adult Women
Davy, K. P., DeSouza, C. A., Jones, P. P., et al. (1998) · Clinical Science · doi:10.1042/cs0940579 · Cited by 130 · see citing works
Human epicardial fat: what is new and what is missing?
Sacks, H. S., & Fain, J. N. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05601.x · Cited by 128 · see citing works
Dinenno, F. A., Masuki, S., & Joyner, M. J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.087668 · Cited by 124 · see citing works
The Conundrum of Arterial Stiffness, Elevated Blood Pressure, and Aging
AlGhatrif, M., & Lakatta, E. G. (2015) · Current Hypertension Reports · doi:10.1007/s11906-014-0523-z · Cited by 123 · see citing works
Low-Level Vagosympathetic Stimulation
Li, S., Scherlag, B. J., Yu, L., Sheng, X., Zhang, Y., Ali, R., Dong, Y., Ghias, M., & Po, S. S. (2009) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.109.868331 · Cited by 122 · see citing works
Immunomodulation of Atherosclerosis
Nilsson, J. Å., Hansson, G. K., & Shah, P. K. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000149142.42590.a2 · Cited by 122 · see citing works
Aging Enhances Autonomic Support of Blood Pressure in Women
Barnes, J. N., Hart, E. C., Curry, T. B., Nicholson, W. T., Eisenach, J. H., Wallin, B. G., Charkoudian, N., & Joyner, M. J. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.02393 · Cited by 121 · see citing works
Mechanisms of Arrhythmias and Conduction Disorders in Older Adults
Mirza, M., Strunets, A., Shen, W.-K., & Jahangir, A. (2012) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2012.08.005 · Cited by 120 · see citing works
Catai, A. M., Chacon‐Mikahil, M. P. T., Martinelli, F., Forti, V. A. M., Silva, E. D. C., Golfetti, R., Martins, L. E. B., Szrajer, J. S., Wanderley, J. S., Lima-Filho, E. C., et al. (2002) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2002000600016 · Cited by 118 · see citing works
Self-citationPal, R., Singh, S. N., Chatterjee, A., & Saha, M. (2014) · AGE · doi:10.1007/s11357-014-9683-7 · Cited by 116 · see citing works
Britton, A. R., Shipley, M. J., Malík, M., Hnatkova, K., Hemingway, H., & Marmot, M. G. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.056 · Cited by 116 · see citing works
Age-related changes in the blood-brain barrier
Shah, G. N., & Mooradian, A. D. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00158-1 · Cited by 115 · see citing works
Kolodgie, F. D., BURKE, A. P., Nakazawa, G., & Virmani, R. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.0000258865.44774.41 · Cited by 107 · see citing works
Horn, M., Graham, H. K., Richards, M. A., Clarke, J. D., Greensmith, D. J., Briston, S. J., Hall, M. C. S., Dibb, K. M., & Trafford, A. W. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.03.011 · Cited by 106 · see citing works
SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity
Rutanen, J., Yaluri, N., Modi, S., Pihlajamäki, J., Vänttinen, M., Itkonen, P., Kainulainen, S., Yamamoto, H., Lagouge, M., Sinclair, D. A., et al. (2010) · Diabetes · doi:10.2337/db09-1191 · Cited by 104 · see citing works
Aging and atherosclerosis in the rabbit
Spagnoli, L. G., Orlandi, A., Mauriello, A., Santeusanio, G., de Angelis, C., Lucreziotti, R., & Ramacci, M. T. (1991) · Atherosclerosis · doi:10.1016/0021-9150(91)90003-l · Cited by 103 · see citing works
Age-related microvascular degeneration in the human cerebral periventricular white matter
Farkas, E., de Vos, R. A. I., Donka, G., Steur, E. N. H. J., Mihály, A., & Luiten, P. G. M. (2006) · Acta Neuropathologica · doi:10.1007/s00401-005-0007-y · Cited by 102 · see citing works
Atherosclerosis and the vascular biology of aging
Crow, M. T. (1996) · Aging Clinical and Experimental Research · doi:10.1007/bf03339572 · Cited by 101 · see citing works
Molecular mechanisms of cardiomyocyte aging
Sheydina, A., Riordon, D. R., & Boheler, K. R. (2011) · Clinical Science · doi:10.1042/cs20110115 · Cited by 101 · see citing works
Increased permeability of blood–brain barrier on the hippocampus of a murine model of senescence
Pelegrı́, C., Canudas, A. M., del Valle, J., Casadesús, G., Smith, M. A., Camins, A., Pallàs, M., & Vilaplana, J. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.07.002 · Cited by 93 · see citing works
Zanetti, M., Cappellari, G. G., Burekovic, I., Barazzoni, R., Stebel, M., & Guarnieri, G. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.07.002 · Cited by 93 · see citing works
Lesniewski, L. A., Connell, M., Durrant, J., Folian, B. J., Anderson, M. C., Donato, A. J., & Seals, D. R. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln049 · Cited by 91 · see citing works
Thijssen, D. H. J., de Groot, P. M., Kooijman, M., Smits, P., & Hopman, M. T. E. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00240.2006 · Cited by 86 · see citing works
Diastolic Dysfunction in the Elderly—The Interstitial Issue
