Are All Clinical Trial Sites Created Equal?
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International trials of various pharmacotherapies have sometimes found discordant results in patients enrolled in the United States than seen in overall trial results.
“International trials of various pharmacotherapies have sometimes found discordant results in patients enrolled in the United States than seen in overall trial results.19–32”
From REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States (2020) · cites this paper as [23]
The reasons for discordant US results range from low numbers of patients enrolled in the United States to potential differences in background medical management or in patient risk profiles.
“The reasons range from low numbers of patients enrolled in the United States to potential differences in background medical management or in patient risk profiles.”
From REDUCE-IT USA: Results From the 3146 Patients Randomized in the United States (2020) · cites this paper as [23]
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Cites
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Ethical and Scientific Implications of the Globalization of Clinical Research
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Influence of Global Region on Outcomes in Heart Failure Beta-Blocker Trials
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Self-citationGuided Antithrombotic Therapy: Current Status and Future Research Direction
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Self-citationInterpreting observational studies—look before you leap
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SGLT-2 Inhibitors and Cardiovascular Risk
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Self-citationREDUCE-IT USA: Results From the 3146 Patients Randomized in the United States
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Self-citationO'Leary, C. P., & Cavender, M. A. (2020) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13948 · Cited by 23 · see citing works
Self-citationCangrelor in Older Patients Undergoing Percutaneous Coronary Intervention
Cavender, M. A., Bhatt, D. L., Stone, G. W., Steg, P. G., Gibson, C. M., Hamm, C. W., Price, M. J., Prats, J., Elkin, S., Deliargyris, E., et al. (2017) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.117.005257 · Cited by 16 · see citing works
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Self-citationIncentivizing Recruitment and Retention to Address Enrollment Challenges in Clinical Research
Dickert, N. W., Halpern, S. D., & Butler, J. (2013) · Circulation Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.113.000176 · Cited by 12 · see citing works
Can BRIGHT Restore the Glow of Bivalirudin?
Cavender, M. A., & Faxon, D. P. (2015) · JAMA · doi:10.1001/jama.2015.2345 · Cited by 8 · see citing works
Self-citationReconfiguring the Cardiovascular Clinical Trial Enterprise in the United States
Bhatt, D. L. (2021) · JAMA Network Open · doi:10.1001/jamanetworkopen.2021.18176 · Cited by 6 · see citing works
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Recruitment Practices in Multicenter Randomized Clinical Trials: Time for a Relook
Gaba, P., & Bhatt, D. L. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.023673 · Cited by 1 · see citing works
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- Authors
- Bhatt, D. L., & Cavender, M. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Bhatt, Deepak L.
- Venue
- Journal of the American College of Cardiology
- Publisher
- Elsevier BV
- Published
- 2013-02
- Volume
- 61
- Issue
- 5
- Pages
- 580-581
- ISSN
- 0735-1097 (ISSN-L)
- OpenAlex
- W55307716
- Cited by
- 10
- References
- 14
- Citations by year
- 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of the American College of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amarin
- AstraZeneca
- Bristol-Myers Squibb
- Eisai
- Ethicon
- Medtronic
- Sanofi Aventis
- The Medicines Company
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmaceutical industry and healthcare
- Keywords
- clinical trial sites, generalizability of trial results, randomized controlled trials
- MeSH terms
- Tolvaptan, Benzazepines, Female, Heart Failure, Humans, Male, Vasopressins, Patient Selection
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