The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Worsening Depressive Symptoms Are Associated With Adverse Clinical Outcomes in Patients With Heart Failure
Open accessAbstract
Objectives The purpose of this study was to assess the impact of changes in symptoms of depression over a 1-year period on subsequent clinical outcomes in heart failure (HF) patients.Background Emerging evidence shows that clinical depression, which is prevalent among patients with HF, is associated with a poor prognosis. However, it is uncertain how changes in depression symptoms over time may relate to clinical outcomes.Methods One-hundred forty-seven HF outpatients with ejection fraction of less than 40% were assessed for depressive symptoms using the Beck Depression Inventory (BDI) at baseline and again 1 year later. Cox proportional hazards regression analyses, controlling for established risk factors, were used to evaluate how changes in depressive symptoms were related to a combined primary end point of death or cardiovascular hospitalization over a median follow-up period of 5 years (with a range of 4 to 7 years and no losses to follow-up).Results The 1-year change in symptoms of depression, as indicated by higher BDI scores over a 1-year interval (1-point BDI change hazard ratio [HR]: 1.07, 95% confidence interval [CI]: 1.02 to 1.12, p = 0.007), was associated with death or cardiovascular hospitalization after controlling for baseline depression (baseline BDI HR: 1.1, 95% CI: 1.06 to 1.14, p < 0.001) and established risk factors, including HF cause, age, ejection fraction, plasma N-terminal pro-B-type natriuretic peptide level, and prior hospitalizations.Conclusions Worsening symptoms of depression are associated with a poorer prognosis in HF patients. Routine assessment of symptoms of depression in HF patients may help to guide appropriate medical management of these patients who are at increased risk for adverse clinical outcomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Worsening depression over a year is also a bad omen, hinting that regular monitoring could allow early intervention with the aim of improving outcomes. 100”
From Prioritizing symptom management in the treatment of chronic heart failure (2020) · cites this paper as [100]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Heart Disease and Stroke Statistics—2009 Update
WRITING GROUP MEMBERS, Lloyd‐Jones, D. M., Adams, R. J., Carnethon, M. R., SIMONE, G. D., Ferguson, T. B., Flegal, K. M., Ford, E. S., Furie, K. L., Go, A. S., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191259 · Cited by 3,915
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
(2003) · JAMA · doi:10.1001/jama.289.23.3106 · Cited by 1,870 · cited 1×
“In the ENRICHD trial, the rates of non-fatal MI and all cause mortality were similar between postMI patients randomized to cognitive behavior therapy (CBT) and education controls (19), although a post-hoc analysis revealed that patients who received anti-depressant medication had improved survival compared to similar…”
MethodAssessment of Depression: The Depression Inventory
Beck, A. T., & Beamesderfer, A. (2015) · Modern problems of pharmacopsychiatry/Modern trends in pharmacopsychiatry · doi:10.1159/000395074 · Cited by 1,860 · cited 1×
“Depression—The Beck Depression Inventory (BDI) is a 21-item self-report measure of depressive symptomatology (14).”
BackgroundDepression and 18-Month Prognosis After Myocardial Infarction
Frasure‐Smith, N., Lespérance, F., & Talajic, M. R. (1995) · Circulation · doi:10.1161/01.cir.91.4.999 · Cited by 1,546 · cited 2×
“These studies also document that the cut point of a BDI score of 10 or greater is applicable in cardiac patient populations, where it has been associated with poorer prognosis (3,16,17).”
BackgroundLichtman, J. H., Bigger, J. T., Blumenthal, J. A., Frasure-Smith, N., Kaufmann, P. G., Lespérance, F., Mark, D. B., Sheps, D. S., Taylor, C. B., & Froelicher, E. S. (2008) · Circulation · doi:10.1161/circulationaha.108.190769 · Cited by 1,482
Sertraline treatment of major depression in patients with acute MI or unstable angina
Glassman, A. H. (2002) · JAMA · doi:10.1001/jama.288.6.701 · Cited by 1,414
Jiang, W., Alexander, J., Christopher, E., Kuchibhatla, M., Gaulden, L. H., Cuffe, M. S., Blazing, M. A., Davenport, C., Califf, R. M., Krishnan, R. R., et al. (2001) · Archives of Internal Medicine · doi:10.1001/archinte.161.15.1849 · Cited by 934 · cited 1×
“Studies from multiple investigative teams, including our own, have found that independent of HF disease severity, depressive symptoms are associated with adverse clinical outcomes for HF patients (3-8).”
