The DOI matches its Crossref record; 87 of the 88 references it cites were found in a registry or an index.
Use of Herbal Products and Potential Interactions in Patients With Cardiovascular Diseases
Open accessAbstract
More than 15 million people in the U.S. consume herbal remedies or high-dose vitamins. The number of visits to providers of complementary and alternative medicine exceeds those to primary care physicians, for annual out-of-pocket costs of $30 billion. Use of herbal products forms the bulk of treatments, particularly by elderly people who also consume multiple prescription medications for comorbid conditions, which increases the risk of adverse herb-drug-disease interactions. Despite the paucity of scientific evidence supporting the safety or efficacy of herbal products, their widespread promotion in the popular media and the unsubstantiated health care claims about their efficacy drive consumer demand. In this review, we highlight commonly used herbs and their interactions with cardiovascular drugs. We also discuss health-related issues of herbal products and suggest ways to improve their safety to better protect the public from untoward effects.
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“Interactions between foods or dietary supplements and drugs are an underappreciated source of therapeutic variability and iatrogenic risk [1,2].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
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“The failure of patient–clinician communication about supplement use amplifies this risk, as physicians rarely initiate the discussion [1,3].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Unlike drug–drug interactions, those involving “natural” products are frequently omitted at history taking, because of the perception that what is natural is harmless [1,3].”
From Berberine-Drug Interactions: Mechanisms, Clinical Relevance and Risk Stratification-A Narrative Review (2026) · cites this paper as [1]
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Trends in Alternative Medicine Use in the United States, 1990-1997
Eisenberg, D. M., Davis, R. B., Ettner, S. L., Appel, S., Wilkey, S. A., Rompay, M. I. V., & Kessler, R. C. (1998) · JAMA · doi:10.1001/jama.280.18.1569 · Cited by 6,693
Unconventional medicine in the United States-Prevalence, costs, and patterns of use
Eisenberg, D. M., Kessler, R. C., Foster, C., Norlock, F. E., Calkins, D. R., & Delbanco, T. L. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280406 · Cited by 4,177 · cited 1×
“(1,3) ound an increased number of visits to CAM providers from 27 million to 629 million, whereas the number of visits o primary physicians remained, in essence, unchanged Fig.”
BackgroundComplementary and alternative medicine use among adults: United States, 2002
Barnes, P. M., Powell‐Griner, E., McFann, K., & Nahin, R. L. (2004) · Seminars in Integrative Medicine · doi:10.1016/j.sigm.2004.07.003 · Cited by 2,183
Urothelial Carcinoma Associated with the Use of a Chinese Herb (Aristolochia fangchi)
Nortier, J., Martinez, M.-C. M., Schmeiser, H. H., Arlt, V. M., Bieler, C. A., Pétein, M., Depierreux, M. F., Pauw, L. D., Abramowicz, D., Vereerstraeten, P., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200006083422301 · Cited by 979
Haller, C. A., & Benowitz, N. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432502 · Cited by 956
Indinavir concentrations and St John's wort
Piscitelli, S. C., Burstein, A. H., Chaitt, D. G., Alfaro, R. M., & Falloon, J. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05712-8 · Cited by 873
UROTHELIAL CARCINOMA ASSOCIATED WITH THE USE OF A CHINESE HERB ( ARISTOLOCHIA FANGCHI )
Ortier, L. N., Arie, M., Chmeiser, H. S., Rlt, V. O. M. A., Ieler, H. A. B., Etein, M. I. P., Epierreux, M. I. F. D., Auw, L., Bramowicz, D. A. A., & Ereerstraeten, P. I. V. (2014) · Cited by 814
Aristolochic acid nephropathy: A worldwide problem
Debelle, F. D., Vanherweghem, J.-L., & Nortier, J. (2008) · Kidney International · doi:10.1038/ki.2008.129 · Cited by 761
Grapefruit juice–drug interactions
Bailey, D. G., Malcolm, J., Arnold, O., & Spence, J. D. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00764.x · Cited by 751
Ginkgo biloba for cognitive impairment and dementia
Birks, J., & Evans, J. G. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003120.pub3 · Cited by 615
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Items 401–422 of 422
Pharmacological Evidence on Drug-Herbal Interactions on the Human Body
Hui, T. C., Chu, J. X., Lee, W. W., & Ng, C. H. (2023) · Advances in medical education, research, and ethics (AMERE) book series · doi:10.4018/978-1-6684-7828-8.ch009
The Prevalence of Acceptable Quality of Women Herbal Products Sold Online in Malaysia
