The risk of thromboembolism and need for oral anticoagulation after successful atrial fibrillation ablation
Open accessAbstract
Objectives The aim of this multicenter study was to evaluate the safety of discontinuing oral anticoagulation therapy (OAT) after apparently successful pulmonary vein isolation.Background Atrial fibrillation (AF) is associated with an increased risk of thromboembolic events (TE) and often requires OAT. Pulmonary vein isolation is considered an effective treatment for AF.Methods We studied 3,355 patients, of whom 2,692 (79% male, mean age 57 +/- 11 years) discontinued OAT 3 to 6 months after ablation (Off-OAT group) and 663 (70% male, mean age 59 +/- 11 years) remained on OAT after this period (On-OAT group). CHADS(2) (congestive heart failure, hypertension, age [75 years and older], diabetes mellitus, and a history of stroke or transient ischemic attack) risk scores of 1 and > or =2 were recorded in 723 (27%) and 347 (13%) Off-OAT group patients and in 261 (39%) and 247 (37%) On-OAT group patients, respectively.Results During follow-up (mean 28 +/- 13 months vs. 24 +/- 15 months), 2 (0.07%) Off-OAT group patients and 3 (0.45%) On-OAT group patients had an ischemic stroke (p = 0.06). No other thromboembolic events occurred. No Off-OAT group patient with a CHADS(2) risk score of > or =2 had an ischemic stroke. A major hemorrhage was observed in 1 (0.04%) Off-OAT group patient and 13 (2%) On-OAT group patients (p < 0.0001).Conclusions In this nonrandomized study, the risk-benefit ratio favored the suspension of OAT after successful AF ablation even in patients at moderate-high risk of TE. This conclusion needs to be confirmed by future large randomized trials.
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Observational studies suggest a relatively low stroke rate in the first few years after catheter ablation of atrial fibrillation.
“Although observational studies suggest a relatively low stroke rate in the first few years after catheter ablation of AF, 737,[771][772][773][774][775][776]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [772]
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Self-citation
- Authors
- Themistoclakis, S., Corrado, A., Marchlinski, F. E., Jais, P., Zado, E., Rossillo, A., Di Biase, L., Schweikert, R. A., Saliba, W. I., Horton, R., Mohanty, P., Patel, D., Burkhardt, D. J., Wazni, O. M., Bonso, A., Callans, D. J., Haissaguerre, M., Raviele, A., & Natale, A.
- Affiliations
- Ospedale dell' Angelo (IT)
- University of Pennsylvania (US)
- Cleveland Clinic Akron General (US)
- Cleveland Clinic (US)
- St David's Medical Center (US)
- Corresponding author
- Raviele, Antonio
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 55
- Issue
- 8
- Pages
- 735-743
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2014353486
- Cited by
- 276
- References
- 31
- Citations by year
- 2026: 7 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 10 · 2020: 21 · 2019: 13 · 2018: 16 · 2017: 22 · 2016: 19 · 2015: 21 · 2014: 26 · 2013: 25 · 2012: 34
- FWCI
- 19.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biosense Webster
- Medtronic
- St. Jude Medical
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- atrial fibrillation, oral anticoagulation, anticoagulation discontinuation, pulmonary vein isolation, catheter ablation, thromboembolism, ischemic stroke, major bleeding, CHADS2 score, risk-benefit assessment
- MeSH terms
- Administration, Oral, Aged, Anticoagulants, Atrial Fibrillation, Female, Humans, Male, Middle Aged, Pulmonary Veins, Risk Factors, Thromboembolism, Time Factors, Treatment Outcome, Catheter Ablation
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