Burlew, B. S. (2004) · The American Journal of Geriatric Cardiology · doi:10.1111/j.1076-7460.2004.00059.x · Cited by 81 · see citing works
Genetic and Epigenetic Regulation of Aortic Aneurysms
Kim, H. W., & Stansfield, B. K. (2017) · BioMed Research International · doi:10.1155/2017/7268521 · Cited by 81 · see citing works
Cardiovascular Disease and Menopause
Patell, R. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/6457.4009 · Cited by 76 · see citing works
Growth Factors, Nutrient Signaling, and Cardiovascular Aging
Fontana, L., Vinciguerra, M., & Longo, V. D. (2012) · Circulation Research · doi:10.1161/circresaha.111.246470 · Cited by 76 · see citing works
High eccentric strength training reduces heart rate variability in healthy older men
de Melo, R. C., Quitério, R. J., Takahashi, A. C. D. M., Silva, E., Martins, L. E. B., & Catai, A. M. (2007) · British Journal of Sports Medicine · doi:10.1136/bjsm.2007.035246 · Cited by 71 · see citing works
Self-citationGalán, M., Varona, S., Orriols, M., et al. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.024513 · Cited by 63 · see citing works
Zhang, Y., Wang, C., Zhou, J., Sun, A., Hueckstaedt, L. K., Ge, J., & Ren, J. T. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.03.016 · Cited by 62 · see citing works
SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease
Furuya, T. K., Silva, P. N., Payão, S. L. M., Rasmussen, L. T., de Lábio, R. W., Bertolucci, P. H. F., Braga, I. L. S., Chen, E., Turecki, G., Mechawar, N., et al. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.07.014 · Cited by 61 · see citing works
Insights into aortic sclerosis and its relationship with coronary artery disease
Milin, A. C., Vorobiof, G., Aksoy, O., & Ardehali, R. (2014) · Journal of the American Heart Association · doi:10.1161/jaha.114.001111 · Cited by 59 · see citing works
Function, Role, and Clinical Application of MicroRNAs in Vascular Aging
Lin, X., Zhan, J., Wang, Y., Tan, P., Chen, Y., Deng, H., & Liu, Y. (2016) · BioMed Research International · doi:10.1155/2016/6021394 · Cited by 59 · see citing works
Wu, B., Yu, L., Wang, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.6814 · Cited by 54 · see citing works
Age-related changes in cyclic GMP and PKG-stimulated cerebellar Na,K-ATPase activity
Scavone, C., Munhoz, C. D., Kawamoto, E. M., et al. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.08.013 · Cited by 53 · see citing works
Staying young at heart: autophagy and adaptation to cardiac aging
Leon, L. J., & Gustafsson, Å. B. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.11.006 · Cited by 53 · see citing works
Jablonski, K., Gates, P. E., Pierce, G. L., & Seals, D. R. (2009) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944709345790 · Cited by 52 · see citing works
Brustovetsky, T., Li, V., & Brustovetsky, N. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.03.017 · Cited by 52 · see citing works
Cardiac hypertrophy is negatively regulated by miR-541
Liu, F., Li, N., Long, B., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.141 · Cited by 50 · see citing works
Walker, A. E., Eskurza, I., Pierce, G. L., Gates, P. E., & Seals, D. R. (2008) · American Journal of Hypertension · doi:10.1038/ajh.2008.353 · Cited by 48 · see citing works
Chakrabarti, S., & Davidge, S. T. (2009) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.07.007 · Cited by 48 · see citing works
Walker, A. E., Seibert, S. M., Donato, A. J., Pierce, G. L., & Seals, D. R. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.145870 · Cited by 48 · see citing works
DeVan, A. E., Eskurza, I., Pierce, G. L., Walker, A. E., Jablonski, K., Kaplon, R. E., & Seals, D. R. (2012) · Clinical Science · doi:10.1042/cs20120291 · Cited by 47 · see citing works
Kaplon, R. E., Walker, A. E., & Seals, D. R. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00721.2011 · Cited by 45 · see citing works
Mendes, A. B. L., Ferro, M., Rodrigues, B., et al. (2012) · PubMed · Cited by 45 · see citing works
Nätt, D., Johansson, I., Faresjö, T., Ludvigsson, J., & Thorsell, A. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0123-z · Cited by 43 · see citing works
Heart rate variability as important approach for assessment autonomic modulation
Ferreira, M. J., & Zanesco, A. (2016) · Motriz Revista de Educação Física · doi:10.1590/s1980-65742016000200001 · Cited by 41 · see citing works
The ageing cardiovascular system
Bolton, E., & Rajkumar, C. (2011) · Reviews in Clinical Gerontology · doi:10.1017/s0959259810000389 · Cited by 40 · see citing works
Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1‐year outcome
Koton, S., Schwammenthal, Y., Merzeliak, O., Philips, T., Tsabari, R., Orion, D., Dichtiar, R., & Tanné, D. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02389.x · Cited by 40 · see citing works
[Aging of the autonomic nervous system].