BackgroundLespérance, F., Frasure‐Smith, N., Talajic, M. R., & Bourassa, M. G. (2002) · Circulation · doi:10.1161/hc0902.104707 · Cited by 722
Depressive symptoms and risk of functional decline and death in patients with heart failure
Vaccarino, V., Kasl, S. V., Abramson, J. L., & Krumholz, H. M. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01334-1 · Cited by 525 · cited 1×
“Studies from multiple investigative teams, including our own, have found that independent of HF disease severity, depressive symptoms are associated with adverse clinical outcomes for HF patients (3-8).”
Background
Cited by
Sorted by citations
Forman, D. E., Arena, R., Boxer, R., Dolansky, M. A., Eng, J. J., Fleg, J. L., Haykowsky, M., Jahangir, A., Kaminsky, L. A., Kitzman, D. W., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000483 · Cited by 319
Blumenthal, J. A., Babyak, M. A., O’Connor, C., Keteyian, S., Landzberg, J., Howlett, J., Kraus, W., Gottlieb, S., Blackburn, G., Swank, A., et al. (2012) · JAMA · doi:10.1001/jama.2012.8720 · Cited by 305
“Diabetes 2322 261 (32) 117 (35) 378 (33) 255 (30) 115 (36) 370 (32)”
InfluentialGoldstein, C. M., Gathright, E. C., & Garcia, S. (2017) · Patient Preference and Adherence · doi:10.2147/ppa.s127277 · Cited by 138
“18 Major depression is associated with increased mortality 3 and 12 months following hospitalization for CVD 19 and 1 year after initial assessment in patients with HF. 20 However, despite decades of research, the scientific community does not fully understand the relationship between depression and mortality.”
InfluentialDepression and cardiovascular disease
Bradley, S. M., & Rumsfeld, J. S. (2015) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2015.02.002 · Cited by 143
“Depression is also associated with an increased risk of recurrent and fatal stroke among patients with prior stoke [12] and an increased risk of heart failure readmission and death among CHF patients [23–25].”
BackgroundTu, R., Zeng, Z., Zhong, G., Wu, W., Lu, Y., Bo, Z., He, Y., Huang, W.-Q., & Yao, L. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.101 · Cited by 132
Depression after heart failure and risk of cardiovascular and all-cause mortality: A meta-analysis
Fan, H., Yu, W., Zhang, Q., Cao, H., Li, J., Wang, J., Shao, Y., & Hu, X. (2014) · Preventive Medicine · doi:10.1016/j.ypmed.2014.03.007 · Cited by 125
Exercise as a therapeutic modality for the prevention and treatment of depression
Blumenthal, J. A., & Rozanski, A. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.02.008 · Cited by 95
Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients
Cooper, L. B., Mentz, R. J., Sun, J., Schulte, P. J., Fleg, J. L., Cooper, L. S., Piña, I. L., Leifer, E., Kraus, W. E., Whellan, D. J., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002327 · Cited by 83
Blumenthal, J. A., Smith, P. J., & Hoffman, B. M. (2012) · ACSMʼs Health & Fitness Journal · doi:10.1249/01.fit.0000416000.09526.eb · Cited by 81
Incidence rates and predictors of major and minor depression in patients with heart failure
Loßnitzer, N., Herzog, W., Störk, S., Wild, B., Müller‐Tasch, T., Lehmkuhl, E., Zugck, C., Regitz‐Zagrosek, V., Pankuweit, S., Maisch, B., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.01.062 · Cited by 73
“Further, recent reports suggest that increasing depressive symptoms may worsen [11], and remission from depression improve cardiovascular outcomes [12].”
BackgroundResultModerators of the relationship between depression and cardiovascular disorders: a systematic review
Baune, B. T., Stuart, M. J., Gilmour, A., Wersching, H., Arolt, V., & Berger, K. (2012) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.05.013 · Cited by 70
Association of Depression and Survival in Patients with Chronic Heart Failure over 12 Years
Adams, J., Kuchibhatla, M. N., Christopher, E. J., Alexander, J. D., Clary, G. L., Cuffe, M. S., Califf, R. M., Krishnan, R. R., O’Connor, C. M., & Jiang, W. (2012) · Psychosomatics · doi:10.1016/j.psym.2011.12.002 · Cited by 66
“In this first prospective study of mortality in HF and depression, worsening depressive symptoms over 1-year follow up was associated with increased hospitalizations or death in HF patients compared to stable or improved symptoms [30].”