Campus), U. T. H. O. M. (., Omar, N. A. A., Sabran, S. F., & Campus), U. T. H. O. M. (. (2023) · Journal of Sustainable Natural Resources · doi:10.30880/jsunr.2022.03.02.006
Shayesteh, S., Garjani, A., Azadi, S., & Asgharian, P. (2023) · Jundishapur Journal of Natural Pharmaceutical Products · doi:10.5812/jjnpp-134493
Role of Integrative Wellness in the Care of Cardiometabolic Disorders
Kaur, N., & Talwar, K. K. (2023) · Journal of Cardio-diabetes and metabolic disorders · doi:10.4103/jcdm.jcdm_2_23
Joachimdass, R. J., Teo, C. H., Subramaniam, K., & Loganathan, A. (2023) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.19.s9.37
EVALUATION OF ANTIHYPERTENSIVE POTENTIAL OF AERIAL PARTS OF BETA VULGARIS
(2023) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2023/12.12.7560
RESCIMENTO E PRODUÇÃO DE BIOMASSA DO ALECRIM EM AMBIENTE URBANO
de Castro, H. G., Paixão, G. M., Morais, F. G. F., Cotta, A. P. D. R. T., Oashi, B. Y. A., Deguenon, E. M., Ribeiro, L. L. B., de Souza, L. D. A., & Braga, K. A. D. S. (2024) · Revista Foco · doi:10.54751/revistafoco.v17n3-052
Mohammed, M., & Ibrahim, R. H. (2023) · Mağallaẗ al-Mawṣil li-l-tamrīḍ/Mosul journal of nursing · doi:10.33899/mjn.2023.180602
Organic rosemary cultivation in an urban environment in Juiz de Fora-MG
de Castro, H. G., Paixão, G. M., Morais, F. G. F., Cotta, A. P. D. R. T., Deguenon, E. M., Oashi, B. Y. A., Ribeiro, L. L. B., de Souza, L. D. A., & Braga, K. A. D. S. (2024) · II INTERNATIONAL SEVEN MULTIDISCIPLINARY CONGRESS · doi:10.56238/sevenvmulti2024-070
Ziyodovna, A. N., & qizi, B. G. I. (2024) · European Science Review · doi:10.29013/esr-24-3.4-3-12
Investigation of herbal products used by patients before surgery
Özşaker, E., Cengiz, H., & Pursal, M. (2024) · Progress in Health Sciences · doi:10.5604/01.3001.0054.6291
Plants and Phytochemicals with Antiarrhythmic Properties
Pullaiah, C. P., Raghavendra, M., Rajesham, V. V., Deborah, K. B., Nuli, M. V., Nelson, V. K., & Pullaiah, T. (2024) · Springer eBooks · doi:10.1007/978-981-97-4627-9_6
Use of herbal remedies in chronic heart diseases
Zörner, C. R., Banke, A., & Schjerning, A.-M. (2024) · Ugeskrift for Læger · doi:10.61409/v02240157
Herbal treatments: are there risks for ENT surgery?
Kolotilov, L. V. (2024) · Folia Otorhinolaryngologiae et Pathologiae Respiratoriae · doi:10.33848/fopr633623
Herbal Supplement Consumption: A Rare Case of Cholinergic Syndrome
Çatal, Y., Erdurmuş, Ö. Y., & Koca, A. (2025) · Namık Kemal Tıp Dergisi · doi:10.4274/nkmj.galenos.2025.93446
SINGH, S., YADAV, A. K., Pichholiya, M., & Gupta, S. (2025) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2025v18i4.53941
Amraei, M., Jahanbani, E., Angali, K. A., & Torabipour, A. (2025) · Payesh (Health Monitor) Journal · doi:10.61186/payesh.24.3.367
Herb-Drug Interactions in Modern Healthcare
Chattaraj, B., Nandi, A., Das, A., Hossain, M. A., & Lin, W. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898811532125010011
Doruker, N. Ç., Korkmaz, F. D., & Hacıoğlu, G. (2026) · Journal of Health Sciences and Medicine · doi:10.32322/jhsm.1799106
Herbal Medicine for Anxiety, Depression and Insomnia-A Review
Prasad, M. D. S., & Kushare, V. N. (2026) · International Journal of Scientific Research in Humanities and Social Sciences · doi:10.32628/ijsrhss25328
Jia-mei, F., Sun, X.-Z., Guo, Z.-Y., Zhao, Q., Ya-Xiong, S., Li, H.-X., & Yu, X. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1806765
Ghosh, P., Roy, D., Manna, S. K., Thakur, N., Rangra, N. K., & Singh, A. K. (2026) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9798898814328126010008
Metadata
- Authors
- Tachjian, A., Maria, V., & Jahangir, A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jahangir, Arshad
- ORCID
- Jahangir, Arshad
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 55
- Issue
- 6
- Pages
- 515-525
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC2831618
- OpenAlex
- W2151268696
- Cited by
- 426
- References
- 88
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 26 · 2023: 19 · 2022: 35 · 2021: 23 · 2020: 38 · 2019: 25 · 2018: 30 · 2017: 28 · 2016: 34 · 2015: 39 · 2014: 23 · 2013: 30 · 2012: 25
- FWCI
- 6.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG021201, AG-21201)
- National Heart, Lung, and Blood Institute (R01HL089542, HL089542)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry Medicinal Plant Applications
- Health Sciences › Medicine › Nephrology › Nephrotoxicity and Medicinal Plants
- Keywords
- herbal products, complementary and alternative medicine, herb-drug interactions, cardiovascular disease, cardiovascular drugs, elderly patients, polypharmacy, herbal medicine safety
- MeSH terms
- Cardiovascular Agents, Cardiovascular Diseases, Humans, Phytotherapy, Plants, Medicinal, Treatment Outcome, Herb-Drug Interactions
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