Shimazu, T., Tamura, N., & Shimazu, K. (2005) · PubMed · Cited by 40 · see citing works
Effects of age and/or puberty on coronary artery atherosclerosis in cynomolgus monkeys
Weingand, K. W., CLARKSON, T., ADAMS, M., & Bostrom, A. (1986) · Atherosclerosis · doi:10.1016/0021-9150(86)90059-6 · Cited by 39 · see citing works
Inflammatory and apoptotic remodeling in autonomic nervous system following myocardial infarction
Gao, C., Howard-Quijano, K. J., Rau, C. D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177750 · Cited by 38 · see citing works
Kanegusuku, H., Queiroz, A. C. C., da Silva, V. J. D., de Mello, M. T., Ugrinowitsch, C., & Forjaz, C. L. M. (2014) · Journal of Aging and Physical Activity · doi:10.1123/japa.2012-0324 · Cited by 36 · see citing works
Epigenetics in Reactive and Reparative Cardiac Fibrogenesis: The Promise of Epigenetic Therapy
Ghosh, A. K., Rai, R., Flevaris, P., & Vaughan, D. E. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25699 · Cited by 34 · see citing works
Kakarla, S. K., Fannin, J. C., Keshavarzian, S., Katta, A., Paturi, S., Nalabotu, S. K., Wu, M., Rice, K. M., Manzoor, K., Walker, E. M., et al. (2010) · Basic Research in Cardiology · doi:10.1007/s00395-010-0094-3 · Cited by 31 · see citing works
MENOPAUSE AND RISK OF CARDIOVASCULAR DISEASE
Gensini, G. F., Micheli, S., Prisco, D., & Abbate, R. (1996) · Thrombosis Research · doi:10.1016/0049-3848(96)00143-0 · Cited by 30 · see citing works
Simões, R. P., Júnior, J. C. B., Beltrame, T., et al. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000056 · Cited by 30 · see citing works
Lipemia pós-prandial: influência do envelhecimento
Issa, J. S., Diament, J., & Forti, N. A. (2005) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2005001400004 · Cited by 27 · see citing works
Shantsila, A., McIntyre, D. B., Lip, G. Y. H., Fadel, P. J., Paton, J. F. R., Pickering, A. E., & Fisher, J. P. (2015) · Experimental Physiology · doi:10.1113/ep085071 · Cited by 23 · see citing works
Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes
Koczor, C. A., Ludlow, I., Fields, E. J., Jiao, Z., Ludaway, T., Russ, R. B., & Lewis, W. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00099.2015 · Cited by 23 · see citing works
Atrial Fibrillation: The Science behind Its Defiance
Czick, M. E., Shapter, C., & Silverman, D. I. (2016) · Aging and Disease · doi:10.14336/ad.2016.0211 · Cited by 23 · see citing works
Costa, E. M., Santos‐Silva, A., Paúl, C., et al. (2015) · BioMed Research International · doi:10.1155/2015/871656 · Cited by 21 · see citing works
Freitas, M., Rodrigues, A. R., Tomada, N., Fonseca, J., Magalhães, A. L., Gouveia, A., & Neves, D. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.13035 · Cited by 21 · see citing works
Masuda, M., Yamada, T., Mizuno, H., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.028 · Cited by 21 · see citing works
Pourrajab, F., Zarch, A. V., Hekmatimoghaddam, S., & Zare‐Khormizi, M. R. (2015) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2015.05.004 · Cited by 18 · see citing works
Longo, A., Ferreira, D., & Correia, M. (1995) · PubMed · Cited by 15 · see citing works
Burkauskienė, A. (2005) · PubMed · Cited by 15 · see citing works
Rebelo, A. C., Tamburús, N., Salviati, M., Celante, V., Takahashi, A., de Sá, M. F., Catai, A., & Silva, E. (2011) · The European Journal of Contraception & Reproductive Health Care · doi:10.3109/13625187.2011.591217 · Cited by 11 · see citing works
Self-citationFrom arterial ageing to cardiovascular disease
Koopman, J. J. E., & Kuipers, R. S. (2017) · The Lancet · doi:10.1016/s0140-6736(17)30763-8 · Cited by 10 · see citing works
Aging-related cerebral microvascular degeneration is an important cause of essential hypertension
Qin, C. C., Hui, R. T., & Liu, Z. H. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.07.038 · Cited by 8 · see citing works
Lemery, R., Cleland, M. J., Bernick, J., et al. (2015) · EP Europace · doi:10.1093/europace/euu336 · Cited by 8 · see citing works
Molecular Mechanisms of Age-Related Cardiac Hypertrophy in the F344XBN Rat Model
Kakarla, N. D. M. S. K. (2014) · Journal of Clinical & Experimental Cardiology · doi:10.4172/2155-9880.1000353 · Cited by 6 · see citing works
Preventive cardiovascular care for older people: fundamental for healthy ageing?