BackgroundPrioritizing symptom management in the treatment of chronic heart failure
Koshy, A. O., Gallivan, E. R., McGinlay, M., Straw, S., Drozd, M., Toms, A. G., Gierula, J., Cubbon, R. M., Kearney, M. T., & Witte, K. K. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12875 · Cited by 66
“Worsening depression over a year is also a bad omen, hinting that regular monitoring could allow early intervention with the aim of improving outcomes.(100)A number of mood assessment tools are available including the Hospital Anxiety and Depression Scale, Geriatric Depression Scale–Short Form, and the Patient Health…”
MethodDepression in heart failure: can PHQ-9 help?
Bhatt, K. N., Kalogeropoulos, A. P., Dunbar, S. B., Butler, J., & Georgiopoulou, V. V. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.07.057 · Cited by 64
Liu, J., Chang, L., Wu, S.-Y., & Tsai, P. (2015) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2015.07.005 · Cited by 68
Kupper, N. H. M., Widdershoven, J. W. M. G., & Pedersen, S. S. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.10.029 · Cited by 57
“In patients with HF, the evidence for the association be-tween depression and cardiovascular mortality is mixed (Pelle et al., 2010; Schiffer, et al., 2009; Sherwood et al., 2011; Testa et al., 2011).”
Kovacs, A. H., & Moons, P. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.09.003 · Cited by 55
Pathophysiological relationships between heart failure and depression and anxiety
Chapa, D. W., Akintade, B., Son, H., Woltz, P., Hunt, D., Friedmann, E., Hartung, M. K., & Thomas, S. A. (2014) · Critical Care Nurse · doi:10.4037/ccn2014938 · Cited by 47
Piepenburg, S. M., Faller, H., Gelbrich, G., Störk, S., Warrings, B., Ertl, G., & Angermann, C. E. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001488 · Cited by 46
Sherwood, A., Blumenthal, J. A., Koch, G. G., Hoffman, B. M., Watkins, L. L., Smith, P. J., O’Connor, C. M., Adams, K. F., Rogers, J. G., Sueta, C., et al. (2017) · Circulation: Heart Failure · doi:10.1161/circheartfailure.116.003410 · Cited by 55
“We and others have previously shown that elevated depressive symptoms, and depressive symptoms that worsen over time regardless of initial severity, are associated with adverse clinical outcomes in HF, independent of HF disease severity and comorbidity.(5)”
Disease management programs in chronic heart failure
Moertl, D., Altenberger, J., Bauer, N., Berent, R., Berger, R., Böhmer, A., Ebner, C., Fritsch, M., Geyrhofer, F., Huelsmann, M., et al. (2017) · Wiener klinische Wochenschrift · doi:10.1007/s00508-017-1265-0 · Cited by 53
Chen, Z., Jiang, X., Shi, G., Wang, Y., Chu, X., Wang, Z., Guo, J., Zhu, Y., Chen, J., Wang, X., et al. (2021) · Psychogeriatrics · doi:10.1111/psyg.12696 · Cited by 42
Page, R. L., II, & Lindenfeld, J. M. (2012) · Current Cardiology Reports · doi:10.1007/s11886-012-0259-9 · Cited by 40
Multivariate Risk Scores and Patient Outcomes in Advanced Heart Failure
Ketchum, E. S., & Levy, W. C. (2011) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2011.00241.x · Cited by 35
Risk factors for onset of depression after heart failure hospitalization
Shimizu, Y., Suzuki, M., Okumura, H., & Yamada, S. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.11.003 · Cited by 35
Trends in hospitalization for congestive heart failure, 1996–2009
Munir, M. B., Sharbaugh, M. S., Thoma, F. W., Nisar, M. U., Kamran, A. S., Althouse, A. D., & Saba, S. (2016) · Clinical Cardiology · doi:10.1002/clc.22638 · Cited by 34
“Atrial fibrillation and depression have also been associated with more advanced symptoms of HF that require hospitalization.(16,17) These comorbid conditions may be the results of severe HF but could also contribute to worsening symptoms and decompensation.”
