The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Composition of Coronary Thrombus in Acute Myocardial Infarction
Open accessAbstract
Objective To analyse composition of coronary thrombus in vivo, in ST-elevation Myocardial Infarction (STEMI) patients. Background The dynamic process of intracoronary thrombus formation in STEMI patients is poorly understood. Methods Intracoronary thrombi (n=45) were obtained by thromboaspiration in 288 consecutive STEMI patients presenting for primary percutaneous intervention and analyzed using high definition pictures taken with a scanning electron microscope. Plasma biomarkers (TnI, CRPus, IL-6, PAI-1, sCD40 ligand and TNF-α) and plasma fibrin clots viscoelastic properties were measured simultaneously on peripheral blood. Results Thrombi were mainly composed of fibrin (55.9±18%) with platelets (16.8±18%), erythrocytes (11.5±9%), cholesterol crystal (5.2±8.4%) and leukocytes (1.3±2.0%). The median ischemic time was 175 min [IQR 140-297]. Ischemic time impacted thrombi composition, resulting in a positive correlation with intracoronary thrombus fibrin content, r=0.38, p=0.01 and a negative correlation with platelet content r=-0.34, p=0.02. Thus, fibrin content increased with ischemic time, ranging from 48.4±21% (<3 hours) up to 66.9±9% (>6 hours) (p=0.02), while platelet content decreased from 24.9±23% (<3 hours) to 9.1±6% (>6 hours) (p=0.07). Soluble CD40 ligand was positively correlated to platelet content in the thrombus (r=0.40, p=0.02) and negatively correlated with fibrin content (r=-0.36; p=0.04). Multivariate analysis indicated that ischemic time was the only predictor of thrombus composition with a 2-fold increase of fibrin-content per ischemic hour (adjusted OR2 [1.03-3.7] p=0.01). Conclusions In acute STEMI, platelet and fibrin contents of the occlusive thrombus are highly dependent of ischemic time, which may have a direct impact on the efficacy of drugs or devices used for coronary reperfusion.
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Cites
Prevalence of Total Coronary Occlusion during the Early Hours of Transmural Myocardial Infarction
DeWood, M. A., Spores, J., Notske, R., Mouser, L. T., Burroughs, R., Golden, M. S., & Lang, H. T. (1980) · New England Journal of Medicine · doi:10.1056/nejm198010163031601 · Cited by 2,740
Collins, T. J. (2007) · BioTechniques · doi:10.2144/000112517 · Cited by 2,124
De Luca, G., Suryapranata, H., Ottervanger, J. P., & Antman, E. M. (2004) · Circulation · doi:10.1161/01.cir.0000121424.76486.20 · Cited by 1,542
Images in Cardiovascular Medicine
(2012) · Wilderness & Environmental Medicine · doi:10.1016/j.wem.2012.05.013 · Cited by 1,519
van ‘t Hof, A. W. J., Liem, A., Suryapranata, H., Hoorntje, J. C. A., de Boer, M.-J., & Zijlstra, F. (1998) · Circulation · doi:10.1161/01.cir.97.23.2302 · Cited by 1,307
Vlaar, P. J., Svilaas, T., van der Horst, I. C., Diercks, G. F., Fokkema, M. L., de Smet, B. J., van den Heuvel, A. F., Anthonio, R. L., Jessurun, G. A., Tan, E.-S., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)60833-8 · Cited by 900
Facilitated PCI in Patients with ST-Elevation Myocardial Infarction
Ellis, S. G., Tendera, M., de Belder, M. A., van Boven, A. J., Widimsky, P., Janssens, L., Andersen, H. R., Betriu, A., Savonitto, S., Adamus, J., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706816 · Cited by 696
Self-citationBoersma, E. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehi810 · Cited by 680
Steg, P. G., Bonnefoy, E., Chabaud, S., Lapostolle, F., Dubien, P.-Y., Cristofini, P., Leizorovicz, A., & Touboul, P. (2003) · Circulation · doi:10.1161/01.cir.0000103122.10021.f2 · Cited by 545
van't Hof, A. W., ten Berg, J., Heestermans, T., Dill, T., Funck, R. C., van Werkum, W., Dambrink, J.-H. E., Suryapranata, H., van Houwelingen, G., Ottervanger, J. P., et al. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61235-0 · Cited by 512
Cited by
Fibrin Formation, Structure and Properties
Weisel, J. W., & Litvinov, R. I. (2017) · Subcellular Biochemistry · doi:10.1007/978-3-319-49674-0_13 · Cited by 729
Self-citationThrombosis formation on atherosclerotic lesions and plaque rupture
Badimon, L., & Vilahur, G. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12296 · Cited by 697
Mechanisms of fibrin polymerization and clinical implications
Weisel, J. W., & Litvinov, R. I. (2013) · Blood · doi:10.1182/blood-2012-09-306639 · Cited by 516
Self-citationCines, D. B., Lebedeva, T., Nagaswami, C., Hayes, V., Massefski, W., Litvinov, R. I., Rauova, L., Lowery, T. J., & Weisel, J. W. (2014) · Blood · doi:10.1182/blood-2013-08-523860 · Cited by 420
Self-citationThrombus Structural Composition in Cardiovascular Disease
Alkarithi, G., Duval, C., Shi, Y., Macrae, F. L., & Ariëns, R. A. S. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.315754 · Cited by 293
Metadata
- Authors
- Silvain, J., Collet, J.-P., Nagaswami, C., Beygui, F., Edmondson, K. E., Bellemain-Appaix, A., Cayla, G., Pena, A., Brugier, D., Barthelemy, O., Montalescot, G., & Weisel, J. W.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 57
- Issue
- 12
- Pages
- 1359-1367
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W2107371049
- Cited by
- 393
- References
- 28
- FWCI
- 21.33
- Type
- journal article
- Language
- en
- Open access
- bronze
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