Hill, K. M., Bara, A.-C., Davidson, S., et al. (2013) · Age and Ageing · doi:10.1093/ageing/aft147 · Cited by 5 · see citing works
Autonomic denervation for the treatment of atrial fibrillation.
Katritsis, D. G. (2011) · Europe PMC (PubMed Central) · Cited by 4 · see citing works
Stirbys, P. (2016) · Journal of Atrial Fibrillation · doi:10.4022/jafib.1503 · Cited by 4 · see citing works
Interval Walking Training for Older People: No Pain and Lots of Gain
DiPietro, L. (2017) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000110 · Cited by 3 · see citing works
Re: Issues concerning sarcopenia in ageing adults
Cruz-Jentoft, A. J., Boirie, Y., & Cederholm, T. (2015) · Age and Ageing · doi:10.1093/ageing/afu208 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [68]Longo M. J. Ferreira D. Correia M. J. Variabilidade da freqüência cardíaca Revista Portuguesa de Cardiologia 1995 14 241 262 7766445
Cited by
Sorted by citations
Age-Related Adaptive Immune Changes in Parkinson’s Disease
Kouli, A., & Williams-Gray, C. H. (2022) · Journal of Parkinson's Disease · doi:10.3233/jpd-223228 · Cited by 20 · see citing works
Kutumova, E., Kiselev, I., Sharipov, R., Lifshits, G., & Kolpakov, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.746300 · Cited by 16 · see citing works
- Authors
- Fajemiroye, J. O., Cunha, L. C. D., Saavedra-Rodríguez, R., Rodrigues, K. L., Naves, L. M., Mourão, A. A., Silva, E. F. D., Williams, N. E. E., Martins, J. L. R., Sousa, R. B., Rebelo, A. C. S., Reis, A. A. D. S., Santos, R. D. S., Ferreira-Neto, M. L., & Pedrino, G. R.
- Affiliations
- Universidade Evangelica de Goiás (BR)
- Center for Studies and Toxicological-Pharmacological Research, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil
- Universidad Santo Tomás (CL)
- Universidade Federal de Goiás (BR)
- Babcock University (NG)
- University Center of Anápolis-Unievangélica, 75083-515 Anápolis, GO, Brazil
- Biological Sciences Institute, Federal University of Goiás, Goiânia, GO, Brazil
- Laboratory of Experimental Physiology, Faculty of Physical Education, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil
- Corresponding author
- Fajemiroye, James Oluwagbamigbe
- ORCID
- Venue
- BioMed Research International
- Publisher
- Wiley
- Published
- 2018-06-10
- Volume
- 2018
- Pages
- 1-14
- ISSN
- 1110-7243 (ISSN-L)
- 2314-6133
- 2314-6141
- PMC
- PMC6015721
- OpenAlex
- W2807041150
- Cited by
- 109
- References
- 190
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 18 · 2023: 8 · 2022: 12 · 2021: 24 · 2020: 16 · 2019: 9 · 2018: 3
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- BioMed Research International (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Goiás
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- aging, cardiovascular disease, autonomic dysfunction, epigenetic modifications, atherosclerosis, stroke, arterial stiffness, collagen deposition, cardiomyocyte loss, cardiovascular homeostasis, therapeutic target
- MeSH terms
- Aging, Cardiovascular Diseases, Cardiovascular System, Cardiovascular Physiological Phenomena, Homeostasis, Humans, Myocytes, Cardiac
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review