BackgroundKourkoveli, P., Rammos, S., Parissis, J., Maillis, A., Kremastinos, D. T., & PARASKEVAIDIS, I. A. (2014) · Congenital Heart Disease · doi:10.1111/chd.12200 · Cited by 33
Depression predicts mortality and hospitalization in heart failure: A six-years follow-up study
Ramos, S., Prata, J., Bettencourt, P., Gonçalves, F. R., & Coelho, R. C. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.024 · Cited by 33
Yost, G. L., Bhat, G., Mahoney, E., & Tatooles, A. J. (2017) · Psychosomatics · doi:10.1016/j.psym.2017.02.001 · Cited by 32
Dornelas, E. A., & Sears, S. F. (2018) · American Psychologist · doi:10.1037/amp0000318 · Cited by 30
Frequency and predictors of depression in congestive heart failure
Zahid, I., Baig, M. A., Gilani, J. A., Waseem, N., Ather, S., Farooq, A. S., Ghouri, A., Siddiqui, S. N., Kumar, R., Sahil, et al. (2018) · Indian Heart Journal · doi:10.1016/j.ihj.2018.10.410 · Cited by 35
Nitric Oxide Dysregulation in Patients With Heart Failure
Mommersteeg, P. M. C., Schoemaker, R. G., Eisel, U. L. M., Garrelds, I. M., Schalkwijk, C. G., & Kop, W. J. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000162 · Cited by 30
“These findings are in line with the study of Sherwood and colleagues (36), showing that in addition to baseline values, a change in depressive symptoms was significantly associated with hospitalization and mortality in patients with HF.”
ResultSherwood, A., Hill, L. K., Blumenthal, J. A., Adams, K. F., Paine, N. J., Koch, G. G., O’Connor, C. M., Johnson, K. S., & Hinderliter, A. L. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.07.003 · Cited by 29
“The present study was designed to further examine the relation of CV reactivity to mental stress to adverse clinical outcomes in patients with HF. AC C EP TE D M AN U SC R IP T Utilizing a simulated public speaking mental challenge, we also examined the association between BP and heart rate reactivity and a composite…”
MethodAssociation of depression with evolution of heart failure in patients with type 2 diabetes mellitus
Wang, Y., Yang, H., Nolan, M. T., Burgess, J. R., Negishi, K., & Marwick, T. H. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0664-5 · Cited by 29
“Depression is an independent predictor of adverse clinical outcomes in HF, and increases the risk of mortality by 40–50% [15] In elderly patients with newly diagnosed HF, the presence of depression increased the risk of hospital admission by 20%, and depression screening has been suggested as a routine assessment at t…”
BackgroundAssociations Between Depressive Symptoms and HFpEF-Related Outcomes
Chandra, A., Alcalá, M. A. D., Claggett, B. L., Desai, A. S., Fang, J. C.-T., Heitner, J. F., Liu, J., Pitt, B., Solomon, S. D., Pfeffer, M. A., et al. (2020) · JACC Heart Failure · doi:10.1016/j.jchf.2020.06.010 · Cited by 29
Healthy ageing in older adults with cardiovascular disease
Schmanske, N., Ngo, J. M., Kalra, K., Nanna, M. G., & Damluji, A. A. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf231 · Cited by 33
Blumenthal, J. A. (2011) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.78.s1.06 · Cited by 28
Endrighi, R., Dimond, A. J., Waters, A. J., Dimond, C. C., Harris, K. M., Gottlieb, S. S., & Krantz, D. S. (2019) · Psychology and Health · doi:10.1080/08870446.2019.1609676 · Cited by 27
Cardiac Depression Scale: Mokken scaling in heart failure patients
Ski, C. F., Thompson, D. R., Hare, D. L., Stewart, A. G. O., & Watson, R. A. (2012) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-10-141 · Cited by 26
“18 for items (†) showing invariant item ord Discussion Depression in patients with HF is associated with increased hospitalisations, decreased medication adherence, poorer health outcomes, increased mortality, and significant economic costs [5-13].”
BackgroundDepression in Heart Failure: A Systematic Review.
Ishak, W. W., Edwards, G., Herrera, N., Lin, T., Hren, K., Peterson, M., Ngor, A., Liu, A., Kimchi, A., Spiegel, B., et al. (2020) · PubMed Central · Cited by 26
Gelbrich, G., Störk, S., Kreißl‐Kemmer, S., Faller, H., Prettin, C., Heuschmann, P. U., Ertl, G., & Angermann, C. E. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.150 · Cited by 25
Time-course of depressive symptoms in patients with heart failure
Johansson, P., Lesman‐Leegte, I., Lundgren, J., Hillege, H. L., Hoes, A. W., Sanderman, R., van Veldhuisen, D. J., & Jaarsma, T. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.09.019 · Cited by 25
“In patients with HF (n=147) an increase in Beck Depression Inventory score (BDI) from baseline to 1-year follow-up was associated with an increased number of cardiovascular hospitalisations and deaths over a median of 5 years follow-up from baseline [12].”
