CoChat
Sign Up
Cited by 934Cardiac Health and Mental HealthHeart Failure Treatment and ManagementMental Health Treatment and Access

Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure

Jiang, Wei, Alexander, Jude, Christopher, Eric, Kuchibhatla, Maragatha, Gaulden, Laura H., Cuffe, Michael S., Blazing, Michael A., Davenport, Charles +3 more·2001·Archives of Internal Medicine
DOI 10.1001/archinte.161.15.1849
Open this paper in CoChat — free account

Abstract

BACKGROUND: Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes. OBJECTIVE: To determine the prevalence and relationship of depression to outcomes of patients hospitalized with CHF. METHODS: We screened patients aged 18 years or older having New York Heart Association class II or greater CHF, an ejection fraction of 35% or less, or both, admitted between March 1, 1997, and June 30, 1998, to the cardiology service of one hospital. Patients with a Beck Depression Inventory score of 10 or higher underwent a modified National Institute of Mental Health Diagnostic Interview Schedule to identify major depressive disorder. Primary care providers coordinated standard treatment for CHF and other medical and psychiatric disorders. We assessed all-cause mortality and readmission (rehospitalization) rates 3 months and 1 year after depression assessment. Logistic regression analyses were used to evaluate the independent prognostic value of depression after adjustment for clinical risk factors. RESULTS: Of 374 patients screened, 35.3% had a Beck Depression Inventory score of 10 or higher and 13.9% had major depressive disorder. Overall mortality was 7.9% at 3 months and 16.2% at 1 year. Major depression was associated with increased mortality at 3 months (odds ratio, 2.5 vs no depression; P =.08) and at 1 year (odds ratio, 2.23; P =.04) and readmission at 3 months (odds ratio, 1.90; P =.04) and at 1 year (odds ratio, 3.07; P =.005). These increased risks were independent of age, New York Heart Association class, baseline ejection fraction, and ischemic etiology of CHF. CONCLUSIONS: Major depression is common in patients hospitalized with CHF and is independently associated with a poor prognosis.

Integrity signals

Registry

Crossref · 10.1001/archinte.161.15.1849

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In people with cardiovascular diseases and stroke survivors, MDD is associated with increased health care costs and unplanned rehospitalizations.

    “In people with cardiovascular diseases and stroke survivors, MDD is associated with increased health care costs and unplanned rehospitalizations23,25, an increased risk of atrial fibrillation and chest pain2, and a significant decrease in quality of life45,46.”

    From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [25]

  • Depressed patients with a chronic medical illness are usually sicker than their counterparts.

    “Depressed patients with a chronic medical illness are usually sicker than their counterparts37–46 and have lower treatment adherence.37,47–51”

    From Anxiety and Depression in COPD (2008) · cites this paper as [46]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Jiang, W., Alexander, J., Christopher, E., Kuchibhatla, M., Gaulden, L. H., Cuffe, M. S., Blazing, M. A., Davenport, C., Califf, R. M., Krishnan, R. R., & O'Connor, C. M.
Affiliations
Duke Medical Center (US)
ORCID
Venue
Archives of Internal Medicine
Publisher
American Medical Association (AMA)
Published
2001-08-13
Volume
161
Issue
15
Pages
1849
ISSN
0003-9926 (ISSN-L)
DOI
10.1001/archinte.161.15.1849
OpenAlex
W2106239116
Cited by
934
References
44
Citations by year
2026: 8 · 2025: 16 · 2024: 19 · 2023: 19 · 2022: 23 · 2021: 16 · 2020: 26 · 2019: 20 · 2018: 24 · 2017: 40 · 2016: 50 · 2015: 50 · 2014: 35 · 2013: 45 · 2012: 66
FWCI
27.92
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (5P60-AG11268, P60AG011268)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
Keywords
depression, congestive heart failure, major depressive disorder, all-cause mortality, hospital readmission, prognosis, depression prevalence, Beck Depression Inventory, NYHA functional class, ejection fraction, psychiatric comorbidity
MeSH terms
Adult, Aged, Analysis of Variance, Depressive Disorder, Major, Major Depressive Disorder, Female, Heart Failure, Humans, Male, Middle Aged, Patient Readmission, Prognosis, Risk, Severity of Illness Index, Prevalence, Logistic Models, Odds Ratio

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review