BackgroundResultHedrick, R., Korouri, S., Tadros, E., Darwish, T., Cortez, V., Triay, D., Pasini, M., Olanisa, L., Herrera, N., Hanna, S., et al. (2020) · Drugs in Context · doi:10.7573/dic.2020-5-4 · Cited by 24
Changes in Depressive Symptoms and Mortality in Patients With Heart Failure
Hwang, B., Moser, D. K., Pelter, M. M., Nesbitt, T. S., & Dracup, K. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000221 · Cited by 23
“(10) reported that worsening depressive symptoms for 1 year were associated with increased risk of hospitalization or mortality in the subsequent 4 years, after controlling for baseline depression and risk factors.”
BackgroundMeyer, T., Hussein, S., Lange, H. W., & Herrmann‐Lingen, C. (2014) · Clinical Research in Cardiology · doi:10.1007/s00392-014-0666-6 · Cited by 23
“while worsening symptoms of depression are associated with a poorer prognosis [5, 6].”
BackgroundMood and Health-Related Quality of Life Among Pediatric Patients With Heart Failure
Menteer, J., Beas, V. N., Chang, J. C., Reed, K. P., & Gold, J. I. (2012) · Pediatric Cardiology · doi:10.1007/s00246-012-0477-3 · Cited by 21
“Depression, a common comorbidity of heart failure (HF) well described and studied in adult patients [6, 7], is associated with morbid and mortal outcomes [16].”
BackgroundPsychological Disorders in Heart Failure
Palo, K. E. D. (2019) · Heart Failure Clinics · doi:10.1016/j.hfc.2019.08.011 · Cited by 20
Depression and Quality of Life Among Heart Failure Patients in Georgia, Eastern Europe
DeWolfe, A., Gogichaishvili, I., Nozadze, N., Tamariz, L. J., Quevedo, H. C., Julian, E., & Hebert, K. A. (2011) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2011.00226.x · Cited by 20
Adhish, V., Husaini, B. A., Taira, D. A., Norris, K., Moonis, M., & Levine, R. S. (2018) · Indian Journal of Community Medicine · doi:10.4103/ijcm.ijcm_151_17 · Cited by 18
“[2] Studies report between 20% and 48% of heart failure (HF) patients who experience depression[3] which adversely affects their quality of life,[4] produces uncertain treatment outcomes,[5] and leads to increased service utilization/hospital re-admissions and premature mortality.”
BackgroundPaine, N. J., Bacon, S., Pelletier, R., Arsenault, A., Diodati, J. G., & Lavoie, K. (2016) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.115.002491 · Cited by 18
Cognitive and Psycholologic Considerations in Pediatric Heart Failure
Hollander, S. A., & Callus, E. (2014) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2014.07.001 · Cited by 17
Comparative Effectiveness of Psychotherapy vs Antidepressants for Depression in Heart Failure
IsHak, W. W., Hamilton, M. A., Korouri, S., Diniz, M. A., Mirocha, J., Hedrick, R., Chernoff, R. A., Black, J. T., Aronow, H. U., Vanle, B., et al. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2023.52094 · Cited by 17
Shen, B., Xu, Y., & Eisenberg, S. (2016) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9579-2 · Cited by 15
Nazir, A., & Smucker, W. D. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.006 · Cited by 15
Figueiredo, J., de Oliveira, G. M. M., Pereira, B. D. B., Figueiredo, A. E. B., do Nascimento, E. M., Garcia, M. I., & Xavier, S. S. (2019) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20190174 · Cited by 14
Prognostic Significance of Depression in Blacks With Heart Failure
Mentz, R. J., Babyak, M. A., Bittner, V., Fleg, J. L., Keteyian, S. J., Swank, A. M., Piña, I. L., Kraus, W. E., Whellan, D. J., O’Connor, C. M., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.001995 · Cited by 15
“Other antidepressant 2% (9) 6% (64) 6% (13) 13% (51) <0.”
Effect of Depression and Sertraline Treatment on Cardiac Function in Female Nonhuman Primates
Groban, L., Kitzman, D. W., Register, T. C., & Shively, C. A. (2014) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000036 · Cited by 14
A Patient’s Guide to Living Confidently With Chronic Heart Failure
Sears, S. F., Woodrow, L. K., Cutitta, K. E., Ford, J. H., Shea, J. B., & Cahill, J. (2013) · Circulation · doi:10.1161/circulationaha.112.000734 · Cited by 13
“This may also be an important opportunity to begin new activities that will help you regain good QoL.”
BackgroundInfluentialIncreased blood pressures in veterans with post traumatic stress disorder
Zadeh, E. M., Khoshdel, A., Avakh, F., & Rahmani, A. (2016) · The International Journal of Psychiatry in Medicine · doi:10.1177/0091217417696734 · Cited by 13
Freedland, K. E., Steinmeyer, B. C., Carney, R. M., Rubin, E. H., & Rich, M. W. (2019) · Health Psychology · doi:10.1037/hea0000682 · Cited by 13
“It has been used in numerous observational, epidemiological, and treatment studies (e.g., Blumenthal et al., 2012; Carney, Freedland, Steinmeyer, Rubin, & Rich, 2016; Sherwood et al., 2011; Wei et al., 2014).”
Ely, A. V., Alio, C., Bygrave, D. C., Burke, M., & Walker, E. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00162 · Cited by 15
“While anxiety has been shown to interfere with cognitive function in healthy individuals (Snyder et al., 2015; Shields et al., 2016), it is also true that cognitive dysfunction is significantly anxiety-provoking, with elevated rates of anxiety reported in treatment-seeking patients with mild…”
BackgroundCall for a Disease-Specific Patient-Reported Outcome Tool in Adult Congenital Heart Disease
Cedars, A. M., & Spertus, J. A. (2014) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.114.001406 · Cited by 12
Podolecki, T., Pudło, R., Mazurek, M., Kozieł, M., Jędrzejczyk‐Patej, E., Boidol, J., Przybylska-Siedlecka, K., Sokal, A., Kowalski, O., Kowalczyk, J. P., et al. (2017) · Cardiology · doi:10.1159/000475522 · Cited by 12
Beniušienė, A., Kontautienė, V., Strukčinskienė, B., Grigolienė, R., Martišauskienė, D., & Jurgaitis, J. (2024) · Healthcare · doi:10.3390/healthcare13010007 · Cited by 13
“It is important to note that scientific research shows that depressive symptoms are common in patients with heart failure and have been associated with increased morbidity and mortality [70,71], as well as impaired health status [72].”
Emotional and behavioral problems in children with dilated cardiomyopathy
van der Mheen, M., van der Meulen, M. H., den Boer, S. L., Schreutelkamp, D. J., van der Ende, J., de Nijs, P. F., Breur, J. M. P. J., Tanke, R. B., Blom, N. A., Rammeloo, L. A. J., et al. (2019) · European Journal of Cardiovascular Nursing · doi:10.1177/1474515119876148 · Cited by 10
Psychological Disorders in Heart Failure
Palo, K. E. D. (2022) · Cardiology Clinics · doi:10.1016/j.ccl.2021.12.014 · Cited by 9
Depression and Severe Heart Failure: Benefits of Cardiac Resynchronization Therapy
Ploux, S., Verdoux, H., Whinnett, Z. I., Ritter, P., Santos, P. D. D., PICARD, F., Clémenty, J., Haı̈ssaguerre, M., & Bordachar, P. (2012) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2011.02258.x · Cited by 9
“Age (years) (n = 68) 69 (12) 69 (13) 68 (11) 68 (13) 69 (11) Male gender (n = 68) 50 (74) 18 (69) 32 (76) 27 (69) 23 (79) Marital status (n = 62)”
Sager, D. M., Burch, A. E., Alhosaini, H., Vaughan, T., & Sears, S. F. (2020) · European Journal of Cardiovascular Nursing · doi:10.1177/1474515120905405 · Cited by 9
Antidepressant use in patients with heart failure
Freedland, K. E., Steinmeyer, B. C., Carney, R. M., Skala, J. A., & Rich, M. W. (2020) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2020.04.006 · Cited by 9
“Antidepressant use also had no effect on event-free survival in an observational study of 209 outpatients with HF [6], hospitalization-free survival in 147 outpatients with HF [7], or mortality in 1,017 outpatients with HF [8], although fluoxetine use predicted mortality in the latter study.”
BackgroundTsuchihashi‐Makaya, M., Matsuo, H., Kakinoki, S., Takechi, S., & Tsutsui, H. (2011) · Journal of Cardiology · doi:10.1016/j.jjcc.2011.04.004 · Cited by 8
Cardiovascular Nursing in Rehabilitative Cardiology: A Review
Izzo, C., Visco, V., Loria, F., Squillante, A., Iannarella, C., Guerriero, A., Cirillo, A., Barbato, M. G., Ferrigno, O., Augusto, A., et al. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12060219 · Cited by 10
“It is a holistic approach which means that people feel supported in mind and body alike [51,52].”
Wang, B., Lei, L., Zhang, H., Miao, F., Zhang, L., Tian, A., & Li, J. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.122.027438 · Cited by 7
“38,39 Our study highlighted that clinicians could easily perform PHQ-2 screening before discharge as well as at 1 month after discharge to identify the patients with high risks of depressive symptoms.”
Neuroimmune Mechanisms of Depression in Heart Failure
Jiménez, J. A., & Mills, P. J. (2012) · Methods in molecular biology · doi:10.1007/978-1-62703-071-7_9 · Cited by 7
Jeong, Y., Yu, H., & Hwang, B. (2022) · Clinical Nursing Research · doi:10.1177/10547738221092864 · Cited by 6
“Psychological problems, such as depression and anxiety, can negatively affect daily activities and are associated with poor prognosis, especially in patients with HF (Falk et al., 2009; Moser et al., 2016; Sherwood et al., 2011).”
BackgroundScreening, assessment and treatment for depression in patients with chronic heart failure
Baird, D. E., Jackson, A. C., Higgins, R. O., Murphy, B. M., & Tully, P. J. (2018) · British Journal of Cardiac Nursing · doi:10.12968/bjca.2018.13.8.386 · Cited by 6
Kao, C. W., Cheng, S. M., Wan, F. J., Lin, W. S., & Chang, Y. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000435 · Cited by 6
“Research findings showed that heart failure patients with higher levels of depression were more likely to die compared with those who had no depressive symptoms [6-12] , and heart failure patients with more depressive symptoms had higher rehospitalization rates [7,10,12,13].”
BackgroundAssessment of Depression in Heart Failure Patients
Connerney, I., & Shapiro, P. A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.030 · Cited by 5
Sherwood, A., Blumenthal, J. A., Mentz, R. J., Koch, G. G., Rogers, J. G., Chang, P. P., Chien, C., Adams, K. F., Rose‐Jones, L. J., Jensen, B. C., et al. (2024) · ESC Heart Failure · doi:10.1002/ehf2.14758 · Cited by 5
“6,8 This limitation is central to understanding the cause – effect nature of the observed association, since worsening depressive symptoms may result in worsening HFrEF disease, or worsening HFrEF disease may result in worsening depressive symptoms.”
BackgroundLugo‐Agudelo, L. H., Navas, C., Contreras, J. A. P., Ortiz, S. D., Caraballo, D., Henao, A. C., García, H. I. G., & Sénior, J. M. (2017) · Revista Colombiana de Cardiología · doi:10.1016/j.rccar.2017.05.018 · Cited by 5
“5 (30-100) 75,5 (20-100) 0,855 Salud general 17 70 (5-95) 80 (5-100) 0,01 22 62,5 (25-95) 65 (0-100) 0,410”
InfluentialQuality of Life and Psychosocial Care in Pediatric Heart Failure
Wilmot, I., & Marino, B. S. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802393-8.00035-1 · Cited by 5
IsHak, W. W., Korouri, S., Darwish, T., Vanle, B., Dang, J., Edwards, G. G., Black, J. T., Aronow, H. U., Kimchi, A., Spiegel, B. M. R., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0244453 · Cited by 5
Escitalopram and Outcomes Among Patients With Depression and Heart Failure—Reply
Angermann, C. E., Deckert, J., & Ertl, G. (2016) · JAMA · doi:10.1001/jama.2016.13888 · Cited by 5
Apoio Social e Coping em Pacientes com Insuficiência Cardíaca
dos Santos, P. A., Ruschel, P. P., & Pfeifer, P. M. (2021) · Revista da SBPH · doi:10.57167/rev-sbph.24.90 · Cited by 4
Epidemiology of Cardiovascular Disease and Depression
Air, T., Tully, P. J., Sweeney, S., & Beltrame, J. F. (2016) · Springer eBooks · doi:10.1007/978-3-319-32480-7_2 · Cited by 4
Reed, J. L., Tulloch, H. E., Ross, H. J., Terada, T., Mistura, M., Marçal, I. R., OH, P. I., & Chih, S. (2025) · CJC Open · doi:10.1016/j.cjco.2025.05.009 · Cited by 3
Polat, S., & Şimşek, N. (2020) · Çukurova medical journal (Online)/Çukurova medical journal · doi:10.17826/cumj.651850 · Cited by 3
The Consultation-Liaison Psychiatry, an effective process between heart and sexuality
Sauvaget, A., & Guitteny, M. (2012) · Sexologies · doi:10.1016/j.sexol.2012.01.007 · Cited by 3
Factors Associated With Depression and Anxiety for Community-Dwelling Patients With Heart Failure
Helal, S. I., Murrells, T., Grealish, A., & Evans, C. (2022) · The Journal of Cardiovascular Nursing · doi:10.1097/jcn.0000000000000958 · Cited by 3
What Treatments Are Effective for Depression in the Palliative Care Setting?
Irwin, S. A., & Block, S. D. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-3796-7.00033-1 · Cited by 2
Developments in Heart Failure 2011
Gaddam, K. K., & Ventura, H. O. (2012) · Congestive Heart Failure · doi:10.1111/j.1751-7133.2012.00292.x · Cited by 2
Depression and race affect hospitalization costs of heart failure patients
Husaini, B. A., Levine, R. S., Novotny, M. L., Cain, V. A., Sampson, U. K. A., & Moonis, M. (2015) · Family Medicine and Community Health · doi:10.15212/fmch.2015.0118 · Cited by 2
Psychological Management of Patients with Heart Failure
Gallagher, J., & Grimaldi, A. S. (2012) · Springer eBooks · doi:10.1007/978-1-4419-5650-7_5 · Cited by 2
Zhang, L., Wang, W., Peng, Y., He, G., Ji, R., Lei, L., Li, J., Pu, B., Liu, Y., Yu, Y., et al. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.01.245 · Cited by 2
Exercise Training as Treatment of Depression in Heart Failure
Milani, R. V., Lavie, C. J., Mehra, M. R., & Ventura, H. O. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.074 · Cited by 2
Podolecki, T., Pudło, R., Mazurek, M., Kozieł-Siołkowska, M. M., Boidol, J., Kowalski, O., Lenarczyk, R., & Kalarus, Z. F. (2024) · Cardiology Journal · doi:10.5603/cj.101837 · Cited by 1
Palagini, L., Bruno, R. M., Guazzelli, M., Taddei, S., Gemignani, A., & Ghiadoni, L. (2012) · CINECA IRIS Institutial research information system (University of Pisa) · Cited by 1
Spiritual Well-Being Of Health Failure Patients
Yusuf, A. M., Pahria, T., & Nuraeni, A. (2019) · Majalah Keperawatan Unpad/Journal of Nursing Care · doi:10.24198/jnc.v2i1.18641 · Cited by 1
“Depression is very dangerous for health failure patients if it is not treated, it worsens the condition of patients, and becomes a risk factor for death (Sherwood et al., 2011).”
BackgroundDepressive symptoms and their associated factors in heart failure patients
He, D., & Pan, M. (2021) · Frontiers of Nursing · doi:10.2478/fon-2021-0039 · Cited by 1
Shafiuzzaman, A. B. M., Chowdhury, A. W., Amin, M. G., Islam, K. N., Hoque, A. M., Ali, I. A., & Kashyapi, B. K. (2024) · Bangladesh Heart Journal · doi:10.3329/bhj.v39i2.75692 · Cited by 1
Kalp Yetersizliği Hastalarında Depresyonun Sol Ventrikül Mekanikleri Üzerine Etkisi
Karakoyun, S., Gürsoy, M. O., Topçu, S., Kalkan, K., Yurttaş, M., Gökdeniz, T., Çağdaş, M., & Aksakal, E. (2016) · Mustafa Kemal Üniversitesi Tıp Dergisi · doi:10.17944/mkutfd.80820 · Cited by 1
Metadata
- Authors
- Sherwood, A., Blumenthal, J. A., Hinderliter, A. L., Koch, G. G., Adams, K. F., Dupree, C. S., Bensimhon, D. R., Johnson, K. S., Trivedi, R., Bowers, M., Christenson, R. H., & O'Connor, C. M.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- University of North Carolina at Chapel Hill (US)
- Cardiovascular Research Foundation (US)
- University of Maryland, Baltimore (US)
- Corresponding author
- Sherwood, Andrew
- ORCID
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 57
- Issue
- 4
- Pages
- 418-423
- ISSN
- 0735-1097 (ISSN-L)
- PMC
- PMC3622450
- OpenAlex
- W2029552522
- Cited by
- 122
- References
- 24
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 4 · 2012: 20
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- National Center for Research Resources
- National Institutes of Health (M01-RR-30)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- heart failure, depression, depressive symptoms, prognosis, mortality, cardiovascular hospitalization, Beck Depression Inventory, symptom change over time, ejection fraction, N-terminal pro-brain natriuretic peptide, depression screening
- MeSH terms
- Aged, Cardiac Output, Cause of Death, Depression, Female, Heart Failure, Hospitalization, Humans, Male, Middle Aged, Outpatients, Predictive Value of Tests, Prognosis, Prospective Studies, Psychiatric Status Rating Scales, Regression Analysis, Severity of Illness Index, Cohort Studies, Incidence, Confidence Intervals, Odds Ratio, Survival Analysis, Hospital Mortality, Age Distribution, Sex Distribution, Sickness Impact Profile, Disease Progression, Risk Assessment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
